Clinical trials: Single Nucleotide Polymorphism
Metalloproteinase SNPs -1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13 and Risk for Developing Knee Osteoarthritis in Greek Population
Association of Single Nucleotide Polymorphisms (SNPs) in Metalloproteinases (MMPs) Genes With the Risk of Primary Knee Osteoarthritis in Greek Population.
Does the presence of gene polymorphisms -1575G / A in the MMP-2 gene, 836A / G in the MMP-9 gene and -77A / G in the MMP-13 gene, affect the risk of developing idiopathic knee osteoarthritis in the Greek population?
- Trial name
- NCT04463290
- Testing
- No intervention, Patients selection based on clinical symptoms and radiological imaging
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Anovulation, Hyperandrogenism
Whole Genome Analysis for the Detection of Key Genes in the Polycystic Ovary Syndrome
Background: Infertility affects up to 15% of married couples. About half are attributable to female factors, among which anovulation is the leading cause.
- Conditions
- Anovulation, Hyperandrogenism, Polycystic Ovary Syndrome, Single Nucleotide Polymorphism
- Trial name
- NCT00665171
- Where
- Israel
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Maaynei Hayesha Medical Center
Genetics, Skin Aging
Relationship of Skin Related SNP to Topical Skin Care Product
Demonstrate the relationship between single nucleotide polymorphisms (SNP) and response to a topical skin care product.
- Trial name
- NCT03446079
- Testing
- Topical Anti Aging Cream
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- HelicalCodeMD
Asthma
The Relationship Between Single Nucleotide Polymorphisms of Chitinase 3-like 1 Gene,YKL-40 Serum Levels and Adult Asthma
The objective of this study was to investigate the relationship between single nucleotide polymorphism of chitinase 3-like 1 and human asthma.
- Trial name
- CHI3L1 (NCT01348932)
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Neonatal Respiratory Distress Syndrome
Association of SCNN1A Single Nucleotide Polymorphisms With Neonatal Respiratory Distress Syndrome
Lung fluid absorption disorders are largely mediated by transepithelial Na+ reabsorption through alpha epithelial sodium channels (α-ENaCs) in alveolar epithelial cells.
- Trial name
- NCT02333669
- Testing
- no intervention
- Where
- China
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Renal Transplantation
Identification of Patients With High Probability of Poorly Responding to Therapy With Mycophenolic Acid Prodrugs
This study is designed to define groups of patients (among patients with a heart or kidney graft or a glomerular disease and nephrotic range proteinuria) who would either not profit from a therapy with mycophenolate-mofetil (MMF)…
- Trial name
- NCT00978965
- Testing
- MPA SNP
- Where
- Austria
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Fatty Acid Desaturases, Polymorphism, Single Nucleotide
Genetic Variants Modulate Association Between Dietary n-3 LCPUFAs and DHA Proportion in Breast Milk
DHA is important for the development of brain and retina in newborns. Considering that exclusive breast feeding for at least 4 ~6 months are globally recommended, plus it is well known that nutrient requirement is determined by…
- Conditions
- Fatty Acid Desaturases, Polymorphism, Single Nucleotide, Milk, Human
- Trial name
- NCT03842891
- Where
- Taiwan
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Parkinson's Disease
Genetic Polymorphism and Parkinson's Disease in Taiwanese
To observe and analyze the correlation between Single Nucleotide polymorphisms (SNPs) and the incidence of Parkinson's disease in Taiwanese.
- Trial name
- NCT01996878
- Where
- Taiwan
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital
Cleft Lip and Cleft Palate
Detection of Single Nucleotide Polymorphism (SNP) Rs2235371 of IRF6 Gene in Egyptian Patients with Non-Syndromic Cleft Lip and Palate
The aim of this work is to study the relation between SNP rs2235371 of IRF 6 gene and Non-Syndromic Cleft Lip and Palate in Egyptian Patients in a prospective study
- Trial name
- NCT06730880
- Testing
- PCR
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
rs185670819 and rs183489969
Genotyping 2 SNPs in Chinese Breast Cancers
The purpose of this study is to determine the frequency of two Single Nucleotide Polymorphisms (SNPs) by sanger-sequencing in Breast Cancers and healthy controls .
- Trial name
- NCT02886845
- Testing
- rs183489969,rs185670819
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Song Hongping
Abortion, Spontaneous
Interleukin-10 Promoter-1082A/G Polymorphism and Idiopathic Recurrent Miscarriage Risk
This study aimed to assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) of Chinese Han.
- Trial name
- NCT02633475
- Testing
- IL-10 polymorphism
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fourth Affiliated Hospital of Guangxi Medical University
Metabolic Syndrome, Diabetes Mellitus, Type 2
Assessing Inherited Markers of Metabolic Syndrome in the Young
The AIMM Young study is a collaboration between Children's National Medical Center (CNMC) and colleges/universities nationwide--currently including Howard University (HU), East Carolina University (ECU), and University of…
- Conditions
- Metabolic Syndrome, Diabetes Mellitus, Type 2, Obesity
- Trial name
- AIMMY (NCT00966407)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Eric Hoffman
Phantom Limb
Study to Identify the Genetic Variations Associated With Phantom Limb Pain
The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group.
- Trial name
- NCT01462448
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Non-alcoholic Fatty Liver Disease
Utilizing Non-Invasive Fibroscan® Technology to Identify Genetic Markers for Fatty Liver Progression
Non-alcoholic fatty liver disease (NAFLD) is a common disorder, affecting ~30% of people in the general population and up to 96% of obese individuals.
- Trial name
- NCT02267148
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- UNC Nutrition Research Institute
Bipolar
Genetic Association Study Between Single Nucleotide Polymorphisms (SNPs) and Cognitive Performance in Young Bipolar Type I Patients: LICAVALGENE
This is a genetic association study of cognitive impairment in young bipolar disease type I patients without medications in mania, depression, hypomania or mixed states.
- Trial name
- Licavalgene (NCT00969930)
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Single Nucleotide Polymorphism
Folate Gene Polymorphisms and Cellular Folate Speciation Pilot Study
This pilot study is designed to investigate differences in folate-related genes (single nucleotide polymorphisms) and their relationship to the species of folate present on red blood cells.
- Trial name
- FolGene (NCT00975364)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Gout, Hyperuricemia
Research and Development of a New Technology for Detection of Abnormal Excretion of Intestinal Uric Acid Involved in the Incidence of Gout
To evaluate differences in specific SNPs and intestinal microflora between patients with gout and hyperuricemia and healthy controls.
- Conditions
- Gout, Hyperuricemia, Gut Microbiota, Uric Acid
- Trial name
- NCT04953533
- Testing
- no intervention
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Healthy
Genetic Polymorphisms Affecting Effect of High Intensity Training
The objective of the study is to investigate the effect of high intensity training on maximal oxygen uptake according to the genetic polymorphisms in healthy Korean volunteers.
- Trial name
- NCT02241850
- Testing
- High intensity training
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Kyunghee University Medical Center
Sleep Apnea Syndrome, Oxidative Stress
NADPH Oxidase Polymorphisms in Obstructive Sleep Apnea Syndrome (OSAS)
Obstructive Sleep Apnea (OSA) is associated with increased oxidative stress. The major sources of Reactive Oxygen Species (ROS) in the vasculature are the NADPH oxidases.
- Conditions
- Sleep Apnea Syndrome, Oxidative Stress, Single Nucleotide Polymorphism
- Trial name
- NCT01141829
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Childhood Obesity
Leipzig Childhood Obesity Study
The aim of this study is to identify polymorphisms that make children and adolescents more prone to obesity and metabolic dysfunction, as well as to identify biomarkers that are linked to causes and consequences of obesity.
- Trial name
- NCT04491344
- Where
- Germany
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Leipzig