Clinical trials: Sodium
Congenital Heart Disease, Repaired Tetralogy of Fallot (rTOF)
Sodium-Glucose Cotransporter 2 Inhibitors for Repaired Tetralogy of Fallot Patients for Enhancement of Cardio-Pulmonary Status Trial
Repaired Tetralogy of Fallot (rTOF) is the leading cause of congenital cyanotic heart disease worldwide, involving up to 7-10% of congenital heart disease.
- Conditions
- Congenital Heart Disease, Repaired Tetralogy of Fallot (rTOF), Pulmonary Regurgitation, Sodium-glucose Cotransporter 2 (SGLT2) Inhibitor
- Trial name
- STEPS (NCT06668389)
- Testing
- SGLT2 inhibitor (Dapagliflozin 10mg)
- Where
- Hong Kong
- Volunteers
- 106 people
- Sponsor
- The University of Hong Kong
No Reflow Phenomenon, Reperfusion Injuries, Myocardial
Evaluating SGLT2 Inhibitors for the Reduction of No-Reflow Phenomenon in Patients Undergoing PCI
Study Background \& Purpose: The no-reflow phenomenon is a significant complication occurring in patients with acute myocardial infarction who undergo percutaneous coronary intervention (PCI).
- Conditions
- No Reflow Phenomenon, Reperfusion Injuries, Myocardial, Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT07898709
- Testing
- Empagliflozin (SGLT2i), dapagliflozin, Standard medical treatment
- Where
- 4 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
End Stage Renal Disease on Dialysis, Peritoneal Dialysis Complication
Empagliflozin on Residual Kidney Function in Incident Peritoneal Dialysis Patients
Empagliflozin, a new class of diabetes medication, has demonstrated a reduction in renal function decline among patients with chronic kidney disease, regardless of their diabetes status.
- Conditions
- End Stage Renal Disease on Dialysis, Peritoneal Dialysis Complication, Sodium-glucose Cotransporter-2 Inhibitor, Residual Kidney Function
- Trial name
- EMPIRIC-PD (NCT06483074)
- Testing
- Empagliflozin 10 MG
- Where
- Hong Kong
- Volunteers
- 48 people
- Sponsor
- Chinese University of Hong Kong
Cognition, Sodium Bicarbonate
Exercise-Induced Lactate and Cognitive Function (ExLBC)
A single bout of exercise can rapidly improve cognitive functions including memory, attention, and executive functions, which help us navigate through everyday life.
- Conditions
- Cognition, Sodium Bicarbonate, Lactate, Exercise
- Trial name
- NCT06817681
- Testing
- Sodium Bicarbonate (NaHCO3)
- Where
- 2 sites in Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- McMaster University
Dialysis Dependent Chronic Kidney Disease, Dialysis Patients
Can Changes in Dialysate Sodium Concentration Improve Blood Pressure and Endothelial Function in Chronic HD Patients?
People with end stage kidney disease cannot regulate salt and water normally, which often leads to high blood pressure, fluid overload, and a higher risk of heart disease.
- Conditions
- Dialysis Dependent Chronic Kidney Disease, Dialysis Patients, Sodium Excess, High Blood Pressure
- Trial name
- NADI (NCT07459348)
- Testing
- Low-Sodium Dialysate (133 mmol/L), Standard-Sodium Dialysate (139 mmol/L)
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Gødstrup Hospital
Sodium Excess, Hypertension
Effects of a Six-Day Whole-Diet Intervention on Taste Perception and Dietary Behaviour in Young Adults
This study aims to investigate the effects of a specific diet modification on the pleasantness, desire, and saltiness intensities of selected foods and an ad libitum breakfast buffet through a randomized controlled trial with…
- Conditions
- Sodium Excess, Hypertension, Salty Taste
- Trial name
- NCT07726394
- Testing
- Experimental: Increased Salty Food Intake, Experimental: Decrease Salty Food Intake, Active Comparator: Maintain Usual Diet
- Where
- Malaysia
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Sunway University
Fontan, Heart Failure
The Effect of Dapagliflozin on Exercise and Cardiac Functional Status of Patients After Fontan Procedure
While the Fontan operation improves survival for patients with a functional single ventricle, complications like heart failure remain prevalent during follow-up, causing frequent hospitalizations and reduced quality of life.
- Conditions
- Fontan, Heart Failure, Dapagliflozin, Cardiovascular Diseases
- Trial name
- NCT07482943
- Testing
- Dapagliflozin (5-10 mg daily) - SGLT2 Inhibitor Therapy
- Where
- 2 sites in Hong Kong
- Volunteers
- 30 people
- Sponsor
- The University of Hong Kong
Kidney Transplant Recipient, Sodium Glucose Co-Transporter 2 Inhibitors
SGLT2i Effect on PTDM Development and Kidney Allograft Function in Non-diabetic Kidney Transplant Recipients: A Randomized, Doubleblind, Placebo Controlled, National Multicenter Trial
The goal of this clinical trial is to find out whether 12 months of treatment with the SGLT2 inhibitor Forxiga® (dapagliflozin 10 mg once daily), compared with placebo, can reduce the risk of developing post-transplant diabetes…
- Conditions
- Kidney Transplant Recipient, Sodium Glucose Co-Transporter 2 Inhibitors, Non-Diabetic Patients, Randomized Controlled Trial (RCT)
- Trial name
- SGL-TX-PTDM (NCT07682350)
- Testing
- SGLT2i
- Where
- 3 sites in Denmark
- Volunteers
- 184 people
- Sponsor
- Odense University Hospital
Dietary Sodium Intake, Peritoneal Dialysis (PD)
A Novel Equation for Estimating Sodium Intake in Peritoneal Dialysis.
This study aims to develop a novel equation for estimating sodium intake in anuric peritoneal dialysis patients, and then to validate its precision and accuracy.
- Trial name
- NCT05955417
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Loxoprofen Sodium Patch, Local Incision
The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Laparoscopic Surgery
Studies have shown that up to 80% of patients experience postoperative pain following laparoscopic surgery due to inflammation caused by surgical incisions and surrounding tissues, necessitating pharmacological relief.
- Conditions
- Loxoprofen Sodium Patch, Local Incision, Laparoscopic Cholecystectomy, Appendectomy, Laparoscopic
- Trial name
- NCT07591207
- Testing
- Loxoprofen Sodium Patch on the contralateral side, Loxoprofen Sodium Patch on the incision site
- Where
- 2 sites in China
- Volunteers
- 134 people
- Sponsor
- Beijing Tiantan Hospital
Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch
The Efficacy and Safety of Loxoprofen Sodium Patch in Relieving Postoperative Pain After Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) is less invasive compared to traditional thoracotomy, but it is still reported that the incidence of acute pain following VATS exceeds 80%.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Loxoprofen Sodium Patch, Local Incision, Postoperative Pain
- Trial name
- NCT07591220
- Testing
- Loxoprofen Sodium Patch on the incision site, Loxoprofen Sodium Patch on the contralateral side
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Pharmacokinetic Profiles, Y-3 for Injection
Pharmacokinetic Effect of Y-3 on Repaglinide，Warfarin and Omeprazole in Healthy Participants
The primary goal of this clinical trial is to evaluate the effect of Y-3 for injection on the pharmacokinetic profile of the sensitive finger substrates repaglinide tablets, warfarin sodium tablets, and omeprazole enteric-coated…
- Conditions
- Pharmacokinetic Profiles, Y-3 for Injection, Drug-drug Interaction, Repaglinide Tablets
- Trial name
- NCT07068841
- Testing
- sequentially single use of repaglinide, warfarin and omeprazole or combined with Y-3
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Neurodawn Pharmaceutical Co., Ltd.
End Stage Renal Disease on Dialysis, Hemodialysis
Interdialytic Peritoneal UltraFiltration in HemoDialysis Patients
Sodium accumulates in the tissues of patients with kidney disease and impairs survival. Three-times weekly, standard hemodialysis alone cannot remove excess sodium efficiently.
- Conditions
- End Stage Renal Disease on Dialysis, Hemodialysis, Peritoneal Dialysis, Nonosmotic Sodium Storage
- Trial name
- IPUF-HD (NCT04603014)
- Testing
- Interdialytic peritoneal ultrafiltration with 10% dextrose solution
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Peritoneal Dialysis Complication, End Stage Kidney Disease
meChANisms and sAfety of SGLT2 Inhibition in peRitoneal dialYsis
The primary aim of this study is to determine the safety and mechanisms of SGLT2 inhibition in individuals on peritoneal dialysis (PD) with residual kidney function (RKF).
- Conditions
- Peritoneal Dialysis Complication, End Stage Kidney Disease, Sodium-glucose Co-transporter-2 Inhibitors, Kidney Dysfunction
- Trial name
- CANARY (NCT05715814)
- Testing
- Empagliflozin 25 MG
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Subarachnoid Hemorrhage, Critical Illness
Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage
Patients with subarachnoid hemorrhage are prone to suffer from dysnatriemia. Evidence shows that hyponatriemia is associated with increased incidence of vasospasm, brain swelling and mortality in these patients.
- Conditions
- Subarachnoid Hemorrhage, Critical Illness, Infusion Fluid, Sodium Disorder
- Trial name
- CRYSTALLBrain (NCT04043598)
- Testing
- 0.9% Sodium-chloride, Ringer's Lactate
- Where
- 3 sites in Switzerland
- Volunteers
- 320 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Kidney Disease (Mild to Moderate), Albuminuria
Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Adolescents With Early Stages of Chronic Kidney Disease
Chronic kidney disease (CKD) is highly prevalent in the state of Aguascalientes, Mexico, particularly among adolescents and young adults.
- Conditions
- Chronic Kidney Disease (Mild to Moderate), Albuminuria, Adolescent, Sodium Glucose Co-Transporter 2 Inhibitors
- Trial name
- IECA-MEX (NCT07405216)
- Testing
- Dapagliflozin (10mg Tab)
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Centenario Hospital Miguel Hidalgo
Lumbar Fusion Surgery, Elderly Patients
Clinical Impact of Different Crystalloid Solution on Early Biomarkers of Kidney Injury After Lumbar Fusion Surgery in Elderly Patients
This study aims to compare the effects of sodium acetate Ringer's solution versus sodium lactate Ringer's solution on early postoperative renal function indicators, renal injury biomarkers, and acute kidney injury (AKI) in…
- Conditions
- Lumbar Fusion Surgery, Elderly Patients, Sodium Acetate Ringer's Solution, Sodium Lactate Ringer's Solution
- Trial name
- NCT07542353
- Testing
- Sodium Acetate Ringer's Solution (Group A), Sodium Lactate Ringer's Solution (Group B)
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Xianping Wu
Healthy Participants Study, The Focus of the Study is to Determine the Comparative Pharmacodynamic of Enoxaparin Sodium With That of Clexane in Healthy Human Participants
Study to Determine the Comparative Pharmacodynamics of Enoxaparin Sodium Biosimilar With That From Clexane
An Open-Label, Single-center, Randomized, Single-Dose, Two-Way Crossover Biosimilarity Study to Determine the Comparative Pharmacodynamics of Enoxaparin Sodium Biosimilar 40mg/0.4ml with that from the Reference IMP, Clexane® (40…
- Trial name
- NCT07517289
- Testing
- Enoxaparin 40 Mg/0.4 mL Injectable Solution
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Egyptian International Pharmaceutical Industries Co
Sweat Sodium Concentration
Methods of Assessing Sweat-Electrolyte Testing (MAST)
If you agree to be in this study, you will be asked to report to our exercise science research center for two total visits (2 separate trials separated by at least 4 days) and the total time commitment for this study will be…
- Trial name
- MAST (NCT07490756)
- Testing
- Wearing the hDrop hydration sensor
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Sweat Rate, Heat Effect
Time Onset Sweat Sodium (TOSS) Study
Prior to each trial, you will be provided with urine jugs and food/fluid logs to record food and drink intake for 24hr. You will be asked to log food/fluid intake 24hr leading into trials.
- Conditions
- Sweat Rate, Heat Effect, Sweat Sodium Concentration
- Trial name
- TOSS (NCT07464743)
- Testing
- Exercise in the heat
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville