Clinical trials: Spasticity as Sequela of Stroke
Stroke, Spasticity as Sequela of Stroke
Radial Extracorporeal Shock Wave Therapy as an Adjunct to Botulinum Toxin Type A for Post-Stroke Lower Limb Spasticity (SOLUTION)
The goal of this pilot clinical trial is to determine whether radial extracorporeal shock wave therapy (rESWT), when used as an adjunct to ultrasound-guided botulinum toxin type A (BoNT-A) injections, can enhance the therapeutic…
- Conditions
- Stroke, Spasticity as Sequela of Stroke, Lower Limb Spasticity, Upper Motor Neuron Syndrome
- Trial name
- SOLUTION (NCT07875868)
- Testing
- Radial shock Wave therapy (3000 pulses, 5 Hz, 2.5 bar)., Ultrasound-guided abobotulinumtoxin A
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Parc de Salut Mar
Spasticity as Sequela of Stroke
Effects of Dry Needling on Electromyographic Activity and Ultrasonographic Characteristics in Post-Stroke Spasticity
Stroke is a global health problem, with an incidence in Europe of 147/100,000 people per year. It is estimated that 43% of them present spasticity throughout the first year, causing disability, hindering mobility and…
- Trial name
- NCT06017960
- Testing
- Dry needling + usual care
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Universidad de Zaragoza
Spasticity as Sequela of Stroke
A Study to Estimate How Often Post-stroke Spasticity Occurs and to Provide a Standard Guideline on the Best Way to Monitor Its Development
This study will monitor patients during the first year following their stroke. Stroke is a very serious condition where there is a sudden interruption of blood flow in the brain.
- Trial name
- EPITOME (NCT06055725)
- Where
- 55 sites in United States, France and 5 more
- Volunteers
- 1,057 people
- Sponsor
- Ipsen
Stroke, Hemiparesis
Fully Remote Use of IpsiHand Device in Hemiparetic Stroke
BCI-REHAB was a randomized clinical trial comparing an at-home brain-computer interface therapy system versus an at-home exercise program for upper-extremity rehabilitation in the chronic phases of stroke.
- Conditions
- Stroke, Hemiparesis, Spasticity as Sequela of Stroke, Brain Computer Interface
- Trial name
- NCT05965713
- Testing
- Neurolutions IpsiHand Upper Extremity Rehabilitation System, Home Exercise rehabilitation regimen Program (HEP)
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Neurolutions, Inc.
Spasticity as Sequela of Stroke
Cryoneurolysis for Spasticity Treatment: Long-term Clinical Outcomes and Mechanisms in the Central Nervous System
Spasticity can make regular daily activities difficult or impossible. Cryoneurolysis is a new technique to treat spasticity that is currently being tested.
- Trial name
- NCT06958289
- Testing
- Cryoneurolysis
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sue Peters
Spasticity as Sequela of Stroke
EXOPULSE Mollii Suit, Motor Function & Stroke (EXOSTROKE)
Spasticity is a common and debilitating complication in neurological conditions such as multiple sclerosis, cerebral palsy, and stroke.
- Trial name
- EXOSTROKE (NCT06702163)
- Testing
- EXOPULSE MOLLII SUIT (active)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut De La Colonne Vertebrale Et Des Neurosciences
Spasticity as Sequela of Stroke
Phenol and Botulinum Toxin vs Botulinum Toxin Alone for Post-Stroke Upper-Limb Spasticity
This study aims to evaluate the efficacy of a combined treatment approach for post-stroke upper limb spasticity using phenol neurolysis and botulinum toxin (BoNT).
- Trial name
- NCT07440173
- Testing
- phenol neurolysis, Botulinum Toxin - A injections
- Volunteers
- 60 people
- Sponsor
- Assiut University
Stroke, Hemiplegia Following Ischemic Stroke
Improving STEP in Stroke Patients
Stroke is the leading cause of acquired disability in adults. Stroke causes death in 10% of patients, disability and functional handicap in 60% of cases.
- Conditions
- Stroke, Hemiplegia Following Ischemic Stroke, Disability Physical, Spasticity as Sequela of Stroke
- Trial name
- I-STEP (NCT07403149)
- Testing
- REMARCHE® shoes
- Volunteers
- 58 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Pain, Spasticity as Sequela of Stroke
Closed Loop Spinal Cord Stimulation for Neuromodulation of Upper Motor Neuron Lesion Spasticity
Spasticity is characterized by increased muscle tension and is a classic consequence of upper motor neuron (UMN) damage in the central nervous system, such as from stroke or trauma.
- Conditions
- Chronic Pain, Spasticity as Sequela of Stroke, Upper Motor Neuron Lesion
- Trial name
- CLONUS (NCT06384170)
- Testing
- Spinal Cord Stimulation- Closed loop
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Spasticity as Sequela of Stroke, Spastic Cerebral Palsy
Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy
A scientific study is being done to test a special treatment for people who have spasticity or tight muscles. This treatment is called "stereotactic radiosurgery dorsal rhizotomy." It uses very accurate beams of radiation to…
- Conditions
- Spasticity as Sequela of Stroke, Spastic Cerebral Palsy, Spasticity, Muscle
- Trial name
- SPASM (NCT06070233)
- Testing
- stereotactic radiosurgery (SRS) dorsal root rhizotomy radiomodulation
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Ohio State University
Aromatherapy, Spasticity as Sequela of Stroke
Aromatherapy on Upper Limb Spasticity on Stroke Survivors
This study employed a double-arm, pre- and post-test design. Stroke survivors aged 65 or above with post-stroke upper limbs spasticity were recruited from two RCHEs in Hong Kong between February and June 2025, and were divided…
- Trial name
- NCT07286825
- Testing
- massage oil with a mixture of sweet marjoram essential oil and fractionated coconut organic carrier oil, plain fractionated coconut organic carrier oil
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Hong Kong Metropolitan University
Stroke, Hemiparesis
Mechanism of Action of Focal Extracorporeal Shock Waves as a Treatment of Upper Limb Stroke Spasticity: a Pilot Study
Spasticity, common after a stroke, aggravates the patient's motor impairment causing pain and limitation in daily activities such as eating, dressing and walking.
- Conditions
- Stroke, Hemiparesis, Hemiplegia, Spasticity as Sequela of Stroke
- Trial name
- SASHA (NCT06311526)
- Testing
- Extracorporeal Shockwave Therapy
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Istituto Auxologico Italiano
Muscle Spasticity, Stroke Sequelae
Comparison of Two Botox Injection Techniques to Improve Gait
According to our hypothesis, the use of HD-EMG shall allow an accurate localization of the innervations zones of the muscles, offering a better complement to the methodology applied so far to define the botulinum neurotoxin…
- Conditions
- Muscle Spasticity, Stroke Sequelae, Spasticity as Sequela of Stroke, Gait Disorders, Neurologic
- Trial name
- NCT07124806
- Testing
- Botulinum toxin guided by ultrasonography and anatomical references, Botulinum neurotoxin guided by ultrasonography and in vivo location of innervation zones guided by high-density electromyography
- Where
- 2 sites in Chile
- Volunteers
- 18 people
- Sponsor
- Universidad de los Andes, Chile
Stroke, Acute, Stroke, Ischemic
Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients
Spasticity, or greater muscle resistance, is a major disabling condition following stroke. Recovery of lost motor function in patients with stroke may be affected by spasticity, which most commonly develops in elbow and ankle…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke
- Trial name
- NCT05179473
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- McGill University
Stroke, Hemiparesis;Poststroke/CVA
Muscle Oxygenation and Spasticity in Hemiparetic Stroke Patients
Conditions such as hemiparesis, sensory and motor impairment, perceptual impairment, cognitive impairment, aphasia, and dysphagia may be observed after stroke.
- Conditions
- Stroke, Hemiparesis;Poststroke/CVA, Spasticity as Sequela of Stroke
- Trial name
- NCT06362954
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Stroke, Spasticity as Sequela of Stroke
Robotic Hand Rehabilitation
The performance of activities of daily living (ADL) depends to a large extent on the functionality of the upper limb and hand. Stroke is the leading cause of disability worldwide, with a significant individual, family and…
- Conditions
- Stroke, Spasticity as Sequela of Stroke, Upper Limb
- Trial name
- RoHa-S (NCT05983822)
- Testing
- Technological Group, Conventional Treatment
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stroke, Ischemic, Stroke Hemorrhagic
Radial Extracorporeal Shock Wave Therapy and Visual Feedback Balance Training on Lower Limb Post-Stroke Spasticity, Trunk Performance and Balance:
This study assess the relationship between lower limb spasticity and trunk movements during static and dynamic balance in post-stroke patients who also underwent conventional physical therapy, visual feedback balance training and…
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke, Spastic Gait
- Trial name
- NCT05196633
- Testing
- radial extracorporeal shock wave therapy
- Where
- Romania
- Volunteers
- 23 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Spasticity as Sequela of Stroke
Anti-Spastic Splint With Focal Muscle Vibration for Stroke Hand Spasticity
Title: The Effect of Vibrating Splint on Hand Function After Stroke Summary: This study aims to investigate the effectiveness of a vibrating splint in improving hand function and reducing spasticity among individuals who have…
- Trial name
- NCT06358976
- Testing
- Vibration plus anti-spastic hand splint, Anti-spastic hand splint, Vibration
- Where
- Palestinian Territories
- Volunteers
- 48 people
- Sponsor
- Arab American University (Palestine)
Stroke, Stroke, Ischemic
Passive Tactile Stimulation for Stroke Rehabilitation
Stroke can lead to weakness and spasticity in the arm or hand. The purpose of this study is to optimize the design of gentle vibratory stimulation delivered to the hands of individuals with chronic stroke, and explore the effect…
- Conditions
- Stroke, Stroke, Ischemic, Stroke Hemorrhagic, Spasticity as Sequela of Stroke
- Trial name
- PTS (NCT03814889)
- Testing
- Vibration pattern, No vibration
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Stanford University
Chronic Stroke, Spasticity as Sequela of Stroke
Effects of EMG-driven Robot-assisted Therapy for the Distal Upper Limb Motor Function in the Chronic Stroke Patients With Botox Injections
Over fifty percent of stroke patients experience chronic arm hand performance problems, compromising independence in daily life activities and quality of life.
- Conditions
- Chronic Stroke, Spasticity as Sequela of Stroke, Robotic Rehabilitation
- Trial name
- NCT04502264
- Testing
- Hand of Hope, Botulinum toxin type A injection
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Cheng-Hsin General Hospital