Clinical trials: Smoking, Cigarette
Nicotine Dependence, Smoking, Cigarette
Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation
The proposed study represents a crucial and important stage in translating basic research to strategies for treating nicotine dependence.
- Conditions
- Nicotine Dependence, Smoking, Cigarette, Smoking Cessation, Smoking Behaviors
- Trial name
- NCT03083353
- Testing
- Isradipine, Cue Exposure
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Jasper A. Smits
Smoking ( Cigarette), Women
Smoking, Pain Threshold, and Hand Strength in Women
This study aims to investigate the effects of smoking on pain threshold, cervical position sense, and grip strength in women. Measurements will include pressure pain threshold (PPT), cervical position sense (CPS), grip strength…
- Conditions
- Smoking ( Cigarette), Women, Pain
- Trial name
- NCT07611760
- Testing
- observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Cigarette Smoking, Tobacco Use
Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
This study aims to investigate harm-reduction sampling in a choice format versus medicinal nicotine sampling on smoking behavior, identify mechanisms of sampling's effects, and explore moderators of these effects among a national…
- Conditions
- Cigarette Smoking, Tobacco Use, Cigarette Smoking Behavior
- Trial name
- NCT07199517
- Testing
- HRP Sampling period, NPL Sampling period
- Where
- United States
- Volunteers
- 472 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cigarette Smoking-Related Carcinoma
Evaluating the Impact of Synthetic Cooling Agents in Combustible Cigarettes on Smoking Perceptions and Use
This clinical trial evaluates the impact of synthetic cooling agents in combustible cigarettes on smoking perceptions and use. Menthol, a natural chemical, is a cooling agent that increases nicotine dependence among smokers.
- Trial name
- NCT06230159
- Testing
- Non-menthol Cigarette Smoking, Menthol Cigarette Smoking, Synthetic Cooling Agent Cigarette Smoking
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Smoking, Smoking, Cigarette
The Efficacy of Conventional Screening Versus mHealth Screening in Early Detection of Oral Potentially Malignant Disorders and Oral Cancer Amongst the Rural Population of Varanasi: A Prospective and Blinded Study
Mobile health (mHealth) will be used for early detection of oral cancer and pre-cancer lesions, and to improve awareness of oral cancer among the population and knowledge of oral cancer diagnosis among frontline health providers.
- Conditions
- Smoking, Smoking, Cigarette, Smoking, Tobacco, Betel Chewer's Mucosa
- Trial name
- NCT06535867
- Testing
- mHealth
- Where
- United States
- Volunteers
- 5,122 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cigarette Smoking-Related Carcinoma
Increasing Access to Smoking Cessation and Smoke Free Home Services for Low-Income Pregnant Women in Northeast Texas
This trial seeks to increase access to smoking cessation services to low-income pregnant women. Smoking is associated with an increased risk of developing cancer.
- Trial name
- NCT05051345
- Testing
- Informational Intervention, Media Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Periodontitis, Gingivitis
Evaluation of the Effect of Smoking on Pyroptosis in Periodontal Pathogenesis
This study investigates the impact of smoking on pyroptosis and inflammatory signaling pathways in systemically healthy individuals with various periodontal conditions.
- Conditions
- Periodontitis, Gingivitis, Periodontal Diseases, Smoking ( Cigarette)
- Trial name
- NCT07563192
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Smoking Cessation, Electronic Cigarette Use
Cessation of Smoking Trial in the Emergency Department
The Cessation of Smoking Trial in the Emergency Department (CoSTED) is an National Institute for Health Research (NIHR) Health Technology Assessment (HTA) funded randomised controlled trial (RCT).
- Conditions
- Smoking Cessation, Electronic Cigarette Use, E-Cig Use, Vaping
- Trial name
- COSTED (NCT04854616)
- Testing
- CoSTED Intervention
- Where
- United Kingdom
- Volunteers
- 972 people, healthy volunteers welcome
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Smoking, Cigarette
Dyadic Financial Incentive Treatments for Dual Smoker Couples
Smokers partnered with other smokers (i.e., dual-smoker couples) represent ~2/3 of all smokers. Dual-smoker couples (DSCs) are less likely to try to quit smoking and more likely to relapse during a quit attempt, reducing overall…
- Trial name
- NCT06296849
- Testing
- Financial Incentive Treatment (FIT)
- Where
- 2 sites in United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Tobacco Use Disorder, Nicotine Dependence
Beta-Adrenergic Modulation of Drug Cue Reactivity
This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in combination on neurobiological and behavioral responses to smoking…
- Conditions
- Tobacco Use Disorder, Nicotine Dependence, Cigarette Smoking
- Trial name
- NCT05587361
- Testing
- Propranolol, Nicotine Patch
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Electronic Nicotine Delivery Systems, Tobacco Products
Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults
Electronic Nicotine Delivery Systems (ENDS) use remains prevalent among young adults, and many have high interest in quitting, yet research on effective intervention is lacking.
- Conditions
- Electronic Nicotine Delivery Systems, Tobacco Products, Cigarette Smoking
- Trial name
- EQUIP (NCT06395415)
- Testing
- EQUIP, Standard Care
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Smoking Cessation, Smoking, Cigarette
Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia
The goal of this clinical trial is to evaluate the effectiveness and implementation of a pharmacist-delivered MTM (medication therapy management) approach, called QuitAid, to quitting cigarette smoking in rural Appalachia.
- Conditions
- Smoking Cessation, Smoking, Cigarette, Smoking Reduction, Smoking
- Trial name
- NCT05660525
- Testing
- 4 weeks of Nicotine lozenge, 8 weeks of Nicotine Replacement Therapy Patch, QuitAid
- Where
- United States
- Volunteers
- 768 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Smoking, Cigarette, Smoking, Tobacco
Examination of Low Wattage and High Wattage E-Cigarettes
The overall aim of the proposed study is to evaluate the effect of switching from conventional cigarettes to either a LWe or HWe on smoking behavior, product use patterns and continued use, as well as biomarkers of toxicant…
- Conditions
- Smoking, Cigarette, Smoking, Tobacco, Nicotine Dependence, Exposure to Toxic Agent
- Trial name
- SWITCH (NCT03113136)
- Testing
- Low wattage E cigarette device, High wattage E cigarette device, Usual brand cigarette
- Where
- United States
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Tobacco Use, Cigarette Smoking
RTMS Targets Neural Circuits for Smoking Cessation
Cigarette smoking is a significant public health concern. Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel…
- Trial name
- NCT04903028
- Testing
- Active rTMS 10 Hz DLPFC
- Where
- 2 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cigarette Smoking, Inflammatory Response
Menthol, Inflammation, and Nicotine Transition Study
This study will focus on examining the potential impact of menthol flavoring in cigarettes on biomarkers of systemic inflammation as a subclinical indicator of cardiovascular disease risk.
- Trial name
- MINT (NCT06232447)
- Testing
- Cigarette Type Switching
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Rosalind Franklin University of Medicine and Science
Smoking, Cigarette Smoking
Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks
The purpose of this study is to assess the effect of the Helpers Stay Quit training on abstinence over time of newly abstinent smokers, and on the interactions they have with their personal network related to smoking and smoking…
- Trial name
- NCT05641974
- Testing
- Helpers Stay Quit Training
- Where
- United States
- Volunteers
- 940 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cigarette Smoking-Related Carcinoma
A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior
This clinical trial compares the use of tobacco flavored electronic cigarettes (ECs) vs. non-tobacco flavored ECs vs. nicotine replacement therapy (patches and lozenges) on smoking behavior in current cigarette smokers.
- Trial name
- NCT06260683
- Testing
- Nicotine Replacement, Questionnaire Administration, Vaping
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cigarette Smoking-Related Carcinoma
Impact of E-cigarette Use on the Body
This study examines how electronic (e)-cigarette use impacts the body, by studying both users and non-users of e-cigarettes. Early evidence indicates that e-cig users experience adverse health effects.
- Trial name
- NCT04972513
- Testing
- Biospecimen Collection, Nitric Oxide Breath Test, Oscillometry
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Smoking Cessation, Weight Gain
Exenatide for Smoking Cessation and Prevention of Weight Gain
The purpose of this study is to determine if exenatide improves end-of-treatment smoking abstinence rates and to determine if exenatide mitigates post-cessation weight gain.
- Trial name
- NCT05610800
- Testing
- Exenatide 2 milligram (mg) Injection, Nicotine patch, Smoking Cessation Counseling
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Sex, Cigarette Smoking
Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers
The proposed study evaluated sex differences in glutamate (Glu), with a focus on the dorsal anterior cingulate cortex (dACC), anterior insula, and thalamus, as well as how it is influenced by sex (males vs.
- Trial name
- NCT05279053
- Testing
- Abstinence and Smoking
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles