Clinical trials: Spinal
Post-Dural Puncture Headache, Headache After Spinal Puncture
Comparison of Post-Dural Puncture Headache After Spinal Anesthesia Using Median Versus Paramedian Approach
This randomized controlled trial will compare two commonly used techniques for performing spinal anesthesia, the median (midline) approach and the paramedian (lateral) approach, in adult patients undergoing elective orthopedic or…
- Trial name
- NCT07436403
- Testing
- Spinal anesthesia using median approach (midline), Spinal anesthesia using paramedian approach
- Where
- Pakistan
- Volunteers
- 142 people
- Sponsor
- Mayo Hospital Lahore
Postoperative Pain
Evaluation of Postoperative Pain Following Bascom Cleft Lift Operation
The purpose of this study is to evaluate postoperative pain in Bascom Cleft Lift operation receiving multimodal analgesia in day-case surgery setting.
- Trial name
- NCT02196727
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Hvidovre University Hospital
Spinal Deformity, Degenerative Lumbar Spinal Stenosis
Tranexamic Acid in Adult Spinal Deformity Surgery
Posterior spinal surgery for adult deformity is associated with high incidence of blood loss and need for blood transfusion and intraoperative blood salvage, with associated increased cost and risk for perioperative…
- Conditions
- Spinal Deformity, Degenerative Lumbar Spinal Stenosis, Blood Loss, Surgical
- Trial name
- NCT03553186
- Testing
- Tranexamic Acid 100 MG/ML
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hospital for Special Surgery, New York
Spinal Disease
A Feasibility Study to Evaluate the TURRIS Facet Fusion System in Lumbar Spinal Surgery
This is a prospective, exploratory study to verify intra-operative handling and safety and to collect preliminary short-term safety and efficacy data of the Turris® Facet Fuser, a small bioresorbable device for the immediate…
- Trial name
- NCT02294669
- Testing
- Turris Facet Fuser
- Where
- 2 sites in Switzerland
- Volunteers
- 3 people
- Sponsor
- SpineWelding AG
Inflammatory Joint Diseases
The Norwegian Antirheumatic Drug Register
NOR-DMARD is a register-based longitudinal observational study of which the main objectives are to study the effectiveness of treatment of inflammatory joint diseases with biological disease modifying anti-rheumatic drugs…
- Trial name
- NOR-DMARD (NCT01581294)
- Where
- 6 sites in Norway
- Volunteers
- 15,000 people
- Sponsor
- Diakonhjemmet Hospital
Spondyloarthropathy
Golimumab Versus Pamidronate for the Treatment of Axial Spondyloarthropathy: a 48-week Trial
To compare the efficacy of golimumab with pamidronate in the treatment of axial spondyloarthropathy
- Trial name
- NCT01718951
- Testing
- golimumab, Pamidronate
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Tuen Mun Hospital
Spinal Anesthesia Induced Hypotension, Caeserian Section
AI Prediction of Post-Induction Hypotension in Cesarean Sections With Spinal Anesthesia
The cesarean section, medically necessary for both the mother and the baby in certain cases, is a life-saving operation.The most commonly used anesthesia method worldwide is spinal anesthesia.
- Trial name
- NCT06158542
- Testing
- Spinal Anesthesia, Blood Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 370 people
- Sponsor
- Hacettepe University
Ankylosing Spondylitis, Spondyloarthritis
Biomarkers in Early-stage Spondyloarthritis
Axial spondyloarthritis (axSpA) is a group of inflammatory rheumatic conditions with inflammatory back pain caused by inflammation in the sacroiliac joints (SIJ) and back as hallmark.
- Trial name
- NCT04095169
- Testing
- Complement C3d test (blood sample)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Spine Centre of Southern Denmark
Amyotrophic Lateral Sclerosis
Exercise and Disease Progression in Amyotrophic Lateral Sclerosis Patients
This study evaluated the influence of a tailored aerobic exercise protocol on the functional outcome in ALS patients. In addition, the investigators compare some CPET variables collected during exercise testing in both groups.
- Trial name
- NCT03326622
- Testing
- standard care, moderate exercise
- Volunteers
- 48 people
- Sponsor
- University of Lisbon
Spinal Cord Injury
At-Home Genital Nerve Stimulation for SCI Bowel
The purpose of this study is to test whether electrical stimulation of the skin in the pelvic area (near the genitals) can reduce the reflexes that cause bowel accidents in people with spinal cord injuries.
- Trial name
- NCT06836739
- Testing
- Genital nerve stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- MetroHealth Medical Center
Axial Spondyloarthritis
British Axial Spondyloarthritis Inception Cohort
The British Axial Spondyloarthritis Cohort (BAxSIC) study has been established under the auspices of the British Society for Spondyloarthritis (BRITSpA) in collaboration with the National Axial Spondyloarthritis Society (NASS) to…
- Trial name
- BAxSIC (NCT05676775)
- Testing
- No intervenetion
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Intraspinal Tumor
Finite Element Study of Biomechanical Changes After Unilateral Hemilamina and Facet Joint Resection of Cervical Spine
Finite element method was used to simulate unilateral hemilaminectomy of cervical spine and facet joint resection of different degrees, and the range of motion and the stress changes of ligament, intervertebral disc and endplate…
- Trial name
- NCT04957056
- Testing
- Hospitalization
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Peking University Third Hospital
Pain, Postoperative, Osteoarthritis
Pain Treatment After Total Knee Replacement - Continuous Epidural Versus Intravenous Patient Controlled Analgesia With Morphine
The study purpose is to compare the effectiveness of different methods for post-operative pain treatment after total knee replacement.
- Trial name
- NCT00270322
- Testing
- Marcaine 0.166% + Fentanyl 3.33 mcg/ml, Morphine sulphate
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rambam Health Care Campus
Lumbar Degenerative Disc Disease
A Prospective Non-concurrent Controlled Evaluation of Open and MAS® PLIF
The study is a prospective non-concurrent controlled observational evaluation of short-term operative results. As such, study sites will capture perioperative (through 6-week postoperative follow-up) case data associated with 10…
- Trial name
- NCT01640977
- Testing
- Open PLIF (posterior lumbar interbody fusion), MAS PLIF
- Where
- 4 sites in United States
- Volunteers
- 67 people
- Sponsor
- NuVasive
ALS (Amyotrophic Lateral Sclerosis)
Developing a Comprehensive Biomarker Panel for Monitoring Progression and Early Detection in ALS Patients
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease for which reliable biomarkers for early diagnosis, prognosis, and patient stratification remain limited.
- Trial name
- UNZUELUZON ALS (NCT07737977)
- Testing
- peripheral venous blood collection, collection of medical data related to patient care
- Where
- 2 sites in France, Spain
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Incomplete Spinal Cord Injury, Exercise Training
Cardiorespiratory Fitness Training in Patients With Incomplete Spinal Cord Injury
The goal of this exploratory randomized controlled trial is to assess the effect of a personalized training intervention during primary rehabilitation of 6 weeks on cardiorespiratory fitness in individuals with subacute (<6…
- Trial name
- FIT@HOME (NCT06259227)
- Testing
- Cardiorespiratory fitness (CRF) training
- Where
- Netherlands
- Volunteers
- 19 people
- Sponsor
- Sint Maartenskliniek
Parkinson's Disease (PD), Spinal Cord Stimulation (SCS)
Trial of Four Spinal Cord Stimulation Paradigms for Gait Impairment in Parkinson's Disease
Patients with PD and SCS treatment for gait impairment entered a cross-over trial of four stimulation paradigms; high frequency/low pulse width, low frequency/high pulse width, Fast-Acting Sub-perception Therapy, and MicroBurst.
- Trial name
- NCT07659405
- Testing
- Stimulation paradigm: High frequency / low pulse width, Stimulation paradigm: Low frequency / high pulse width, MicroBurst
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- University of Aarhus
ALS
NF-κB Inhibition in Amyotrophic Lateral Sclerosis
This is a Phase II, single centre, randomized, parallel, double blind, placebo-controlled clinical trial to determine the safety of Withania somnifera in participants with Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- NIALS (NCT05031351)
- Testing
- Withania somnifera
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Sunnybrook Health Sciences Centre
Spinal Stenosis, Lumbar Region, With Neurogenic Claudication
The MOTION Study - Treatment of LSS With the MILD Procedure
Prospective, multicenter, randomized controlled clinical study examining functional improvement in lumbar spinal stenosis (LSS) patients with neurogenic claudication who are treated with the MILD procedure plus conventional…
- Trial name
- NCT03610737
- Testing
- MILD Procedure, Conventional Medical Management (CMM)
- Where
- 18 sites in United States
- Volunteers
- 155 people
- Sponsor
- Vertos Medical, Inc.
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Alzheimer Disease
- Trial name
- MESO7 (NCT07202494)
- Testing
- Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging)
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
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