Clinical trials: Spasticity, Muscle
Multiple Sclerosis, Spasticity
One Year, Open Label, Dose Escalation Long-term Safety Study in Multiple Sclerosis (MS) Subjects With Spasticity
Clinical protocol OS440-3003 is a multicenter, open-label, non-randomized, uncontrolled, dose escalation study to evaluate the safety and tolerability of Arbaclofen Extended Release Tablets over 1 year in Multiple Sclerosis (MS)…
- Trial name
- NCT01844232
- Testing
- arbaclofen
- Where
- 35 sites in United States, Russia and 1 more
- Volunteers
- 150 people
- Sponsor
- RVL Pharmaceuticals, Inc.
Spasticity
Definition, Assessment and Treatment of Spasticity According to Physiotherapists and Occupational Therapists in Flanders, Belgium: A Cross-sectional Qualitative Study.
The definition of spasticity described by Lance in 1980 provided a strong academic foundation for characterizing this neurological symptom.
- Trial name
- NCT06956534
- Testing
- Questionnaire and Physical Exam
- Where
- Belgium
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Lower Limb Spasticity
Trial to Test the Effectiveness of Vibrotactile Stimulation for Lower Limb Spasticity
The goal of this clinical trial is to find out if Vibrotactile Stimulation (VTS) can help improve mobility and reduce spasticity (muscle stiffness) in people with lower limb spasticity.
- Trial name
- NCT07447934
- Testing
- Vibrotactile Stimulation (Static Use), Vibrotactile Stimulation (Dynamic Use), Vibrotactile Stimulation (Neurophysiological Mechanism)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease
Levetiracetam (Keppra) is used to treat partial onset seizures. Its biological effects suggest it might also be useful in treating 3 aspects of human motor neuron diseases (MNDs) for which no effective therapy exists: cramps…
- Conditions
- Motor Neuron Disease, Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis, Progressive Muscular Atrophy
- Trial name
- NCT00324454
- Testing
- Levetiracetam
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Spasticity in Participants With Multiple Sclerosis
Trial to Evaluate the Effect of Nabiximols Oromucosal Spray on Clinical Measures of Spasticity in Participants With Multiple Sclerosis
This study will be conducted to evaluate the effect of multiple doses of nabiximols as adjunctive therapy compared with placebo on a clinical measure of velocity-dependent muscle tone in the lower limbs (Modified Ashworth Scale…
- Trial name
- RELEASE MSS1 (NCT04657666)
- Testing
- Nabiximols
- Where
- 16 sites in Czechia, Poland
- Volunteers
- 68 people
- Sponsor
- Jazz Pharmaceuticals
Spasticity, Muscle
Does ESWT With BoNTA Treatment Improve Outcomes When Compared to Standard Management for Upper Limb Spasticity Patient.
Background Effective management of spasticity, a debilitating and challenging condition afflicting many recovering from and living with neurological conditions, may reduce long term consequences such as limb contracture, skin…
- Trial name
- NCT05226637
- Testing
- ESWT (extra-corporeal shock wave therapy)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Stroke, Hemiplegia
Robot-Assisted Therapy in Chronic Stroke Patients
Considering the paucity of studies on robotic hand therapy, larger-scale and long-term follow-up studies are needed. The aim in this study is to demonstrate the effectiveness of robot-assisted hand therapy in patients with…
- Trial name
- NCT06692829
- Testing
- robotic rehabilitation, conventional rehabilitation
- Volunteers
- 80 people
- Sponsor
- Afyonkarahisar Health Sciences University
Stroke, Spasticity, Muscle
REHABOTICS: Integrated Rehabilitation System for People With Motor Disabilities
The goal of the Rehabotics project is the development of a comprehensive rehabilitation system to provide highly individualized treatment of upper limb function in patients with motor disorders due to acquired brain damage (eg…
- Conditions
- Stroke, Spasticity, Muscle, Upper Extremity Dysfunction
- Trial name
- NCT06519630
- Testing
- Rehabotics Physiotherapy, Traditional Physiotherapy
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Pantelis Syringas
Hereditary Spastic Paraplegia
Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia
Hereditary spastic paraplegias constitute a heterogeneous group of diseases with the common predominant feature of spasticity of the lower limbs.
- Trial name
- SPASTOX (NCT02604186)
- Testing
- Botulinum Toxin Injections
- Where
- Brazil
- Volunteers
- 55 people
- Sponsor
- University of Campinas, Brazil
Spasticity, Multiple Sclerosis, Stroke, Trauma
Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity
Spasticity - movement disorder, which is part of the syndrome of defeat top motor-neuron, characterized by the rate-dependent increase in muscle tone and increased dry-core reflections from hyperexcitability of stretch receptors…
- Trial name
- ANTMS (NCT01786005)
- Testing
- Transcranial magnetic stimulation
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Russian Academy of Medical Sciences
Cerebral Palsy, Whole Body Vibration
Effects of WBV in Children With Hemiparetic CP
The aim of this study was to investigate short and long-term effects of Whole Body Vibration therapy on spasticity and motor performance in children with hemiparetic cerebral palsy in addition to conventional physiotherapy.
- Conditions
- Cerebral Palsy, Whole Body Vibration, Spastic Hemiplegia, Motor Performance
- Trial name
- NCT04528966
- Testing
- Whole-Body Vibration, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Pamukkale University
Stroke
Kinesiotaping and Constraint Induced Movement Therapy in Subacute Stroke
In stroke patients, the most common neurological deficits were motor impairment, loss of somatosensation, abnormal muscle tone, and impaired fractionated movement at affected limbs.
- Trial name
- NCT03682666
- Testing
- Kinesiotaping, modified Constraint Induced Movement Training
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- Chang Gung Memorial Hospital
Cerebral Palsy, Muscle Spasticity
Dysport® Pediatric Lower Limb Spasticity Follow-on Study
The purpose of this research study was to determine the long term safety and efficacy of repeated treatments with Dysport® used in the treatment of lower limb spasticity in children with dynamic equinus foot deformity due to…
- Conditions
- Cerebral Palsy, Muscle Spasticity, Children
- Trial name
- NCT01251380
- Testing
- Botulinum toxin type A
- Where
- 27 sites in United States, Chile and 4 more
- Volunteers
- 216 people
- Sponsor
- Ipsen
Stroke, Spasticity
Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroke
Stiff knee gait is defined as the lack of knee flexion in the swing phase of gait. Stiff knee gait is a frequent condition among stroke patients leading to reduce gait speed and increase energy cost.
- Trial name
- NCT02114736
- Testing
- Tenotomy of the proximal rectus femoris tendon, Botulinum Toxin injection in the rectus femoris muscle
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital of Mont-Godinne
Upper Limb Spasticity
Randomised, Evaluation-blinded, Crossover, Controlled Study Assessing Dynamic Hand Splinting in Adults With Post-stroke Hemiplegia (Orthox)
Upper limb spasticity is currently mainly managed with local toxin treatments. Recent studies suggested combining botulinum toxin injections with splinting to optimise rehabilitation in spastic patients.
- Trial name
- ORTHOX (NCT02888548)
- Testing
- botulinum toxins (Dysport°) alone, orthosis (Saebo Strech°) + botulinum toxins (Dysport°) combined
- Where
- France
- Volunteers
- 1 people
- Sponsor
- CHU de Reims
SCI - Spinal Cord Injury, Spasticity
Addressing Spasticity and Motor Function With Epidural Spinal Cord Stimulation
The purpose of this study is to investigate treating severe spasticity in persons with spinal cord injury by implanting a device in the body that delivers electrical stimulation around the spinal cord (spinal cord epidural…
- Trial name
- NCT07890558
- Testing
- Epidural implant stimulation device
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Kessler Foundation
Muscle Spasticity
Study of Nighttime Dosing of Sublingual Tizanidine (12 mg) in Multiple Sclerosis (MS) Patients With Significant Spasticity
Nightly administration of 8 mg of a unique sublingual (under the tongue) formulation of tizanidine, a known anti-spasticity medication, has been shown in a previous study to improve next-day spasticity, about 12 hours following…
- Trial name
- NCT00358293
- Testing
- Tizanidine (sublingual or oral)
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Teva GTC
Cerebral Palsy, Spastic
Progressive Supervised Home-based Strength Training in Children With Spastic Cerebral Palsy
A randomized controlled trail will be carried out to investigate the effect of a 12-week supervised home-based progressive strength intervention in children with spastic cerebral palsy aged 5-11 years.
- Trial name
- NCT03863197
- Testing
- Progressive strength training
- Where
- 2 sites in Belgium
- Volunteers
- 49 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Spastic Hemiplegic Cerebral Palsy
Effect of Augmented Reality Intervention on the Range of Motion, Muscle Strength, Function of Upper Extremity and Balance in Children With Spastic Hemiplegic Cerebral Palsy: A Randomized Clinical Trial
Cerebral Palsy (CP) is a disorder of the development of movement and posture, causing activity limitations attributed to nonprogressive disturbances of the fetal or infant brain that may also affect sensation, perception…
- Trial name
- NCT04171232
- Testing
- Balance It, Bubble Pop, Scoop'd
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Zohra Institute of Health Sciences
Cerebral Palsy (CP)
The Effect of Hip Joint Orthotic Intervention and Conventional Exercise Training on Spasticity, Balance and Walking Performance in Children With Cerebral Palsy
Cerebral palsy (SP) is defined as a group of persistent disorders that cause activity limitation of movement and postural development. Children with cerebral palsy are typically born with a normal anatomical hip sequence.
- Trial name
- NCT07000578
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people
- Sponsor
- Medipol University