Clinical trials: Sperm Selection
Infertility
A Comparative Study of Sibling Oocytes: ICSI vs. the IMSI Sperm Selection Method
The aim of this research is to compare sibling oocytes using two sperm selection methods for choosing the best quality spermatozoa before they are injected into oocytes and the influence of each of these methods on embryo quality…
- Trial name
- NCT03240276
- Testing
- Standard ICSI procedure for sperm injection into oocyte, MSOME, IMSI Procedure
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Infertility, IVF
Outcomes of 36 vs 38 Hour Intervals From Ovulation Trigger To Oocyte Pick-Up:A Multi-Center Randomized Controlled Trial
Women who undergo assisted reproduction technology (ART) treatment will be eligible for this study. The goal of this randomized clinical trial is to compare the outcomes of ART treatment between women who have 36 and 38 hours…
- Trial name
- NCT05803655
- Testing
- 36-hour duration between ovulation triggering and oocyte pick-up procedure, 38-hour duration between ovulation triggering and oocyte pick-up procedure
- Where
- 7 sites in Turkey (Türkiye)
- Volunteers
- 850 people
- Sponsor
- Koç University
Sperm Capacitation
Capacitation-associated Protein Tyrosine Phosphorylation As a Possible Biomarker of Sperm Selection
Sperm undergo complex selection processes and physiological changes as they move through the female reproductive tract. Ejaculated-sperm must undergo a set of molecular and biochemical changes globally named as capacitation in…
- Trial name
- FOSFOTIR (NCT04962100)
- Testing
- Analysis of capacitation-associated tyrosine phosphorylation in human sperm by flow cytometry
- Where
- Spain
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Vida Recoletas Sevilla
Infertility, Male
Reproductive Outcomes of Different Sperm Selection Techniques for ICSI Patients With Abnormal Sperm DNA Fragmentation.
Comparing the reproductive outcomes of different sperm selection techniques; Density gradient centrifugation (DGC), Testicular sperm (Testi), Physiological ICSI (PICSI), and Magnetic activated cell sorting (MACS) in abnormal…
- Trial name
- NCT04482517
- Testing
- Density Gradient Centrifugation, Physiological ICSI, Magnetic activated cell sorting
- Where
- Egypt
- Volunteers
- 320 people
- Sponsor
- Ganin Fertility Center
Gender Ratio of ICSI Outcome
Effect of Sperm Selection Techniques on Human Neonatal Gender Ratio in Patients Undergoing ICSI
babies of known gender born out of 388 ICSI cycles were investigated for the gender ratio and then divided into three groups according to the sperm selection technique used before performing sperm injection.
- Trial name
- NCT03922568
- Testing
- Density Gradient Centrifugation, Physiological ICSI, Magnetic Activated Cell Sorting
- Where
- Egypt
- Volunteers
- 388 people
- Sponsor
- Ganin Fertility Center
Infertility
PICSI Impact on Euploidy in Assisted Reproduction
Hyaluronic acid (HA) is a major component of the cumulus complex surrounding oocytes. Intracytoplasmic sperm injection (ICSI) involves injection of a selected sperm into the oocyte.
- Trial name
- NCT06602687
- Testing
- PICSI
- Where
- Ireland
- Volunteers
- 142 people
- Sponsor
- Merrion Fertility Clinic
Oxidative Stress
What is the Best Sperm Source and Way of Sperm Selection in Cases With Abnormal sORP Levels on the Day of ICSI?
Does the level of statistic oxidation reduction potential (sORP) affects the choice of sperm source or sperm selection method used during ICSI.
- Trial name
- NCT03360526
- Testing
- PICSI, TESA
- Where
- Egypt
- Volunteers
- 820 people
- Sponsor
- Ganin Fertility Center
Infertility
SprmPik AI Sperm Selection Study SiD, an Assistant for Sperm Selection During Intracytoplasmic Sperm Injection in Medically Assisted Reproduction: Effect on Fertilization, Blastocyst Formation, Early Pregnancy Loss, and Consistent Practice. A Prospective Pilot Study.
SprmPik AI Assisted Sperm Selection Study SiD, an assistant for sperm selection during intracytoplasmic sperm injection in medically assisted reproduction: effect on fertilization, blastocyst formation, early pregnancy loss, and…
- Trial name
- SprmPik (NCT06518928)
- Testing
- Artificial Intelligence assisted sperm selection
- Where
- 2 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Ovation Fertility
Infertility, IVF
Sex Selection of Human Spermatozoa
This study aims to demonstrate a reliable method of selecting gender specific sperm. X-bearing spermatozoa and Y-bearing spermatozoa will be identified from the density gradient layers.
- Trial name
- NCT05500573
- Testing
- Sperm Sorting
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
to Aid in Sperm Selection for ICSI
User Site Testing Study to Evaluate Usability of the Q300™ Device Under "Real-life Conditions" in a Reproductive Laboratory Environment Use
User Site Testing Study to evaluate usability of the Q300™ device under "real-life conditions" in a reproductive laboratory environment use.
- Trial name
- NCT06232720
- Testing
- Q300 QART Medical
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- QART Medical
Assisted Reproductive Technology, Infertility
Sperm Micro-swim up Technique; Process and Select in the Same Dish: a Sibling-oocyte-split Design
A sibling-Oocyte-split design will be conducted on oocytes before denudation and divided into two groups : control group (MII oocytes will be injected using sperm processed by Density gradient method) and sample group ( MII…
- Trial name
- NCT05113225
- Testing
- Micro-swim up technique
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Royal Fertility Center, Egypt
Male Infertility
Strategies for Reducing Sperm DNA Fragmentation in ICSI Semen Samples: a Prospective Randomized Controlled Trial
Comparing second ejaculate and physiological ICSI (PICSI) as strategies for improvement of abnormal sperm DNA fragmentation in patients undergoing ICSI.
- Trial name
- NCT04496232
- Testing
- PICSI, Second ejaculate
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ganin Fertility Center
Female Infertility
Use of IMSI in Poor Responders to IVF
This is a pilot study which aims to determine the role of IMSI in poor responders.
- Trial name
- NCT02358733
- Testing
- Intra-cytoplasmic Sperm Injection, Intra-cytoplasmic Morphologically-selected Sperm Injection
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Centro de Infertilidad y Reproducción Humana
Female Infertility
Intracytoplasmic Morphologically Selected Sperm Injection and Advanced Maternal Age
The objective of this study was to evaluate the advanced maternal age as a rationale for performing intracytoplasmic morphologically selected sperm injection (IMSI).
- Trial name
- IMSIAMA (NCT01620346)
- Testing
- Intracytoplasmic sperm injection (ICSI), Intracytoplasmic morphologically selected sperm injection
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Sapientiae Institute
Fertility Disorders
Human Chorionic Gonadotropin Versus Granulocyte Colony Stimulating Factor in Increasing Pregnancy Rate in ICSI
Intrauterine Granulocyte colony stimulating factor (GCSF) was compared with intrauterine Human Chorionic Gonadotropin (HCG) in increasing clinical pregnancy rate as a primary outcome and ultrasound imaging of gestational sac as a…
- Trial name
- NCT04606082
- Testing
- Granulocyte Colony Stimulated Factor, Human Chorionic Gonadotropins
- Volunteers
- 200 people
- Sponsor
- Al-Azhar University
Sperm DNA Fragmentation
Sperm Selection by Either PICSI or MACS in Cases With Abnormal Sperm DNA Fragmentation Index for ICSI
On the day of ICSI, choosing the best sperm by either PICSI or magnetic activated cell sorting (MACS) in cases with abnormal DNA is not fully investigated.
- Trial name
- NCT03398317
- Testing
- PICSI, MACS
- Where
- Egypt
- Volunteers
- 396 people
- Sponsor
- Ganin Fertility Center
Infertility, Male Infertility
To Investigate if the Harvester® Improves Sperm Motility and Blastocyst Utilization (the Percent of Fertilized Eggs That Develop to the Point That They Are Able to be Transferred) in IVF Cycles.
The goal of this prospective, multicenter randomized controlled clinical trial is to evaluate whether the SwimCount Harvester microfluidic sperm preparation device can achieve equivalent or superior clinical outcomes compared to…
- Conditions
- Infertility, Male Infertility, InVitro Fertilization, Aneuploidy Rate
- Trial name
- NCT07369362
- Testing
- microfludics semen processing device
- Where
- United States
- Volunteers
- 1,600 people
- Sponsor
- MotilityCount aps
Infertility
Evaluation of SiD's System for Improving Assisted Reproduction Treatments
According to the WHO, infertility affects 15% of reproductive age couples worldwide. Among the assisted reproductive technologies available for patients with infertility, intracytoplasmic sperm injection (ICSI) has become one of…
- Trial name
- NCT05611164
- Testing
- Software assisted selection of individual spermatozoa for intracytoplasmic sperm injection
- Where
- 2 sites in Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IVF 2.0 Limited
Unexplained Infertility
The Effects of Using Fertile Chip in Sperm Selection for Intracytoplasmic Sperm Injection in Unexplained Infertility
The aim of the current study is to evaluate to effectiveness of sperm selection by using fertile chip in unexplained infertile couples on intracytoplasmic sperm injection (ICSI) cycles.
- Trial name
- NCT02488434
- Testing
- fertile chip
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Baskent University
Unexplained Infertility, Recurrent Implantation Failure
Using Microfluidic Separation Sperm Selection for Unexplained Infertility and Reccurrent Implantation Failure
In order to increase the likelihood of achieving IVF-treated pregnancy, good quality embryo transfer is important. To get good quality embryos, good quality gametes are needed.
- Trial name
- NCT03355937
- Testing
- Sperm Chip
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Acibadem University