Clinical trials: Spastic Esophageal Motility Disorders
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Achalasia, Esophageal, Esophagogastric Junction Outflow Obstruction
The Impact of Anesthetics on FLIP
To understand the impact of commonly used anesthetics on esophageal motility during FLIP topography.
- Conditions
- Achalasia, Esophageal, Esophagogastric Junction Outflow Obstruction, Spastic Esophageal Disorders
- Trial name
- NCT07458555
- Testing
- FLIP Imaging under various standard of care anesthetics in the context of endotracheal intubation.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
Type I Achalasia, Type II Achalasia
PREcision MEDicine In Achalasia (PREMEDIA)
The goal of this clinical trial is to learn if shorter Per-Oral Endoscopic Myotomy (POEM) works as well as a longer POEM in patients with trouble swallowing due to certain conditions.
- Conditions
- Type I Achalasia, Type II Achalasia, EGJ Outflow Obstruction Without Spastic/Hypercontractile Features
- Trial name
- PREMEDIA (NCT07293650)
- Testing
- Standard Myotomy, Tailored Short Myotomy
- Where
- 16 sites in United States
- Volunteers
- 372 people
- Sponsor
- Northwestern University
Type III Achalasia, EGJ Outflow Obstruction With Spastic/Hypercontractile Features
PREcision MEDicine In Achalasia (PREMEDIA) - Cohort
The goal of this observational study is to learn about how the doctor decides how long to cut t the esophageal muscle during Per-Oral Endoscopic Myotomy (POEM) in patients with difficulty swallowing due to certain conditions.
- Conditions
- Type III Achalasia, EGJ Outflow Obstruction With Spastic/Hypercontractile Features, Jackhammer Esophagus, Distal Esophageal Spasm
- Trial name
- PREMEDIA (NCT07293689)
- Where
- 16 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Esophageal Achalasia, Spastic Esophageal Motility Disorders
Transverse vs Longitudinal Mucosal Incision During POEM
Peroral endoscopic myotomy (POEM) is a minimally invasive endoscopic procedure used to treat achalasia and other spastic esophageal motility disorders.
- Trial name
- NCT07425977
- Testing
- Transverse Mucosal Incision During POEM, Longitudinal Mucosal Incision During POEM
- Where
- Colombia
- Volunteers
- 140 people
- Sponsor
- Universidad Nacional de Colombia
Esophageal Achalasia, Esophageal Spasm, Diffuse
Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in Spastic Esophageal Disorders
To compare the efficacy of peroral endoscopic myotomy and Botulinum toxin injection in spastic esophageal disorders.
- Conditions
- Esophageal Achalasia, Esophageal Spasm, Diffuse, Esophageal Motility Disorders
- Trial name
- NCT02663206
- Testing
- peroral endoscopic myotomy, Botulinum toxin injection
- Where
- United States
- Sponsor
- Johns Hopkins University
Esophageal Achalasia
POEM for Spastic Esophageal Disorders
This study evaluates the efficacy and safety of the Per-Oral Endoscopic Myotomy (POEM) technique for lower esophageal sphincter myotomy in patients suffering from spastic esophageal disorders such as achalasia at a Canadian…
- Trial name
- NCT02425033
- Testing
- POEM
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto