Clinical trials: Spinal
Spinal Cord Injury, Tetraplegia
Abdominal Functional Electrical Stimulation (AFES) to Assist Ventilator Weaning in Tetraplegia
Compromised respiratory function as a result of tetraplegia leads to many tetraplegics requiring mechanical ventilation during the acute phase of injury.
- Trial name
- NCT02200393
- Testing
- Abdominal FES
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Glasgow
Hypotension
Transcutaneous Electrical Acupoint Stimulation (TEAS) on Prevention Hypotension in Elderly
Despite prophylactic measures, hypotension remains a common side-effect of spinal anesthesia. Electroacupuncture influences hemodynamics.
- Trial name
- NCT05272033
- Testing
- Transcutaneous Electrical Acupoint Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Konya Meram State Hospital
Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in Inflammatory Rheumatic Disease (PREVENER)
PREVENER is a randomized, open-label, multicenter, phase IV clinical trial designed to evaluate the efficacy and safety of a carotid ultrasound-based strategy for the primary prevention of cardiovascular events in patients with…
- Conditions
- Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Axial Spondy, Systemic Lupus Erythematosus (SLE)
- Trial name
- PREVENER (NCT07611747)
- Testing
- Carotid Ultrasound, High-intensity lipid-lowering therapy, Standard care according to ESC 2021 guidelines
- Where
- 17 sites in Spain
- Volunteers
- 1,944 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Amyotrophic Lateral Sclerosis, Motor Neuron Disease
Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used in Daily Practice by ALS People
"Brain-computer interfaces (BCIs) are computer-based systems that acquire brain signals, analyze them, and translate them into commands that are relayed to an output device to carry out a desired action.
- Conditions
- Amyotrophic Lateral Sclerosis, Motor Neuron Disease, Spinal Cord Diseases, Alternative Communication Devices
- Trial name
- TECH-ICOPA (NCT04380649)
- Testing
- New headset prototype
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Amyotrophic Lateral Sclerosis, Health Adult Subjects
Alter-Ego as an Assistive Robotic Device.
The ALTER-EGO study is a monocentric, observational clinical investigation designed to evaluate the safety, usability, and feasibility of the humanoid robotic platform Alter-Ego as an assistive device in hospital and simulated…
- Trial name
- Alter-Ego (NCT07572838)
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- University of Pisa
Spinal Cord Injury
The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study
To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B)…
- Trial name
- NCT06839300
- Where
- 8 sites in United States, Australia and 6 more
- Volunteers
- 260 people
- Sponsor
- AO Foundation, AO Spine
Spinal Disorder
Multimodal Pain Package vs. Regular Formulation for Pain Management in Ambulatory Spinal Surgery
The purpose of this research is to compare two outpatient pain management strategies in patients undergoing spinal surgeries such as microdiscectomies, foraminotomies, and spinal decompressions.
- Trial name
- NCT05965492
- Testing
- Acetaminophen, Celebrex, Gabapentin
- Sponsor
- University of Miami
Spinal Cord Injuries
Long Duration Activity and Metabolic Control After Spinal Cord Injury
Skeletal muscle is the largest endocrine organ in the body, playing an indispensable role in glucose homeostasis. Spinal cord injury (SCI) prevents skeletal muscle from carrying out this important function.
- Trial name
- NCT03139344
- Testing
- Low-frequency Exercise, High-frequency Exercise
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Richard K Shields
Amyotrophic Lateral Sclerosis
The Effect of Intensive Controlled Exercise in the Early Stages of Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurological disorder characterized by amongst others asymmetric muscle weakness, respiratory insufficiency and spasticity.
- Trial name
- NCT00160004
- Testing
- Intensive Controlled Exercise
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Ankylosing Spondylitis
Efficacy and Safety of Tofacitinib in Subjects With Active Ankylosing Spondylitis (AS)
The purpose of this study is to determine if tofacitinib is safe and effective in subjects with active ankylosing spondylitis.
- Trial name
- NCT03502616
- Testing
- Tofacitinib
- Where
- 99 sites in United States, Australia and 12 more
- Volunteers
- 270 people
- Sponsor
- Pfizer
Lumbar Spinal Stenosis
Postmarket Outcomes Study for Evaluation of the Superion™ Spacer
To compile real-world outcomes of the Superion™ IDS in routine clinical practice.
- Trial name
- PRESS2 (NCT04563793)
- Testing
- Superion™ IDS
- Where
- 23 sites in United States
- Volunteers
- 129 people
- Sponsor
- Boston Scientific Corporation
Neuromyelitis Optica Spectrum Disorder, Transverse Myelitis
Central Pain Study for ABX-1431
This study will determine the safety and tolerability of ABX-1431 in patients with central pain when added on to background pain therapy.
- Conditions
- Neuromyelitis Optica Spectrum Disorder, Transverse Myelitis, Multiple Sclerosis, Longitudinally Extensive Transverse Myelitis
- Trial name
- NCT03138421
- Testing
- ABX-1431 HCl
- Where
- 2 sites in United Kingdom
- Volunteers
- 9 people
- Sponsor
- Abide Therapeutics
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Pregnancy
Optimizing Dose of Bupivacaine in Combined Spinal Epidurals To Reduce Side Effects
The purpose of this study is to determine what dose of medication administered through a combined spinal epidural (CSE) provides the optimal pain relief with the minimal amount of side effects.
- Trial name
- NCT02159807
- Testing
- Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Scoliosis
Value of 3D Modeling in Spine Surgery
Adults (18 years and over) and children (10-17 years of age) scheduled for surgery to correct scoliosis will be included in this study, for which participation will last 6 months.
- Trial name
- NCT02771899
- Testing
- spineEOS software, EOS
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Columbia University
Lumbosacral Radiculopathy
Effects of Multimodal Physical Therapy in Patients With Lumbosacral Radiculopathy
Purposes of the study To investigate the effect of Multimodal Physical Therapy on pain, daiablility H-reflex, and Diffusion Tensor Imaging (DTI) Parameters in Patients With Lumbosacral Radiculopathy.
- Trial name
- NCT06058806
- Testing
- Multimodal Physical Therapy
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Cairo University
Spinal Hypotension, Doppler
Doppler Indices to Predict Spinal Hypotension During Cesarean Section
Spinal anesthesia is safe and advisable anesthetic during cesarean section, despite that spinal induced hypotension is a common associated problem.
- Trial name
- NCT06825806
- Testing
- Femoral artery Doppler
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Chronic Low Back Pain (CLBP)
A Prospective Evaluation of Spinal Cord Induced Muscle Stimulation (MuscleSCS) for the Treatment of Chronic Low Back Pain
This study is a prospective, multi-center study designed to compare the safety and efficacy of spinal cord induced muscle stimulation (MuscleSCS) for the treatment of chronic low back pain.
- Trial name
- MuscleSCS (NCT07215104)
- Testing
- MuscleSCS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Saint Francis Hospital
Gastrointestinal Disease
The Treatment of Acute Gastrointestinal Injury Via Ultrasound-guided Erector Spinae Plane Block
In this single-center, randomized, parallel control clinical trial, patients will be randomly assigned to two groups. The treatment group receives ultrasound-guided erector spinae plane block with routine treatment of Acute…
- Trial name
- NCT04934904
- Testing
- Ropivacaine injection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Amyotrophic Lateral Sclerosis
Contralateral R1 in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Electroneuromyography is an important tool for the diagnosis.
- Trial name
- MOTOBLINK (NCT06206629)
- Testing
- blink reflex evaluation
- Where
- 2 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
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