Clinical trials: Skull
Optic Neuritis
Privosegtor Investigation in Optic Neuropathies Efficacy Evaluation Research
The goal of this clinical trial is to evaluate the safety and efficacy of privosegtor, a neuroprotective candidate, in patients diagnosed with optic neuritis (ON).
- Trial name
- PIONEER-1 (NCT07623668)
- Testing
- Privosegtor, Methylprednisolone
- Where
- 4 sites in United States
- Volunteers
- 210 people
- Sponsor
- Oculis
Central Nervous System Vulnerabilities in Preterm Infants
Comparison of Brain Volumes Measured by 2D USG and MRI
Cranial USG is simple and easy method to assess preterm infant brain. Some studies showed that brain volumes of preterm infants could be calculated by measurement of 2D distances.
- Trial name
- NCT04190017
- Testing
- Cranial MRI
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Ankara City Hospital Bilkent
Strabismus, Regional Anesthesia Morbidity
Peribulbar Rocuronium in Adult Strabismus Surgery
This is a prospective randomized clinical study that will be carried on adult patients aged from 21-60 years and presented for strabismus surgery under peribulbar anesthesia.
- Conditions
- Strabismus, Regional Anesthesia Morbidity, Rocuronium
- Trial name
- NCT04821817
- Testing
- Normal saline, Rocuronium
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Tanta University
Mandible Fracture
Computer Guided Lag Screw Fixation Versus Conventional Lag Screw Fixation in Anterior Mandibular Fractures
Comparison between computer guided lag screw fixation versus traditional lag screw fixation in open reduction and internal fixation of anterior mandibular fractures.
- Trial name
- NCT03530891
- Testing
- Computer guided lag screw fixation, Conventional lag screw fixation
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Cairo University
Humoral Rejection, Guillain-Barre Syndrome
Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation
Plasma exchange procedures remove procoagulant and anticoagulant factors. Every procedure increases the risk of bleeding and repeated procedures increase the risk of bleeding mostly because lower fibrinogen levels.
- Conditions
- Humoral Rejection, Guillain-Barre Syndrome, Miller Fisher Syndrome, CIDP
- Trial name
- NCT03801135
- Testing
- Fibrinogen concentrate, Fresh Frozen Plasma
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Post Operative Care, Endoscopic Skull Base Surgery
Prospective Quality of Life Study in Pituitary Surgery
Post-operative assessment and debridement are key components in patient care for surgery patients. However, a standardized protocol for management after endoscopic skull base surgery is unavailable.
- Conditions
- Post Operative Care, Endoscopic Skull Base Surgery, Postoperative Period
- Trial name
- NCT03694990
- Testing
- Follow-up schedule
- Volunteers
- 165 people
- Sponsor
- University of Virginia
Optic Neuritis, Optic; Neuritis, With Demyelination
BN201 SAD MAD Study in Healthy Subjects
The purpose of this study is to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of BN201 in healthy subjects.
- Trial name
- NCT03630497
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Accure Therapeutics
Schwannoma, Vestibular
CyberKnife Radiotherapy for the Treatment of Schwannomas
Historically, the management of schwannomas has relied primarily on observation, surgery, or conventional radiotherapy techniques.
- Trial name
- Schwannomas (NCT07801560)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hartmann Oncology Radiotherapy Group, France
Breast Cancer, Head and Neck Cancer
Photodynamic Therapy in Treating Patients With Skin Cancer or Solid Tumors Metastatic to the Skin
RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. This may be effective treatment for skin cancer and cancer that is metastatic to the skin.
- Conditions
- Breast Cancer, Head and Neck Cancer, Lymphoma, Metastatic Cancer
- Trial name
- NCT00023790
- Testing
- silicon phthalocyanine 4
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Case Comprehensive Cancer Center
Zygomatic Fractures
Evaluation of Navigation Assisted Reconstruction of Posttraumatic Zygomatic Deformity
Treatment of late deformities following fractures of the orbitozygomaticomaxillary complex can be considered a formidable challenge, even to the skilled surgeon.
- Trial name
- NCT01487018
- Testing
- Navigation Surgery, Traditional Surgery
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Peking University
Trigeminal Neuralgia
Safety and Efficacy of Botulinum Toxin A in Patients With Trigeminal Neuralgia
This is a double-blind randomized clinical trial comparing the pain reduction of individuals treated with BTX-A and placebo as well as evaluating possible changes in neuroinflammatory biomarkers.
- Trial name
- NCT06315790
- Testing
- Botulinum toxin A, Isotonic saline
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Henrik Schytz
Breast Cancer, Brain Metastasis
PCI in Advanced Triple Negative Breast Cancer Patients Who Response to 1st Line Chemotherapy
The purpose of this study is to compare whether prophylactic cranial irradiation in patients with advanced triple negative breast cancer who had a response to first line chemotherapy could prolong brain-metastasis free survival.
- Trial name
- NCT02448576
- Testing
- prophylactic cranial irradiation
- Where
- China
- Volunteers
- 326 people
- Sponsor
- wang shusen
Cancer
Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer
RATIONALE: Cyproheptadine hydrochloride may prevent weight loss caused by cancer or cancer treatment. It is not yet known whether cyproheptadine is more effective than a placebo in preventing weight loss in young patients…
- Trial name
- NCT01132547
- Testing
- cyproheptadine hydrochloride
- Where
- 14 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of South Florida
Atherosclerosis of Artery, Metabolic Syndrome
Carotid Atherosclerotic Plaque Load and Neck Circumference
The aim of this study is to establish a deep learning model to automatically detect the presence and scoring of carotid plaques in neck CTA images, and to determine whether this model is compatible with manual interpretations.
- Conditions
- Atherosclerosis of Artery, Metabolic Syndrome, Machine Learning
- Trial name
- NCT05040958
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Vocal Cord Paralysis Unilateral
Laryngeal Reinnervation Versus Thyroplasty in Patients With Vocal Fold Weakness.
The purpose of this study is to help determine the most effective treatment for participants with Unilateral Vocal Fold Paralysis. There are currently two types of operations used to treat this condition.
- Trial name
- VOCALIST (NCT02973152)
- Testing
- Thyroplasty, Reinnervation
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Royal National Throat, Nose and Ear Hospital
Orofacial Pain, Trigeminal Neuralgia
An Follow-up Study of Occlusal Adjustment for Orofacial Pain
The purpose of this study is to determine whether what kind of occlusion are related the orofacial pain under investigation, and whether occlusal adjustment have an effect in relief of this kind of orofacial pain.
- Trial name
- NCT02856906
- Testing
- occlusal adjustment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Meiqing Wang
Brain and Central Nervous System Tumors, Metastatic Cancer
Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors
RATIONALE: Photodynamic therapy uses light and photosensitizing drugs to kill tumor cells and may be an effective treatment for refractory brain tumors.
- Trial name
- NCT00002647
- Testing
- verteporfin, conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Medical College of Wisconsin
Progressive Supranuclear Palsy
GV1001 Subcutaneous(SC) for the Treatment of Progressive Supranuclear Palsy (PSP)
The study will be conducted by the Sponsor to evaluate the efficacy and safety of GV1001 (0.56 mg and 1.12 mg) administered subcutaneously as a treatment for Progressive Supranuclear Palsy, (PSP).
- Trial name
- NCT05819658
- Testing
- GV1001 0.56mg, GV1001 1.12mg
- Where
- 5 sites in South Korea
- Volunteers
- 78 people
- Sponsor
- GemVax & Kael
Neuromyelitis Optica Spectrum Disorder
Inebilizumab in Acute Neuromyelitis Optica Spectrum Disorders
This study is aimed to observe the effectiveness and safety of inebilizumab in the acute phase of neuromyelitis optica spectrum disorders.
- Trial name
- NCT05891379
- Testing
- Inebilizumab, oral immunosuppressant
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xuanwu Hospital, Beijing
Optic Neuritis
Edaravone in the Treatment of Optic Neuritis
Edaravone has demonstrated a beneficial effect in promoting remyelination and protecting axons in animals with NMOSD. The researchers posit that edaravone may enhance visual outcomes in patients with aquaporin-4 antibody-positive…
- Trial name
- NCT05540262
- Testing
- Edaravone
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
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