Clinical trials: Spermatogenesis
Contraception
Male Hormonal Contraceptive Development-ACY-5
The purpose of this research study is to help in the development of male contraception (birth control).
- Trial name
- ACY-5 (NCT00161447)
- Testing
- Acyline, Testosterone Gel, Depo-Medroxyprogesterone
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Washington
Abnormal Spermatogenesis, Azoospermia
Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility
The aim of this study was to assess meiotic recombination in primary spermatocytes, synaptonemal complex length and the correlation with chromosomal abnormalities in testicular spermatozoa from infertile men with idiopathic…
- Trial name
- NCT02339272
- Testing
- non interventional
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Igenomix
Erectile Dysfunction
Assess the Effect of Daily Treatment of Vardenafil 20mg or Sildenafil 100mg and Placebo on Sperm Function
Assess the effect of daily treatment of vardenafil 20mg or sildenafil 100mg and placebo on sperm function
- Trial name
- NCT00655590
- Testing
- Levitra (Vardenafil, BAY38-9456), Sildenafil
- Where
- 18 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bayer
Spermatogenesis, Erectile Dysfunction
Effect of Udenafil on Spermatogenesis
Study of udenafil daily in subjects with mild or no erectile dysfunction to evaluate effects on semen characteristics.
- Trial name
- NCT01230541
- Testing
- Udenafil
- Where
- 23 sites in United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Warner Chilcott
Azoospermia, Oligozoospermia
Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility
Severe Oligospermia (oligozoospermia) refer to semen with a low concentration of sperm and is a common finding in male infertility.
- Trial name
- NCT03762967
- Testing
- Lipoaspiration and SVF introduction., Standard therapy.
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- State-Financed Health Facility "Samara Regional Medical Center Dinasty"
Nephropathy, Diabetes
Atrasentan Spermatogenesis and Testicular Function
This study is being conducted to evaluate the effects of Atrasentan on sperm production and testicular function in male subjects with Type 1 or 2 Diabetes and Nephropathy.
- Trial name
- NCT02118714
- Testing
- Atrasentan
- Where
- 13 sites in United States, Germany and 2 more
- Volunteers
- 20 people
- Sponsor
- AbbVie
Cancer, Hematologic Diseases
Autologous Transplantation of Human Cryopreserved Testis Tissue
For pre-pubertal boys undergoing gonadotoxic therapies, freezing immature testicular tissue (ITT) containing spermatogonial stem cells (SSCs) is currently the only option to potentially preserve future fertility.
- Conditions
- Cancer, Hematologic Diseases, Infertility, Male, Azoospermia, Nonobstructive
- Trial name
- ReSTORE (NCT07364409)
- Testing
- Autologous Transplantation of Testis Tissue
- Where
- Denmark
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Drepanocytic Men Treated by Hydroxyurea for the First Time
Future of Spermatogenesis in Men With Sickle Cell Disease Medically Treated
The project's background: Sickle cell disease is, at present in France, the most frequent genetic illness. Recent progress in its treatment, in particular the use of hydroxyurea, has considerably modified the prognosis of this…
- Trial name
- HYDREP (NCT01609192)
- Testing
- Hydrea® (hydroxyurea )
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility, Male, Infertility Unexplained
Using of Testes Shocker in Improving the Spermatogenesis and Sperms Activity
Infertility was reported in approximately 15% of all heterozygous couples, with male factor accounting for nearly half the cases.
- Conditions
- Infertility, Male, Infertility Unexplained, Infertility Due to Complete Spermatogenic Arrest, Oligospermia
- Trial name
- NCT05506722
- Testing
- Testes shocker
- Where
- Iraq
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Bariatric Surgery Candidate, Sexual Function and Fertility Disorders
The Effect of Bariatric Surgery on Spermatogenesis
Little is known about the effects of weight loss surgery on male reproductive health. This study will investigate the effect of bariatric surgery on male infertility by evaluating sexual health, blood hormone levels, and semen…
- Trial name
- NCT03725696
- Testing
- Semen Analysis, Hormonal panel, RYGB Gastric Bypass
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Rectal Cancer
Sexual Function and Wellbeing in Males With Rectal Cancer
Preoperative radiotherapy and pelvic surgery is recommended to many patients with rectal cancer. For men there are theoretical reasons to believe that the treatment may effect hormone levels, spermatogenesis, sexual function and…
- Trial name
- NCT01216202
- Testing
- Preoperative radiotherapy
- Where
- 2 sites in Sweden
- Volunteers
- 178 people
- Sponsor
- Karolinska Institutet
Chronic Myeloid Leukemia, Gastrointestinal Stromal Tumors
Impact of the Inhibitors of Tyrosine Kinase on the Male Fertility
Evaluate the possible deleterious effects of tyrosine kinase inhibitors on sperm concentration, after 6 months of therapy, which corresponds to 2 cycles of spermatogenesis and on the sperm nuclear integrity.
- Trial name
- GLIFERTI (NCT01114087)
- Testing
- Imatinib treatment
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy
Evaluate the Pharmacokinetics and Gonadotropin Suppression of Nestorone®-Testosterone (NES/T) Combination Gel in Men
This is a prospective, randomized, double-blinded, two-center trial to evaluate the gonadotropin suppressive activity of transdermal treatment with a combined NES/T gel, or T gel alone, for 28 days.
- Trial name
- NCT02432261
- Testing
- Nestorone® /testosterone gel, Testosterone only gel
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kimberly Myer
Spermatogenesis and Semen Disorders, DNA Double Strand Break
In Vitro Effects of Procyanidine on Semen Parameter and DFI
Proanthocyanidins are a class of polyphenols found in a variety of plants that have antioxidant activity in vitro, which is stronger than vitamin C or vitamin E.
- Trial name
- NCT03414164
- Testing
- procyanidine
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Aristotle University Of Thessaloniki
Azoospermia, Nonobstructive, Varicocele
Seminal TEX101 as a Predictor of Recovery of Spermatogenesis in Azoospermic Men With Palpable Varicocele
The aim of the study is to assess if seminal TEX 101 can predict the restoration of spermatogenesis and appearance of sperms in the ejaculate after micro-surgical varicocelectomy among azoospermic patients.
- Trial name
- NCT04397887
- Testing
- micro-surgical varicocelectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Klinefelter Syndrome
Fertility Assessment in Patients With Klinefelter Syndrome
Klinefelter syndrome is characterized by primary testicular failure and progressive infertility. The objective of this study is to determine if sperm are present and can be observed in semen samples of adolescent and young adult…
- Trial name
- NCT02461303
- Testing
- Counseling
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Pittsburgh
Hypogonadism
Influence of Administration Route of Testosterone on Male Fertility
Exogenously administered testosterone will override the normal negative feedback of endogenous testosterone on the hypothalamus and pituitary.
- Trial name
- NCT00705796
- Testing
- MPP10, testosterone, Testosterone
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Acerus Pharmaceuticals Corporation
Non-obstructive Azoospermia With Testicular Biopsy for Spermatozoa Extraction
Estradiol and Testosterone Levels in Seminal Plasma of Men With Non-obstructive Azoospermia
Estradiol and Testosterone are two important hormones for the regulation of an effective spermatogenesis in human testis. The evaluation of levels of estradiol and testosterone in seminal plasma of men with non-obstructive…
- Trial name
- NCT02255396
- Testing
- ESTRADIOL
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Oligospermia, Azoospermia
Genetic Studies Spermatogenic Failure
The proposed study is designed to test the following hypotheses: 1. Mouse autosomal or X-linked genes which are exclusively expressed in mouse spermatogonia are also spermatogonia-specific in human. 2.
- Conditions
- Oligospermia, Azoospermia, Male Infertility
- Trial name
- NCT00548977
- Testing
- Drawing blood to study genetic polymorphism
- Where
- Taiwan
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Male Contraception
First in Human Study Evaluating Single Ascending Oral Doses of YCT-529 in Healthy Males
A single ascending oral dose(s) study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of YCT-529 in healthy male subjects.
- Trial name
- NCT06094283
- Testing
- YCT-529
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- YourChoice Therapeutics, Inc.