Clinical trials: Spectrum
Schizophrenia, Autism Spectrum Disorder
A Computational Neuroscience Perspective on the Shared Social Cognitive Deficits of Autism and Schizophrenia
This retrospective cohort study will examine shared neural mechanisms of social cognitive deficits in adults with autism spectrum disorder and adults with schizophrenia using existing clinical, behavioral, and neuroimaging data…
- Trial name
- NCT07618767
- Where
- Taiwan
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Schizophrenia
Bifrontal and Bitemporal Electroconvulsive Therapy (ECT) in Treatment of Patients With Schizophrenia
Electroconvulsive therapy has been used in clinical practice since 1938, a number of randomized trials found significant differences favoring ECT in response rates between individuals with depression receiving real and sham ECT.
- Trial name
- ESBECT (NCT02511509)
- Testing
- Bifrontal electroconvulsive therapy, Bitemporal electroconvulsive therapy
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lodz
Schizophrenia
Antipsychotic Discontinuation in High-risk Subjects
Would be there any difference in dopamine synthesis between remitted clinical high risk subjects for psychosis and healthy control? What would happen to dopamine synthesis after antipsychotic discontinuation in clinical high risk…
- Trial name
- NCT01758887
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Schizophrenia, Communication
The Two-Way Communication Checklist (2-COM) in First Episode Psychosis Patients in Hong Kong
The Two-Way Communication Checklist (2-COM) is a communication tool developed by van Os et al. (2002). It aims to provide an opportunity for patients to voice their needs and problem to minimize the discrepancy and…
- Trial name
- NCT02435784
- Testing
- The Two-Way Communication Checklist, Treatment as usual
- Where
- Hong Kong
- Volunteers
- 84 people
- Sponsor
- The University of Hong Kong
Schizophrenia
Fingolimod in Schizophrenia Patients
This will be a single site safety and proof of concept study conducted at the Indiana University Psychotic Disorders Program. Forty subjects with schizophrenia or schizoaffective disorders will be randomized 1:1 to double-blind…
- Trial name
- STEP (NCT01779700)
- Testing
- Fingolimod
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Schizophrenia
The Effectiveness of the Meta-cognitive Training Among Patients With Chronic Schizophrenia
The aim of the study is to compare the effectiveness of the meta-cognitive training (MCT) for schizophrenia against treatment as usual (TAU) among patients who attends community support groups.
- Trial name
- NCT02187692
- Testing
- MCT
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
OT Intervention Via Telehealth for Children With ASD and ADHD
This study aims to measure the impact of a telehealth-based model of occupational therapy (OT) treatment on clinical outcomes for children with autism spectrum disorder (ASD) and/or attention deficit hyperactivity disorder…
- Trial name
- NCT03957993
- Testing
- Occupational Therapy via Telehealth, Standard of Care Occupational Therapy
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Autism Spectrum Disorder
Parent Skills Training for Families of Children With Autism Spectrum Disorder
The study is focused on helping parents master the basic intervention skills and evaluate the effectiveness of this parental training style for children with autism spectrum disorder in China.
- Trial name
- NCT03864289
- Testing
- Parent skills training
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Fudan University
Autism Spectrum Disorder, Autistic Disorder
Risk Factors and Prognosis of Autism Spectrum Disorder
This case-control study with prospective follow-up aims to identify risk factors associated with autism spectrum disorder and to evaluate the prognosis of children with ASD attending Assiut University Children's Hospital.
- Conditions
- Autism Spectrum Disorder, Autistic Disorder, Child Development Disorders, Pervasive
- Trial name
- NCT07818460
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Assiut University
Schizophrenia
Study of SPG302 in Adults With Schizophrenia
This Phase 2 study described herein will evaluate the safety, efficacy, tolerability, and pharmacodynamics of SPG302 in adults with a primary diagnosis of schizophrenia.
- Trial name
- NCT06442462
- Testing
- SPG302
- Where
- 3 sites in United States, Australia
- Volunteers
- 32 people
- Sponsor
- Spinogenix
Schizophrenia Disorders
Effect of AQW051 on Cognitive Function in Patients With Chronic Stable Schizophrenia
This PoC study is designed to assess the cognitive effects of doses of AQW051 in patients with chronic stable schizophrenia.
- Trial name
- NCT01163227
- Testing
- AQW051 2 mg (single and multiple doses), AQW051 15mg (single and multiple doses), AQW051 100mg (single dose), and 50mg (multiple doses)
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- Novartis Pharmaceuticals
Mental Disorder, Schizophrenia
A Trial to Assess a Wearable Patch's Functioning to Detect Medication Ingestion
The primary purpose of the study is to evaluate the positive detection accuracy (PDA) and detection latency measures of the D-Tect patch.
- Conditions
- Mental Disorder, Schizophrenia, Major Depressive Disorder, Bipolar I Disorder
- Trial name
- NCT06372210
- Testing
- Abilify MyCite®, D-Tect Patch
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Schizophrenia and Related Disorders
Alternative Stimulation Mode and Location for Auditory Hallucination Neuromodulation Treatment
The purpose of the study is to test the hypothesis that functionally navigated repetitive TMS stimulations to the prefrontal cortex (PFC) modulate aberrant cortical electrical activities at PFC circuitry.
- Trial name
- NCT02916810
- Testing
- Active rTMS stimulation
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- The University of Texas Health Science Center, Houston
Bipolar I Disorder, Schizophrenia
Study in Adolescents With Schizophrenia or Bipolar Disorder
Open-label safety study of oral olanzapine treatment in adolescents, aged 13 to 17 years, with bipolar I disorder (manic or mixed episodes) or schizophrenia.
- Trial name
- NCT00982020
- Testing
- Olanzapine, Standard behavioral weight intervention, Intense behavioral weight intervention
- Where
- 14 sites in United States, Poland and 2 more
- Volunteers
- 203 people
- Sponsor
- Eli Lilly and Company
Autistic Disorder, Catatonia
Improving the Understanding of Catatonia in Autism
Catatonia is a neuropsychiatric syndrome which is frequently missed or misdiagnosed among psychiatric patients. The current project is a systematic examination of catatonia which will characterize the phenotype and identify…
- Trial name
- A-CAT (NCT02945423)
- Sponsor
- University of Michigan
Self-Injurious Behavior, Autism Spectrum Disorder
Deep Brain Stimulation for Severe Self-Injurious Behaviour in Children
Deep Brain Stimulation for the Treatment of Severe Refractory Self-Injurious Behaviour in Children with Autism Spectrum Disorder: A Randomized Trial To evaluate the effectiveness of deep brain stimulation (DBS) of the nucleus…
- Trial name
- NCT06529380
- Testing
- DBS ON, DBS OFF
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- The Hospital for Sick Children
Schizophrenia, Schizoaffective Disorder
Mobile-Assisted Cognitive Behavior Therapy for Negative Symptoms in Schizophrenia
This clinical trial will test a combined group therapy plus mobile cognitive behavioral therapy intervention targeting defeatist attitudes in consumers with schizophrenia in order to change motivational negative symptoms linked…
- Trial name
- mCBTn (NCT03179696)
- Testing
- Mobile-assisted CBT
- Volunteers
- 31 people
- Sponsor
- Eric Granholm
Major Depression
Pharmacotherapy in Depression With Panic Spectrum
This research study is being conducted to find out if certain individuals benefit from taking medication for their depression with a low dose of the antidepressant medication Zoloft.
- Trial name
- NCT00177996
- Testing
- sertraline hydrochloride
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Neuromyelitis Optica Spectrum Disorder, NMOSD
A Study to Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, and Pharmacodynamics of Satralizumab in Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD)
This study will primarily evaluate the pharmacokinetics of satralizumab in pediatric patients aged 2-11 years with anti-aquaporin-4 (AQP4) antibody seropositive neuromyelitis optica spectrum disorder (NMOSD).
- Trial name
- SAkuraSun (NCT05199688)
- Testing
- Satralizumab
- Where
- 14 sites in United States, Argentina and 7 more
- Volunteers
- 8 people
- Sponsor
- Hoffmann-La Roche
Bipolar Disorder
Open-Label Study of N-Acetylcysteine in Children and Adolescents 5-17 With Bipolar Spectrum Disorders
Children between the ages of 5-17 years old who have or display symptoms of emotional dysregulation (explosiveness, mood swings, irritability, and/or violent behavior) are invited to participate in a 12-week research study to…
- Trial name
- NCT02357290
- Testing
- Open-label Treatment with N-Acetylcysteine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital