Clinical trials: Skull Base Tumors
Head and Neck Cancer, Skull Base--Cancer
HRQoL in Patients With Solid Tumors Treated With Hadrontherapy
The Quality of Life of patients treated with hadrontherapy is still limited. Two cohorts are established, they will be receiving specific standardized questionnaires to be evalutaed in their results.
- Conditions
- Head and Neck Cancer, Skull Base--Cancer, Brain Cancer
- Trial name
- HadroQoL (NCT05947149)
- Testing
- questionnaires administration
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- CNAO National Center of Oncological Hadrontherapy
Meningioma, Pituitary Disease
The Impact of Endoscopic Endonasal Skull Base Surgery on Olfaction
In this study, the research team will investigate the incidence and etiology of olfactory dysfunction following endoscopic endonasal skull base surgery, by combining clinical assessments with histomolecular analysis.
- Conditions
- Meningioma, Pituitary Disease, Pituitary Adenoma, Craniopharyngioma
- Trial name
- Endo-Olfact (NCT06874426)
- Testing
- Endoscopic endonasal skull base surgery
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 154 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Head and Neck Cancer, Squamous Cell Carcinoma
Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)
The NeoScorch HN study is a single institution multisite phase II trial including 3 cohorts of 25 patients each for patients with newly diagnosed locoregionally advanced, histologically confirmed, head and neck cancer eligible…
- Conditions
- Head and Neck Cancer, Squamous Cell Carcinoma, Oral Cavity Cancer, Oropharyngeal Cancer
- Trial name
- (NeoScorch HN) (NCT07209189)
- Testing
- Toripalimab + Chemotherapy, Toripalimab, Chemoradiotherapy or radiation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Chordoma, Tumor
Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base
This study is a prospective randomised clinical phase III trial. The primary objective of this study is to evaluate, if the innovative therapy (carbon ion irradiation) in chordomas is superior to the standard proton treatment…
- Conditions
- Chordoma, Tumor, Treatment
- Trial name
- HIT-1 (NCT01182779)
- Testing
- Carbon ion, Protons
- Where
- Germany
- Volunteers
- 319 people
- Sponsor
- Heidelberg University
Facial Palsy
Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery
Facial palsy after surgical removal of cranial base tumors adherent to the nerve can partly be explained by inflammation.
- Trial name
- NCT00438087
- Testing
- methylprednisolone
- Where
- France
- Volunteers
- 313 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head and Neck Cancer Squamous Cell Carcinoma, Skull Base--Cancer
Neoadjuvant Immunochemotherapy and Postoperative Adjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma Invading the Skull Base
This prospective, single-arm, Phase II clinical trial aims to evaluate the efficacy and safety of tislelizumab combined with chemotherapy as neoadjuvant therapy and postoperative adjuvant immunotherapy in patients with skull…
- Conditions
- Head and Neck Cancer Squamous Cell Carcinoma, Skull Base--Cancer, Neoadjuvant Chemoimmunotherapy, Objective Response Rate
- Trial name
- NCT07145931
- Testing
- Neoadjuvant chemoimmunotherapy, Tislelizumab Nab paclitaxel
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Sun Yat-sen University
Skull Base Neoplasms
Surgical Outcomes of Extended Endoscopic Endonasal Approach for Skull Base Lesions.
Aim of this study is to evaluate the surgical and functional outcomes of the extended endoscopic endonasal approach (EEEA) in the management of skull base lesions, including extent of resection, postoperative complications, and…
- Trial name
- NCT07788300
- Testing
- Endoscopic Endonasal Approach for Skull Base Lesions.
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Anosmia, Skull Base Neoplasms
Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery
The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the…
- Trial name
- NCT05912881
- Testing
- Olfactory training
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Chordoma, Chondrosarcoma
Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull Base
The project is planned as a phase II clinical trial with a low level of intervention, for the prospective evaluation of the clinical results of radical or adjuvant treatment by proton therapy in chordomas and chondrosarcomas of…
- Trial name
- NCT05861245
- Testing
- 5-fraction hipofractionated protontheray, 25-fraction hypofractionated proton therapy
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Quironsalud
Skull Base Pathology
Olfactory Function Following Endoscopic Endonasal Skull Base Surgery
The purpose of this study is to compare a subject's sense of smell before and after endoscopic endonasal surgery to remove a skull base abnormality (i.e.
- Trial name
- UPSIT (NCT02165969)
- Testing
- endoscopic endonasal surgery with UPSIT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ricardo L. Carrau, MD
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Chondrosarcoma
Proton Beam Therapy for Chondrosarcoma
The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chondrosarcoma.
- Trial name
- NCT00496522
- Testing
- Proton Beam Therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Brain Tumor, Brain Cancer
Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.
This is a prospective, observational clinical trial investigating the morphological and volumetric changes in the brain following cranial Radiation Therapy in pediatric patients with brain or skull base tumors.
- Conditions
- Brain Tumor, Brain Cancer, Skull Base Tumor
- Trial name
- NCT03972514
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baptist Health South Florida
Meningioma, Radiation Toxicity
Neurocognitive Impact of Different Irradiation Modalities for Patients With Grade I-II Skull Base Meningioma:
For the purpose of this research, investigator will constitute several cohorts of patients, treated either by intensity-modulated radiotherapy, stereotactic radiotherapy or proton-therapy.
- Trial name
- CANCER-COG (NCT06036706)
- Testing
- Normo-fractionated intensity-modulated brain irradiation with or without stereotactic positioning, Hypo-fractionated stereotactic brain irradiation, Normo-fractionated proton therapy brain irradiation
- Where
- 3 sites in France
- Volunteers
- 108 people
- Sponsor
- Centre Francois Baclesse
Pituitary Neoplasms
Application of Augmented Reality Neuronavigation in Transnasal Endoscopic Skull Base Surgery
"For lesions in the skull base, including meningiomas, chordomas and pituitary tumors, endoscopic surgery has replaced traditional microscopes as the mainstream procedure.
- Trial name
- NCT06282224
- Testing
- Performing endoscopic transnasal skull base surgery with AR-integrated endoscope
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Chordoma
Proton Beam Therapy for Chordoma Patients
The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chordoma. The safety of this treatment will also be studied.
- Trial name
- NCT00496119
- Testing
- Proton Beam Therapy, Photon Beam Therapy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- M.D. Anderson Cancer Center
Malignancy, Glioma
Skull Base and Low Grade Glioma Neurocognitive Magnetic Resonance Imaging (MRI) Study
The purpose of this study is to: estimate the degree of memory loss, if any following radiotherapy to the base of skull or brain as measured by standard neurocognitive battery testing.
- Conditions
- Malignancy, Glioma, Radiotherapy
- Trial name
- NCT01212731
- Testing
- Photon treatment plans, Proton Treatment Plans, Neurocognitive evaluation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Vestibular Schwannoma, Acoustic Neuroma
Auditory Nerve Test System During Vestibular Schwannoma Resection
The Auditory Nerve Test System (ANTS) is a novel device that stimulates the auditory nerve much like a cochlear implant. The purpose of this study is to demonstrate feasibility of the ANTS during translabyrinthine surgery for…
- Conditions
- Vestibular Schwannoma, Acoustic Neuroma, Sensorineural Hearing Loss, Asymmetric Sensorineural Hearing Loss
- Trial name
- ANTS (NCT04241679)
- Testing
- Auditory Nerve Test System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Esophageal Neoplasm, Anastomotic Leak
Prediction of Anastomotic Complications and Recurrent Laryngeal Nerve Injury Based on Postoperative Early Endoscopic Evaluation
Analyze the correlation between the conformity of the anatomy (based on endoscopic examination) and postoperative anastomotic fistula and anastomotic stenosis; establish an anastomotic classification; and construct a predictive…
- Conditions
- Esophageal Neoplasm, Anastomotic Leak, Recurrent Laryngeal Nerve Injuries, Anastomotic Stenosis
- Trial name
- NCT06348381
- Testing
- No intervention
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Chest Hospital
Brain Tumor
Comparing Cosmetic Outcomes: Endoscopic vs. Conventional Craniotomy for Frontal Skull Base Lesions
This research study will compare the cosmetic outcomes, specifically scar assessment and complications, between two surgical approaches for treating frontal skull base lesions: the endoscopic supraorbital eyebrow craniotomy and…
- Trial name
- NCT06417658
- Testing
- Endoscopic Supraorbital Eyebrow Craniotomy, Conventional Frontal Craniotomy
- Volunteers
- 42 people
- Sponsor
- University of Health Sciences Lahore