Clinical trials: Solid Lesion Biopsies
Pancreatic Solid Lesions
Contrast-Enhanced Harmonic vs Conventional EUS-guided Fine Needle Biopsy for Solid Pancreatic Lesions: Randomized Controlled Trial
In the previous studies, EUS-guided fine needle aspiration (FNA) with fanning technique in solid pancreatic lesions (SPLs) with avascular areas had a negative impact on diagnostic accuracy of FNA.
- Trial name
- NCT04924751
- Testing
- Endoscopic ultrasound-guided fine needle biopsy
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Pancreas Neoplasms, Lymphatic Metastasis
Prospective Multi-center, Single Blinded, Randomized, Controlled Trial of EUS-FNB and EUS-FNA on Solid Occupying Lesion
The purpose of this study is to compare the diagnosis accuracy of FNA and FNB biopsy on pancreatic, retroperitoneal, mediastinum and pelvic cavity solid occupying lesions.
- Conditions
- Pancreas Neoplasms, Lymphatic Metastasis, Neoplasm Metastases, Unknown Primary Neoplasm Metastasis
- Trial name
- NCT02327065
- Testing
- EUS-FNA (EchoTip Ultra), EUS-FNB (EchoTip ProCore)
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Huazhong University of Science and Technology
Pancreatic Diseases
Fine-needle Biopsy Combined With Macroscopic On-site Evaluation for Diagnosis of Solid Pancreatic Lesions
The goal of this clinical trial is to compare the diagnostic efficacy, core tissue acquisition ability, number of punctures and puncture time of macroscopic on-site evaluation (MOSE) and two punctures alone in Endoscopic…
- Trial name
- NCT06994611
- Testing
- MOSE application, Conventional processing
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Changhai Hospital
Pancreatic Diseases
Red Cell Lysis Buffer Application Versus Conventional Sample Processing in EUS-FNB
The goal of this clinical trial is to evaluate the application of red cell lysis buffer (RCLB) versus conventional sample processing in endoscopic ultrasonography (EUS)-guided biopsy for solid pancreatic lesions.
- Trial name
- NCT05954221
- Testing
- Red cell lysis buffer (RCLB) application, Conventional processing
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Changhai Hospital
Pancreatic Neoplasms
EUS-FNB With MOSE vs EUS-FNA With ROSE
Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is an indispensable tool for tissue acquisition for pancreatic lesions.
- Trial name
- MORE (NCT03766659)
- Testing
- MOSE, ROSE
- Where
- Hong Kong
- Volunteers
- 340 people
- Sponsor
- Chinese University of Hong Kong
Abdominal Neoplasms
22 Gauge Needle for EUS Guided Tissue Acquisition of Samples for Histologic Examination
To determine the yield of tissue biopsy specimen and the diagnostic accuracy of tissue acquisition using a newly developed 22 gauge needle in patients with solid lesions throughout the GI tract.
- Trial name
- EUSFNTA (NCT04032951)
- Testing
- Fine Needle Tissue Acquisition
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Catholic University of the Sacred Heart
Pancreatic Carcinoma, Pancreatic Neuroendocrine Tumor
Study on Microflora Characteristics of Pancreatic Solid Lesions Via Endoscopic Ultrasound-guided Fine Needle Aspiration/Biopsy
Study objective: To describe the microflora characteristics of the pancreatic solid lesions via the tissue acquired via the endoscopic ultrasound-guided fine needle aspiration/biopsy (EUS-FNA/B).
- Conditions
- Pancreatic Carcinoma, Pancreatic Neuroendocrine Tumor, Autoimmune Pancreatitis, Microflora
- Trial name
- NCT05171517
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Tumor, Gastric Tumor
Comparing the Efficacy of Endoscopic FNA vs FNB in Diagnosing Solid Gastrointestinal Lesions
The purpose of this study is to determine if fine needle aspiration or fine needle biopsy is more efficacious and cost-effective than the other while maintaining diagnostic accuracy in the setting of solid gastrointestinal…
- Conditions
- Pancreatic Tumor, Gastric Tumor, Esophageal Tumor, Lymphadenopathy
- Trial name
- NCT01698190
- Testing
- Endoscopic ultrasound guided needle tissue acquisition.
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Stony Brook University
Pancreatic Cancer, Lymphadenopathy
Beacon BNX™ Endoscopic Ultrasound (EUS)-Needle vs SharkCore™ Needle
The primary objective of this proposed prospective randomized, multi-center study is to evaluate the capability of the new 22G SharkCore™ needle to obtain tissue specimens and to compare its performance against the standard 22G…
- Conditions
- Pancreatic Cancer, Lymphadenopathy, Cholangiocarcinoma
- Trial name
- NCT02872831
- Testing
- 22G SharkCore™ needle, 22G BNX EUS-FNA Needle
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Solid Pancreatic Mass Lesions, Malignant Neoplasm of Pancreas
Comparison of a Novel 22-gauge Core Biopsy Needle
The goal of this clinical research study is to compare the performance of a newly available needle with reverse bevel design (called the EchoTip® Procore™ needle) with standard needles to see which needle gives better diagnostic…
- Trial name
- NCT01598194
- Testing
- Novel 22-gauge Core Biopsy Needle + Standard Biopsy Needle
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Mass
Comparing the Diagnostic Efficacy of Different Suction Techniques for EUS-FNB of Pancreatic Solid Lesions
There are many factors that can affect the diagnostic yield of EUS-FNA, including lesion factors, the endoscoist experience, the needle size, the number of needle passes, and the suction technique.
- Trial name
- NCT04100941
- Testing
- standard suction, slow pull, wet suction
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Changhai Hospital
Pancreatic Solid Lesions
Different Suction Techniques For Endoscopic Ultrasound-Guided Fine-Needle Biopsy In Pancreatic Solid Lesions
Ultrasound-guided fine-needle aspiration represents the gold-standard for the pathological diagnosis of solid pancreatic lesions.
- Trial name
- NCT03849209
- Testing
- Stylet slow-pull technique, Standard suction technique
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- ARNAS Civico Di Cristina Benfratelli Hospital
Biopsy, Fine-needle, Pancreatic Neoplasm
EUS-FNB With ROSE Vs. EUS-FNB Without ROSE
Rationale: Rapid on-Site Evaluation (ROSE) of cytologic specimens acquired with EUS-guided fine needle aspiration (EUS-FNA) represents the most accurate available technique to reach a definitive diagnosis in patients with…
- Trial name
- FROSENOR (NCT03322592)
- Testing
- Rapid on-site evaluation (ROSE), Histologic evaluation
- Where
- 13 sites in United States, Australia and 6 more
- Volunteers
- 800 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pancreatic Neoplasms
Fine Needle Biopsy of Solid Pancreatic Mass Lesions
This is a randomized trial to evaluate and directly compare the tissue quality, diagnostic sucess and safety profile of four different Fine Needle Biopsy needles.
- Trial name
- NCT04085055
- Testing
- Solid pancreatic mass lesion biopsy
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- AdventHealth
Pancreatic Neoplasm
22G FNA Needle vs. 22G ProCore Needle
The aim of this research study is to identify the best needle for performing biopsy during EUS procedures. There are two types of needles for performing biopsy: A FNA needle that provides a small sample of tissue for analysis and…
- Trial name
- NCT01394159
- Testing
- 22G ProCore biopsy needle, 22G standard FNA needle
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- AdventHealth
Pancreatic Neoplasm
Comparison of EUS-FNB Biopsy Techniques of Solid Pancreatic Lesions
Patients with a diagnosis of solid pancreatic lesions evidenced by imaging studies (CT, MRI) and who undergo endoscopic ultrasound-guided biopsy will be selected.
- Trial name
- NCT04843956
- Testing
- Endoscopic ultrasound-guided biopsy
- Where
- Mexico
- Volunteers
- 41 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Biopsy, Fine-Needle, Endosonography
Impact of Suction in the EUS-guided Fine Needle Biopsy of Solid Pancreatic Lesions
Tissue acquisition by Endoscopic Ultrasound (EUS) has become a modality of diagnosis and clinical orientation for several diseases.
- Conditions
- Biopsy, Fine-Needle, Endosonography, Pancreatic Neoplasm
- Trial name
- NCT04164017
- Testing
- EUS-guided FNB with Syringe Suction, EUS-guided FNB without Syringe Suction
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Centro Hospitalar De São João, E.P.E.
Pancreatic Diseases
The 22G Franseen Needle Combined With Different Aspiration Techniques for Endoscopic Ultrasound-guided Fine-needle Biopsy
The goal of this clinical study is to compare the tissue adequacy, cellularity, blood contamination, accuracy, sensitivity, specificity of the 22G Franseen needle combined with three different suction techniques (dry-suction…
- Trial name
- NCT07023549
- Testing
- ABC, ACB, BAC
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Changhai Hospital
Biopsy, Fine-needle, Pancreatic Neoplasm
EUS-FNB for Solid Pancreatic Lesions: Side-fenestrated Vs Fork-tip Needle
Rationale: Until now there are no prospective studies comparing the 22 gauge and 25 gauge side-fenestrated and fork-tip needles.
- Trial name
- NCT03622229
- Testing
- Histologic evaluation
- Where
- 2 sites in Italy
- Volunteers
- 192 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pancreatic Solid Lesions
Prospective Comparison of Diagnostic Accuracy Between Contrast-enhanced Harmonic and Conventional EUS-guided Fine-needle Biopsy in Solid Pancreatic Lesions
Endoscopic ultrasonography (EUS)-guided fine-needle aspiration/biopsy (FNA/B) is used to collect biopsy samples from many organs throughout the digestive tract and is useful in diagnosing solid pancreatic lesions (SPLs).
- Trial name
- NCT04924725
- Testing
- Endoscopic ultrasound-guided fine needle biopsy
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital