Clinical trials: Sleep Obstructive Apnea
Obstructive Sleep Apnea
Oropharyngeal Exercises and Inspiratory Muscle Training in Obstructive Sleep Apnea
The effects of orofarangeal exercises (OE) and inspiratory muscle training (IMT) on sleep quality, disease severity, and airway muscle tone have been investigated in several studies.
- Trial name
- NCT04201236
- Testing
- respiratory muscle strengthening exercise, oropharyngeal muscles strengthening exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital
Obstructive Sleep Apnea
New Perspective on Exploring the Post-apneic BP Surge in Patients With OSA
The nocturnal short-term BPV induced by sleep-breathing events is affected by many factors. The purpose of the study is as follows: (1) to explore the relationship between nocturnal short-term BPV and vascular endothelial…
- Trial name
- NCT06172998
- Testing
- Phentolamine Injection
- Where
- China
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Xu J
Obstructive Sleep Apnea of Adult
Vascular Endothelial Dysfunction in Sleep Apnea
This double-blind placebo-controlled parallel group randomized study design will be used to test whether 4 weeks of atorvastatin 10 mg daily reduces levels of inflammatory markers in OSA patients treated with CPAP (standard of…
- Trial name
- NCT05289063
- Testing
- Atorvastatin 10mg, Continuous Positive Airway Pressure Therapy
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Columbia University
Obstructive Sleep Apnea
Somnodent vs Herbst in Mild and Moderate OSA Patients
Obstructive sleep apnea (OSA) is a common chronic sleep disorder that often requires lifelong care. The prevalence in the Netherlands is estimated around 300.000 patients.
- Trial name
- COSH (NCT02724865)
- Testing
- Somnodent® (Oral appliance therapy), Herbst® (Oral appliance therapy)
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Adropin In Patients of OSA
Serum Adropin as an Indicator of Endothelial Dysfunction and Disease Severity in Obstructive Sleep Apnea in Obese Patients
1. Objectives (Aim): To evaluate the role of serum adropin as a potential biomarker of endothelial dysfunction in OSA 1. Compare serum adropin levels between Obese patients with and without OSA. 2.
- Trial name
- NCT07829809
- Testing
- Adropin
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aswan University
Hypertension, Resistant to Conventional Therapy, Obstructive Sleep Apnea
CPAP Effect on Blood Pressure and Arterial Stiffness in Obstructive Sleep Apnea Patients With Resistant Hypertension
Resistant hypertension is defined as uncontrolled blood pressure (BP ≥ 140/90mmHg) despite the current use of three or more antihypertensive drugs at full doses, including a diuretic.
- Trial name
- POP-ART (NCT02385864)
- Where
- 4 sites in France
- Volunteers
- 166 people
- Sponsor
- University Hospital, Grenoble
Hypertension, Sleep Apnea
Losartan in Hypertensive Men and Women With Sleep Apnea Before and on Continuous Positive Airway Pressure (CPAP) Treatment
Obstructive sleep apnea (OSA) is a highly prevalent condition in hypertensive patients. The renin-angiotension-aldosterone-system (RAAS) has a central role in blood pressure control.
- Trial name
- LosartanPAP (NCT00701428)
- Testing
- Losartan, CPAP
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Skaraborg Hospital
Obstructive Sleep Apnea
Implant Supported Oral Appliance Treatment of OSA
Mandibular advancing oral appliances (OAm) are an effective and increasingly common treatment modality for the management of obstructive sleep apnea (OSA) in adults.
- Trial name
- BIMA (NCT03362671)
- Testing
- Implant Supported Mandibular Advancement Oral Appliance, Orthodontic Mini Implant
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of British Columbia
Childhood Obesity, Childhood Obstructive Sleep Apnea
Co-existent Obstructive Sleep Apnea (OSA) and Obesity: Finding Non-exercise Activity Thermogenesis (NEAT) Targets for Intervention
Rationale: Obesity is an increasing childhood epidemic in Canada. Obstructive sleep apnea (OSA) is a complication of obesity which causes cardiovascular disease, reduced quality of life, and premature death.
- Trial name
- NCT00854334
- Where
- Canada
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Katz, Sherri Lynne, M.D.
Chronic Obstructive Pulmonary Disease, Sleep Related Hypoventilation
Health Outcomes With CPAP or NIV in Patients With COPD and a Sleep Related Breathing Disorder
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease affecting an estimated 1 in 10 Canadians. Symptoms include persistent shortness of breath, cough and sputum production.
- Conditions
- Chronic Obstructive Pulmonary Disease, Sleep Related Hypoventilation, Obstructive Sleep Apnea, Hypoventilation
- Trial name
- NCT05623709
- Testing
- Positive airway pressure with continuous positive airway pressure or noninvasive ventilation
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Moderate Obstructive Sleep Apnea Syndrome
Upper Airway Reeducation in Moderate Obstructive Sleep Apnea Syndrome
The aim of this study is to evaluate the effectiveness of a specific reeducation performed by speech therapists in moderate obstructive sleep apnea syndrome, as an alternative to the continuous Positive Anyway Pressure (CPAP) and…
- Trial name
- SAOSGENIO (NCT05911971)
- Testing
- Experimental
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
OSA
Long Follow up on Patients With Obstructive Sleep Apnea That Undergo Diagnosis and Surgical Treatment
Long follow up on patients with obstructive sleep apnea that undergo diagnosis and surgical treatment
- Trial name
- OSA (NCT02976207)
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center
Obstructive Sleep Apnea, Non-healing Wounds
The Prevalence and Implications of Obstructive Sleep Apnea in the Population of a Wound Center
This study is looking at the prevalence of sleep apnea in a wound center population. It uses both screening surveys and take home devices. Some measures of wound healing ability are being looked at as well.
- Trial name
- NCT00679757
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Ohio State University
Sleep Apnea
Artificial Neural Network Directed Therapy of Severe Obstructive Sleep Apnea
The investigators have developed a simple, accurate, and a point-of-care, computer-based clinical decision support system (CDSS) not only to detect the presence of sleep apnea but also to predict its severity.
- Trial name
- NCT01286636
- Testing
- computer model, Polysomnogram
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Obstructive Sleep Apnea
Study of AD128 Versus Placebo in Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is the most common and serious of the sleep disorders. Long-term, OSA is associated with increased morbidity and mortality, with a number of adverse cardiovascular, neurocognitive, metabolic, and…
- Trial name
- NCT04449133
- Testing
- AD128
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Auxologico Italiano
Obstructive Sleep Apnea
Can Postoperative Outcomes be Predicted From Asking OSA Screening Questions Pre-operatively?
The proposed research will determine whether a 6-item screening questionnaire previously shown to correlate with moderate or severe OSA is useful for predicting postoperative outcomes in children undergoing surgery under general…
- Trial name
- NCT02930538
- Testing
- Survey
- Where
- United States
- Sponsor
- Nationwide Children's Hospital
Obstructive Sleep Apnea
A Pilot Study of Biomarkers in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is common and is a risk factor for postoperative complications, including respiratory and cardiac events and delirium.
- Trial name
- Cytokine OSA (NCT02325687)
- Testing
- Lumbar Puncture (Standard-of-Care)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Hospital for Special Surgery, New York
Obstructive Sleep Apnea
Domiciliary Diagnosis and Follow up in Obstructive Apnoea Syndrome
The aim of the investigators study was to evaluate the effectiveness of a home programme (diagnosis and follow-up) in patients with Obstructive Sleep Apnea (OSA) syndrome treated with CPAP and to analyze the cost of this approach.
- Trial name
- NCT01001858
- Testing
- Diagnosis and monitoring of OSA patients
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospital Universitario San Juan de Alicante
Sleep Apnea Syndromes
Left Atrial Volume and Function Evaluation in Patients With Obstructive Sleep Apnea
The purpose of this study is to determine whether patients with obstructive sleep apnea have any changes in left atrial morphology and function evaluated by echocardiography three dimensional
- Trial name
- NCT00570115
- Where
- Brazil
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Sleep Apnea, Obstructive, Hypertension
Epidemiology and Intervention of Obstructive Sleep Apnea Based on Community
This observational study in a real-world community was designed to perform epidemiological investigation and assess effect of CPAP intervention of obstructive sleep apnea.
- Conditions
- Sleep Apnea, Obstructive, Hypertension, Obesity, Diabetes
- Trial name
- NCT03280914
- Testing
- Auto-CPAP
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Guangdong Provincial People's Hospital
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