Clinical trials: Smoking Behaviors
Smoking
Reduced Exposure Study in Smokers Using THS 2.2 With 5 Days in a Confinement Setting.
The overall goal of the study is to evaluate if the ad libitum use of the Tobacco Heating System 2.2 (THS 2.2) for 5 days by adult healthy smokers results in a reduction in the levels of biomarkers of exposure (BoExp) for…
- Trial name
- NCT01959932
- Testing
- Tobacco Heating System (THS 2.2), Smoking abstinence (SA), Conventional cigarette (CC)
- Where
- Poland
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking Cigarette
A Consumer Use Behavior Study to Evaluate Puffing Topography and Average Daily Consumption of Heated Tobacco Products
This is a parallel design cohort consumer use study to measure the puffing topography of two HTP devices, with three variants of HTP consumables ("sticks,"), collectively referred to as the study investigational products (Study…
- Trial name
- NCT07175987
- Testing
- RDTH002581, RDTH002580, RDTH002582
- Where
- United Kingdom
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking Cessation
Safety and Pharmacodynamics of SEL-068 Vaccine in Smokers and Non-Smokers
The purpose of this study is to evaluate the safety and pharmacodynamics of SEL-068. Increasing subcutaneous doses of SEL-068 will be administered to healthy non-smoker and smoker volunteers.
- Trial name
- NCT01478893
- Testing
- SEL-068, Saline
- Where
- Belgium
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Selecta Biosciences, Inc.
Smoking Cessation
Enhanced E-cigarette Coaching Intervention for Dual Users of Cigarettes and E-cigarettes
The purpose of this study is to develop and pilot test an enhanced behavioral coaching intervention for dual users of cigarettes and electronic nicotine delivery systems (ENDS) who call tobacco quitlines for help quitting smoking.
- Trial name
- NCT03575468
- Testing
- Enhanced E-cigarette Coaching, Quitline treatment as usual
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Consumer Wellness Solutions
Smoking Cessation
CoQuit Study for Smoking Cessation
This study investigated the feasibility of a cognitive dissonance-based mobile app for smoking cessation (CDI). Cognitive dissonance refers to the conflict between beliefs and behaviors; interventions are designed to promote this…
- Trial name
- NCT04893460
- Testing
- CoQuit App
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Smoking Cessation, Pharmacokinetics
A Clinical Trial to Compare Pharmacokinetics of the "CDFF0318" and "Champix Tab. 1mg"
A Phase 1 Clinical Trial to Compare and Evaluate Safety and Pharmacokinetic Characteristics after Administration of the "CDFF0318" and "Champix Tab. 1mg (Varenicline tartrate)" in Healthy Male Volunteers
- Trial name
- NCT04631874
- Testing
- CDFF0318, Champix
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- CTC Bio, Inc.
Tobacco Use
Changes in Biomarker of Exposure in Adults Who Smoke Cigarettes Switching From Cigarettes to Heated Tobacco Products
The purpose of the study is to evaluate changes in biomarkers of exposure (BoE) to harmful and potentially harmful constituents (HPHCs) in adult smokers who completely switch to Ploom heated tobacco products (HTPs) compared to…
- Trial name
- NCT06179290
- Testing
- Ploom HTP Menthol HTS; MX3 (681), Ploom HTP Tobacco HTS; R8 (120), Smoking Abstinence (menthol)
- Where
- 8 sites in United States
- Volunteers
- 921 people
- Sponsor
- Altria Client Services LLC
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes
This study will evaluate a reward devaluation strategy in which smokers use the JUUL e-cigarette immediately before any combustible cigarettes (CCs) are smoked.
- Conditions
- Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking
- Trial name
- RECON (NCT04188197)
- Testing
- JUUL
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Smoking Cessation
Nicotine Lozenge Bioequivalence Study
To compare the bio equivalence of new nicotine lozenge formulation with the reference nicotine lozenge so as to deliver the same nicotine blood profile.
- Trial name
- NCT01536704
- Testing
- Nicotine (2 mg), Nicotine (4 mg)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Smoking
CSD170401: Study to Assess Elements of Abuse Liability for Three Electronic Tobacco Vapor Products During an 11-Day In-Clinic Confinement
This study will examine elements of abuse liability (AL) related to potential product adoption of three electronic tobacco vapor products by current smokers relative to high and low AL comparator products (usual brand cigarette…
- Trial name
- NCT03126357
- Testing
- Product A, Product B, Product C
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Tobacco Dependence
Bioequivalence Between Two Oral Nicotine Sublingual Tablets, 2 mg and 4 mg
The purpose of this study is to assess the bioequivalence between two oral nicotine sublingual tablets, 2 mg and 4 mg.
- Trial name
- NCT01238627
- Testing
- Nicotine Sublingual Tablet Mint (NSTM), Marketed Nicotine Tablet
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- McNeil AB
COPD, Smoking
Effect of Switching From Cigarette Smoking to THS on Disease Progression in Mild to Moderate COPD Subjects With Chronic Bronchitis Symptoms.
The purpose of this study is to demonstrate the slowing of the disease progression including the improvement of Chronic Obstructive Pulmonary Disease (COPD) symptoms in smoking subjects with mild to moderate COPD and a history of…
- Conditions
- COPD, Smoking, Tobacco Use
- Trial name
- NCT05569005
- Testing
- THS use, Cigarette, Smoking Abstinence
- Where
- 170 sites in United States, Bulgaria and 6 more
- Volunteers
- 715 people
- Sponsor
- Philip Morris Products S.A.
Malformations
Varenicline Pregnancy Cohort Study
A prospective population-based cohort study to examine whether varenicline use during pregnancy is associated with an increased risk of major congenital malformations in infants above that associated with smoking during pregnancy.
- Trial name
- NCT01290445
- Testing
- varenicline, cigarette smoke from maternal smoking, Non-Exposure
- Volunteers
- 885,185 people
- Sponsor
- Pfizer
Smoking, Tobacco
CSD201204 An Actual Use Study of P12 Electronic Nicotine Delivery System Among U.S. Adult Smokers
The purpose of this Actual Use Study (AUS) is to investigate how United States (US) adult tobacco consumers 21 to 60 years of age, inclusive, who are regular smokers (≥5 cigarettes/day on at least 20 of the past 30 days) will use…
- Trial name
- NCT05960305
- Testing
- P1213416, P1213422, P1213716
- Where
- 12 sites in United States
- Volunteers
- 1,845 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking Cessation
Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes
This single-group, small-scale, open-label study (N= 25 to 50) will evaluate the impact of combination zonisamide and bupropion on the process of switching from combustible cigarettes (CC) to an e-cigarette.
- Trial name
- BuZonE (NCT04388319)
- Testing
- Zonisamide, Bupropion, Halo G6 e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Smoking Cessation, Smoking, Tobacco
Pivot Breath Sensor Performance Study
A clinical study enrolling 70 subjects to: evaluate the user performance of the Pivot Breath Sensor compare measurements from the Pivot Breath Sensor to a similar device assess user documentation comprehension obtain feedback on…
- Trial name
- NCT03870022
- Testing
- Pivot Breath Sensor System, Similar Carbon Monoxide breath sensor system
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Jennifer Marler, MD
Smoking Cessation
A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo for Smoking Cessation
The primary purpose of this study is to evaluate the safety and efficacy of varenicline given for a twelve week treatment period in comparison with placebo for smoking cessation.
- Trial name
- NCT00141167
- Testing
- varenicline
- Where
- 10 sites in South Korea, Taiwan
- Volunteers
- 250 people
- Sponsor
- Pfizer
Smoking
European Exposure Study
The current study was designed to determine the exposure of adult smokers and non-smokers to cigarette smoke constituents through evaluation of selected biomarkers of exposure.
- Trial name
- NCT01237912
- Where
- United Kingdom
- Volunteers
- 1,667 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Substance Abuse
Substance Treatment and HIV Testing and Referral System
The lack of substance screening and referral in healthcare settings is a significant problem with far-reaching consequences, including excess morbidity, premature mortality, and inflated healthcare costs.
- Trial name
- STaRS (NCT01488630)
- Testing
- STaRS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Polaris Health Directions
Smoking Cessation
Cumulative Skin Irritation Potential of a New 25 mg Nicotine Patch
An investigation on the cumulative skin irritation potential of a newly developed 25 mg nicotine patch. Evaluation of skin irritation of a newly developed 25 mg nicotine transdermal patch
- Trial name
- NCT00967174
- Testing
- Nicotine Patch, SLS Comparator Patch
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- McNeil AB