Clinical trials: Small-Bowel Disorders
Lynch Syndrome, Lynch Syndrome I
Videocapsule Endoscopy in Lynch Syndrome
Background Lynch syndrome is caused by a pathogenic variant in one of the four Mismatch Repair genes (MMR): MLH1, MSH2/Epcam, MSH6, or PMS2.
- Conditions
- Lynch Syndrome, Lynch Syndrome I, Lynch Syndrome II, MLH1 Gene Mutation
- Trial name
- NCT05704010
- Testing
- Video capsule endoscopy
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- San Raffaele University
Obesity
Obeticholic Acid in Morbidly Obese Patients and Healthy Volunteers
OCAPUSH (EudraCT 2014-002313-33) is a double-blind placebo-controlled parallel-arms study of the effects of obeticholic acid on farnesoid X receptor expression in jejunum and on gut microbiota in morbidly obese patients and…
- Trial name
- OCAPUSH (NCT02532335)
- Testing
- Obeticholic acid
- Where
- 2 sites in Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Small Intestinal Bacterial Overgrowth
Methane and Hydrogen Breath Test for the Diagnosis of Small Intestinal Bacterial Overgrowth
To investigate whether the positive rates of methane and hydrogen breath test were different between the experimental group and the control group.
- Trial name
- NCT06483360
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Liver Disease
The Effect of Probiotics on Non Alcoholic Fatty Liver Disease
Nonalcoholic Fatty Liver Disease (NAFLD) has been suggested to be the most common cause of chronic liver disease in the general population in the Western World.
- Trial name
- NCT00808990
- Testing
- BioFemale
- Where
- Israel
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Rectal Cancer
The Impact of Patient Positioning and Use of Belly Board on Small Bowel and Urinary Bladder Volume Irradiated in Patients Receiving Radiotherapy for Rectal Cancer: A Prospective Phase II Study
Radiotherapy has a significant impact on local control, disease free survival and overall survival in patients with rectal cancer T2, N1, M0 and T3-4, any N, M0.
- Trial name
- NCT01142713
- Testing
- Patient Position During Radiotherapy
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Irritable Bowel Syndrome
1H-19F Gastrointestinal MRI in Health and IBS
The aim of this project is to demonstrate and validate the ionizing radiation free and non invasive assessment of small intestinal anatomy, content and function in healthy and disease by a newly developed combined proton (1H) and…
- Trial name
- NCT01347918
- Testing
- 19F capsule, sterculia
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Crohn Disease
Effect of SB CD on Chylomicron
It is often suggested that lymphatic vessels are ineffective in transporting cargo in Crohn's disease. Our own work on surgically resected tissue supports this concept (1), but the concept has not been directly tested.
- Trial name
- NCT03496818
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Small Intestine Length Measurement
Digital 3D Reconstruction Predicts Small Bowel Length
The prevalence of type 2 diabetes mellitus (T2DM) has been increasing annually worldwide, and the prevalence of diabetes has reached 11.6% in China.
- Trial name
- DTDRPSBL-BS (NCT05338567)
- Testing
- Small intestine length measurement method
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Irritable Bowel Syndrome, Crohn Disease
Evaluation of the SIMBA Capsule for Small Intestinal Dysbiosis
The SIMBA Capsule is a small, single-use, ingestible capsule that allows for the non-invasive sampling of small bowel contents using purely mechanical means.
- Conditions
- Irritable Bowel Syndrome, Crohn Disease, Celiac Disease, Ulcerative Colitis
- Trial name
- NCT05633706
- Testing
- fluid biopsy capsule
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
IBS - Irritable Bowel Syndrome, Healthy
Capsule Microbiota Sampling in IBS/Functional Gastrointestinal Disease
We will sample intestinal microbiota using a microbiome sampling capsule in Healthy, Irritable Bowel Syndrome (IBS), and Functional Gastrointestinal Disease.
- Conditions
- IBS - Irritable Bowel Syndrome, Healthy, Functional Bloating, Functional Gastrointestinal Disorders
- Trial name
- NCT06215222
- Testing
- Microbiota Sampling
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stanford University
Intestine Disease
Effect of Antigens or Therapeutic Agents on in Vitro Human Intestinal Organoids
The study evaluates the effect of nutrient antigens or therapeutic agents on human small intestinal organoids.
- Trial name
- NCT03256266
- Where
- Germany
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Irritable Bowel Syndrome
Efficacy of Rifaximin to Treat Diarrhea-predominant Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common disease and the pathogenesis of this disease includes central and peripheral mechanisms.
- Trial name
- NCT02565654
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Metabolic Syndrome, Obesity
Elucidating the Role of Human Small Intestine Microbiota in Explaining Differences in Postprandial Glucose Responses
It has been shown that person-specific factors, such as the fecal microbiome, influenced postprandial glycemia. The small intestine is the site of nutrient digestion and absorption.
- Conditions
- Metabolic Syndrome, Obesity, Overweight, Microbiota
- Trial name
- GLYSIMI (NCT05120661)
- Testing
- food product
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Obesity
Effect of Oral Feeding on Gastric Emptying, Gut Blood Flow, and Hormone Responses in Obese and Healthy Weight Subjects
Obesity is a complicated condition that is poorly understood. The aim of this study is to increase our knowledge of how the condition may arise, and what makes obese people remain obese.
- Trial name
- NCT03860623
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Small Bowel Disease
Novel Motorized Spiral Enteroscopy Vs Single Balloon Enteroscopy In Patients With Small Bowel Disorders- A RCT
STUDY OBJECTIVES: 1. Primary objective: Rate of total enteroscopy (TER) by means of NMSE or SBE with: Complete antegrade approach or combined antegrade and retrograde approach 2. Secondary objective: 1.
- Trial name
- MOTOR-AIG-01 (NCT05548140)
- Testing
- Novel Motorized Spiral Enteroscopy
- Where
- 2 sites in India
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
GastroIntestinal Bleeding
Video Capsule Endoscopy for Detection of Gastrointestinal Bleeding in the Small Bowel
Small bowel capsule endoscopy is the main diagnostic standard for small bowel bleeding. This study investigates the detection rate of small bowel bleeding in capsule endoscopy and further endoscopic treatment in a prospective and…
- Trial name
- NCT05949268
- Testing
- Small bowel capsule endoscopy
- Where
- Germany
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- University Hospital Freiburg
Crohn's Disease
PBMC (Peripheral Blood Mononuclear Cells) /Lymphocyte SPECT (Single Photon Emission Computerized Tomography) Imaging in Crohn's Disease
Using scintigraphic imaging including planar scintigraphy and SPECT, this study will evaluate the utility of two different ex vivo 99mTc-HMPAO labelled mononuclear cell populations in order to select the optimal methodology…
- Trial name
- NCT01051622
- Testing
- Labeling Ceretec
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Parkinson Disease
Observational Small Intestine and Blood Fingerprint (SmIle) Study in Parkinson's Disease
Observational cross-sectional study in PD patients and healthy controls (HC) using an investigational medical device consisting of a passive small intestine microbiome aspiration (SIMBA) system (capsule) that is ingested orally…
- Trial name
- SmIle (NCT06003608)
- Testing
- Fluid biopsy capsule, Levodopa-Carbidopa Immediate Release
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
Irritable Bowel Syndrome, Inflammatory Bowel Disease
Assessment of Small Intestinal Bowel Epithelial Gaps in Irritable Bowel Syndrome
The study aims to: 1. Determine whether the density of epithelial gaps in terminal ileum of patients with irritable bowel syndrome (IBS) is different from that in inflammatory bowel disease (IBD) patients and normal controls by…
- Trial name
- NCT01632488
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shandong University