Clinical trials: Skin Diseases, Papulosquamous
Psoriasis, Plaque-type
Thalidomide in the Treatment of Chronic Plaque Psoriasis.
The objective of this study is to obtain information on the effectiveness of thalidomide in psoriasis.
- Trial name
- NCT01891019
- Testing
- Thalidomide oral
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Wake Forest University
Psoriasis
A Study of IBI112 in Chinese Patients With Psoriasis Who Were Previously Treated With Biologics
This is a multicenter, open-label study aim to evaluate the efficacy and safety of IBI112 in Chinese participants with plaque psoriasis who were treated with biologics and switched to IBI112.
- Trial name
- NCT05970978
- Testing
- regular treatment, Intensive treatment
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Psoriasis
A Study of Efalizumab in Participants With Moderate to Severe Chronic Psoriasis Who Have Failed, Have a Contraindication to, or Are Intolerant of Other Systemic Therapies
This is a Phase IIIb/IV, open label, multicentre study of efalizumab (anti cluster of differentiation [CD] 11a recombinant human monoclonal antibody) in participants with moderate to severe plaque psoriasis who have failed to…
- Trial name
- NCT00249808
- Testing
- Efalizumab - anti-CD11a recombinant human monoclonal antibody
- Where
- United Kingdom
- Volunteers
- 1,266 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Psoriasis
Efficacy and Safety Study of Subcutaneous Secukinumab in Treatment of Subjects With Moderate to Severe Chronic Plaque-type Psoriasis as Compared to Etanercept and Placebo.
This withdrawn study was to assess the safety and efficacy of secukinumab compared to etanercept and placebo in patients who have moderate to severe, chronic, plaque-type psoriasis.
- Trial name
- NCT01900782
- Testing
- Intervention A, Intervention B
- Sponsor
- Novartis Pharmaceuticals
Psoriasis
Randomized Study of PH-10 for Psoriasis
PH-10 is an aqueous hydrogel formulation of rose bengal disodium (RB) for topical administration to the skin, and is being studied for the treatment of cutaneous skin disorders, specifically psoriasis and atopic dermatitis.
- Trial name
- NCT01247818
- Testing
- PH-10 (0.002% Rose Bengal), PH-10 (0.005% Rose Bengal), PH-10 (0.01% Rose Bengal)
- Where
- 4 sites in United States
- Volunteers
- 99 people
- Sponsor
- Provectus Pharmaceuticals
Lichen Planus
Treatment Of Oral Lichen Planus
This novel project aims to explore an alternative treatment for oral lichen planus (OLP), a challenging condition with limited therapeutic options.
- Trial name
- NCT06327620
- Testing
- Daivobet ointment, topical steroids
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University
Moderate and Severe Plaque Psoriasis
A Dose Finding Study of AEB071 Assessing Psoriasis Area and Severity Index in Patients With Plaque Psoriasis
This study is designed to provide efficacy and safety data of several doses of AEB071 so that the optimal dose and treatment duration can be chosen for testing in later studies in patients with plaque psoriasis (with a disease…
- Trial name
- NCT00885196
- Testing
- AEB071
- Where
- 40 sites in United States, Argentina and 7 more
- Volunteers
- 336 people
- Sponsor
- Novartis Pharmaceuticals
Psoriatic Arthritis
REPArE: Rating Evaluations in Psoriatic Arthritis (PsA) With Etanercept (Enbrel®)
The overall objective of the study was to describe the long-term effectiveness and safety of etanercept in patients with psoriatic arthritis in a Canadian clinical practice setting.
- Trial name
- NCT00127842
- Testing
- Etanercept
- Volunteers
- 110 people
- Sponsor
- Amgen
Lichen Plano-Pilaris
Nemolizumab to Treat Lichen Planopilaris, a Noncontrolled, Prospective, Pilot Study.
Lichen planopilaris (LPP) is a primary lymphocytic cicatricial alopecia characterized by progressive, permanent hair loss and scalp symptoms such as pruritus and burning.
- Trial name
- NCT07396168
- Testing
- Nemolizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Skin Center Dermatology Group
Psoriasis
Assessing Psoriasis Treatment Outcomes
To assess the feasibility of AIGPP video interactions with psoriasis patients. To explore patient attitudes, trust, and comfort levels concerning AIGPP interactions in a healthcare setting, and to understand their influence on…
- Trial name
- NCT07391423
- Testing
- Artificial intelligence, Human, Standard of Care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Wake Forest University Health Sciences
Psoriatic Arthritis
DC-STAMP: Regulators of Osteoclastogenesis and Response Marker in PsA
The Investigators will examine if DC-STAMP can serve as an early marker of TNFi response in PsA. Identification of such a biomarker would permit rapid transition to a new agent, a major treatment advance.
- Trial name
- NCT03011242
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Psoriasis
Narrow-Band UVB-Therapy in Psoriasis
Study on two different irradiation schemes in UVB phototherapy for psoriasis. Previous studies demonstrated a similar clinical effect in erythematogenic and suberythematogenic irradiation, with less complications in…
- Trial name
- NCT00748020
- Testing
- UVB phototherapy
- Where
- Netherlands
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Plaque Psoriasis
A Comparison of 000-0551 Lotion Versus Vehicle Lotion in Subjects With Plaque Psoriasis (Study -305)
This Phase 3 study has been designed to determine and compare the efficacy and safety of 000-0551 Lotion and Vehicle Lotion applied twice daily for two weeks in subjects with plaque psoriasis.
- Trial name
- NCT01882647
- Testing
- 000-0551 Lotion, Vehicle Lotion
- Where
- 11 sites in United States
- Volunteers
- 222 people
- Sponsor
- Therapeutics, Inc.
Psoriasis
Nailfold Capillaroscopic Changes in Psoriasis
The goal of this observational study is to evaluate nailfold capillaroscopic changes in patients with psoriasis and to assess their correlation with disease severity.
- Trial name
- NCT07693595
- Testing
- Nailfold Capillaroscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Psoriatic Arthritis
A Study to Evaluate the Efficacy and Safety of Bimekizumab in the Treatment of Subjects With Active Psoriatic Arthritis
This is a study to demonstrate the clinical efficacy, safety and tolerability of bimekizumab administered subcutaneously (sc) compared with placebo in the treatment of tumor necrosis factor alpha-inadequate responders (TNFα-IR)…
- Trial name
- BE COMPLETE (NCT03896581)
- Testing
- Bimekizumab
- Where
- 92 sites in United States, Australia and 9 more
- Volunteers
- 400 people
- Sponsor
- UCB Biopharma SRL
Psoriasis, Ulcerative Colitis
Study to Evaluate APVO210 in Healthy Subjects, Patients With Psoriasis, and Patients With Ulcerative Colitis
Phase 1 study in 2 stages with 2 expansion cohorts. The first stage is a single ascending dose (SAD) study of APVO210 in healthy volunteers.
- Trial name
- NCT03768219
- Testing
- APVO210
- Where
- Australia
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Aptevo Therapeutics
Psoriasis
The Effect of Dietary Intervention on Endothelial Glycocalyx in Psoriasis
The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis.
- Trial name
- NCT05184699
- Testing
- Food supplement Endocalyx
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Athens
Psoriasis
Comparison of Efficacy and Safety of Deucravacitinib Versus Methotrexate in the Treatment of Moderate-to-Severe Plaque Psoriasis .
Background: Psoriasis is a chronic , immune-mediated inflammatory skin disorder affecting millions globally, the disease presents a major challenge to the physicians.
- Trial name
- NCT07915492
- Testing
- Participants in group B will receive Methotrexate ,10mg tablets , once weekly for 28 weeks
- Where
- Bangladesh
- Volunteers
- 106 people
- Sponsor
- Bangladesh Medical University
Psoriasis
Study of the Efficacy of Cloderm® Cream in the Treatment of Moderate Plaque Psoriasis
The purpose of this study is to determine whether Cloderm Cream is effective for topical treatment of moderate psoriasis over 28 days.
- Trial name
- NCT01714544
- Testing
- Cloderm Cream
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Promius Pharma, LLC
Psoriasis
Study Evaluating Safety of Etanercept in Treatment of Patients With Moderate to Severe Psoriasiswith Etanercept
Evaluate (i) safety of etanercept in patients with moderate to severe psoriasis in Spain; (ii) the incidence of adverse events reported in these patients, and (iii) the role that age and concomitant therapy might play in the…
- Trial name
- NCT00581165
- Testing
- Etanercept
- Volunteers
- 500 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
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