Clinical trials: Sickle Cell Disorders
Hemoglobin SC Disease
Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE)
Sickle cell disease (SCD), specifically hemoglobin SC disease (HbSC), is a subtype of sickle cell disease with typically higher hemoglobin and milder or later disease complications.
- Trial name
- NCT02640573
- Testing
- Hydroxyurea
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
Sickle Cell Disease (SCD)
Megakaryocyte Heterogeneity in Sickle Cell Disease
Sickle cell disease (SCD) is characterized by chronic hemolytic anemia, painful crisis called vaso-occlusive crisis (VOC) and chronic inflammation.
- Trial name
- MegaDrep (NCT06850337)
- Where
- Guadeloupe
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Anemia, Sickle Cell, Hematologic Diseases
Pediatric Hydroxyurea in Sickle Cell Anemia (PED HUG)
To determine whether hydroxyurea prevents the onset of chronic end organ damage in young children with sickle cell anemia.
- Conditions
- Anemia, Sickle Cell, Hematologic Diseases, Hemoglobinopathies
- Trial name
- NCT00000602
- Testing
- hydroxyurea
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sickle Cell Disease
Acupressure in Patients With Sickle Cell Disease
The proposed research is to determine the clinical efficacy and neurobiological mechanisms of acupressure analgesia in patients with sickle cell disease (SCD).
- Trial name
- NCT06511453
- Testing
- Verum Acupressure (using AcuWand)
- Where
- 2 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Indiana University
Sickle Cell Disease
Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness
This study is for caregivers of young children with sickle cell disease and adolescents with sickle cell disease who are currently prescribed hydroxyurea and are receiving care at one of the study sites.
- Trial name
- ADHERE (NCT06264700)
- Testing
- Video Directly Observed Therapy (VDOT), Health Reminder Tip Alerts
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Nationwide Children's Hospital
Anemia, Sickle Cell, Blood Disease
Investigation of Selected Patient Groups From The Cooperative Study of Sickle Cell Disease
To continue to follow the newborn cohort and the over-35 years of age cohort from the Cooperative Study of Sickle Cell Disease (CSSCD), a study of the natural history of sickle cell disease.
- Trial name
- NCT00005300
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sickle Cell Disease, Stress
The Feasibility of the Pray Until Something Happens (PUSH) Intervention-OUTPATIENT
The goal of this research study is to reduce stress and improve sickle cell disease (SCD) pain control and sleep quality with less opioid use by determining the feasibility of an intervention with self-management combined…
- Conditions
- Sickle Cell Disease, Stress, Pain
- Trial name
- ESPIRITU (NCT06580067)
- Testing
- Pray Until Something Happens (PUSH), Self-monitoring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Anemia, Sickle Cell Disease
Screening for Renal Complications in Children and Young Adults With Major Sickle Cell Disease
Sickle cell disease is the subject of targeted neonatal screening (carried out when one of the two parents is from an endemic country - sub-Saharan Africa, South-East Asia, Central America, the Caribbean) during the Guthrie test.
- Trial name
- NEPHRO-DREPA (NCT05211037)
- Testing
- Kidney function assessment
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sickle Cell Disease
Characteristics and Treatment Patterns of Patients With Sickle Cell Disease in Globin Research Network for Data and Discovery Registry
This was a retrospective observational cohort study. This study was a secondary analysis of individuals with sickle cell disease (SCD) enrolled in the GRNDaD registry.
- Trial name
- NCT06662812
- Where
- United States
- Volunteers
- 1,665 people
- Sponsor
- Novartis
Sickle Cell Disease
Microvessels and Heart Problems in Sickle Cell Disease
Background: Small blood vessels (microvessels) in many different organs are affected by diseases such as diabetes and atherosclerosis. These microvessels may also be abnormal in people who have sickle cell disease.
- Trial name
- NCT01602809
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Iron Overload, Excessive Body Iron Burden
Massive Iron Deposit Assessment
Iron overload is a severe complication of multiple blood transfusions. As the body has no physiologic mechanism for clearing iron, repeated transfusions cause iron accumulation in organs and lead to iron toxicity.
- Trial name
- NCT01572922
- Testing
- R2*-UTE, R2*-GRE, Liver biopsy
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- St. Jude Children's Research Hospital
Anemia, Sickle Cell, Pneumonia
Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients
This is a study to determine if oral arginine will increase nitric oxide in sickle cell disease (SCD) patients with acute chest syndrome (ACS).
- Trial name
- NCT00029731
- Testing
- Arginine hydrochloride
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Sickle Cell, Sickle Cell Disease
Sickle Cell, Pain and Mediterranean Diet
The goal of this study is to compare pain levels in individuals with Sickle Cell Disease while following the Mediterranean Diet to pain levels while following their usual diet.
- Conditions
- Sickle Cell, Sickle Cell Disease, Sickle Cell Disease Without Crisis, Mediterranean Diet
- Trial name
- MedSCP (NCT06886477)
- Testing
- Mediterranean Diet, Usual Diet
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Illinois Chicago
Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes
Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT
The objective of this study is to evaluate the efficacy of using a reduced-intensity condition (RIC) regimen with umbilical cord blood transplant (UCBT), double cord UCBT, matched unrelated donor (MUD) bone marrow transplant…
- Conditions
- Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes, Inherited Metabolic Disorders (IMD), Hereditary Anemias
- Trial name
- HSCT+RIC (NCT01962415)
- Testing
- Hydroxyurea, Alemtuzumab, Fludarabine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Paul Szabolcs
Sickle Cell Disease, Thalassemia Major
Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies
This is a single arm pilot study of peripheral stem cell transplantation (PSCT) with ex vivo t-cell receptor alpha beta+(TCRαβ+) T cell and cluster of differentiation 19+ beta (CD19+ B) cell depletion of unrelated donor (URD)…
- Trial name
- NCT04523376
- Testing
- CliniMACS
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Timothy Olson
Sickle Cell Disease
HRV-B for Symptom Management in Sickle Cell Patients
This study will test the hypothesis that Heart Rate Variability Biofeedback (HRV-B) restores autonomic balance and reduces pain and other symptoms among patients with sickle cell disease (SCD).The specific aims of this study are…
- Trial name
- NCT03383913
- Testing
- Heart Rate Variability Biofeedback
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Prisma Health-Upstate
Sickle Cell Disease
Hemoglobin Desaturation in Sickle Cell Disease
As part of routine care for SCD, some people are found to have low oxygen levels (≤ 88%) while sleeping, at rest, or with exercise.
- Trial name
- NCT03908385
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University Hospitals Cleveland Medical Center
Anemia, Sickle Cell, Hematologic Diseases
Penicillin Prophylaxis in Sickle Cell Disease (PROPS)
To determine whether the regular daily administration of oral penicillin would reduce the incidence of documented infection due to Streptococcus pneumoniae in children with sickle cell anemia.
- Conditions
- Anemia, Sickle Cell, Hematologic Diseases, Hemoglobinopathies, Infection (S. Pneumoniae)
- Trial name
- NCT00000585
- Testing
- penicillin
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sickle Cell Disease, Sickle Cell Anaemia
Efficacy and Safety of SIL-8301 for Control of Hemolysis in a Uniform Sickle Cell Disease Endotype
SIL-8301 (senicapoc) is being developed for the chronic treatment of patients with sickle cell disease in both adults and children.
- Conditions
- Sickle Cell Disease, Sickle Cell Anaemia, Sickle Cell Anemia
- Trial name
- RESCUE (NCT07282210)
- Testing
- Senicapoc
- Where
- 4 sites in Canada
- Volunteers
- 65 people
- Sponsor
- Biossil Inc.
Anemia, Sickle Cell
Systematic Psychological and Medical Care for Children With SCD
Sickle cell disease (SCD), a genetically transmitted blood disease, necessitates life-long care. In children, the disease may cause intense pain and other severe complications.
- Trial name
- Drépano (NCT02022891)
- Testing
- systematic psychological care
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
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