Clinical trials: Smokeless Tobacco Use
Tobacco Product Beliefs and Use
Effects of FDA Authorized Smokeless Tobacco Claims Among US Adults Who Smoke Cigarettes
This study will be an online survey experiment conducted with adults who smoke cigarettes (ages 21+) to examine their reactions to modified risk advertising claims authorized by the Food \& Drug Administration (FDA) for two…
- Trial name
- NCT06927700
- Testing
- Modified Risk Claim Type - None, Product Brand - General Snus, Product Brand - Copenhagen
- Where
- United States
- Volunteers
- 1,257 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
DENTAL CARIES
Incidence of Caries in Smoking and Smokeless Tobacco
The following observational study evaluates incidence of caries in smoking and smokeless tobacco based on habit history by clinical examination and DMFT index.
- Trial name
- ICSSLT (NCT02767050)
- Where
- India
- Volunteers
- 613 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Smokeless Tobacco Cessation
Testing ANSOS for Efficacy in Multi-Tribal Urban Communities
This is a wait-list control trial to test for efficacy of the All Nations Snuff Out Smokeless (ANSOS) recreational tobacco cessation program in multi-tribal American Indian (AI) communities.
- Trial name
- NCT06566703
- Testing
- All Nations Snuff Out Smokeless, Healthy Living
- Where
- United States
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Lehigh University
Smokeless Tobacco Use
Highdose Nicotine Patch Therapy for Smokeless Tobacco Use
Smokeless tobacco use ("chewing") is associated with negative health effects. To date, no medications have been shown to help chewers quit long-term.
- Trial name
- NCT00939029
- Testing
- nicotine replacement therapy (nicotine patches)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smokeless Tobacco Use, Tobacco Dependence
Novel Determinants and Measures of Smokeless Tobacco Use: Study 1
The extent of toxicity varies considerably across different brands of smokeless tobacco (ST) products and data suggest that greater toxicity may result in greater health risks.
- Trial name
- NCT01067586
- Where
- 3 sites in United States
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Use
CSD190102: A Study to Assess Nicotine Pharmacokinetic Parameters After Use of Two Smokeless Tobacco Products
The purpose of this study is to compare plasma nicotine uptake in adult snus consumers after using investigational snus products (A19010-R and B19010-O).
- Trial name
- NCT03993782
- Testing
- A19010-R, B19010-O
- Where
- 6 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smokeless Tobacco, Nicotine Dependence
Treating Smokeless Tobacco Use in Rural Veterans
This is a pilot study designed in an effort to develop and improve access to effective treatments for tobacco use in rural Veterans using a tailored intervention approach.
- Trial name
- NCT02994082
- Testing
- Tailored behavioral intervention, Behavioral activation for elevated depressive symptoms, Post-cessation weight gain management
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Mark Vander Weg
Tobacco Dependence
Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction
Smokeless tobacco (ST) is a known human carcinogen. Long-term ST use is known to increase the risk for oropharyngeal cancer. Extant literature on cigarette smokers suggests that smoking reduction increases smoking abstinence…
- Trial name
- NCT01018394
- Testing
- nicotine lozenges, tobacco-free snuff
- Where
- 2 sites in United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smokeless Tobacco
Bupropion SR for Treating Smokeless Tobacco Use
To determine the efficacy and safety of bupropion SR for quitting tobacco in smokeless tobacco users.
- Trial name
- NCT00414180
- Testing
- Bupropion SR
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking Cessation, Smokeless Tobacco
In-vivo Extraction of Pb, Cd and TSNA From Swedish Snus
In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini".
- Conditions
- Smoking Cessation, Smokeless Tobacco, Harm Reduction
- Trial name
- SMWS03 (NCT01369693)
- Testing
- Buccal administration of nicotine
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Contract Research Organization el AB
Smokeless Tobacco Cessation
A Text-based Reduction Intervention for Smokeless Tobacco Cessation
Participants will be randomly assigned (like the flip of a coin) to one of the two groups after completing the baseline survey. Participants have a 50% of being in either the #EnufSnuff.TXT intervention group or the Enough Snuff…
- Trial name
- NCT04315506
- Testing
- #EnufSnuff.TXT Intervention, Enough Snuff Intervention
- Where
- United States
- Volunteers
- 532 people, healthy volunteers welcome
- Sponsor
- Duke University
Nicotine Dependence
Varenicline for the Treatment of Smokeless Tobacco
Varenicline (Chantix™, Pfizer) is a novel selective nicotinic receptor partial agonist with specificity for the α4β2 nicotine acetylcholine receptor that has demonstrated remarkable efficacy for increasing long-term tobacco…
- Trial name
- CHANCHEW (NCT00813917)
- Testing
- varenicline
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cigarette Smoking
Development of Biomarkers of Effect From Chronic Tobacco Usage
This study was conducted to develop biomarkers of tobacco effect that would indicate potential harm related to tobacco consumption.
- Trial name
- NCT01923402
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Tobacco Company
Tobacco Use Disorder
Effectiveness of a Web-Assisted Quitline for Smokeless Tobacco Users
The purpose of this record is to test whether (a) participants who receive a Web-based smokeless tobacco cessation intervention will be more likely to be abstinent than participants who do not receive this intervention, and (b)…
- Trial name
- NCT00820495
- Testing
- Web + Phone, Web Only, Phone Only
- Where
- 2 sites in United States
- Volunteers
- 1,683 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Tobacco Use
Effects of an Oral Nicotine Product in Smokeless Tobacco Users
The purpose of this research study is to find out how three different nicotine pouches and participant's own brand of smokeless tobacco affect blood nicotine levels and how participants feel.
- Trial name
- NCT05280769
- Testing
- oral nicotine pouch - 2 mg, oral nicotine pouch - 4 mg, oral nicotine pouch - 8 mg
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Tobacco Use, Tobacco Smoking
Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study]
To pilot test the appeal of non-tobacco oral nicotine products in cigarette smokers, smokeless tobacco users, and oral nicotine users.
- Conditions
- Tobacco Use, Tobacco Smoking, Cigarette Smoking, Smokeless Tobacco Cessation
- Trial name
- NCT05030194
- Testing
- Electronic Cigarette, Oral Nicotine Pouch
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute