Clinical trials: Small Intestine Disease
SIBO, Endometriosis
Prevalence of Small Intestinal Bacterial Overgrowth (SIBO) in Women With Endometriosis
This is a prospective, single-arm observational diagnostic study without therapeutic intervention or control arm. Participants undergo diagnostic assessment for SIBO including lactulose hydrogen/methane breath testing and…
- Trial name
- Endo-SIBO (NCT07922408)
- Testing
- Gastroduodenoscopy, luminal aspirate, mucosal biopsies, collection of mucus, lactulose breath test
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Melanoma Neoplasms
Evaluation of Skin Tests in Biotherapy Allergies
Biotherapies are biological (extracted from an organism or living tissue) or biotechnological drugs used in the treatment of multiple conditions, such as autoimmune inflammatory diseases, cancers, and hematologic diseases.
- Conditions
- Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Melanoma Neoplasms, Small Cell Bronchial Carcinomas, Bronchial Carcinoma
- Trial name
- ETCABIO (NCT06971848)
- Testing
- Drug skin tests (investigating hypersensitivity to a biotherapy)
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Rheumatoid Arthritis, Crohn's Disease
Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium Absorption
This study is a pilot study to determine whether patients with TNFα excess have decreased calcium absorption in response to calcitriol (1,25-dihydroxyvitamin D, the active form of vitamin D) compared to normal controls.
- Trial name
- NCT00427804
- Testing
- calcitriol
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Atlanta VA Medical Center
Reduction of Small Intestinal Ulceration Risk
Mapping the MoA Behind GI Protection From Bif195
The trial will investigate effects of daily intake of the bacterial strain Bif195 or placebo when co-administered to once-daily oral intake of 300 mg of Acetylsalicylic Acid (ASA).
- Trial name
- PIP-M (NCT04448847)
- Testing
- Bif195
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Stomach Diseases, Small Intestine Disease
Magnetically Controlled Capsule Endoscopy in Visualization of the UGI and Small Intestine
In this study, we retrospectively analyzed the videos of combined upper digestive tract and small intestine examination under MCE, so as to clarify the feasibility and diagnostic efficacy of MCE in one-time examination of the…
- Trial name
- NCT05069233
- Testing
- UGI+SB
- Where
- China
- Volunteers
- 593 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Obesity
Obeticholic Acid in Morbidly Obese Patients and Healthy Volunteers
OCAPUSH (EudraCT 2014-002313-33) is a double-blind placebo-controlled parallel-arms study of the effects of obeticholic acid on farnesoid X receptor expression in jejunum and on gut microbiota in morbidly obese patients and…
- Trial name
- OCAPUSH (NCT02532335)
- Testing
- Obeticholic acid
- Where
- 2 sites in Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Proof of Concept, Irritable Bowel Syndrome
Validation of the Small Intestine Microbiome Aspiration (SIMBA) Capsule
Prospective, open label trial to establish the ability of the SIMBA Capsule to accurately obtain a sample from the small bowel of participants with IBS (10 constipation-predominant (IBS-C) and 10 diarrhea-predominant (IBS-D)) and…
- Trial name
- NCT04094558
- Testing
- Ingestible capsule, Sedated EGD, Lactulose Breath Test
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Breast Cancer, Colorectal Cancer
Family Quality of Life Among Families With a Member Who is a Cancer Patient
RATIONALE: Developing a questionnaire that can be used to assess the quality of life among people who have a family member with cancer may help the study of cancer in the future.
- Conditions
- Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00544336
- Testing
- questionnaire administration, survey administration, quality-of-life assessment
- Where
- 3 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Vanderbilt-Ingram Cancer Center
Bowel Obstruction, Artificial Intelligence
Deep Learning-based Artificial Intelligence for the Diagnosis of Small Bowel Obstruction
The study will compare the diagnostic accuracy and time to diagnosis of computed tomography images of patients with suspected intestinal obstruction seen in the emergency room by residents and surgeons, with and without…
- Trial name
- NCT06481358
- Testing
- Artificial intelligence
- Where
- Japan
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nagoya University
Irritable Bowel Syndrome
1H-19F Gastrointestinal MRI in Health and IBS
The aim of this project is to demonstrate and validate the ionizing radiation free and non invasive assessment of small intestinal anatomy, content and function in healthy and disease by a newly developed combined proton (1H) and…
- Trial name
- NCT01347918
- Testing
- 19F capsule, sterculia
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Lynch Syndrome, Lynch Syndrome I
Videocapsule Endoscopy in Lynch Syndrome
Background Lynch syndrome is caused by a pathogenic variant in one of the four Mismatch Repair genes (MMR): MLH1, MSH2/Epcam, MSH6, or PMS2.
- Conditions
- Lynch Syndrome, Lynch Syndrome I, Lynch Syndrome II, MLH1 Gene Mutation
- Trial name
- NCT05704010
- Testing
- Video capsule endoscopy
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- San Raffaele University
Gastric Cancer, Colorectal Cancer
Development and Utilization of an Integrated Clinical Genomic Database
This observational study aims to develop an integrated genomic and clinical database to support the discovery and validation of biomarkers for cancer diagnosis, treatment selection, and prediction of treatment response.
- Conditions
- Gastric Cancer, Colorectal Cancer, Lung Cancer (NSCLC), Liver Cancer
- Trial name
- SMC-4S (NCT07911267)
- Where
- South Korea
- Volunteers
- 118,750 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Preterm Birth, Low Birth Weight
Description and Comparison of Biological Vulnerability in Small Vulnerable Newborns Versus Healthy Community Controls in Urban Burkina Faso
The aim of the DenBalo study is to apply integrated multi-omics methods to examine the biological mechanisms underlying this vulnerability in Small Vulnerable Newborns (SVNs) in LMICs, with the ultimate goal of identifying…
- Conditions
- Preterm Birth, Low Birth Weight, Small for Gestational Age at Delivery
- Trial name
- DenBalo (NCT05730569)
- Where
- Burkina Faso
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Ghent
Bladder Cancer, Colorectal Cancer
The Molecular Predisposition to Hereditary Nonpolyposis Colon Cancer (HNPCC)
The goal of this study is to understand factors which may influence risk for colorectal and other cancers in families. These factors include genetic variability, in combination with diet and lifestyle.
- Conditions
- Bladder Cancer, Colorectal Cancer, Endometrial Cancer, Kidney Cancer
- Trial name
- NCT01447199
- Testing
- Health and Diet Questionnaire
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Irritable Bowel Syndrome, Visceral Hypersensitivity
Gut Permeability, Sensitivity and Symptomatology
To better understand the relationship between gut barrier function and the symptomatology and pathophysiology of irritable bowel syndrome (IBS).
- Trial name
- GPSS (NCT02358564)
- Testing
- Gastrointestinal Permeability Test, Upper Endoscopy, Rectal Barostat and Infusion of Fats
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Appendicitis Acute, Disbiosis
Differences In Microbiota Profiles Of Pediatric Appendicitis Cases
The microbial profile varies between simple appendicitis (SA) and complicated appendicitis (CA) cases. An appendectomy has been noted to temporarily diminish gut bacterial diversity.
- Conditions
- Appendicitis Acute, Disbiosis, Complicated Appendicitis, Simple Appandiscitis
- Trial name
- NCT07860307
- Testing
- Appendectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Small Bowel Disease
Mini-sized MCE for Detection of Small Bowel in Children Under the Age of 10 Years
In this prospective randomized controlled trial, pediatric volunteers were enrolled and randomly underwent mini-sized MCE and normal-sized CE to compare the success rate of self-swallowing between mini-sized MCE and normal-sized…
- Trial name
- NCT05522101
- Testing
- Mini-sized MCE, Normal-sized MCE
- Where
- 4 sites in China
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Microbial Colonization, Small Intestinal Bacterial Overgrowth
High-fat Diet (HFD) and Small Intestinal Microbiome
The investigators aim to characterize the upper small intestinal microbiome in healthy conditions in dependency on feeding condition (starved vs.
- Trial name
- FATBOM (NCT07019142)
- Testing
- HFD
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Gulf War Syndrome
Bacterial Overgrowth Associated With Chronic Multisymptom Illness Complex
The adverse impact of Gulf War Syndrome (GWS) on the health of veterans and on the resources of the VA Healthcare System underscores the need to resolve its underlying cause.
- Trial name
- NCT00956150
- Testing
- Lactulose Breath Test, Rifaximin
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Henry C. Lin, MD