Clinical trials: Spinal
Hepatitis B, Tetanus
Immunogenicity and Safety of GSK Biologicals' Infanrix Hexa in Infants
This study will evaluate GSK Biologicals' DTPa-HBV-IPV/Hib vaccine given as a three-dose primary vaccination course at 2, 4 and 6 months of age, in terms of safety and immunogenicity in different population of infants residing in…
- Conditions
- Hepatitis B, Tetanus, Poliomyelitis, Diphtheria
- Trial name
- NCT00753649
- Testing
- Infanrix™ hexa
- Where
- 3 sites in Canada
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Neurogenic Bladder, Neurogenic Bowel
The Role of Active Administration of Peristeen Bowel Evacuation for the Management of Urinary Tract Infection
This study investigates whether active use of transanal irrigation (Peristeen®) effectively manages urinary tract infection among patients with the diagnosis of neurogenic bladder.
- Conditions
- Neurogenic Bladder, Neurogenic Bowel, Spina Bifida, Fecal Incontinence
- Trial name
- NCT04815226
- Testing
- Peristeen Transanal Irrigation
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Vaginal Delivery, Normal Labor
Comparative Analysis of Analgesic Efficacy: by Single Shot Intrathecal Analgesia (SSSA) in Normal Labor
the goal of this randomized control trial is to compare the effect of adding fentanyl v.s dexmedetomidine to bupivacaine in single shot spinal analgesia in achievement of analgesia by decreasing visual analogue scale, onset and…
- Trial name
- SSSA (NCT06823349)
- Testing
- Dexmedetomidine, fentanyl, Saline 0.9%
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Jehan George Sadek
Scoliosis
Body Structure and Capacity Evaluation of Adults With Scoliosis
Adults with scoliosis have not been the focus of much research in physical therapy despite their prevalence being very important. Adults with idiopathic scoliosis have a reported prevalence of about 2-11%.
- Trial name
- NCT05538871
- Testing
- Survey + Physical exam
- Where
- Canada
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Manipulation, Psychologic, Proprioception
Does Spinal Manipulation Therapy Impact Lumbar Proprioception
Spinal manipulation therapy (SMT) has long been a component of manual therapy and physical rehabilitation programs, especially as a modality for pain relief.
- Conditions
- Manipulation, Psychologic, Proprioception, Vibration; Exposure
- Trial name
- NCT04869514
- Testing
- spinal manipulation
- Where
- Switzerland
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Chemotherapy-induced Peripheral Neuropathy
Spinal Cord Stimulation in Chemotherapy Induced Neuropathy
This is an observational based pilot study evaluating the use of spinal cord stimulators for the treatment of chemotherapy induced peripheral neuropathy will lead to an increase in quality of life and decrease in pain.
- Trial name
- NCT03764514
- Testing
- Spinal Cord Stimulator
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Rheumatoid Arthritis, Ankylosing Spondylitis
Assessment of Pain Management in Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Patients Who Are About to be Treated With Adalimumab
The purpose of this study is to assess whether or not adalimumab (Humira®) can influence pain medication in participants with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) with or without…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01273519
- Where
- 15 sites in Austria
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- AbbVie (prior sponsor, Abbott)
Degenerative Disc Disease
Spine Unit Modelling Coupled With hIgh Throughput Analysis (SUIT)
Ageing and inflammation represent two main drivers of DDD, a progressive, chronic condition involving vertebral bone, cartilaginous endplate and intervertebral disc.
- Trial name
- SUIT (NCT06490887)
- Testing
- Use of patient-derived biological samples
- Where
- 2 sites in Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Rheumatoid Arthritis, Psoriatic Arthritis
Assessment of Tender & Swollen Joints Count Score Performed by a Rheumatologist And Rheumatology Nurses in Patients With RA and PsA.
This study will establish a comparison in follow-up care of 100 patients between Health Care Practitioners, more specifically the rheumatologist and a trained nurse.
- Trial name
- APRAN (NCT02556034)
- Testing
- Disease evaluation.
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Isabelle Fortin
Poliomyelitis, Polio
Study of IMOVAX POLIO® Subcutaneous as a Booster Vaccine in Pre-school Age Children in Japan
The aim of the study is to assess the immunogenicity of SP059 (IMOVAX POLIO®: Inactive Poliovirus Vaccine) vaccine against poliovirus and safety after fifth dose.
- Trial name
- NCT02005536
- Testing
- IMOVAX POLIO®: Inactive Poliovirus Vaccine
- Where
- 4 sites in Japan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Spondyloarthropathy and Sacroilitis
Added Value of Diffusion Weighted MRI in Evaluation of Sacroiliitis in Newly Diagnosed Patients of Spondyloarthropathy.
Spondyloarthropathy encompasses a group of chronic immune-mediated rheumatic inflammatory diseases characterized by axial joint inflammation, peripheral arthritis, enthesitis, dactylitis and extra-articular features.
- Trial name
- NCT05655533
- Testing
- Magnetic resonance Imaging scanners of sacroiliac joints.
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Dementia, Alzheimer Disease
The Swedish BioFINDER 2 Study
The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g.
- Conditions
- Dementia, Alzheimer Disease, Parkinson Disease, Lewy Body Disease
- Trial name
- BioFINDER2 (NCT03174938)
- Testing
- Flutemetamol F18 Injection, [18F]-RO6958948, Elecsys (Roche) Abeta42, Ttau and Ptau
- Where
- 2 sites in Sweden
- Volunteers
- 2,950 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Ankylosing Spondylitis (AS), Irisin
The Effect of Exercise on Serum Irisin Levels and Clinical Parameters in Patients With Axial Spondyloarthritis.
This study aimed to investigate the effects of high-intensity intermittent exercise and moderate-intensity continuous exercise on serum irisin levels, disease activity, functional status, and quality of life in patients with…
- Trial name
- NCT07327073
- Testing
- High-Intensity Interval Training, Moderate-Intensity Continuous Exercise, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Spinal Cord Ischemia
Prophylactic vs Therapeutic Cerebrospinal Fluid Drain Placement During Endovascular Thoracoabdominal Aortic Aneurysm Repair
This is a pilot study to be performed at the University of Alabama at Birmingham (UAB) and the University of Massachusetts to determine the feasibility and develop the processes for a future randomized controlled trial to…
- Trial name
- NCT04941157
- Testing
- Cerebrospinal Fluid Drain Placement
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Adolescent Idiopathic Scoliosis, Multimodal Analgesia
Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery
Patients with Adolescent Idiopathic Scoliosis may need surgery to correct their scoliosis. General anesthesia is required for this surgery, and a multimodal analgesic regimen using combinations of opioid and non-opioid…
- Conditions
- Adolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, Remifentanil
- Trial name
- NCT06096181
- Testing
- Remifentanil TIVA, Dexmedetomidine TIVA, Propofol TIVA
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Post Operative Pain, Spinal Surgery
Methadone to Reduce Chronic Opioid Use After Major Spine Surgery: The MEND Pilot Feasibility Study
The investigators propose a randomized, triple-blinded (patients, investigators, outcomes assessors), placebo-controlled pilot feasibility trial (Methadone to End Narcotic Dependence, MEND trial) to assess the feasibility and…
- Trial name
- MEND (NCT07222072)
- Testing
- Methadone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Arthritis, Spondylitis, Ankylosing
Natural History and Development of Spondyloarthritis
Background: Spondyloarthritis (SpA) is a group of bone and joint disorders that may cause back and joint pain and stiffness. In some cases, SpA can lead to abnormal bone growth affecting the joints and spine.
- Trial name
- NCT01422694
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Spinal Cord Injuries, Tetraplegia
Human Factors Validation Testing of the Wandercraft Personal Exoskeleton
The goal of this interventional, national, prospective, open and monocentric study is to demonstrate that a personal exoskeleton can be used by the intended users without serious use errors or problems, for the intended uses and…
- Conditions
- Spinal Cord Injuries, Tetraplegia, Paraplegia
- Trial name
- ExoUser (NCT06715631)
- Testing
- Hands-free exoskeleton
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wandercraft
Spinal Cord Injury
Development of a Model of Shoulder Pain Following Spinal Cord Injury
This study will investigate the progression of musculoskeletal (shoulder muscle flexibility, muscle strength, movement coordination, and rotator cuff health) and psychosocial (fear of movement, pain catastrophizing) impairments…
- Trial name
- NCT03137394
- Testing
- Observation
- Where
- 2 sites in United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Drexel University
Healthy Volunteer Study
Efficacy of Spinal Oxytocin in Healthy Volunteers
The purpose of this study is to determine the effect of intrathecal oxytocin on areas and intensity of hyperalgesia and allodynia induced by topical capsaicin.
- Trial name
- NCT01996605
- Testing
- Oxytocin 15 mcg, Oxytocin 150 mcg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
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