Clinical trials: Spinal
Chronic Pain
Optimal Duration of Spinal Cord Stimulation Trial Procedure: Length and Diagnostic Accuracy
This study aims to find out the optimal duration (in days) needed for a spinal cord stimulator (SCS) trial procedure for treating chronic pain.
- Trial name
- NCT07016581
- Testing
- Daily survey
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Hyperkyphosis, Adolescent Idiopathic Scoliosis
Validation of Clinical Assessment of Spinal Stiffness
This study aims to validate and verify the reliability of the clinical measures used in the daily routine by doctors and therapists that allow assessing the spinal stiffness in all spatial planes.
- Trial name
- NCT05924581
- Testing
- Clinical assessment of spinal stiffness
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Scientifico Italiano Colonna Vertebrale
Degenerative Disc Disease, Lumbar, Disc Herniation, Lumbar
Satellite™ PEEK Nucleus Replacement Retrospective Analysis
The Satellite™ Retrospective Analysis is an international, retrospective, multi-center, non-interventional post-marketing study designed to document and analyze existing data with the device in a "real-world" setting.
- Trial name
- NCT01110967
- Where
- 3 sites in Czechia, Slovakia and 1 more
- Volunteers
- 40 people
- Sponsor
- Medtronic Spinal and Biologics
Cervical Spinal Cord Injury
Comparing Outcomes of Elbow Extension Tendon Transfers
Active elbow extension has significant functional benefits for individuals with tetraplegia. The proposed work will provide information to assess how effectively people are using their elbow extension tendon transfers, and…
- Trial name
- NCT01204736
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- VA Office of Research and Development
Spinal Anesthesia, Ultrasound
Comparison of the Efficacy of Conventional Landmark, Ultrasound-Assisted, and Real-Time Ultrasound-Guided Techniques in Spinal Anesthesia for Obese Patients
Spinal anesthesia is frequently administered using the conventional landmark technique. Ultrasound is a non-invasive and safe approach.
- Trial name
- NCT06191445
- Testing
- Conventional Landmark Technique, Ultrasound Assisted Technique, Real-Time Ultrasound Guided Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 126 people
- Sponsor
- Uludag University
Spondylolisthesis, Scoliosis
A Prospective Study of Instrumented, Posterolateral Lumbar Fusions (PLF) With OsteoAMP®
OsteoAMP is a novel allograft bone graft substitute (BGS) that has been processed to retain multiple endogenous growth factors for use in spinal fusion.
- Conditions
- Spondylolisthesis, Scoliosis, Intervertebral Disc Disease
- Trial name
- NCT02225444
- Testing
- OsteoAMP
- Where
- 9 sites in United States
- Volunteers
- 42 people
- Sponsor
- Bioventus LLC
Spinal Stenosis Occipito-Atlanto-Axial, Spinal Disease
Streamline Occipito-Cervico-Thoracic System Post-Market Clinical Follow-up
This is a multi-center, post-market, retrospective study design to collect safety and performance data for patients implanted with the Streamline OCT System.
- Conditions
- Spinal Stenosis Occipito-Atlanto-Axial, Spinal Disease, Spinal Stenosis Cervical, Spinal Stenosis Cervicothoracic Region
- Trial name
- OCT PMCF (NCT04171544)
- Testing
- Streamline Occipito-Cervico-Thoracic Spinal Fixation System
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- RTI Surgical
Degenerative Disc Disease
Trial for Treating Painful Degenerative Disc Disease
To evaluate and compare two platelet-based treatments of the functional spinal unit spaced 4 weeks apart to sham procedures for the treatment of degenerative disc disease.
- Trial name
- NCT05287867
- Testing
- Platelet-rich plasma (PRP), Platelet lysate (PL), and Platelet Poor Plasma (PPP)
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Regenexx, LLC
Ossification of Posterior Longitudinal Ligament
A Multi-center Study：Comparison of ACAF and ACCF in the Treatment of Cervical OPLL
Background:The ACAF technology has been in clinical trials for some time. More and more doctors are starting to pay attention to this technology. There are many hospitals in China that have developed this technology.
- Trial name
- NCT03591692
- Testing
- ACAF surgery, ACCF surgery
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Shanghai Changzheng Hospital
Poliomyelitis
Study of Trivalent and Bivalent (Types 1 & 2) Novel Oral Poliomyelitis Vaccines
The main objectives of this study are to : evaluate the safety and tolerability of trivalent novel oral poliovirus vaccines (tnOPV) in healthy adults, young children, and neonates, relative to those receiving control vaccines…
- Trial name
- NCT06137664
- Testing
- Novel oral poliomyelitis vaccine type 1 (nOPV1), Novel oral poliomyelitis vaccine type 2 (nOPV2), Novel oral poliomyelitis vaccine type 3 (nOPV3)
- Where
- 2 sites in Bangladesh
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- PATH
Chronic Spinal Cord Injury
A Trial Investigating the Efficacy and Safety of NVG-291 in Subjects With Chronic Spinal Cord Injury
The goal of this clinical trial is to learn if NVG-291 can improve function in adults with chronic cervical motor-incomplete spinal cord injury. It will also learn about the safety of NVG-291.
- Trial name
- RESTORE (NCT07799532)
- Testing
- NVG-291
- Where
- 23 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- NervGen Pharma
Spinal Cord Injury
Scheduled Telephone Intervention for Individuals With Spinal Cord Injury and Their Families
The purpose of this study is to evaluate whether scheduled telephone intervention with individuals with spinal cord injury (SCI) and their caregivers in the first year following discharge from acute inpatient rehabilitation will…
- Trial name
- SCILink (NCT00693563)
- Testing
- Scheduled Telephone Intervention
- Where
- 2 sites in United States
- Volunteers
- 168 people
- Sponsor
- Jeanne Hoffman
Psoriasis and Psoriatic Arthritis
Bioequivalence Study of Two Products of Apremilast 30 mg Tablets in Healthy, Adult, Human Subjects
An open label, balanced, randomized, two-sequence, two-treatment, two-period, single oral dose, crossover, bioequivalence study in normal, healthy, adult, human subjects under fasting condition
- Trial name
- NCT06084663
- Testing
- Apremilast 30 mg Tablets, Otezla 30 mg film-coated tablets
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Spinal Muscular Atrophy
A Study of Risdiplam (RO7034067) in Adult and Pediatric Participants With Spinal Muscular Atrophy
This is a multi-center, exploratory, non-comparative, and open-label study to investigate the safety, tolerability, PK, and PK/PD relationship of risdiplam in adults, children and infants with Spinal Muscular Atrophy (SMA)…
- Trial name
- Jewelfish (NCT03032172)
- Testing
- Risdiplam
- Where
- 24 sites in United States, Belgium and 7 more
- Volunteers
- 174 people
- Sponsor
- Hoffmann-La Roche
Amyotrophic Lateral Sclerosis
Resting Energy Expenditure Equations in Amyotrophic Lateral Sclerosis, Creation of a ALS-specific Equation
Introduction: Resting energy expenditure (REE) formulas for healthy people (HP) are used to calculate REE (cREE) in amyotrophic lateral sclerosis (ALS) patients.
- Trial name
- NCT03378375
- Testing
- nutritional assessement
- Where
- France
- Volunteers
- 315 people
- Sponsor
- University Hospital, Limoges
Back Pain, Back Pain Lower Back
Use of Ultrasound Imaging in Confirming Osteopathic Spinal Diagnosis
In the field of Osteopathic Medicine, diagnosis of potential areas of dysfunction are diagnosed by the physician using their hands and expertise in noticing subtle differences in symmetry, tone, swelling etc..
- Conditions
- Back Pain, Back Pain Lower Back, Back Pain Lower Back Chronic, Back Pain With Radiation
- Trial name
- NCT07858071
- Testing
- Spinal Ultrasound
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- The Touro College and University System
Stroke, Postural; Defect
Spinal Straightness, Posture And Balance, Physical Performance And Energy Consumption In Individuals With Stroke
Patients diagnosed with ischemic or hemorrhagic stroke who applied to Kırıkkale University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation will be included in the study.
- Conditions
- Stroke, Postural; Defect, Energy Supply; Deficiency
- Trial name
- NCT06699381
- Testing
- use of spinal mouse, Brunnstrom's Hemiplegia Recovery Staging, The six minute walking test (6MWT)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kırıkkale University
Postoperative Pain, Fracture Femur
Preoperative and Postoperative Comparison of Two Nerve Blocks in Intertrochanteric Fracture Surgery
Patients with intertrochanteric femur fractures experience significant perioperative and postoperative pain. Perioperative pain can complicate and prolong the anesthesia process for patients undergoing spinal anesthesia, leading…
- Trial name
- NCT07075432
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Erzincan University
Cervical Spinal Cord Injury, Spine Injury
Dose Escalation Study of AST-OPC1 in Spinal Cord Injury
The purpose of this study is to evaluate the safety of cross sequential escalating doses of AST-OPC1 administered among 5 cohorts at a single time-point between 21 and 42 days post injury, inclusively, to subjects with subacute…
- Conditions
- Cervical Spinal Cord Injury, Spine Injury, Spinal Cord Trauma
- Trial name
- NCT02302157
- Testing
- AST-OPC1
- Where
- 9 sites in United States
- Volunteers
- 25 people
- Sponsor
- Lineage Cell Therapeutics, Inc.
Spinal Cord Injuries
Lower-Limb Exoskeleton Technology for Non-Ambulatory Individuals With Spinal Cord Injury
The purpose of this study is to compare two types of wearable lower-extremity exoskeletons -a self-balancing device lower-extremity exoskeleton and a user-balancing device lower-extremity exoskeleton-to better understand their…
- Trial name
- NCT07128901
- Testing
- Ekso Indego Therapy, Wandercraft Atalante X
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Georgia Institute of Technology
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