Clinical trials: Sperm Count, Low
Oligospermia, Sperm Count, Low
Creatine and Ubiquinol for Sperm Quality
This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men.
- Trial name
- CRESPAQ10 (NCT06202469)
- Testing
- Supplement 1, Supplement 2
- Where
- Serbia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Reproductive Issues, Male Infertility
Efficacy and Safety of a New Sperm Capacitation Method
Prospective, multicenter research study with a split-sample design on semen samples, without intervention, to evaluate the efficacy and safety of HyperSperm, a new sperm capacitation method, in 300 semen samples with various…
- Conditions
- Reproductive Issues, Male Infertility, Asthenozoospermia, Oligozoospermia
- Trial name
- HyperSperm01 (NCT06742437)
- Testing
- Standard sperm preparation, HyperSperm
- Where
- 4 sites in Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fecundis Lab SL
Severe Oligoasthenoteratozoospermia, Sperm Quality
PRP Improves Blastocyst Formation in ICSI Cycles
The goal of this clinical trial is to learn if platelet rich plasma (PRP) works to improve embryo development rates and embryo quality in IVF cycles, involving male adult patients with severe sperm disorders.
- Conditions
- Severe Oligoasthenoteratozoospermia, Sperm Quality, Spermatazoa Disorders, Sperm Parameters in Fertile and Infertile Men
- Trial name
- PRP ICSI SOAT (NCT07579858)
- Testing
- Platelet Rich Plasma
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stella Maris Women and Children Hospital
Infertility, Male, Infertility Unexplained
Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity
Infertility was reported in approximately 15% of all heterozygous couples, with male factor accounting for nearly half the cases.
- Conditions
- Infertility, Male, Infertility Unexplained, Infertility Due to Complete Spermatogenic Arrest, Oligospermia
- Trial name
- NCT05506722
- Testing
- Testes shocker
- Where
- Iraq
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Varicocele, Male Infertility
Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele
Varicose veins in the scrotum (varicocele) are responsible for >20% of male infertility in the US. Varicocele are associated with decreased sperm number and markedly reduced sperm fertilizing ability.
- Conditions
- Varicocele, Male Infertility, Hypospermatogenesis, Non-Obstructive Azoospermia
- Trial name
- NCT00044369
- Testing
- Varicocele repair
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Azoospermia, Nonobstructive, Oligozoospermia
Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia.
The investigators hope to learn if Letrozole is effective and safe in improving severe male infertility by increasing testosterone, decreasing oestradiol and stimulating sperm production thereby improving sperm motility…
- Trial name
- NCT02900105
- Testing
- Letrozole
- Where
- Singapore
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Male Infertility
Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia
Single center, prospective, open clinical study to determine the genomic imprint (epigenetic modification) in a series of male infertility patients with alterations in their spermiogram (oligozoospermia) compared to a group of…
- Trial name
- NCT02605070
- Testing
- Bravelle
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Oligospermia, Teratospermia
Ramipril for the Treatment of Oligospermia
This is a randomized controlled trial to evaluate the effect of ramipril in stimulating and promoting sperm production in men with low sperm count.
- Conditions
- Oligospermia, Teratospermia, Asthenozoospermia, Male Infertility
- Trial name
- NCT01856361
- Testing
- Ramipril
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Asthenozoospermia, Oligospermia
Myo-inositol on Human Semen Parameters
Many clinical evidences suggest that Myo-inositol plays a crucial role in human reproduction. Also, it was shown that Myo-inositol concentration in the seminiferous tubules was higher than in serum, and interestingly it was…
- Trial name
- NCT01828710
- Testing
- Myo-inositol normospermic, Myo-inositol OAT, Folic Acid normospermic
- Where
- Italy
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Oligospermia
Supplement Intake in Infertile Men;the Effect on Sperm Parameters,Fertilization Rate and Embryo Quality
The vitamin,minerals and amino acid supplementation for 3 months will improve the semen parameters,fertilization rate and embryo quality in subfertile men undergoing IVF treatment
- Trial name
- NCT01520584
- Testing
- Vitamale
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Oligospermia, Azoospermia
Genetic Studies Spermatogenic Failure
The proposed study is designed to test the following hypotheses: 1. Mouse autosomal or X-linked genes which are exclusively expressed in mouse spermatogonia are also spermatogonia-specific in human. 2.
- Conditions
- Oligospermia, Azoospermia, Male Infertility
- Trial name
- NCT00548977
- Testing
- Drawing blood to study genetic polymorphism
- Where
- Taiwan
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Infertility, Male, Azoospermia
The Association of Gut Microbiota and Spermatogenic Dysfunction
This is a multicenter, case-control study that aims to investigate the relationship between microbiota and sperm quality via stool, blood, and urine microbiome, metabolomics, and collected clinical metadata.
- Conditions
- Infertility, Male, Azoospermia, Oligozoospermia, Asthenozoospermia
- Trial name
- NCT05628987
- Testing
- no intervention
- Where
- 3 sites in China
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Oligospermia
Hyperbaric Oxygen Therapy for Men Suffering From Infertility Due to Oligospermia.
Infertility in a couple is defined as the inability to achieve conception despite one year of frequent, unprotected intercourse. Infertility affects approximately 12% of couples attempting to conceive.
- Trial name
- NCT05842239
- Testing
- Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Male Infertility
Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ β-carotene) for Infertile Males
Infertility is defined as the inability of a couple to get pregnant after one year of regular and unprotected sexual intercourse.
- Trial name
- NCT06100432
- Testing
- DLBS5055 200mg, Multivitamin (Vitamin C 500mg + Vitamin E 100IU + Beta Carotene 10000IU)
- Where
- Indonesia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Duta Wacana Christian University
Beta-hCG Positivity, Clinical Pregnancy
Evaluation of Assisted Reproductive Technology (ART) Outcomes in Couples With Nonobstructive Azoospermia, Cryptozoospermia, and Severe Oligozoospermia
This study aims to compare the In Vitro Fertilization (IVF/ICSI) outcomes of patients with a sperm concentration of <5 million/mL (severe oligozoospermia) and <1 million/mL (cryptozoospermia) to those diagnosed with…
- Conditions
- Beta-hCG Positivity, Clinical Pregnancy, Miscarriage, Multiple Pregnancy
- Trial name
- ART (NCT07897279)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duzce University
Insulin Resistance, Oligospermia
Insulin Resistance in Idiopathic Oligospermia and Azoospermia
Insulin resistance in men can be the underlying major factor in reproductive abnormalities ( chronic hypospermatogenesis ) as well as metabolic abnormalities similar to polycystic ovarian syndrome ( PCOS ) in women.
- Conditions
- Insulin Resistance, Oligospermia, Azoospermia
- Trial name
- NCT01509482
- Testing
- blood samples
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Egyptian IVF-ET Center
Oligospermia
A Preliminary Study on Effect of Omega-3 on Human Sperm
The phospholipids of mammalian spermatozoa possess a distinctive fatty acid composition with high proportion of long chain polyunsaturated fatty acids.
- Trial name
- NCT00479960
- Testing
- commercially available omega-3 fatty acids supplementation
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Oligozoospermia
A Study to Evaluate the Safety and Tolerability of Single and Multiple Dose of STSP-0902 in Healthy Subjects
This is a Phase 1b, randomized, double-blind, placebo-controlled, single and multiple ascending dose (MAD) study to evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of STSP-0902
- Trial name
- NCT06948799
- Testing
- STSP-0902 injection
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Idiopathic Infertility
Effect of Pentoxifylline and Zinc Co-administration in Patients With Oligoasthenoteratozoospermia
The aim of this study is to investigate the impact of co-administration of Pentoxifylline and Zinc sulfate on oxidative stress, apoptosis, and inflammation, sperm capacitation and parameters in infertile men.
- Trial name
- OAT (NCT05156684)
- Testing
- Pentoxifylline, zinc, zinc + pentoxifylline
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Arak University of Medical Sciences
Oligozoospermia, Asthenozoospermia
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of STSP-0902 in Healthy Subjects
This is a Phase 1a, randomized, double-blind, placebo-controlled, single ascending dose (SAD) study to evaluate the safety, tolerability, pharmacokinetics (PK), and immunogenicity of STSP-0902.
- Trial name
- NCT06563713
- Testing
- STSP-0902 injection
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd