Clinical trials: Slow Breathing
Respiratory Sinus Arrhythmia, Heart Rate Variability
Smartphone Camera Measurement of Breathing-Related Heart Rate Variability Compared With ECG in Healthy Adults
This study examines how accurately a smartphone can measure the rhythmic rise and fall of heart rate that occurs with breathing (respiratory heart rate variability).
- Conditions
- Respiratory Sinus Arrhythmia, Heart Rate Variability, Healthy Volunteers
- Trial name
- NCT07922161
- Testing
- Smartphone simultaneous facial and fingertip photoplethysmography (research app), Audio-guided paced breathing
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- BELL Therapeutics Inc.
Autoimmune Diseases
Increasing Plasma Adrenaline Levels Through Breathing Techniques - an Explorative Study
Inflammatory cytokines play a pivotal role in rheumatoid arthritis (RA) and innovative non-pharmacological therapies aimed at limiting cytokine production are highly warranted.
- Trial name
- INADRI (NCT02417155)
- Testing
- Hyper/hypoventilation, Strength ventilation
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Pain
The Role of Opioidergic Systems in Breathing Based Analgesia
The purpose of this psychophysical and pharmacologic study is to determine if slow-breathing induced pain relief is mediated by endogenous opioids in response to intravenous (IV) administration of the opioid antagonist naloxone…
- Trial name
- NCT03419858
- Testing
- Mindfulness Meditation, Slow-Breathing, Naloxone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity Hypoventilation Syndrome (OHS)
Pathophysiology of Hypoventilation in Obesity and Effects of Bariatric Intervention
Breathing is impacted by obesity. Early changes are characterised by significant breathing abnormalities during sleep (a condition called sleep disordered breathing, the most common of which is obstructive sleep apnoea).
- Trial name
- PHOEBI (NCT04025528)
- Testing
- Bariatric Surgery
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Congenital Central Hypoventilation Syndrome, Patients With Nocturnal Ventilatory Assistance
Evaluation of the Awakening Capability by a Vibrating Bracelet (BRASSARD)
As part of developing a relay alarm project, the aim of the study is to test a sleeper's capability to wake up via a vibrating alarm around the wrist (vibrating bracelet).
- Conditions
- Congenital Central Hypoventilation Syndrome, Patients With Nocturnal Ventilatory Assistance, Healthy Volunteers
- Trial name
- BRASSARD (NCT03053011)
- Testing
- Vibrating bracelet
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
Chronic Obstructive Pulmonary Disease, Sleep Related Hypoventilation
Health Outcomes With CPAP or NIV in Patients With COPD and a Sleep Related Breathing Disorder
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease affecting an estimated 1 in 10 Canadians. Symptoms include persistent shortness of breath, cough and sputum production.
- Conditions
- Chronic Obstructive Pulmonary Disease, Sleep Related Hypoventilation, Obstructive Sleep Apnea, Hypoventilation
- Trial name
- NCT05623709
- Testing
- Positive airway pressure with continuous positive airway pressure or noninvasive ventilation
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Slow Breathing
Assessing the Acute Effects of Virtual Reality Interventions on Stress
A Four-Arm RCT, testing the acute effects of a Virtual Reality (VR)- based slow-paced breathing intervention on subjective and physiological markers of stress.
- Trial name
- VR_Stress_25 (NCT07191288)
- Testing
- VR (VR-Breathing+Mystical), VR (VR-Mystical), Computer (Non-VR-Breathing)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prof. Dominique de Quervain, MD
Obstructive Sleep Apnoea (OSA), Hypoventilation Syndrome
Sleep-disordered Breathing Database
The goal of this study is to collect clinical data on patients who have had a sleep study and are given a diagnosis of a sleep related breathing disorder such as obstructive sleep apnoea.
- Trial name
- NCT07402603
- Where
- United Kingdom
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Urinary Incontinence, Urge
Slow Paced-Respiration Intervention to Reduce Incontinence Trial (SPIRIT)
Urgency incontinence is a common and burdensome problem in women. Current treatments for this condition, while effective, are associated with potentially disabling side effects and high rates of discontinuation.
- Trial name
- SPIRIT (NCT01048424)
- Testing
- RESPeRATE, Urinary Incontinence Pamphlet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Normobaric Hypoxia, Hypoventilation
Influence of Hypoxic, Normobaric and Hypobaric Training on the Immunometabolism of Post-covid-19 Athletes
COVID-19 has significantly impacted sports globally, with event postponements, training disruptions, and wide-ranging concerns. SARS-CoV-2 infection can result in hyperinflammation and cardiopulmonary changes, with hypoxia as an…
- Conditions
- Normobaric Hypoxia, Hypoventilation, Normoxia
- Trial name
- NCT06128941
- Testing
- Repeated sprint
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Hypoventilation, Hyperventilation
Investigating the Effect of Yoga-based Breathing Styles on the Human Brain, With a Focus on Memory
The goal of this clinical trial is to learn if yoga-based breathing styles could improve memory performance in adult persons without relevant prior experience in yoga, meditation or similar disciplines and without existing health…
- Trial name
- NCT05846425
- Testing
- Nose-breathing training, Mouth-breathing training
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universität des Saarlandes
Sleep Wake Disorders
The Effectiveness of Lavender Aromatherapy Combined With Slow Breathing Exercises in Improving Occupational Burnout and Sleep Disorders Among Nursing Staff
This study investigates the effects of breathing exercises combined with lavender essential oil inhalation on occupational burnout and sleep disturbances in rotating shift nurses.
- Trial name
- NCT06914167
- Testing
- Slow Breathing Exercises, Lavender Essential Oil Inhalation, linalyl acetate essential oil Inhalation
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Breathing Rate
Coherence Breathing Before Cardiopulmonary Exercise Testing
This randomized crossover trial will examine the acute effects of pre-exercise coherence breathing on cardiopulmonary exercise responses in recreationally active adults.
- Trial name
- NCT07650279
- Testing
- Coherence Breathing, Spontaneous Breathing
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Human Performance Lab of Monmouth University
Anxiety, Stress
Breathing for Adolescent Stress Reduction Feasibility RCT
The purpose of this study was to test a simple slow breathing curriculum for reducing stress among high school students. The curriculum was developed by the Health and Human Performance Foundation and implemented for this study…
- Trial name
- NCT05266833
- Testing
- Slow diaphragmatic breathing
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Health and Human Performance Foundation
Morbid Obesity, Bariatric Surgery
Study to Determine Incidence of Hypoventilation in Patients Who Have Undergone Gastric Bypass
The purpose of this study is to determine if gastric bypass patients experience hypoventilation in the immediate postoperative period, and to what degree.
- Trial name
- NCT00316446
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Heart Failure
Short Term Hemodynamic Effects of Controlled Slow Breathing With Biofeedback in Patients With Heart Failure
Heart failure is associated with faster breathing, which has a negative impact on the functioning of the heart. This leads to fatigue, shortness of breath, and exercise intolerance.
- Trial name
- NCT00971386
- Testing
- Slow breathing
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Albert Einstein Healthcare Network
Stress, Stress, Psychological
Interactive Effects of Mindfulness and Slow-paced Breathing
The purpose of this study is to better understand specific stress-management practices on mood, sleep, and physiology. Participants will be assigned to one of three interventions (they all active interventions - none are a…
- Conditions
- Stress, Stress, Psychological, Stress Physiology, Sleep
- Trial name
- NCT04866901
- Testing
- Slow-Paced Breathing (SPB), Mindfulness (M), Yogic Breathing (SPB+M)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Congenital Central Hypoventilation Syndrome
Late-onset Congenital Central Hypoventilation Syndrome and the Mutation of Phox2B Gene
Congenital central hypoventilation syndrome (CCHS) is a rare disorder of respiratory control characterized by ventilatory impairment that results in arterial hypoxemia.
- Trial name
- CCHS (NCT01225679)
- Testing
- positive airway pressure, Non-invasive mechanic ventilation
- Where
- Brazil
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Elderly
The Big Squeeze (Lessening the Big Squeeze: The Effect of the Trunk Release on Interface Pressures of Individuals Seated in a High Fowler's Positions)
Older adults with a disability tend to spend greater periods of time in bed each day and often over a mealtime. To make it safe for them to eat in bed, the patient is placed in a high Fowler's position.
- Trial name
- NCT00961012
- Testing
- The Big Squeeze
- Where
- 4 sites in Canada
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- University of British Columbia