Clinical trials: Sleep Hypopnea
Obstructive Sleep Apnea, Sleep Apnea
Inflammation and Neurocognitive Damage Markers in Elderly People With Obstructive Sleep Apnea
The aging process tends to promote an overall increase in inflammation compromising the immunologic system regulation, sleep/wakefulness pattern, and neurocognitive performance.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Apnea, Obstructive, Obstructive Sleep Apnea Syndrome
- Trial name
- NCT04882020
- Testing
- cortisol, BDNF, s100B, IL-1B, IL-6, IL-10, TNF-alpha
- Where
- Brazil
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
OSA - Obstructive Sleep Apnea, Cognitive Functions
Cognitive Function in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder and has been increasingly recognized as a contributor to cognitive decline and a potential risk factor for neurodegeneration.
- Trial name
- CUFM1DN (NCT07364318)
- Where
- Slovakia
- Volunteers
- 30 people
- Sponsor
- Comenius University
Obstructive Sleep Apnea, Atrial Fibrillation
Effects of PAP on Afib Recurrence Risk After Catheter Ablation in OSA Patients
With this pilot study, we are hoping to test the feasibility of a larger study in the future and to learn whether positive airway pressure therapy reduces the recurrence risk of atrial fibrillation after successful catheter…
- Trial name
- OSA-AFIB (NCT03242720)
- Testing
- Cardiac Ablation for Atrial Fibrillation
- Where
- United States
- Sponsor
- Stanford University
Hypoxia, Sleep Apnea
Intermittent Hypoxia 2: Cardiovascular and Metabolism
The purpose of this study is to compare cardiovascular physiological adaptation to intermittent hypoxia (IH) of nonobese healthy subjects. The exposure will be two periods of two weeks (IH versus exposure "placebo hypoxia").
- Conditions
- Hypoxia, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- IH2 (NCT02058823)
- Testing
- Valsartan, Amlodipine
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Sleep Disordered Breathing, Alzheimer's Disease
Sleep, Aging and Risk for Alzheimer's Disease
Our preliminary data show for in cognitively-normal elderly, that Sleep Disordered Breathing (SDB) is associated with the increase of cerebrospinal fluid (CSF) phosphorylated-Tau (P-Tau) and total-Tau (T-Tau), decreases in medial…
- Trial name
- SARA (NCT01962779)
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- 2 sites in United States
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
ESRD, Sleep Apnea
Identification of Desaturation Episodes by Means of Continuous Measurement of Oxygen Saturation During Hemodialysis
The clinical diagnosis of sleep apnea is difficult among ESRD patients since the characteristic clinical features of sleep apnea may be absent and since sleep-related symptoms, such as fatigue and sleepiness, may be attributed to…
- Conditions
- ESRD, Sleep Apnea, Oxygen Deficiency
- Trial name
- NCT02987179
- Testing
- Observational
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Renal Research Institute
Non-Alcoholic Fatty Liver Disease, Obstructive Sleep Apnea
Fatty Liver and Obstructive Sleep Apnea
Non-alcoholic fatty liver disease is associated with obstructive sleep apnea. Abnormalities in liver enzymes can improve following continuous positive airway pressure in patients with obstructive sleep apnea.
- Trial name
- NCT00730873
- Testing
- Continuous positive airway pressure
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Lung Transplantation, Sleep-disordered Breathing
Sleep-disordered Breathing After Solid Organ Transplantation
Sleep-disordered breathing (SDB) describes a group of disorders in which partial or complete cessation of breathing occurs many times throughout the night, resulting in daytime sleepiness or fatigue that interferes with a…
- Trial name
- NCT03142022
- Testing
- No intervention - Diagnostic polysomnography at 1 year after lung transplantation
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hypertension (HTN), Sleep Apnea Syndrome, Obstructive
A Cohort Study on Increasing Blood Pressure Benefits in Sleep Apnea Patients After CPAP Treatment
Research Title "Quadruple-Blind Randomized Controlled Trial of the Effect of CPAP on Blood Pressure in Patients with Sleep Apnea" Why are we conducting this study? Sleep apnea (OSA) is very common, affecting approximately one in…
- Trial name
- NCT07357272
- Testing
- continuous positive airway pressure
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Epilepsy, Obstructive Sleep Apnea
Investigation of Sleep Quality and Prevalence of Sleep-disordered Breathing in Children and Young People With Epilepsy
Obstructive sleep apnoea (OSA) is a condition that affects around one in 20 children. In children with OSA, repeated episodes of airway obstruction can severely disturb and fragment sleep, leading to subsequent cognitive and…
- Trial name
- NCT03103841
- Testing
- Sleep studies [Polysomnography]
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Down Syndrome
Role of Sleep Apnea in the Neuropsychological Function in Down Syndrome People
This is the first study about Neuropsychological function and OSAS in Taiwan. Although the correlation between OSAS and neuropsychological abnormalities had been reported, it is worth to understand more about the detailed domains…
- Trial name
- NCT03267602
- Testing
- CPAP
- Volunteers
- 45 people
- Sponsor
- National Taiwan University Hospital
Alzheimer Disease, Sleep Apnea, Obstructive
The Effect of Anticholinesterase Drugs on Sleep in Alzheimer's Disease Patients
The purpose of this study is to determine the effects of the anticholinesterase drug donepezil on sleep in Alzheimer disease patients. Sleep structure and respiratory parameters will be analyzed by polysomnography.
- Trial name
- ACHALZSLEEP (NCT00480870)
- Testing
- donepezil
- Where
- Brazil
- Volunteers
- 65 people
- Sponsor
- Associacao Fundo de Incentivo a Psicofarmcologia
Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD)
Immune Status and Disease Control of Inflammatory Airway Diseases
The goal of this study is to learn how the body's immune system affects disease control in people with different airway inflammatory diseases.We want to understand: 1.Whether specific immune cell patterns in the blood are linked…
- Conditions
- Airway Inflammation, Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis), Bronchiectasis
- Trial name
- ISDC-IAD (NCT07493629)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Ningbo University
Obstructive Sleep Apnea
Ergometer Training in Patients With OSA
Patients with suspected OSA (obstructive sleep apnoea syndrome) are asked to use a standard bike ergometer which is additionally equipped with a system to gather training data and the ability to send daily training time to an…
- Trial name
- NCT01457729
- Testing
- Motivation by Telephone Call
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV
Obstructive Sleep Apnea
Extended Evaluation of the Efficacy of a Proactive FOT-based Auto-CPAP Algorithm
This study implements an extended (post marked) examination of the efficacy of a proactive auto-CPAP algorithm, which is based on the forced oscillation technique (FOT) in a sample of patients with predominantly obstructive sleep…
- Trial name
- NCT03070756
- Testing
- Minimal-Intervention - Specification of device settings
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Heinen und Löwenstein GmbH & Co. KG
Obstructive Sleep Apnea (OSA), Orofacial Myofunctional Disorders
Oromyofunctional Therapy: a Rehabilitation Program for OSA in Children With Down Syndrome and Prader-Willi Syndrome
Obstructive sleep apnea (OSA) is a prevalent medical condition with important implications for overall health and quality of life in both children. Therefore, it is important to treat OSA early and effectively.
- Trial name
- OROFIT-P (NCT07122505)
- Testing
- Orofacial myofunctional therapy
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Ghent
Sleep Apnea, Obstructive, Sleep Disorder
Home Apnea Testing in CHildren Trial
This clinical trial will compare home sleep apnea testing with the gold standard in-lab polysomnography in terms of 1) accuracy, 2) therapeutic decision-making, and 3) parent/child acceptability in children referred for…
- Conditions
- Sleep Apnea, Obstructive, Sleep Disorder, Sleep Apnea Syndromes, Sleep Disturbance
- Trial name
- HATCH (NCT05382754)
- Testing
- Home sleep apnea test, In-lab polysomnography
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Children's Hospital of Philadelphia
Type 2 Diabetes, Obstructive Sleep Apnea
Sleep Disordered Breathing and Diabetes
The hypothesis of this study is: sleep disordered breathing (SDB), specifically, obstructive sleep apnea, is associated with poorer glucose in the existing type 2 diabetic condition.
- Trial name
- NCT00901472
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Chicago
Cardiomyopathy
Sleep Apnea and CRT Upgrading
Cardiac resynchronization therapy may reduce central sleep apnea, but there is no prospective randomized study so far demonstrating such an effect in patients with conventional pacemaker undergoing upgrading to CRT because of…
- Trial name
- NCT01970423
- Testing
- CRT, conventional right ventricular stimulation
- Where
- 2 sites in Austria
- Volunteers
- 56 people
- Sponsor
- Medical University Innsbruck
Obstructive Sleep Apnea, Insomnia
Multidisciplinary Approach to the Treatment of Insomnia and Comorbid Sleep Apnea
The overall goal of this project is to determine the efficacy of a multidisciplinary treatment model for patients with Obstructive Sleep Apnea (OSA) and comorbid Insomnia.
- Trial name
- MATRICS (NCT01785303)
- Testing
- CBT-I, CPAP
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Northwestern University
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