Clinical trials: Sperm Quality
Fertility, Spermatic Parameters
Cryogenic Preservation of Spermatozoa
The reference technique for the conservation of gametes is storage in liquid nitrogen but new vats of nitrogen vapor (storage over liquid nitrogen) or in dry phase (storage in an insulated compartment of liquid nitrogen in a tank…
- Trial name
- NCT03734120
- Testing
- cryopreservation
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Semen Quality
The Impact of Probiotics on Sperm Quality in Middle-aged Men
The clinical trial aims to investigate the impact of probiotic strain BL21 on sperm quality among 46 middle-aged male participants.
- Trial name
- NCT06544278
- Testing
- probiotic product, Maltodextrin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Fertilization in Vitro
Ejaculation Abstinence Time and Assisted Reproductive Technology Outcomes
The goal of this clinical trial is to learn if reducing the ejaculation abstinence time can improve the outcome of assisted reproductive technology.
- Trial name
- NCT06410417
- Testing
- Shorten abstinence time
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Sperm Quality
Evaluation of the Effects of Certolizumab Pegol on Semen Quality in Healthy Male Volunteers
The primary objective of this study is to evaluate the effect of certolizumab pegol (CZP) on the quality of sperm obtained from healthy male volunteers.
- Trial name
- NCT01091220
- Testing
- Certolizumab pegol
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- UCB Pharma
Healthy Volunteers, Normocholesterolaemic Men
Effects of Atorvastatin on Human Semen and Gonadal Hormones
Recently, concerns about the effect of atorvastatin intake on men fertility have been raised. However, this statin has never been investigated regarding its influence on male fertility, notably sperm quality.
- Conditions
- Healthy Volunteers, Normocholesterolaemic Men, Normozoospermic Men
- Trial name
- NCT02094313
- Testing
- Atorvastatin
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Oligospermia, Sperm Count, Low
Creatine and Ubiquinol for Sperm Quality
This randomized controlled double-blind parallel-group interventional trial explores the impact of 8-week creatine supplementation, with or without ubiquinol, on sperm quality biomarkers in normospermic and oligospermic men.
- Trial name
- CRESPAQ10 (NCT06202469)
- Testing
- Supplement 1, Supplement 2
- Where
- Serbia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Severe Oligoasthenoteratozoospermia, Sperm Quality
PRP Improves Blastocyst Formation in ICSI Cycles
The goal of this clinical trial is to learn if platelet rich plasma (PRP) works to improve embryo development rates and embryo quality in IVF cycles, involving male adult patients with severe sperm disorders.
- Conditions
- Severe Oligoasthenoteratozoospermia, Sperm Quality, Spermatazoa Disorders, Sperm Parameters in Fertile and Infertile Men
- Trial name
- PRP ICSI SOAT (NCT07579858)
- Testing
- Platelet Rich Plasma
- Where
- Indonesia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Stella Maris Women and Children Hospital
Autologous Platelet-rich Plasma Supplement, Sperm Cryopreservation
The Effects of Autologous Platelet-rich Plasma Supplement During Sperm Cryopreservation on Post-cryopreserved Sperm Quality
Sperm cryopreservation is an essential procedure for male fertility in certain situations, like cancer, vasectomy or other obstructive surgeries, autoimmunity diseases, immunosuppressive therapeutic strategies, or when the male…
- Conditions
- Autologous Platelet-rich Plasma Supplement, Sperm Cryopreservation, Post-cryopreserved Sperm Quality, Semen Analysis
- Trial name
- NCT06258759
- Testing
- autologous platelet-rich plasma supplement, no autologous platelet-rich plasma supplement
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Infertility
Adding Insulin to IVF Culture Media Significantly Improve Outcome
Add insulin to a single step culture media for IVF embryo culture from day 0 to day 5/6 of In Vitro culture and detect the the effect upon embryo quality and implantation potential.
- Trial name
- NCT02420171
- Testing
- Adding insulin to In Vitro culture media
- Where
- 2 sites in Egypt
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Poor Semen Quality
Effects of Plant Extracts on Semen Quality
this is a prospective randomized placebo-controlled double-blinded trial investigating the effect of plant extracts from Alpinia galanga and Punica granatum on human semen quality.
- Trial name
- NCT01357044
- Testing
- Extracts of Punica granatum and Alpinia galanga
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Horsens Hospital
Virtual Reality
Erotica by Virtual Reality on Sperm Donors
Objective To study whether erotica by virtual reality (VR) during masturbation influences the quality of sperm donor ejaculates. Hypothesis Erotica by virtual reality improves ejaculate quality.
- Trial name
- NCT05457764
- Testing
- Virtual reality headset
- Where
- 4 sites in Denmark
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cryos International
Sperm DNA Fragmentation, Embryo Quality
Sperm Selection by Microfluidic Separation Improves Embryo Quality
This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility.
- Conditions
- Sperm DNA Fragmentation, Embryo Quality, Fertility Disorders, Infertility
- Trial name
- SPERM (NCT03085433)
- Testing
- Microfluidic Sperm Sorting, in vitro fertilization
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility, Male
Selection of Non Apoptotic Human Sperm for in Vitro Fertilization by Using Magnetic Activated Cell Sorting (MACS)
This clinical study has been organised to help improve the embryo quality in couples having high rate of sperm showing apoptotic signs.
- Trial name
- MACS-HS (NCT03988361)
- Testing
- Magnetic Activated Cell Sorting
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Spermatogenesis and Semen Disorders, Infertility, Male
Power Prenatal Supplements for Sperm Quality
Male factor infertility is a leading cause of primary and secondary infertility. Poor sperm quality is defined as having an abnormal semen analysis [WHO 2020 - https://www.who.int/publications/i/item/9789240030787].
- Trial name
- NCT05410782
- Testing
- Power Prenatal for Sperm
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Bird and Be Co Inc
Sperm Parameters in Fertile and Infertile Men
Evaluation of New Semen Collection & Transportation Kit
Examine the effect of overnight transport conditions on sperm parameters on semen samples collected and mailed to Cleveland Clinic Andrology center.
- Trial name
- NCT04536545
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Turtle Health, Inc.
Male Infertility
Effect of Antioxidant Probiotic Administration on Seminal Quality and Reproductive Outcomes.
The quality of semen plays a fundamental role in correct fertilization and development of normal embryos that result in a live birth. Unfortunately, semen quality has declined during the last decades, and reduced more and more.
- Trial name
- NCT04585984
- Testing
- Experimental - Probiotic
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Fundación IVI
Healthy
Evaluation Of Sperm Production With Healthy Male Volunteers Receiving Lyrica Or Placebo
This study is being performed as a Phase IV FDA commitment study and is being powered adequately to assess changes in sperm concentration, FSH and testosterone in healthy male subjects treated with pregabalin as compared to…
- Trial name
- NCT00631696
- Testing
- Pregabalin
- Where
- 13 sites in United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Male Infertility With Severe Oligo-terato-asteno-spermia
Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.
Some animal studies revealed that the pomegranate juice may improve sperm quality in terms of concentration, motility and morphology, as well as in fertilization rate. Minor data is available regarding the influence on male sperm.
- Trial name
- Pomegranate (NCT01918163)
- Testing
- Pomegranate pills
- Where
- Israel
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Unrecognized Condition
Male Supplements for Sperm Quality and Aging
This study investigates the effects of a new supplement on sperm quality in men with poor sperm quality. Fifty patients will receive the supplement for three months, followed by semen analysis and assessment of sperm aging and…
- Trial name
- NCT06339996
- Testing
- Male supplement
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Veterans General Hospital.