Clinical trials: Skeletal Muscle
Aging, Muscle Damage
Eccentric Exercise and Oxidative Stress
The purpose of the present investigation is to compare the responses and adaptations of young and elderly individuals to repeated eccentric exercise in regards to muscle function and redox homeostasis in a side-by-side comparison.
- Conditions
- Aging, Muscle Damage, Oxidative Stress
- Trial name
- NCT01728675
- Testing
- Exercise
- Where
- Cyprus
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- European University Cyprus
Sarcopenia, Anabolic Resistance
Strength Training and Resveratrol
The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether…
- Trial name
- STaR (NCT06585865)
- Testing
- Resistance training, Resveratrol 500 mg oral once daily.
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Aging
Bloodflow Restricted Exercise in Healthy Ageing
The overall objective of this study is to investigate the efficacy of low-intensity blood flow restricted resistance exercise (BFRRE) to promote health beneficial skeletal muscle adaptations and augment muscle function in a…
- Trial name
- NCT04712955
- Testing
- Bloodflow restricted exercise
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Insulin Resistance
Determining Cell- and Spatially-distinct Skeletal Muscle Transcriptional Aberrations in Insulin Resistance
The purpose of this study is to find new signs or signals in muscle cells that can help us understand when the body isn't responding well to insulin (a condition called insulin resistance).
- Trial name
- POINTS 2 (NCT07516509)
- Testing
- VO2 Max, DEXA, Peripheral Microvascular Reactivity
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Muscle Strength
Effects of Photobiomodulation Therapy in Strength Training and Detraining in Humans
In last years it has been demonstrated that photobiomodulation therapy (PBMT) has ergogenic effects, improving muscular performance and accelerating post-exercise recovery.
- Trial name
- NCT03858179
- Testing
- PBMT
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Muscle Loss in Elderly
The Effects of Resistance Training and Protein Supplementation in Healthy Elderly Men and Women.
The main objective of this study is to examine the effects of resistance type exercise training combined with nutritional support on body composition and muscle characteristics in healthy elderly men and women.
- Trial name
- NCT01004588
- Testing
- Protein drink
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Sarcopenia
Effects of Graded Protein Intake on Body Composition in Older Adults
This clinical trial is intended to evaluate the effects of protein intake graded to resistance training volume over a 10-week period on macroscopic skeletal muscle adaptations and body composition.
- Trial name
- GPI (NCT04845282)
- Testing
- Graded Protein plus Resistance Training, RDA Protein plus Resistance Training
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Atrophy, Disuse, Muscle Atrophy
Molecular Mechanisms Underlying Anabolic Resistance to Protein Intake During Muscle Disuse
This study will characterize intramuscular molecular mechanisms underlying anabolic resistance to protein ingestion during muscle disuse.
- Conditions
- Atrophy, Disuse, Muscle Atrophy, Muscular Disorders, Atrophic, Disuse Atrophy
- Trial name
- NCT06228742
- Testing
- Unilateral leg immobilization, Contralateral active leg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Diabetes, Obesity
Multi-Tracer PET Quantitation of Insulin Action in Muscle (Phase 1, Phase 2, Phase 3, Phase 4)
The purpose of this research is to develop a new method to study insulin action using positron emission tomography (PET). Insulin is the hormone made by your body to control the blood sugar level.
- Trial name
- NCT00222885
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy Adult Male and Female Volunteers
Effects of Exercise Frequency on Muscle Size and Strength in Healthy, Untrained Young Adults
Resistance training (RT) is important for building and maintaining healthy muscles. An exercise frequency called "exercise snacks" involves short bursts of exercise throughout the day (~5-15 minutes), but no studies have examined…
- Trial name
- FREQ (NCT07760597)
- Testing
- 10 sessions per week of resistance training, Two sessions per week of resistance training
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cameron Mitchell
Healthy
BCAAs, Muscle Protein Synthesis and Glucose Uptake
The present study aims to quantify the insulin sensitivity and the skeletal muscle protein synthetic response to consuming a test drink containing all amino acids or all amino acids except for BCAAs.
- Trial name
- NCT06218264
- Testing
- Ingestion of an amino acid supplement
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Healthy
Investigation of the Effects of Exercise on Gene Expression
The investigators have previously shown that mild exercise training at the level of lactate threshold (LT) intensity (60 min/day, 5 days/week) improves peripheral insulin sensitivity and insulin-independent glucose disposal of…
- Trial name
- NCT00916019
- Testing
- exercise training
- Where
- Japan
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Fukuoka University
Muscle Atrophy
The Effects of 17β-estradiol on Skeletal Muscle
The maintenance of skeletal muscle mass and function is critical for healthy aging. Muscle loss with disuse, termed muscle disuse muscle atrophy, leads to impaired functional capacity, the onset of insulin resistance, as well as…
- Trial name
- NCT03069781
- Testing
- 17β-estradiol, Polycose
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Physical Function, Vitamin D Insufficiency
Vitamin D Supplementation and Physical Function in Older Adults
A growing body of evidence suggests that vitamin D status is important in biologic processes involved in the maintenance of physical function.
- Trial name
- NCT01179503
- Testing
- calcium, Vitamin D plus calcium
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Healthy
Branched-chain Amino Acids, and Resistance Exercise on Skeletal Muscle Signaling Pathways
This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.
- Trial name
- NCT01350427
- Testing
- Leucine supplementation, BCAA supplementation, Alanine supplementation
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Peripheral Artery Disease (D058729), Oxidative Stress (D018384)
Improving Exercise Rehabilitation Efficacy Outcomes Veterans Peripheral Artery Disease
Physical activity is the most beneficial and cost-effective treatment for Veterans with PAD, however, issues with oxygen delivery and utilization dramatically impair exercise compliance.
- Conditions
- Peripheral Artery Disease (D058729), Oxidative Stress (D018384), Inflammation (D007249)
- Trial name
- NCT05648630
- Testing
- PB125, Exercise Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cushing Syndrome
Alterations of Muscle Secretome Associated With Muscle Atrophy Caused by Glucocorticoids
Several studies have shown that lean mass, in particular muscle mass, is an excellent predictive survival factor in many diseases.
- Trial name
- MYOSECRET (NCT03229395)
- Where
- Belgium
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Iron Deficiency
Effects of Iron Supplementation on Skeletal Muscle Properties in Females With Suboptimal Iron Storage
The goal of this clinical trial is to learn whether oral iron supplementation will increase skeletal muscle iron storage and its effects on exercise capacity in females with suboptimal iron status.
- Trial name
- MyoIRON (NCT07084298)
- Testing
- Oral iron supplement
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Iron Deficiency
Iron Status and Human Metabolism
Iron deficiency is common in cardiorespiratory diseases and appears to contribute to a worse outcome. This human physiology study will examine the extent to which human skeletal muscle metabolism and exercise physiology are…
- Trial name
- NCT02308449
- Testing
- Ferric carboxymaltose
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Sepsis
Effect of Lipopolysaccharide on Skeletal Muscle Functions
The investigators aim to examine how the skeletal muscles of the human volunteers respond to experimental septic conditions to aid understanding of muscle wasting and its biology..
- Trial name
- LPS (NCT01423968)
- Testing
- Lipopolysaccharide infusion, saline
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Nottingham