Clinical trials: Sperm Quality
SPERM
Effect of Dietary DHA Supplementation on Sperm Quality
The aim of this study is evaluated the effect of dietetic supplementation with DHA on human sperm quality, antioxidant capacity and sperm DNA damage.
- Trial name
- NCT01368484
- Testing
- Sunflower oil, Docosahexanoic acid
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Testicular Neoplasms, Spermatic Cord Torsion
Quality of Life Among Testicular Cancer Survivors
Testicular Cancer is the most prevalent malignancy among men between 20 and 34 years of age, with incidence rates rising in western countries including Israel. Cure rate of testicular cancer exceeds 90% with modern treatments.
- Conditions
- Testicular Neoplasms, Spermatic Cord Torsion, Varicocele, Testicular Hydrocele
- Trial name
- NCT02304575
- Testing
- Questionnaires, Hormonal Function measurement
- Where
- Israel
- Volunteers
- 330 people
- Sponsor
- Rabin Medical Center
Crohn's Disease, Ulcerative Colitis
The Effect of Infliximab on Sperm Quality
Background: The treatment of inflammatory bowel diseases (IBD) is based mainly on 3 compounds: 1- 5 aminosalysilates . 2- immunomodulators (Azathioprines). 3- Biologic therapies (Infliximab, Adalimumab) .
- Trial name
- NCT00745329
- Testing
- sperm quality test
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Infertility, Endometriosis
The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis.
In this study of endometriosis patients we compare a common treatment of surgical therapy and medical treatment for 3 months (Zoladex) with patients receiving only surgical therapy.
- Trial name
- NCT01682642
- Testing
- Zoladex
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- AZ Jan Palfijn Gent
Obesity-related Poor Sperm Quality, Gut Microbiota
Effects of Soluble Fiber Supplements on Sperm Quality in Males With Obesity: a Randomized Trial
Obesity-related poor sperm quality is a significant public health issue, acting as a major contributor to male infertility. Dietary intervention has emerged as an effective strategy to manage obesity and improve sperm quality.
- Trial name
- NCT07112248
- Testing
- inulin
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Infertility, Male
Selection of Non Apoptotic Human Sperm for in Vitro Fertilization by Using Magnetic Activated Cell Sorting (MACS)
This clinical study has been organised to help improve the embryo quality in couples having high rate of sperm showing apoptotic signs.
- Trial name
- MACS-HS (NCT03988361)
- Testing
- Magnetic Activated Cell Sorting
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Obesity-related Male Infertility
Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health
Why is this study being done? Obesity can harm men's fertility by lowering sperm quality and hormone levels, making it harder to have children. Weight loss through diet and exercise helps, but it's often hard to stick with.
- Trial name
- NCT07179120
- Testing
- Semaglutide (Rybelsus®), Tirzepatide, Standardized Lifestyle Intervention
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Gout
The Influence of Urate-lowering Therapy on Sperm Quality of Male Gouty Patients：A Prospective Cohort Study
Gout is a kind of crystal-associated arthropathy caused by monosodium urate deposition, which is directly related to hyperuricemia caused by purine metabolic disorder and/or decreased uric acid excretion.
- Trial name
- INITIAL (NCT04213534)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Type 2 Diabetes Mellitus, Obesity
The Effects of Semaglutide vs Testosterone Replacement Therapy on Functional Hypogonadism and Sperm Quality in Men With Type 2 Diabetes Mellitus and Obesity
The goal of this study is to learn whether semaglutide (treatment for type 2 diabetes and obesity) can improve signs and symptoms of hypogonadism in men with type 2 diabetes, obesity and hypogonadism (a condition when levels of…
- Conditions
- Type 2 Diabetes Mellitus, Obesity, Functional Hypogonadism
- Trial name
- SEMAT (NCT06489457)
- Testing
- Semaglutide, Testosterone Undecanoate
- Where
- Slovenia
- Volunteers
- 25 people
- Sponsor
- University Medical Centre Ljubljana
Male Infertility
Investigation of The Effectiveness of Antioxidant Therapy in Oligoasthenoteratozoospermic Infertile Men
Approximately 30% of the factors that cause male infertility are due to idiopathic causes. Increased reactive oxygen species (ROS) due to many known and unknown factors cause male infertility by affecting spermatogenesis and…
- Trial name
- NCT06042738
- Testing
- proxeed plus
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ondokuz Mayıs University
Human Sperm Survival Assay, Embryotoxicity
The Human Sperm Survival Assay (HSSA) as an Internal Quality Control for the IVF Consumables (REPROTOX 2)
The main embryotoxicity quality controls are the mouse embryo test (MEA = Mouse Embryo Assay) and the human sperm survival test (HSSA = Human Sperm Survival Assay).
- Conditions
- Human Sperm Survival Assay, Embryotoxicity, in Vitro Fertilization
- Trial name
- REPROTOX 2 (NCT05100784)
- Testing
- HSSA test
- Where
- France
- Volunteers
- 826 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Male Infertility, Infertility
The Therapeutic Effects of Bu Shen Yi Jing Pill on Semen Quality in Sub Fertile Males: a Randomized Controlled Trial
This study aims to evaluate the safety and efficacy of Bu Shen Yi Jing (BSYJ) Pill , a type of traditional Chinese medicine, in improving male subfertility and semen parameters.
- Conditions
- Male Infertility, Infertility, Traditional Chinese Medication (TCM), Reproductive Issues
- Trial name
- NCT05290558
- Testing
- Bu Shen Yi Jing Pill
- Where
- Singapore
- Volunteers
- 59 people
- Sponsor
- KK Women's and Children's Hospital
Male Infertility With Severe Oligo-terato-asteno-spermia
Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.
Some animal studies revealed that the pomegranate juice may improve sperm quality in terms of concentration, motility and morphology, as well as in fertilization rate. Minor data is available regarding the influence on male sperm.
- Trial name
- Pomegranate (NCT01918163)
- Testing
- Pomegranate pills
- Where
- Israel
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Infertility, Male, Semen Analysis
The Influence of Fit of Underpants Worn on Semen Quality
The goal of this observational study is to investigate the impact of underpants fit among Thai males attending the Infertility Clinic, whether alone or with their spouses.
- Trial name
- NCT06335706
- Testing
- Fit of underpants worn
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Aging, Epigenetic Aging
Human Sperm Cryopreservation as an Alternative to the Decline of Sperm Quality With Aging
This observational study will evaluate whether sperm cryopreservation can help preserve sperm quality and molecular characteristics that may be affected by increasing paternal age.
- Conditions
- Aging, Epigenetic Aging, Infertility, Assisted Reproduction Technologies
- Trial name
- NCT07814235
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- IVI Murcia
Male Infertility, Oxidative Stress
Effect of Daily Intake of Gazpacho on Semen Quality and Oxidative Stress
The goal of this clinical trial is to learn whether drinking a daily serving of gazpacho can improve semen quality in men with reduced sperm quality.
- Conditions
- Male Infertility, Oxidative Stress, Subfertility, Oligozoospermia
- Trial name
- G-OXSEM (NCT07375238)
- Testing
- Standardized Mediterranean Diet, Gazpacho
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Ginefiv
Male Infertility
A Clinical Evaluation of Semen Quality Using the MiOXSYS™ System 2.0
The purpose of this study is to determine if elevations in oxidative stress, as measured by oxidation-reduction potential (ORP), can distinguish between semen samples from men with abnormal semen parameters from those with normal…
- Trial name
- NCT02839447
- Testing
- Diagnostic
- Where
- 6 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aytu BioPharma, Inc.
Infertility, Female
The Effect of the Mind/Body Program for Fertility, Hungarian Version, on Well-Being and Assisted Reproduction Outcomes
Involuntary childlessness is an emotionally stressful experience; however, psychosocial counseling is typically not available in Hungarian routine fertility care.
- Trial name
- NCT04151485
- Testing
- Mind/Body Program for Fertility (Domar et al., 2011), Fertility Support Program
- Where
- 2 sites in Hungary
- Volunteers
- 177 people
- Sponsor
- Semmelweis University
Sperm DNA Fragmentation, Embryo Quality
Sperm Selection by Microfluidic Separation Improves Embryo Quality
This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility.
- Conditions
- Sperm DNA Fragmentation, Embryo Quality, Fertility Disorders, Infertility
- Trial name
- SPERM (NCT03085433)
- Testing
- Microfluidic Sperm Sorting, in vitro fertilization
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility, Infertility, Male
Scanning the Meiotic Spindle in Assisted Reproductive Techniques to Assess Oocyte Quality
The assisted reproduction success rate is affected by several factors including the age of the women, oocyte quality and maturation state, as well as sperm quality.
- Conditions
- Infertility, Infertility, Male, Infertility, Female
- Trial name
- SMART (NCT06539585)
- Testing
- Meiotic spindle status observation in polarized light, ICSI
- Where
- Czechia
- Volunteers
- 164 people
- Sponsor
- Charles University, Czech Republic