Clinical trials: Spasticity, Muscle
Stroke, Cerebral
Benefits of Extracorporeal Shockwave Therapy to Reduce Spasticity in Stroke/CP
This Study will help to explain us that ExtracorporealShockwave therapy can reduce spasticity in Stroke Patient,help them to restore their abilities and ROM.Therapy reduces dependency rate of patient.Also seen this therapy shows…
- Trial name
- NCT06548321
- Testing
- Extracorporeal Shockwave Therapy
- Where
- Pakistan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Superior University
Vibration, Electrophysiology
Developing Optimal Focal Muscle Vibration for Improving Spasticity
The overall aim of the proposed study is to determine optimal parameter of focal muscle vibration for improving spasticity and identify neurophysiological mechanism in healthy subjects.
- Conditions
- Vibration, Electrophysiology, Muscle Spasticity
- Trial name
- NCT01915342
- Testing
- Focal muscular vibration
- Where
- South Korea
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Diplegic Cerebral Palsy
"Immediate Effect of DAFO on Gross Motor Function and Balance in Diplegic Cerebral Palsy
" Study will investigate the immediate effect of DAFO usage on balance and gross motor functions in individuals with spastic diplegic cerebral palsy.
- Trial name
- NCT06343688
- Testing
- "Assessment of Balance and Lower Extremity Gross Motor Function with and without DAFO"
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Stroke
Robot Aided Rehabilitation - Multi-joint Evaluations
Sensory and motor impairments following stroke can lead to substantial disability involving the arm and hand. The investigator hypothesized that excessive local and cross-coupled stiffness, diminished individuation and…
- Trial name
- Aim1 (NCT02359812)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Stroke, Spasticity, Muscle
Individualized rTMS Based on fNIRS to Spasticity
Stroke is of high morbidity and mortality, and surviving patients are often unable to take care of themselves because of severe motor dysfunction.
- Conditions
- Stroke, Spasticity, Muscle, Rehabilitation
- Trial name
- NCT05318586
- Testing
- individual rTMS based on fNIRS, Traditional rTMS strategy
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Cerebral Palsy, Spasticity
Power Wheelchair Joystick Use in Spastic Cerebral Palsy
There are over 750,000 individuals in the U.S. with Cerebral Palsy (CP). Up to 46% of adults with CP report limited mobility in their communities.
- Trial name
- NCT00337688
- Testing
- isometric joystick
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cerebral Palsy, Spastic, Posture
The Effect of Trunk Control on Respiratory Muscle Strength
Cerebral palsy (CP) can be defined as a group of disorders of movement and posture, causing activity limitation that are attributed to nonprogressive deficits that take place in the immature brain.
- Conditions
- Cerebral Palsy, Spastic, Posture, Respiratory Muscle Strength, Activities of Daily Living
- Trial name
- NCT03209310
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gazi University
Spastic Cerebral Palsy (sCP)
Botulinum Neurotoxin for Children With CP: a Delicate Balance Between Clinical Benefits and Muscular Harm
A cross-sectional design study will be carried out to explore the morphological muscle properties and alterations in muscle composition on a macroscopic level in children with spastic cerebral palsy (CP).
- Trial name
- Bo-Balance (NCT06991725)
- Where
- Belgium
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gait, Spastic, Reliability
Reliability of Newly-acquired Gait in Toddlers With a Typical Development and a Unilateral Cerebral Palsy
gait reliability study of toddlers with typically developing and with unilateral cerebral palsy during the first 6 months of independent walking
- Trial name
- ReliabBB-AQM (NCT04559776)
- Testing
- gait analysis
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National Clinical Center for Neuropsychomotor Recovery for Children Dr. Nicolae Robanescu
Spasticity
A Prospective Study of Spasticity in Individuals With Multiple Sclerosis
This study is expected to contribute to the body of knowledge on the benefits of individuals with MS taking glatiramer acetate (Copaxone®).
- Trial name
- NCT01111435
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Fraser, Cira, Ph.D., RN, ACNS-BC
Cerebral Palsy, Muscle Spasticity
Effect of Botox and Vibration on Bone in Children With Cerebral Palsy
Cerebral palsy (CP) is a neuromuscular disorder that affects approximately 800,000 individuals in the U.S. An estimated 70-80% of these individuals have spasticity which affects ambulation and requires management.
- Trial name
- NCT01803464
- Testing
- Low-magnitude vibration, Botox
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Injuries, Spinal Cord, CVA (Cerebrovascular Accident)
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
Comparing the efficacy of Intracthecal Baclofen dose between the Prometra II and Medtronic SynchroMed II for patients with spasticity and with current a current SyncroMed II pump needing replacement.
- Conditions
- Injuries, Spinal Cord, CVA (Cerebrovascular Accident), Traumatic Brain Injury, MS (Multiple Sclerosis)
- Trial name
- NCT04530955
- Testing
- Prometra II Programmable Pump - Flowonix Medical
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Culicchia Neurological Clinic
Muscle Spasticity
H-reflex in Spastic Lower Limb Cryoneurotomy
Spasticity is a common complication after many upper motor neurone disorders. Many surgical techniques have been introduced for patients with refractory spasticity though they are not without peri-operative risks.
- Trial name
- NCT04907201
- Testing
- Cryoneurotomy
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vancouver Island Health Authority
Stroke
Investigation of the Use of Acupuncture for the Treatment of Spasticity in Chronic Stroke Participants
The purpose of this study is to investigate if acupuncture is more effective than sham treatment in reducing lower extremity spasticity, and improving gait speed in the chronic phase of stroke recovery.
- Trial name
- HHSCSTROKEAC (NCT02085642)
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Safety and Pharmacokinetics of Intravenous Baclofen
Dose Escalation Study of Intravenous Baclofen in Healthy Adult Volunteers
The objective of this study is to determine safety and characterize pharmacokinetics of higher doses of intravenous baclofen in healthy subjects.
- Trial name
- NCT01931319
- Testing
- Intravenous baclofen
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Stroke, Spasticity, Muscle
Analysis of the Correlation Between Ultrasound Imaging and Functional Parameters in the Medial Gastrocnemius Muscle in Post-stroke Patients With Spasticity in the Lower Limb
The goal of this observational study is to understand the impact of spasticity on muscle changes and functional performance in stroke patients with lower limb spasticity in comparison to non-stroke individuals.
- Trial name
- US-function (NCT06411587)
- Testing
- Ultrasound imaging and functional assessment
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Spasticity, Muscle, Spinal Cord Injuries
Effects of Baclofen on Presynaptic Inhibition in Humans
This study examines the role of the GABA-B receptor in long-lasting presynaptic inhibition of primary afferents in human participants.
- Trial name
- NCT04471714
- Testing
- Baclofen
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Cerebral Palsy (CP), Typically Developing Children
The Effect of Perturbation Training on Reactive Balance in Children With Cerebral Palsy
The aim of this project was to evaluate whether perturbation training influences reflex modulation in children with spastic CP and whether changed reflex modulation leads to improved reactive balance and walking.
- Trial name
- NCT07818928
- Testing
- Balance training on a moving platform
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spasticity, Lokomat
Reliability of Spasticity Measurement With Lokomat
The purpose of the study is to evaluate the reliability of spasticity measurement with Lokomat
- Trial name
- NCT02718053
- Testing
- L-stiff, Ashworth
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Baclofen Withdrawal Syndrome
Oral and IV Baclofen in Adult Volunteers
The primary objective of this study is to characterize baclofen pharmacokinetics following oral and intravenous administration in patients who are on chronic oral baclofen therapy.
- Trial name
- NCT01749319
- Testing
- Oral baclofen, Intervenous baclofen
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Minnesota