Clinical trials: Siblings
Breast Cancer
Blood Sample Collection and Health Information Collection From Patients With Invasive Breast Cancer and Their Brothers and Sisters
RATIONALE: Collecting blood samples and health information from patients with invasive breast cancer and from their brothers and sisters over time may help the study of cancer in the future.
- Trial name
- NCT00445562
- Testing
- biologic sample preservation procedure, informational intervention
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- GenBasix Incorporated
Autism, Autism Spectrum Disorder
Milieu Teaching-AV: Adaptation of Milieu Teaching That Encourages Looking to the Mouth
This project will look at Milieu Teaching (i.e., a language intervention) that encourages looking to audiovisual speech cues (Milieu Teaching-AV) for infants with autistic older siblings (Baby Sibs), who are highly likely be…
- Conditions
- Autism, Autism Spectrum Disorder, Autism, Susceptibility to, 6
- Trial name
- MilieuTeach-AV (NCT07494513)
- Testing
- Milieu Teaching-AV, Milieu Teaching-NoAV
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Father Flanagan's Boys' Home
Immunosuppression, Kidney Transplantation
HLA-Identical Sibling Renal Transplant Tolerance
The purpose of this study is to attempt to eliminate the necessity of immunosuppressive therapy for HLA-identical sibling Kidney Transplants, examine cellular chimerism of donor hematopoietic stem cell (DHSC) lineages for pairs…
- Conditions
- Immunosuppression, Kidney Transplantation, Graft Rejection
- Trial name
- NCT00619528
- Testing
- Infusion of Donor Hematopoietic Stem Cells and Campath-1H
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Autism Spectrum Disorder
Feasibility Controlled Trial of an 8-session Group Intervention for Siblings of Children Who Have ASD
A feasibility controlled trial of an eight-session group intervention for siblings of children who have an Autism Spectrum Disorder (ASD). Children will be recruited from a multi-academy trust of nine schools.
- Trial name
- NCT04714606
- Testing
- Sibling support group, None - control condition
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Embryonic Mosaicism, Embryo Culture Media
Media, Morphokinetics, and Mosaicism
Embryonic aneuploidy is the underlying etiology for the majority of failed implantation and miscarriage. Preimplantation genetic screening (PGS) with transfer of a euploid embryo has been advocated as a strategy for increasing…
- Conditions
- Embryonic Mosaicism, Embryo Culture Media, Embryo Morphokinetics, Infertility
- Trial name
- 3M (NCT03503877)
- Testing
- EmbryoScope Plus, GLOBAL MEDIA, SAGE MEDIA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy, Epidural Analgesia, Obstetric
Intelligence and Neurodevelopmental Outcome After Prenatal Exposure to Labour Epidural Analgesia: a Sibling Matched Clinical Ambidirectional Cohort Study
In Belgium, labour epidural analgesia (LEA) has been used for decades in the vast majority of vaginal deliveries (up to 83% of deliveries).
- Trial name
- NCT07014956
- Testing
- Labour epidural analgesia
- Where
- Belgium
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type1diabetes, Type1 Diabetes Mellitus
Modulation of Type 1 Diabetes Susceptibility Through the Use of Probiotics
Investigators aim to further the understanding of environmental factors that underlie the progression to Type 1 diabetes (T1D). Dysbiosis, defined as alterations in intestinal microbiota composition and function, has been…
- Trial name
- NCT03423589
- Testing
- VSL#3
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Anxiety, Depression
Sibling-Support for Adolescent Girls (SSAGE)
Forcibly displaced adolescents face increased risks for mental illness and distress, with adolescent girls disproportionately affected in part due to the heightened gender inequity that often accompanies forced displacement.
- Conditions
- Anxiety, Depression, Mental Illness
- Trial name
- NCT06078124
- Testing
- Sibling Support for Adolescent Girls in Emergencies
- Where
- Colombia
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Children With Chronic Illnesses, Caregiver Burden
Siblings as Caregivers
The current body of research fails to acknowledge or understand what type of care children are giving to their siblings, yet it appears to be a common practice in many cultures.
- Trial name
- NCT05937724
- Testing
- Family Caregiving
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Utah
Acute Leukemia, Acute Lymphoblastic Leukemia
Anti-Covid-19 Vaccine in Children With Acute Leukemia and Their Siblings
Mortality in case of SARS-CoV-2 infection (Covid-19) during acute leukemia (AL) treatment is around 30%, i.e. more than 10 times the one of general population. Severe forms are reported in children receiving chemotherapy for AL.
- Conditions
- Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- PACIFIC (NCT04969601)
- Testing
- vaccine COMIRNATY® (BNT162b2)
- Where
- 2 sites in France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pseudoxanthoma Elasticum
Pseudoxanthoma Elasticum (PXE) Natural History Biomarkers in PXE Individuals and Their Biological Non-PXE Siblings
This PXE biomarker study aims to characterize the levels of inorganic pyrophosphate (PPi), pyridoxal 5´-phosphate (PLP), and other biomarkers relevant to PXE and ectopic calcification in both PXE patients and their biological…
- Trial name
- NCT05025722
- Testing
- Non Interventional
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo
Suicide
Tool for Sibling and Children of Someone With Suicidal Thoughts
This study aims to investigate to what extent a website developed for siblings and children (16-25 years old) of someone with suicidal thoughts and/or behaviors is effective in improving perceived pressure, knowledge, attitudes…
- Trial name
- NCT06100575
- Testing
- Website (www.mee-leven.be)
- Where
- Belgium
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Ghent
Type 1 Diabetes Mellitus
Biomarkers of Type 1 Diabetes in Children and Their Healthy Siblings
This prospective observational cohort study evaluated genetic, immunologic, and environmental factors associated with type 1 diabetes in children.
- Trial name
- NCT07627230
- Where
- Russia
- Volunteers
- 1,034 people, healthy volunteers welcome
- Sponsor
- Privolzhsky Research Medical University
Retinoblastoma, Cancer Survivor
Studying Health Outcomes After Treatment in Patients With Retinoblastoma
This trial studies health outcomes after treatment in patients with retinoblastoma. Gathering health information over time from patients and family members through vision assessments, samples of tissue and saliva, and…
- Conditions
- Retinoblastoma, Cancer Survivor, Biological Sibling, Intraocular Retinoblastoma
- Trial name
- RIVERBOAT (NCT03932786)
- Testing
- Biospecimen collection, Vision assessment, Questionnaire administration
- Where
- 11 sites in United States, Canada
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Stress
Evaluation of a Resiliency Intervention for Siblings of Children With Autism Spectrum Disorder (ASD)
The proposed research has the following objectives: Based off findings from the "Development of a Resiliency Program for Siblings of Children with Autism Spectrum Disorder" qualitative focus group study (protocol 2019P002284)…
- Trial name
- SibChat (NCT04369417)
- Testing
- Relaxation Response Resiliency Program for Siblings of Children with ASD
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Genetic Disease, Communication
The Role of Family Functioning in Promoting Adaptation in Siblings of Individuals With Duchenne Muscular Dystrophy (DMD)
Background: We want to learn more about the relationship between the way families function and how children adapt to having a sibling with Duchenne muscular dystrophy (DMD).
- Trial name
- NCT01386515
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Survival, Embryo Quality
Oocyte Survival After Vitrification in an Open or Closed Device With Closed Storage.
The survival rate (and embryo quality) of donor oocytes with two commercially available devices.
- Trial name
- NCT01952184
- Testing
- CBSvit HS device, Cryotop SC device
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Healthy, Schizophrenia
Electrophysiology and Blood Flow in Patients With Schizophrenia and Their Siblings
This study will explore how the brain works during memory testing in an effort to understand why some patients with schizophrenia have memory difficulties.
- Trial name
- NCT00001921
- Where
- United States
- Volunteers
- 1,386 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Infertility
Oocyte Cryopreservation Comparing Fresh and Vitrified Sibling Oocytes
Vitrification is a method to cryopreserve biological specimens that are sensitive to chilling injury such as oocytes and embryos, and it has been employed with increased survival rate and live births (Hong et al., 1999; Kuleshova…
- Trial name
- NCT00986687
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- UConn Health
Healthy
Effectiveness of the Serious Game 'Broodles' for Siblings of Children With Visual Impairment and/or Intellectual Disability
The support for siblings of children with disabilities is scarce and fragmented, even though studies have shown that these siblings can benefit from support.
- Trial name
- NCT05376007
- Testing
- Serious game 'Broodles'
- Where
- Netherlands
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- VU University of Amsterdam