Clinical trials: Soilings, Fecal
Obstetric Anal Sphincter Injury, Anal Incontinence
Pelvic Floor Function After Obstetric Injury to the Anal Sphincter
The goal of this observational study is to learn more about the effect a pregnancy and delivery has on the function of the anal musculature.We will compare women who had a new delivery after suffering a severe tear in the anal…
- Conditions
- Obstetric Anal Sphincter Injury, Anal Incontinence, Urinary Incontinence, Sexual Dysfunction
- Trial name
- PFF (NCT05832268)
- Testing
- Obstetric Anal Sphincter Injury
- Where
- Norway
- Volunteers
- 900 people
- Sponsor
- Oslo University Hospital
Faecal Incontinence
A Multi-centre, Phase II, Double-blind, Randomised, Placebo-controlled, Parallel Group, Dose-ranging Study in Patients With Faecal Incontinence; to Evaluate the Efficacy, Safety and Tolerability of Locally Applied NRL001 Over an 8 Week Treatment Period
The purpose of this study is to evaluate the safety, tolerability and efficacy of NRL001 in the treatment of faecal incontinence, compared against placebo
- Trial name
- NCT01656720
- Testing
- 1R, 2S-methoxamine hydrochloride
- Where
- 51 sites in Czechia, France and 7 more
- Volunteers
- 417 people
- Sponsor
- Norgine
Fecal Incontinence, Anal Incontinence
Treatment of Fecal Incontinence by Injection of Autologous Muscle Fibers Into the Anal Sphincter
Aim: To investigate efficacy and safety in a new treatment with injection of autologous muscle fibers into the anal sphincter in patients with fecal incontinence.
- Trial name
- NCT01949922
- Testing
- Injection of autologous muscle fibers into the anal sphincter., Pelvic floor muscle training, Dietary intervention
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Herlev Hospital
Fecal Incontinence
Vaginal Estrogen for the Treatment of Faecal Incontinence in Women
This study will address the following questions: Does the use of oestrogen inserted vaginally with an applicator, help with the symptoms of faecal (bowel) incontinence in women who are past the age of menopause? Do women find it…
- Trial name
- NCT00307775
- Testing
- oestradiol
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- London North West Healthcare NHS Trust
Obstetrical Perineal Injury and Anal Incontinence
Pelvic-perineal Disorders in Women With Sphincter Tears
According to INSEE, in 2016, in France, there were 785,000 births. According to the latest national perinatal survey in 2016, 80.4% of women gave birth by vaginal delivery.
- Trial name
- PAPOASI (NCT04862299)
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Anal Incontinence
Does the Negativation of the Glucose Hydrogen Breath Test Come Along With a Reduction of the Symptoms of Gaz Incontinence ?
The objectives of this work are: 1/to estimate the frequency of a positive glucose breath test in favour of a small intestinal bacterial overgrowth in a population of patients consulting for gaz incontinence by comparison to a…
- Trial name
- NCT01275560
- Testing
- Metronidazole, CArbosylane
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Spinal Cord Injuries, Constipation
Neostigmine and Glycopyrrolate by Iontophoresis
To determine a lower effective dose of neostigmine to induce bowel evacuation by transcutaneous administration by iontophoresis.
- Conditions
- Spinal Cord Injuries, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT06351995
- Testing
- Combination of Neostigmine and Glycopyrrolate, I-Box by Dynatronics
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Pelvic Floor Disorders, Fecal Incontinence
Lateral Episiotomy or Not in Vacuum Assisted Delivery in Non-parous Women
Nulliparous women with a live singleton pregnancy in cephalic presentation past 34 gestational weeks will be randomized to lateral episiotomy or no episiotomy when operative vaginal delivery by vacuum extraction is indicated.
- Conditions
- Pelvic Floor Disorders, Fecal Incontinence, Dystocia, Fetal Hypoxia
- Trial name
- EVA (NCT02643108)
- Testing
- Lateral episiotomy
- Where
- 8 sites in Sweden
- Volunteers
- 717 people
- Sponsor
- Karolinska Institutet
Anal Sphincter Injury, Obstetrics Trauma
External Phase MRI in Diagnosis of OASI
There is around 60 000 births annually in Finland. Around 1-5% of all vaginal deliveries in Finland complicate in a Grade III- IV perineal tear.
- Trial name
- NCT03039374
- Testing
- Magnetic resonance imaging
- Volunteers
- 53 people
- Sponsor
- University of Turku
Faecal Incontinence, Fecal Incontinence
Sacral Nerve Stimulation for Faecal Incontinence - Placebo or Clinical Effective
Sacral nerve stimulation (SNS) has over the last 20 years been recognised as an efficient treatment option for faecal incontinence (FI).
- Trial name
- SNS (NCT03261622)
- Testing
- Sacral nerve stimulation at different stimulation amplitudes
- Where
- Denmark
- Volunteers
- 73 people
- Sponsor
- University of Aarhus
Rectal Cancer, Low Anterior Resection Syndrome
Feasibility and Impact of a Prehabilitation and Rehabilitation Program for the Continuity of Care in Severe Low Anterior Resection Syndrome.
Patients with sphincter saving procedures of rectal cancer usually experience intestinal dysfunction, including difficulty emptying the bowel and faecal incontinence, leading to a detriment in the quality of life.
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, Faecal Incontinence
- Trial name
- PRELARS (NCT04612569)
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Donostia
Obstetric Anal Sphincter Injury, Episiotomy Wound
Mediolateral Episiotomy and Obstetric Anal Sphincter Injuries in Instrumental Delivery
Literature is contradictory about the impact of mediolateral episiotomy during operative vaginal delivery in obstetric anal sphincter injuries prevention explaining the absence of international guidelines.
- Conditions
- Obstetric Anal Sphincter Injury, Episiotomy Wound, Anal Incontinence, Pelvic Floor Disorders
- Trial name
- INSTRUMODA (NCT04446780)
- Testing
- Mediolateral episiotomy
- Where
- France
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Pelvic Floor Injury, Urinary Incontinence
3D Ultrasound in Women With Vacuum or Forceps Deliveries
The purpose of this study is to investigate of the differences in pelvic floor anatomy and function in women who have undergone a vacuum assisted vaginal delivery (VAVD) versus a forceps assisted vaginal delivery (FAVD) using…
- Conditions
- Pelvic Floor Injury, Urinary Incontinence, Stool Incontinence
- Trial name
- VADUS (NCT01680731)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Rochester
Irritable Bowel Syndrome, Functional Dyspepsia
The Multi-disciplinary Treatment of Functional Gut Disorders Study
Randomised controlled trial comparing standard outpatient clinic treatment with multi-disciplinary clinic treatment for functional gastrointestinal disorders.
- Conditions
- Irritable Bowel Syndrome, Functional Dyspepsia, Constipation - Functional, Faecal Incontinence
- Trial name
- MANTRA (NCT03078634)
- Testing
- Multi-disciplinary clinic model, Standard outpatient care
- Where
- Australia
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- St Vincent's Hospital Melbourne
Faecal Incontinence
Controlling Faecal Incontinence With a Novel Anal Device: a Cost-effectiveness Trial
The purpose of this study is to assess the cost-effectiveness and improvement in quality of life of using a novel anal insert (navina)
- Trial name
- CONFIDEnCE (NCT04657588)
- Testing
- Navina anal insert, Care as usual
- Where
- Netherlands
- Volunteers
- 73 people
- Sponsor
- Maastricht University Medical Center
Faecal Incontinence
Pelvipower for Faecal Incontinence
Faecal incontinence (FI) is a common condition which drastically reduces patient's quality of life and for which there are few effective treatments.
- Trial name
- NCT05900726
- Testing
- High Resolution Anorectal Manometry, Endoanal Ultrasound, Bowel diary
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- The Functional Gut Clinic
Pelvic Floor Disorders, Obstetric Trauma
Correlation Pelvic Floor Function and Ultrasound Findings One Year After Childbirth
This is a single-center prospective cohort study sponsored by the University Hospitals Leuven (UZ). Women will undergo a pelvic floor ultrasound and will be asked to fill out a questionnaire at the time of their admission into…
- Conditions
- Pelvic Floor Disorders, Obstetric Trauma, Urinary Incontinence, Anal Incontinence
- Trial name
- DeliverUU (NCT05530681)
- Testing
- Questionnaire, Pelvic floor ultrasound
- Where
- Belgium
- Volunteers
- 320 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Incontinence, Urinary, Incontinence Bowel
Mind Over Matter: Electronic Bladder and Bowel Continence Self-management Program
The objective of this study is to (1) use participatory ergonomics to adapt and in-person 3-session intervention: Mind Over Matter: Healthy Bowels, Healthy Bladder (MOM) to an electronic program (eMOM), and to (2) compare and…
- Trial name
- NCT03976414
- Testing
- eMOM
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Anal Incontinence
ORALIA Trial Medical Treatment vs Anoperineal Physiotherapy for Adult Anal Incontinence.
The purpose of this study is to evaluate the impact of anoperineal physiotherapy in adjunction to standard medical treatment on symptoms and quality of life of adults with anal incontinence, in comparison with standard treatment…
- Trial name
- NCT00387439
- Testing
- standard medical treatment + anoperineal physiotherapy., Standard medical treatment
- Where
- France
- Volunteers
- 173 people
- Sponsor
- Hospices Civils de Lyon
Fecal Incontinence
Treatment of Fecal Incontinence After Obstetric Anal Sphincter Injuries
Fecal incontinence (FI), the involuntary loss of solid or liquid stool, is a stigmatising condition. It can have a distressing impact and restriction on quality of life.
- Trial name
- KISS (NCT01528995)
- Testing
- Medtronic Interstim II-3058, Anal bulking injection
- Where
- Norway
- Volunteers
- 68 people
- Sponsor
- University Hospital of North Norway