Clinical trials: Sperm
Healthy Lifestyle, Obese
Project 1: Diet and Exercise Modulate the Sperm Epigenome in Men
This is a rigorous, controlled clinical trial designed to show that diet, exercise training, and their combination in overweight, inactive men will alter epigenetic programming to create a "healthy" sperm epigenome.
- Conditions
- Healthy Lifestyle, Obese, Men
- Trial name
- NCT04175678
- Testing
- Diet, Exercise, Standard care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Repeated Implantation Failure
Intrauterine Injection of Human Chorionic Gonadotrophin and Pregnancy Rate in ICSI
Despite recent advances in clinical and laboratory techniques of Assisted Reproductive Technology (ART), the pregnancy rate remains around 30% per cycle.
- Trial name
- NCT03445910
- Testing
- Human chorionic gonadotropin
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Recurrent Pregnancy Loss, Infertility, Female
Effects of PGS2.0 in Patients With Unexplained RPL
50%-60% of the known causes of recurrent pregnancy loss(RPL) are associated with embryonic aneuploidy, such that preimplantation genetic screening (PGS) on embryos acquired by assisted reproductive treatment should improve the…
- Trial name
- NCT03214185
- Testing
- IVF/ICSI, PGS 2.0, Conventional embryo morphology evaluation
- Where
- China
- Volunteers
- 710 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Spermatozoa, Abnormal, in Vitro Fertilization
The Influence of Sperm Morphology and Functional Indices on Blastocyst Development in Assisted Reproduction
Samples from male partners of 120 infertile couples undergoing IVF were analyzed. Sperm morphology was assessed using the SpermBlue staining method, while TZI, MAI, and SDI were calculated.
- Conditions
- Spermatozoa, Abnormal, in Vitro Fertilization, Blastocyst, Aneuploidy
- Trial name
- NCT06801652
- Testing
- Sperm morphology indexes
- Where
- Romania
- Volunteers
- 120 people
- Sponsor
- Calla IVF Center
Infertility
Split Cohort Trial Comparing IVF Outcomes After the Use of Testicular vs. Ejaculated Sperm for ICSI
The primary objective of this study is to determine if there is a difference in in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) outcomes when using testicular sperm versus ejaculated sperm in couples…
- Trial name
- NCT03483298
- Testing
- ICSI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Orchiectomy, Spermatic Cord Block
Comparison of Spinal Anesthesia and Spermatic Cord Block for Bilateral Orchiectomy
The goal of this randomized controlled trial is to compare intraoperative pain score, Morphine consumption during 6 and 12 hour after surgery, and postoperative complications between SA and SCB groups in metastatic prostate…
- Conditions
- Orchiectomy, Spermatic Cord Block, Spinal Anesthesia, Pain Score
- Trial name
- NCT06313775
- Testing
- bilateral orchiectomy
- Where
- Thailand
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sanpasitthiprasong Hospital
Infertility
The Presence of Microbes in the Sperm and Their Impact on Sperm Capacitation and IVF Treatment
Study Goals: 1. Finding the prevalence of bacteria of the sperm in an innovative and more accurate methode 2. Understanding the effect of microbes on the process of capacitation 3.
- Trial name
- NCT02585297
- Testing
- no intervention
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Fertility, Spermatic Parameters
Cryogenic Preservation of Spermatozoa
The reference technique for the conservation of gametes is storage in liquid nitrogen but new vats of nitrogen vapor (storage over liquid nitrogen) or in dry phase (storage in an insulated compartment of liquid nitrogen in a tank…
- Trial name
- NCT03734120
- Testing
- cryopreservation
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Male Infertility, Testicular Diseases
Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm
Our data indicate that environmental exposure to the heavy metal lead are more widespread than currently appreciated and that such exposures are associated with the production of human male subfertility.
- Conditions
- Male Infertility, Testicular Diseases, Urologic and Male Genital Diseases, Lead Poisoning
- Trial name
- NCT00012480
- Where
- 3 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Male Reproductive Problem
The Effects of Cannabis on Male Reproductive Functions
The purpose of this study is to understand the direct effects of cannabis on male reproductive functions. The investigators plan to conduct a double-blind, placebo-controlled clinical trial to examine both the chronic and acute…
- Trial name
- NCT06755346
- Testing
- Cannabis plant (THC 20mg), Cannabis (0%/ THC / 0% CBD), Cannabis plant (THC 40mg)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kanako Hayashi
Infertility
Evaluation Study Between Density Gradient and Swimming Down for Semen Processing
This study evaluates the quality of sperm produced after semen processing using Density Gradient (DG) and swimming down (SD).
- Trial name
- NCT02329704
- Testing
- Diff-Quik staining for morphology evaluation, Motility Evaluation for grade A and B, Concentration (mil/ml)
- Where
- 2 sites in Bahrain, Egypt
- Volunteers
- 100 people
- Sponsor
- Ahmad Mustafa Mohamed Metwalley
Infertility
Correlation Between Serum Anti-Müllerian Hormone & Müllerian Ducts Anomalies in Infertility
Anti-Müllerian hormone (AMH), also known as Müllerian inhibiting substance, is a dimeric glycoprotein that belongs to the transforming growth factor-beta family.
- Trial name
- NCT02436538
- Testing
- Anti Mullerian hormone level; Mullerian duct anomaly type
- Where
- Egypt
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Ahmed M.Kamel
In Vitro Fertilization, Ovarian Stimulation
Age Versus Ovarian Reserve Markers Based Therapy in IVF (IVF)/Intracytoplasmic Sperm Injection (ICSI) Cycles
This randomized controlled trial has been designed for carrying out a comparison of new AMH (Anti-Müllerian Hormone)-based individualized treatment (using a nomogram) with the wide accepted age-based strategy.
- Trial name
- NCT01816789
- Testing
- rFSH, buserelin
- Where
- Italy
- Volunteers
- 194 people
- Sponsor
- Andros Day Surgery Clinic
Infertility, Male Factor
FemaSeed LOCAL Artificial Insemination Trial
Brief Summary: The objectives of the trial are to evaluate the safety and effectiveness of the FemaSeed Localized Directional Insemination for artificial insemination, now known as the FemaSeed Intratubal Insemination since FDA…
- Trial name
- LOCAL (NCT04968847)
- Testing
- FemaSeed Localized Directional Insemination
- Where
- 18 sites in United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Femasys Inc.
Sperm Quality, Oligoasthenospermia
Effect of Treatment With Myo-inositol on Human Semen Parameters in Patients Undergoing In Vitro Fertilization Cycles
Myo-Inositol (MI) is a precursors for the synthesis of phosphatidylinositol polyphosphates (PIPs). In male reproduction, it was shown that MI concentration in the seminiferous tubules is higher than in serum and it was increasing…
- Trial name
- NCT01560065
- Testing
- myo-inositol + folic acid
- Where
- Italy
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Conventional IVF, ICSI
Child Follow-up in Women Treated With Conventional IVF or ICSI
To compare the physical, mental and motor development of babies born from pregnancy using ICSI technique and and conventional IVF in non-male factor infertile couples.
- Trial name
- NCT04866524
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3, Physical development and General Health, Developmental Red flags
- Where
- Vietnam
- Volunteers
- 322 people
- Sponsor
- Mỹ Đức Hospital
IVF
Luteal Phase Estradiol Support for In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles
Optimizing in vitro fertilization (IVF) success is more important than ever, in light of new public funding of IVF in Ontario, Canada.
- Trial name
- NCT02677259
- Testing
- 17-beta estradiol, Micronized progesterone
- Volunteers
- 506 people, healthy volunteers welcome
- Sponsor
- One Fertility
DNA Damage, Other Complications Associated With Artificial Fertilization
Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm
The purpose of this study is to find a non-invasive way to discover DNA (deoxyribonucleic acid, which is the genetic material inside your cells) alterations in the sperm's head, in the near future leading us to choose the "good…
- Trial name
- NCT01461395
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Crohn's Disease, Ulcerative Colitis
The Effect of Infliximab on Sperm Quality
Background: The treatment of inflammatory bowel diseases (IBD) is based mainly on 3 compounds: 1- 5 aminosalysilates . 2- immunomodulators (Azathioprines). 3- Biologic therapies (Infliximab, Adalimumab) .
- Trial name
- NCT00745329
- Testing
- sperm quality test
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Unexplained Infertility, Male Infertility
Royal Jelly Supplementation in Unexplained Male Infertility
This randomized, double-blind, placebo-controlled clinical trial investigates the effects of oral Royal Jelly supplementation on sperm DNA fragmentation and pregnancy rates in couples with unexplained infertility.
- Conditions
- Unexplained Infertility, Male Infertility, Sperm DNA Fragmentation
- Trial name
- NCT07337265
- Testing
- Lyophilized Royal Jelly
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Medipol University