Clinical trials: Spinal
Amyotrophic Lateral Sclerosis (ALS)
PET Imaging in ALS Patients
This is a pilot study to evaluate a potential imaging biomarker for aiding diagnosis and monitoring progression of ALS, based on a well established basic science pathway, published human autopsy data, preliminary data in ALS…
- Trial name
- NCT02236897
- Testing
- PET Scanning
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Weakness, Muscle
The Effect of Spinal Manipulation on Hip Extension Strength and Jump Height
The purpose of this study is to study the effects of lumbar manipulation on hip extension strength and jump height in healthy subjects.
- Trial name
- NCT05689723
- Testing
- Lumbar manipulation
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Messiah College
Anesthesia
Comparison of 3 Different Density Levobupivacaine Solutions + Fentanyl for Spinal Anaesthesia for Caesarean Delivery.
The investigator's aim is to compare the efficacy of 3 levobupivacaine solutions with different density on spinal anesthesia for caesarean delivery.
- Trial name
- NCT03956303
- Testing
- Chirocaine %0.5, Chirocaine Heavy 40, Chirocaine Heavy 60
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Diphtheria, Tetanus
Regulatory Post-Marketing Surveillance Study for TETRAXIM™
The purpose of this study is to assess the safety of TETRAXIM™ administered in routine clinical practice according to Korea Food and Drug Administration Notification No.
- Conditions
- Diphtheria, Tetanus, Pertussis, Poliomyelitis
- Trial name
- NCT01437423
- Testing
- TETRAXIM™: Combined adsorbed diphtheria, tetanus, acellular pertussis and enhanced inactivated polio
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Poliomyelitis
Comparison of Immune Response Using 2 Vaccination Schedules Using Inactivated Polio Vaccine
As poliovirus eradication progresses rapidly, strategies to discontinue oral poliovirus vaccination need to be established. One strategy would be to use inactivated poliovirus vaccine (IPV) transitionally, and this has already…
- Trial name
- NCT00137696
- Testing
- Vaccination with inactivated polio vaccine, Collection of serum
- Where
- Puerto Rico
- Volunteers
- 473 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Spinal Cord Injury Cervical
Access-H20 Faucet for Spinal Cord Injury
The Phase I SBIR objective is to design, develop \& demonstrate feasibility of Access-H2OTM, a sensor driven smart faucet to enable and empower independent drinking and grooming for individuals impacted by spinal cord injury…
- Trial name
- NCT06159946
- Testing
- Access-H2O faucet
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Old Dominion University
Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder
The Longitudinal CONQUER Study of Rare Neuroimmunologic Disorders
This study seeks to determine the biologic causes of inflammation in patients with Transverse Myelitis (TM) Neuromyelitis Optica Spectrum Disorder (NMOSD) and related conditions.
- Conditions
- Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder, Transverse Myelitis, Optic Neuritis
- Trial name
- NCT01623076
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Spinal Cord Injury
Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury
As the spinal cord injured population ages, these individuals are being exposed to an increased prevalence of age-associated diseases, which coupled with the secondary complications of the injury may contribute to the reduced…
- Trial name
- NCT01984476
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Ankylosing Spondylitis (AS) / Radiographic Axial SpA (r-axSpA)
Biomarkers in Ankylosing Spondylitis
In this study, we aimed to compare serum PGRN(progranulin) and TNF-α levels in AS patients with healthy controls and to determine the relationship between TNF-α inhibitor use and PGRN levels in AS patients.
- Trial name
- NCT07117344
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Lumbar Disc Herniation
Brain Connectomic Mechanisms of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRI
Low back and leg pain caused by lumbar disc herniation (LDH) is common. Lever positioning manipulation (LPM) is a spinal manual therapy used to relieve this pain, but how it affects the brain is unclear.
- Trial name
- NCT07728149
- Testing
- Active Lever Positioning Manipulation
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated hospital of Zhejiang Chinese Medical University
Lumbar Spinal Stenosis
Effect of Muscle Fatigue on Spinal Imbalance and Motion in Lumbar Spinal Stenosis
This study assesses spinal imbalance and motion in patients with sLSS and elicits fatigue via back exercises and compares spinal imbalance and motion before and after the fatigue exercise and compares these to healthy controls…
- Trial name
- MuscLSS (NCT05309447)
- Testing
- data collection
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Lower Back Pain, Lumbar Spondylosis
Using Music During Lumbar Medial Branch Block Procedure
The purpose of this study is to determine if music therapy during interventional lumbar medial branch blocks for chronic lower back pain will lower pain scores and anxiety levels, while increasing patient desire for repeat…
- Trial name
- NCT04091607
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Spinal Cord Injury, Neurogenic Bowel Dysfunction
Artificial Int: Neurogenic Bowel Education in Spinal Cord Injury Patients
The aim of this study is to evaluate the effectiveness of patient education delivered through an artificial intelligence (AI)-based mobile application in the management of neurogenic bowel dysfunction in individuals with spinal…
- Trial name
- ArtInt (NCT07369349)
- Testing
- Mobil Application
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Senem Duman
Cross-sectional Study, Degenerative Disease Joint
The Prevalence of Bone Degenerative Diseases in Beijing - a Cross-sectional Study
The purpose of this observational study is to investigate the prevalence and risk factors of bone degenerative diseases
- Conditions
- Cross-sectional Study, Degenerative Disease Joint, Degenerative Disc Disease
- Trial name
- NCT03086109
- Testing
- Risk factors
- Where
- China
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Beijing Jishuitan Hospital
Spasticity, Muscle, Spinal Cord Injuries
Effects of Baclofen on Presynaptic Inhibition in Humans
This study examines the role of the GABA-B receptor in long-lasting presynaptic inhibition of primary afferents in human participants.
- Trial name
- NCT04471714
- Testing
- Baclofen
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Ankylosing Spondylitis
Inturlekin L33 in Ankylosing Spondylities Patients and Its Relation to Subclinical Atherosclerosis
detect level of Inturlekin 33 in ankylosing spondyilits patient measure CIMT (carotid intima media thickness ) by carotid duplex to detect subclinical atherosclerosis in ankylosing spondyitis patients detect the relation between…
- Trial name
- NCT06564155
- Testing
- carotid duplex
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Poliomyelitis
A Study to Evaluate the Safety and Immunogenicity of VLP-Polio in Infants and Toddlers
This is a phase I/II randomized, double-blind, and positive-controlled study. Participants in the phase I toddler group will receive 1 dose of either high dose VLP-Polio (Dose H) or control vaccine in a ratio of 3:1.
- Trial name
- NCT06577298
- Testing
- Recombinant Trivalent Poliomyelitis Vaccine (Sf-RVN Cell) (VLP-Polio) low adjuvant dose, VLP-Polio medium dose, VLP-Polio high dose
- Where
- Indonesia
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Healthy Individuals
Comparison of the Effectiveness of Spinal Stabilization Exercises and Chiropractic Spinal Manipulation
It is the study of the effectiveness of spinal stabilization exercises and chiropractic spinal manipulation in healthy individuals.
- Trial name
- NCT04830098
- Testing
- Spinal stabilization exercises, Chiropractic manipulation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Sarcopenia
Combined Exercise and Nutrition Intervention for Spinal Sarcopenia
Sarcopenia in the lumbar paraspinal muscles is receiving renewed attention as a cause of spinal degeneration. However, there were few studies on the precise concept and diagnostic criteria for spinal sarcopenia.
- Trial name
- NCT04810312
- Testing
- Combined exercise and nutrition intervention
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Lumbar Disc Herniation
Effects of Whole-Body Electromyostimulation Application in Individuals With Lumbar Disc Hernia
To determine the effects of WB-EMS application on balance, pain, muscle strength, muscle endurance, flexibility, muscle shortening and quality of life in individuals with Lumbar Disc Hernia and compare it with individuals who…
- Trial name
- NCT04329598
- Testing
- Whole-Body Electromyostimulation Group, Exercise Group
- Where
- 2 sites in Cyprus
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
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