Clinical trials: Spinal
Healthy
A Study in Healthy Men to Test How Different Doses of BI 474121 Are Taken up and How They Influence the Amount of a Molecular Messenger (cGMP) in the Spinal Fluid
The main objectives of this trial are: To evaluate the effect of BI 474121 on cyclic guanosine monophosphate (cGMP) levels in cerebrospinal fluid (CSF) To assess the exposure of BI 474121 in CSF relative to plasma To determine…
- Trial name
- NCT04672954
- Testing
- 2.5 milligram (mg) BI 474121, 10 milligram (mg) BI 474121, 20 milligram (mg) BI 474121
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Scoliosis Idiopathic, Scoliosis; Adolescence
Trunk Proprioception in Adolescent Idiopathic Scoliosis
Aims of this clinical research: To investigate trunk proprioception in all three planes in individuals with adolescent idiopathic scoliosis (AIS), To investigate the pelvis orientation sense in all three planes in individuals…
- Trial name
- NCT05326256
- Testing
- Exercise training- PSSE, Exercise training- PSSE with vestibular exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Degenerative Cervical Spinal Myelopathy, Cervical Spinal Cord Compression
Quantitative MR Parameters in Non-myelopathic Degenerative Cervical Spinal Cord Compression: a Longitudinal Study.
Quantitative Magnetic Resonance Imaging Parameters as Predictors of Outcome for Non-Myelopathic Degenerative Cervical Cord Compression: A Longitudinal Study
- Trial name
- NOLOST (NCT06094166)
- Testing
- MRI
- Where
- Czechia
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Spinal Cord Injuries
Transforming Research and Clinical Knowledge in Spinal Cord Injury
The overall goal of Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI) study is to determine the relationships among the clinical, neuroimaging, cognitive, genetic and proteomic biomarker…
- Trial name
- TRACK-SCI (NCT04565366)
- Where
- 5 sites in United States
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
FTLD, Progressive Supranuclear Palsy (PSP)
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)
Frontotemporal Lobar Degeneration (FTLD) is the neuropathological term for a collection of rare neurodegenerative diseases that correspond to four main overlapping clinical syndromes: frontotemporal dementia (FTD), primary…
- Conditions
- FTLD, Progressive Supranuclear Palsy (PSP), Frontotemporal Dementia (FTD), Corticobasal Degeneration (CBD)
- Trial name
- ARTFL (NCT02365922)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,489 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Carpal Tunnel Syndrome, Psoriatic Arthritis
Carpal Tunnel Syndrome in Patients With Psoriatic Arthritis; Ultrasonography and Magnetic Resonance Imaging Findings
This study aimed to investigate relationship between CTS diagnosis with electrodiagnostic studies and median nerve's cross-sectional area measered by US and MRI in PsA patients.
- Trial name
- NCT05086042
- Testing
- Ultrasonography, Magnetic resonance imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Spinal Anesthesia
Ultrasound Identification Automation Study
The overall aim of this study is to develop an automated spinal landmark identification system to improve patient safety and efficacy of neuraxial procedure needle insertion success.
- Trial name
- NCT03535155
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Hypertension
Effect of Spinal Stabilization Exercises on Epicardial Fat Tissue and Exercise Capacity in Hypertensives
It has been suggested that Epicardial Adipose Tissue (EAT) may be an adjunctive marker to classical risk factors for the presence and severity of coronary artery disease.
- Trial name
- NCT06083376
- Testing
- Spinal Stabilization Exercise, physical activity counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Rheumatoid Arthritis, Psoriatic Arthritis
GOTHA - The Early Arthritis and Psoriasis Study of Region Västra Götaland, Sweden
GÖTHA- The early arthritis and psoriasis study of Region Västra Götaland, Sweden - is a longitudinal observational study, which will prospectively and in parallel follow patients with newly diagnosed rheumatoid arthritis (RA…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Arthritis, Psoriasis
- Trial name
- GOTHA (NCT04190758)
- Testing
- Care as usual
- Where
- Sweden
- Volunteers
- 5,100 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Perfusion Index, Position Differences
Evaluation Of The Effects Of Changes In Operating Table Position On Perfusion Index And Spinal Anesthesia
The aim of this observational study is to investigate how table position affects the development of block in patients undergoing spinal anesthesia. Perfusion index measurements will be used to answer this question.
- Trial name
- Perfusion (NCT07400185)
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Enes Celik
Adequate Anesthesia With Unimpaired Motor Strength
Comparison of Intrathecal Fentanyl or Sufentanil in 1 mg Bupivacaine Spinal Anesthesia for TURP in Elderly Patients
Adequate sensory block for surgical procedure without side effects and immediate mobilization after surgery are desirable anesthetic technique in various surgeries.
- Trial name
- NCT01608334
- Testing
- Fentanyl, Sufentanil
- Where
- South Korea
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Amyotrophic Lateral Sclerosis
Mesenchymal Stem Cell Injection in Amyotrophic Lateral Sclerosis
Whether the mesenchymal injection on ALS patients is effective or not?
- Trial name
- NCT02116634
- Testing
- mesenchymal stem cell
- Where
- Iran
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alzahra Hospital, Iran
Diphtheria, Tetanus
Immunogenicity Study of Antibody Persistence and Booster Effect of PENTAXIM™ at 18 Months in Healthy Argentinean Infants
This study will assess both the antibody persistence of the investigational vaccine and the immune response and safety of a booster dose of PENTAXIM™ vaccine in 18 months-old toddlers who participated in an earlier study in order…
- Conditions
- Diphtheria, Tetanus, Pertussis, Poliomyelitis
- Trial name
- NCT00303316
- Testing
- DTaP-IPV//PRP~T combined vaccine
- Where
- Argentina
- Volunteers
- 458 people, healthy volunteers welcome
- Sponsor
- Sanofi
Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc
The Underlying Mechanism of Spinal Manipulative Therapy and the Effect of Pain on Physical Outcome Measures
The purpose of this study is to compare changes in spinal stiffness and back muscle activity between spinal manipulative therapy (SMT) responders, non-responders and asymptomatic participants.
- Conditions
- Low Back Pain, Degeneration of Lumbosacral Intervertebral Disc, Muscle Weakness, Spine Stiffness
- Trial name
- NCT01761838
- Testing
- SMT for low back pain patients, Pain induction (optional), Low back pain participants without SMT
- Where
- Canada
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Spinal Mobility, Thoracic Spine
Effects of Thoracic Spine Exercises on Spinal Alignment and Mobility in Male Soccer Players
Thoracic spine mobility is essential for trunk stability, rotational movement, and athletic performance in soccer players. This study aimed to investigate the effects of adding thoracic spine exercises to routine soccer training…
- Trial name
- NCT07253415
- Testing
- Thoracic spine exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Injuries, Spinal Cord, CVA (Cerebrovascular Accident)
Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)
Comparing the efficacy of Intracthecal Baclofen dose between the Prometra II and Medtronic SynchroMed II for patients with spasticity and with current a current SyncroMed II pump needing replacement.
- Conditions
- Injuries, Spinal Cord, CVA (Cerebrovascular Accident), Traumatic Brain Injury, MS (Multiple Sclerosis)
- Trial name
- NCT04530955
- Testing
- Prometra II Programmable Pump - Flowonix Medical
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Culicchia Neurological Clinic
Postoperative Pain, Pain
Comparison of Analgesic Efficacy of Intrathecal Bupivacaine Versus Bupivacaine Plus Dexmedetomidine in Patients Undergoing Orthopedic Surgeries.
Clinical Trial Overview: Intrathecal Bupivacaine vs. Bupivacaine + Dexmedetomidine Primary Objective Duration of Analgesia:** To compare the mean duration of postoperative pain relief between hyperbaric bupivacaine alone versus…
- Conditions
- Postoperative Pain, Pain, Orthopaedic Surgery, Anesthesia, Spinal
- Trial name
- NCT07866508
- Testing
- Dexmedetomidine plus Hyperbaric Bupivacaine, Hyperbaric bupivacaine % 0.5
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheikh Khalifa Bin Zayed Al Nahyan Combined Military Hospital Muzaffarabad
Spinal Cord Injury
The Effect of FES on Children With Spinal Cord Injury
Regular exercise is strongly recommended to help maintain a healthy lifestyle. Unfortunately, children and young adults with damaged spinal cords may not be able to exercise regularly.
- Trial name
- NCT00291317
- Testing
- RT 300-P FES Cycle
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Children's Specialized Hospital
Labor and Delivery
Epidural Loading: High Volume, Low Concentration
This prospective, randomized, single blinded control trial will investigate the effects of epidural loading with a high volume, low concentration local anesthetic solution via the epidural needle versus the epidural catheter.
- Trial name
- NCT02803450
- Testing
- Epidural needle, Catheter Administration, Standard of Care Epidural Administration
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ohio State University
Obstetric Anesthesia Problems, High-Risk Pregnancy
Effect of Intra-abdominal Pressure to the Level of the Sensory Block at Caesarean Section Under Spinal Anesthesia
It is known that an increase in intra-abdominal pressure (IAP) causes a decrease in the volume of cerebrospinal fluid in the lumbar and lower thoracic region, which may contribute to the development of more high spinal block.
- Trial name
- IAPSB (NCT02237092)
- Testing
- Measurement of IAP
- Where
- Russia
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Tver Regional Perinatal Center
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