Clinical trials: Sickle Cell Disorders
Discrimination, Racial, Pain Management
Opioid Prescribing in the Emergency Department for Sickle Cell Disease
This study consists of a clinical vignette presented to emergency physicians asking them what they would prescribe to a patient with acute abdominal pain.
- Conditions
- Discrimination, Racial, Pain Management, Emergency Medicine, Sickle Cell Disease
- Trial name
- DOPED-SCD (NCT06835335)
- Testing
- opioid prescription
- Where
- 2 sites in France, United Kingdom
- Volunteers
- 1,063 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Sickle Cell Disease, Sickle Cell Disorder
A Blood Stem Cell Transplant for Sickle Cell Disease
Blood stem cells can produce red blood cells (which carry oxygen), white blood cells of the immune system (which fight infections) and platelets (which help the blood clot).
- Conditions
- Sickle Cell Disease, Sickle Cell Disorder, Hemoglobinopathies, Thalassemia
- Trial name
- NCT03249831
- Testing
- Cyclophosphamide, Pentostatin, Rabbit anti-thymocyte globulin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- City of Hope Medical Center
Sickle Cell Disease, Aging
SickleFit Exercise and Nutrition Study
To goal of this study is to pilot the SickleFit exercise and nutrition intervention in adults with sickle cell disease in a randomized control trial
- Trial name
- NCT07442851
- Testing
- SickleFit Exercise plus Nutrition
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Osteonecrosis
Functional Outcomes Following Hip Core Decompression in Younger Participants With Osteonecrosis
Although uncommon in the general pediatric population, osteonecrosis (ON) is prevalent in children and adolescents with cancer, particularly among those that have had chronic exposure to glucocorticoids and among those having…
- Trial name
- NCT02458937
- Testing
- Functional Mobility Assessment, GAITRite® System, Range of Motion
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- St. Jude Children's Research Hospital
Sickle Cell Disease
MACS Study - Microparticles and Coagulation in Sickle Cell Disease
Sickle cell disease (SCD) is an inherited disorder of the red blood cell. It is now the commonest genetic disorder in the UK and of childhood stroke, with up to 40% of children having a stroke (clinical or picked up on a scan) by…
- Trial name
- MACS (NCT01242878)
- Where
- 3 sites in United Kingdom
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University College, London
Sickle Cell Nephropathy
Nephropathy in Patients With Sickle Cell Disease
There are some diseases that give rise to diverse renal manifestations as does sickle cell disease
- Trial name
- NCT03680547
- Testing
- patient with sickle cell disease
- Volunteers
- 25 people
- Sponsor
- Assiut University
Sickle Cell Disease
A Study Evaluating Gene Therapy With BB305 Lentiviral Vector in Sickle Cell Disease
This is a non-randomized, open-label, multi-site, single-dose, Phase 3 study in approximately 35 adults and pediatric subjects ≥2 and ≤50 years of age with sickle cell disease (SCD).
- Trial name
- NCT04293185
- Testing
- bb1111
- Where
- 9 sites in United States
- Volunteers
- 35 people
- Sponsor
- Genetix Biotherapeutics Inc.
Anemia, Sickle Cell Disease
Screening for Renal Complications in Children and Young Adults With Major Sickle Cell Disease
Sickle cell disease is the subject of targeted neonatal screening (carried out when one of the two parents is from an endemic country - sub-Saharan Africa, South-East Asia, Central America, the Caribbean) during the Guthrie test.
- Trial name
- NEPHRO-DREPA (NCT05211037)
- Testing
- Kidney function assessment
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sickle Cell Disease, Cognitive Impairment
Cognitive Remediation Intervention to Prepare for Transition of Care
Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents with sickle cell disease for…
- Conditions
- Sickle Cell Disease, Cognitive Impairment, Adolescent Behavior, Self Efficacy
- Trial name
- NCT05336201
- Testing
- CREADY (Cognitive-Remediation of Executive and Adaptive Deficits in Youth)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Sickle Cell Disease
Prevalence of Osteoporosis in Sickle Cell Disease
Sickle cell disease is the most common single-gene disease in the world. Its prevalence is increasing in France, with patients' life expectancy increasing into developed countries.
- Trial name
- DREPAN'OS (NCT04299594)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 142 people
- Sponsor
- Hospices Civils de Lyon
Sickle Cell Disease, Vitamin D Deficiency
Vitamin D for Sickle-cell Respiratory Complications
This study aims to answer the question whether oral vitamin D supplementation can decrease lung complications in children and adolescents with sickle cell disease.
- Conditions
- Sickle Cell Disease, Vitamin D Deficiency, Acute Chest Syndrome, Asthma
- Trial name
- NCT01443728
- Testing
- Experimental: Vitamin D3 100,000 IU, Active Comparator: Vitamin D3 12,000 IU
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Gary M Brittenham, MD
Sickle Cell Disease
Ketamine as an Adjuvant Therapy for Acute Vaso Occlusive Crisis in Pediatric Patients With Sickle Cell Disease
The primary objective of the proposed study is to determine the potential role of Ketamine as an analgesic agent in pediatric sickle cell disease patients with refractory symptoms in acute (VOC).
- Trial name
- KSickle (NCT02801292)
- Testing
- Ketamine
- Volunteers
- 20 people
- Sponsor
- Augusta University
Vaso-occlusive Crisis, Sickle Cell Disease
Evaluation of Virtual Reality to Save Morphinic in the Treatment of Vaso-occlusive Seizures of Sickle Cell Patients Consulting in the Emergency Room
The management of pain in the emergency department is a major issue, especially for sickle cell patients who regularly consult for vaso-occlusive seizure (VOS).
- Trial name
- ReVCVO (NCT04756375)
- Testing
- Virtual Reality, Usual Care
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sickle Cell Anemia
Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea
The primary goal of the Phase III TWiTCH trial is to compare 24 months of alternative therapy (hydroxyurea) to standard therapy (transfusions) for pediatric subjects with sickle cell anemia and abnormally high (≥200 cm/sec)…
- Trial name
- TWiTCH (NCT01425307)
- Testing
- Hydroxyurea
- Volunteers
- 159 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sickle Cell Disease
Substudy of CADRE: for People With Extreme Phenotype: BIOCADRE
BIOCADRE is a CADRE substudy and aims to characterize more precisely the sickle cell patients with extreme phenotype.
- Trial name
- BIOCADRE (NCT03352986)
- Testing
- biological analysis, peripheral arterial tonometry
- Where
- 2 sites in Mali, Senegal
- Volunteers
- 300 people
- Sponsor
- Cardiologie et Développement
Sickle Cell Disease, Hb-SS Disease With Vasoocclusive Pain
Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis
The purpose of this study is to determine whether giving abciximab (ReoPro) to children with sickle cell disease who are hospitalized for acute pain crisis will improve their pain and shorten the time spent in the hospital, when…
- Conditions
- Sickle Cell Disease, Hb-SS Disease With Vasoocclusive Pain, Hemoglobin SS Disease With Vasoocclusive Crisis, Other Sickle Cell Disease With Vaso-Occlusive Pain
- Trial name
- NCT01932554
- Testing
- Abciximab, Intravenous hydration, Ibuprofen
- Where
- United States
- Sponsor
- St. Louis University
Sickle Cell Disease
Clinical Study of BRL-101 in the Treatment of Sickle Cell Disease
This is a single center, non-randomized, open label, single-dose study in subjects with Sickle Cell Disease (SCD). The study will evaluate the safety and efficacy of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem…
- Trial name
- NCT06287099
- Testing
- BRL-101
- Volunteers
- 5 people
- Sponsor
- Bioray Laboratories
Sickle Cell Disease
Virtual Reality for SCD VOC
This randomized pilot study will evaluate the feasibility, tolerability, and preliminary analgesic effect of headset-based virtual reality (VR) interventions for adults with sickle cell disease (SCD) experiencing vaso-occlusive…
- Trial name
- RELIEVE-SCD (NCT07674277)
- Testing
- Passive Immersive 3D Virtual Reality, Active Immersive Interactive 3D Virtual Reality
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, Baltimore
Sickle Cell Disease, Cerebral Stroke
Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography
The purpose of the study protocol is to identify imaging biomarkers for brain tissue under high metabolic stress at risk for permanent injury.
- Trial name
- HDDOT CVR (NCT07776444)
- Testing
- Carbon Dioxide
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Sickle Cell Disease, Asthma
Inhaled Corticosteroid Use to Prevent Acute Chest Syndrome Recurrence in Children Between 1 and 4 With Sickle Cell Disease: a Feasibility Trial
Acute and chronic pulmonary complications with concomitant inflammatory response are a leading cause of morbidity and mortality in children with sickle cell disease (SCD).
- Conditions
- Sickle Cell Disease, Asthma, Acute Chest Syndrome
- Trial name
- NCT02187445
- Testing
- Budesonide inhalation suspension
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Vanderbilt University
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