Clinical trials: Skeletal Muscle Function
Mitochondrial Diseases
Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic Capacity
The purpose of this study is to test how different doses of a statin, Lipitor, affect muscle health and function, and cardiovascular fitness.
- Trial name
- NCT03351998
- Testing
- Lipitor 20Mg Tablet, Lipitor 80Mg Tablet
- Where
- 2 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Dietary Nitrate Supplementation
Evaluating the Metabolic Effects of Dietary Nitrate Supplementation
Dietary nitrate is found to enhance muscle fatty acid oxidation/glucose uptake and increase mitochondrial biogenesis, which in turn, aid in the prevention and management of metabolic diseases.
- Trial name
- NIMMI (NCT05579262)
- Testing
- Beetroot juice
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Healthy Adult Participants, Exercise Training
The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers
The goal of this study is to investigate the effect of combining olive leaf extract supplementation with endurance training (moderate intensity continuous training or sprint interval training).
- Conditions
- Healthy Adult Participants, Exercise Training, Neuromuscular Adaptations, Nutritional Intervention
- Trial name
- OLE_Training_1 (NCT07729072)
- Testing
- Olive leaf extract
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Metabolic Syndrome, Insulin Resistance
High-intensity Interval, Low Volume Training in Metabolic Syndrome
The primary objective of the study is to compare the efficacy of an intervention with high-intensity interval, low volume training (HIIT-LV) or continuous aerobic exercise (CAE) on insulin resistance, insulin sensitivity and…
- Trial name
- Intraining-MET (NCT03087721)
- Testing
- HIIT-LV, CAE
- Where
- Colombia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Heart Failure, Type 2 Diabetes
Effects of Dark Chocolate on Exercise Capacity, and Mitochondrial Structure and Function
The major goal of this study is to characterize the ability of dark chocolate enriched in epicatechin (a component of dark chocolate) to improve the structural and functional features of mitochondria in two groups 1.
- Trial name
- NCT01671514
- Testing
- Epicatechin-enriched dark chocolate, Low-epicatechin dark chocolate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Sarcopenia
Carnitine Supplementation and Skeletal Muscle Function
Research project objectives The primary aim of the current research project is to use carnitine supplementation as the anti-inflammatory intervention for exploring the relationship between inflammation and associated with aging…
- Trial name
- NCT02692235
- Testing
- carnitine
- Where
- Poland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Muscular Diseases
The Effect of Statin Medications on Muscle Performance (The STOMP Study)
Statins are a group of medications that are used to lower cholesterol levels. Although serious side effects are rare, some people taking statins experience muscle pain or weakness.
- Trial name
- STOMP (NCT00609063)
- Testing
- Atorvastatin
- Where
- 3 sites in United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Ischemic Preconditioning, Coenzyme Q Deficiency
Effect of CoQ10 on the Endocrine Function of Skeletal Muscle
Recent studies have also shown that repeated episodes of ischemia, followed by reperfusion (IPC), can contribute to the development of adaptive changes not only in the area of the heart muscle, but also in the structure of the…
- Conditions
- Ischemic Preconditioning, Coenzyme Q Deficiency, Exercise Training
- Trial name
- NCT05412888
- Testing
- CoQ10 supplementation, Ischemic preconditioning training, IPC training combined with CoQ10 supplementation
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Unilateral Lower Limb Suspension (Simulated Microgravity)
Unloaded Minds - How Prolonged Unloading Shapes Human Performance in Lunar Gravity
During spaceflight and lunar missions, reduced gravitational loading causes the muscles and nervous system to decondition rapidly.
- Trial name
- UnloadedMinds (NCT07607340)
- Testing
- Unilateral lower limb suspension
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Muscle Loss
Galactooligosaccharide and Aging
Sarcopenia is a progressive muscle disease, most commonly affecting older individuals, that is categorised by 1) low muscle strength, 2) low muscle quantity or quality, and 3) low physical performance.
- Trial name
- NCT06411964
- Testing
- Prebiotic
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Spinal Cord Injuries
The Effect of FES and Therapeutic Exercise on SCI Patients Skeletal Muscles, Sitting Balance, Posture and Quality of Life
Aim of the current study is to evaluate the effect functional electrical stimulation and therapeutic exercise on traumatic spinal cord injured participants'skeletal muscle characteristics, sitting balance, lung function and…
- Trial name
- NCT03517787
- Testing
- FES+TE, TE, REF-FES+TE
- Where
- Estonia
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Tartu University Hospital
CKD Stage 3, CKD Stage 4
The Iron and Muscle Study
This is a multi-center randomized controlled trial that will examine the efficacy of IV iron supplementation when compared to placebo, with and without exercise training, on changes in patient exercise capacity.
- Conditions
- CKD Stage 3, CKD Stage 4, Iron-deficiency
- Trial name
- NCT04862715
- Testing
- Ferinject
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Physical Function, Vitamin D Insufficiency
Vitamin D Supplementation and Physical Function in Older Adults
A growing body of evidence suggests that vitamin D status is important in biologic processes involved in the maintenance of physical function.
- Trial name
- NCT01179503
- Testing
- calcium, Vitamin D plus calcium
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Cachexia, Neoplasms
Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms
Muscle mass loss is a common adverse effect of cancer. Muscle mass loss occurs with or without reduction in body weight. Cancer cachexia (CC) is the involuntary loss of body weight of >5% within 6 months and it occurs in 50-80%…
- Conditions
- Cachexia, Neoplasms, Exercise, Metabolism
- Trial name
- PANACEA (NCT05307367)
- Testing
- Exercise training
- Where
- Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Exercise, Ultra-endurance Running
Effect of Exogenous Ketosis During Ultra-endurance Exercise
The aim of this study is to investigate the effect of oral ketone administration during and immediately after an ultramarathon. Potential changes in cognitive function (reaction time, number of errors), running performance, jump…
- Conditions
- Exercise, Ultra-endurance Running, Ketosis, Skeletal Muscle
- Trial name
- NCT05407753
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Resistance Exercise, Muscle Hypertrophy
Muscle Adaptations in Children and Adults Following Twelve Weeks of Flywheel or Weight Stack Resistance Exercise
The goal of this trial is to compare resistance exercise using traditional techniques and flywheel training to controls in healthy children ages nine to 13 and adults ages 18 to 50.
- Conditions
- Resistance Exercise, Muscle Hypertrophy, Skeletal Muscle, EMG
- Trial name
- KidREx (NCT06698055)
- Testing
- Flywheel Resistance Exercise, Weight Stack Resistance Exercise
- Where
- Sweden
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Björn Alkner
Skeletal Muscle Hypertrophy
Effects of a Multi-ingredient Supplement Study: a Randomized Controlled Trial in Men and Women
Resistance exercise training is a known stimulant for muscle protein synthesis (MPS) to occur, however the consumption of protein is also necessary to induce a shift towards a positive net protein balance.
- Trial name
- SRCT (NCT03525197)
- Testing
- Whey protein-based supplement, Collagen protein-based supplement
- Where
- 2 sites in Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- McMaster University
Copd, Athletes
Effects of CreaSafe® on Kidney, Muscle, and Cardiopulmonary Function in Athletes and COPD Patients
Creatine supplementation (CS) offers numerous health benefits, with no proven side effects reported to date. CS positively impacts all organs and systems of the body.
- Trial name
- NCT06991426
- Testing
- CreaSafe® creatine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Metabolic Syndrome
Effect of Physical Activity and Diet on the Treatment of Metabolic Syndrome
Metabolic syndrome has been defined as a group of associated risk factors for cardio-vascular diseases and diabetes. It is usually treated with an association of restrictive diet, physical exercise and drugs.
- Trial name
- NCT00917917
- Testing
- Type of physical activity (resistance, endurance), Restrictive diet
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand