Clinical trials: Spinal
Vertebral Fracture
Early Percutaneous Vertebroplasty Versus Standard Conservative Treatment in Thoracolumbar Vertebral Fractures
The aim of this study is to evaluate the efficacy of carrying out early vertebroplasty procedure, compared to the standard conservative treatment (corset), in order to prevent residual deformations that could occur in…
- Trial name
- AGIL11 (NCT03617094)
- Testing
- Early percutaneous vertebroplasty (EPV), Standard Conservative treatment (CT)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Postoperative Delirium, Postoperative Neurocognitive Disorder
Correlation Analysis of POD and pNCD in Elderly Spinal Surgery Patients
This study is a prospective cohort study to investigate the differences in serum indexes between elderly spinal surgery patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative…
- Conditions
- Postoperative Delirium, Postoperative Neurocognitive Disorder, Spinal Surgery
- Trial name
- NCT06466083
- Testing
- no intervention
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Xuanwu Hospital, Beijing
Psoriatic Arthritis
Metformin in Psoriatic Arthritis
Psoriatic arthritis (PsA) is a systemic, inflammatory disease. The chronic inflammation in PsA predisposes patients to the metabolic syndrome (MetS). MetS is associated with systemic inflammation and proinflammatory cytokines.
- Trial name
- NCT02188654
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- University of Alexandria
Pressure Ulcer, Spinal Cord Injuries
Use of Adhesive Elastic Taping for the Therapy of Medium/Severe Pressure Ulcers in Spinal Cord Injured Patients
All patients with a significant deficiency of skin sensitivity and reduced mobility are potentially at risk of Pressure Ulcers (PUs), in particular the persons affected by Spinal Cord Injury (SCI), also due to their frequent…
- Trial name
- NCT03220451
- Testing
- Adhesive elastic taping
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Post-operative Pain, Osteoarthritis
Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty
The purpose of this study is to determine the contribution of spinal epimorph to patient's perioperative pain management in Total Knee Arthroplasty (TKA).
- Trial name
- NCT01667445
- Testing
- Epimorph, Spinal analgesia
- Where
- Canada
- Volunteers
- 113 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Familial Amyotrophic Lateral Sclerosis
Treatment of FUS-Related ALS With Betamethasone - The TRANSLATE Study
By doing this study the investigator hopes to learn more about a potential cause of amyotrophic lateral sclerosis (ALS) called "oxidative stress".
- Trial name
- TRANSLATE (NCT03707795)
- Testing
- Betamethasone sodium phosphate/betamethasone acetate (Celestone® Soluspan®), 30 mg IM once a day for four days
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Edward Kasaraskis
TURP Syndrome, Spinal Anesthesia
Comparison of Hemodynamic Effect Between the Spinal Anesthesia and Saddle Block Using Levobupivacaine During Transurethral Resection of the Prostate in Cardiac Elderly Patients
Transurethral resection of the prostate (TURP) is the most common surgical intervention for patients with benign prostatic hyperplasia.
- Trial name
- NCT06014957
- Testing
- spinal anesthesia, saddle block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- New Valley University
Amyotrophic Lateral Sclerosis, Adenosine Triphosphate Activities
Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis
This will be a single center, randomized, double-blind, placebo-controlled pilot study to assess the safety and tolerability of terazosin (TZ) at a dose of 5 milligrams (mg) per os (PO) daily for patients with amyotrophic lateral…
- Trial name
- TZ-ALS (NCT07224269)
- Testing
- Terazosine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Iowa
Lumbar Spondylolisthesis, Arthrosis; Spine
Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope, Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion
To study the clinical efficacy of carosodiumsulfonate and desmopressin in improving the clarity of vision under endoscope, perioperative bleeding volume and anti-inflammatory effect in endoscopic lumbar fusion
- Trial name
- NCT06255366
- Testing
- Caroxime sodium sulfonate, Desmopressin, 0.9% Sodium Chloride Injection
- Volunteers
- 126 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Surgical Site Infections, Lumbar Disc Herniation
The Effect of Number of Showers With 4% Chlorhexidine Gluconate on Prevention of Surgical Site Infections
Surgical site infections (SSIs) are the most common type of nosocomial infection in surgical departments. Although lumbar disc herniation (LDH), which is one of the common cases in neurosurgery, is a serious problem affecting…
- Trial name
- SSI (NCT06801275)
- Testing
- 1 shower with 4% chlorhexidine gluconate, 2 shower with 4% chlorhexidine gluconate
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Lowback and Leg Pain
Analgesic Efficacy of High Frequency Spinal Cord Stimulation
The aim of the study is to compare the efficacy of high frequency (HF SCS) stimulation and sham stimulation (Sham SCS - i.e. no stimulation) and conventional spinal cord stimulation (Conv SCS) on the patient reported global…
- Trial name
- NCT01400282
- Testing
- High frequency spinal cord stimulation
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Ensemble Hospitalier de la Côte
Arthritis, Psoriatic
A Study to Evaluate the Efficacy and Safety of JNJ-88545223 for the Treatment of Participants With Active Psoriatic Arthritis
The purpose of this study is to evaluate how well the study drug JNJ-88545223 works compared with a placebo (an inactive substance) in adults with active psoriatic arthritis (PsA).
- Trial name
- VELOTA (NCT07321873)
- Testing
- JNJ-88545223
- Where
- 75 sites in United States, China and 6 more
- Volunteers
- 157 people
- Sponsor
- Janssen Research & Development, LLC
Spinal Cord Injuries, Spasticity, Muscle
Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury
Spasticity develops months after spinal cord injury (SCI) and persists over time. It presents as a mixture of tonic features, namely increased muscle tone (hypertonia) and phasic features, such as hyperactive reflexes…
- Trial name
- NCT05457205
- Testing
- Electrical neuromodulation
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Mississippi Medical Center
Cesarean Section Complications
Factors Influencing Bradycardia During Spinal Anesthesia in Obstetric Patients Undergoing Cesarean Section
The study titled "Factors Influencing Bradycardia During Spinal Anaesthesia in Obstetric Patients Undergoing Caesarean Section"" aims to investigate the causes and patterns of bradycardia in pregnant women receiving spinal…
- Trial name
- NCT07049705
- Where
- Pakistan
- Volunteers
- 289 people
- Sponsor
- Superior University
Spinal Cord Injury
Cardiovascular Disease Study
Coronary heart disease (CHD) is a leading cause of death in the spinal cord injured (SCI) population, occurring at younger ages than in the able-bodied population.
- Trial name
- NCT00857194
- Testing
- 2 hour Oral Glucose Tolerance Test, Fat Meal Test
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Incomplete Spinal Cord Injury
Mental Practice Impact on Gait and Cortical Organization in Spinal Cord Injury (SCI)
Spinal cord injury (SCI) is a disabling condition that impairs fundamental abilities, such as ambulation, respiration, and toileting. Compromised ambulation is a common, devastating impairment following SCI.
- Trial name
- NCT01302522
- Testing
- Mental practice
- Sponsor
- University of Cincinnati
Spinal Cord Injuries
The Effectiveness of the Wim Hof Method in People with Spinal Cord Injury
People with a spinal cord injury (SCI) often experience secondary medical complications. One of the methods that may help to prevent or deal with secondary complications in people with SCI is the Wim Hof Method (WHM).
- Trial name
- NCT05704322
- Testing
- Wim Hof Methode
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stichting Reade
Ankylosing Spondylitis
16.0040 Ankylosing Spondylitis Study
The purpose of this study was to evaluate extended safety and efficacy of etanercept in adults with Ankylosing Spondylitis.
- Trial name
- NCT00356356
- Testing
- Etanercept
- Volunteers
- 257 people
- Sponsor
- Amgen
ALS (Amyotrophic Lateral Sclerosis)
Safety and Feasibility of the EyeControl Device
The EyeControl device is an eye movement-based communication device in the form of wearable glasses with connected infrared cam-era that tracks the pupil and translates blinks and movements into commands.This study is aimed to…
- Trial name
- NCT02891629
- Testing
- EyeControl device
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Eyefree Assisting Communication Ltd
Brain Injuries, Respiratory Failure
Epidural Spinal Cord Stimulation for Respiratory Recovery in Brain Injury
Patients with severe brain injury may develop impaired respiratory drive, diaphragm dysfunction, prolonged mechanical ventilation, and difficulty recovering spontaneous breathing.
- Trial name
- BREATH (NCT07766681)
- Testing
- Epidural Electrode Implantation
- Where
- 3 sites in China
- Volunteers
- 10 people
- Sponsor
- Zhongda Hospital
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