Clinical trials: Spinal Bone Metastases
Cancer, Hematologic Malignancies
Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid in the treatment of bone disease from multiple myeloma.
- Conditions
- Cancer, Hematologic Malignancies, Multiple Myeloma, Oncology
- Trial name
- NCT01345019
- Testing
- Denosumab, Zoledronic acid, Denosumab (for the open-label treatment phase)
- Where
- 309 sites in United States, Australia and 27 more
- Volunteers
- 1,718 people
- Sponsor
- Amgen
Vertebral Bony Metastases
Isometric Muscle Training in Patients With Spinal Bony Metastases Under Radiation Therapy
Standard indications for palliative radiation of bony metastases include pain, spinal cord compression, and impending pathologic fractures.
- Trial name
- DISPO (NCT01409720)
- Testing
- exercise
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heidelberg University
Spinal Diseases, Spinal Metastases
Intra-arterial Chemotherapy for Spinal Metastases
Metastatic malignant tumors comprise the vast majority of spinal tumors in adults. The most devastating complication of spinal metastatic disease (SMD) is invasion of the spinal canal and compression of the spinal cord or the…
- Conditions
- Spinal Diseases, Spinal Metastases, Spinal Tumors
- Trial name
- SIAC (NCT01637766)
- Testing
- Melphalan (intra-arterial infusion)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Weill Medical College of Cornell University
Acute Sciatica, Lumbar Disc Herniation
Chiropractic Spinal Manipulative Therapy for Acute Sciatica Secondary to Lumbar Disc Herniation
Comparisons of surgical and non-operative treatment of patients with acute sciatica secondary to lumbar intervertebral disc herniation (AS/LDH) have shown no appreciable difference in outcome.
- Trial name
- NCT01552486
- Testing
- Chiropractic Spinal Manipulative Therapy, Usual Care
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Vancouver General Hospital
Bone Metastases
Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid (Zometa®) in the treatment of bone metastases (lytic bone lesions from multiple myeloma) in subjects with advanced cancer and multiple…
- Trial name
- NCT00330759
- Testing
- Denosumab, Zoledronic Acid
- Volunteers
- 1,779 people
- Sponsor
- Amgen
Spinal Metastases
Preoperative Embolization in Surgical Treatment of Spinal Metastases.
The main purpose of this study is to assess the efficacy of preoperative embolization in decreasing operative blood loss, decreasing the need for intraoperative transfusion and facilitate surgical resection in metastatic spine…
- Trial name
- NCT01365715
- Testing
- Arteriography and preoperative embolization, Arteriography
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord
This phase II clinical trial studies how well thermal ablation and spine stereotactic radiosurgery work in treating patients with cancer that has spread to the spine (spine metastases) and is at risk for compressing the spinal…
- Conditions
- Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine
- Trial name
- NCT02713269
- Testing
- Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Adult Spinal Cord Neoplasm, Recurrent Adult Spinal Cord Neoplasm
Minimally Invasive Surgery in Treating Patients With Spinal Tumors
This randomized clinical trial studies minimally invasive surgery in treating patients with spinal tumors. Posterior spinal tumor resection and anterior and posterior spinal tumor resection are less invasive types of surgery for…
- Conditions
- Adult Spinal Cord Neoplasm, Recurrent Adult Spinal Cord Neoplasm, Spinal Bone Metastases, Spinal Cord Metastases
- Trial name
- NCT01308489
- Testing
- therapeutic conventional surgery, quality-of-life assessment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- City of Hope Medical Center
Degenerative Arthropathy of Lumbar Spinal Facet Joint
Prognostic Factors in Zygapophyseal Osteoarthritis Infiltration: a Prospective Cohort Study
Magnet Resonance Image findings of facet osteoarthritis and patient characteristics are prognostic factors for improving or worsening the clinical outcome after treatment with facet infiltration.
- Trial name
- NCT03304730
- Where
- Brazil
- Volunteers
- 147 people
- Sponsor
- Hospital Israelita Albert Einstein
Spinal Metastases, Breast Cancer
Pathological Fracture in Potentially Unstable Spinal Metastases of Breast Cancer
The purpose of this study is to identify potential risk factors for and determine the rate of pathological fracture for patients which having spine metastases from breast cancer and be defined as potentially unstable (SINS 7-12)…
- Trial name
- NCT03365973
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Ruijin Hospital
Lumbar Herniated Disc
Percutaneous HydroDiscectomy Compared to TESI for Radiculopathy
To compare the outcomes of percutaneous lumbar Hydrodiscectomy (HydroD) with the SpineJet Hydrodiscectomy System to transforaminal epidural steroid injections (TESI) in patients with lumbar radiculopathy due to contained disc…
- Trial name
- NCT02414698
- Testing
- Percutaneous Hydrodiscectomy, TESI
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Montefiore Medical Center
Chronic Low Back Pain (CLBP), Intervertebral Disc Displacement
Sustained Acoustic Medicine for Chronic Low Back Pain Secondary to Herniated Nucleus Pulposus or Other Conditions
ZetrOZ's Ultrasonic Diathermy device is intended for use as a portable and wearable medical device which, when applied to various areas of the body applies Low Intensity Therapeutic Ultrasound (LITUS) to deep tissues.
- Trial name
- NCT02609854
- Testing
- Sustained Acoustic Medicine (SAM)
- Where
- 3 sites in United States
- Volunteers
- 65 people
- Sponsor
- ZetrOZ, Inc.
Metastatic Breast Cancer in the Spine
ZETAMET™ BONE GRAFT IN THE REPAIR OF BONE DEFECTS FROM METASTATIC BREAST CANCER IN VERTEBRAL BONES
ZetaMet™ is indicated for patients with destructive, lytic lesions due to metastatic breast cancer to bone, with or without involvement of other sites, with at least one metastatic lesion located in a vertebral body of the spine…
- Trial name
- ZGMBC (NCT05280067)
- Testing
- ZetaMet™ (ZetaFuse™ Bone Graft)
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Zetagen Therapeutics, Inc
Spinal Neoplasms, Neoplasm Metastasis
Stereotactic Body Radiotherapy Followed by Surgical Stabilization in Spinal Metastases
The aim of this study is to assess pain response after combining stereotactic body radiotherapy (SBRT) and pedicle screw fixation in a 48-hour window for the treatment of painful unstable metastases of the thoracic and/or lumbar…
- Conditions
- Spinal Neoplasms, Neoplasm Metastasis, Radiosurgery, Surgery
- Trial name
- BLEND-II (NCT05060653)
- Testing
- SBRT followed by surgical stabilization within 24-48 hours
- Where
- Netherlands
- Sponsor
- UMC Utrecht
Secondary Bone Cancer, Bone Metastases
MRgFUS Versus EBRT in Patients With Metastatic Non-spinal Bone Disease
The objective of this trial is to collect and compare safety and effectiveness data of Magnetic Resonance guided Focused Ultrasound (MRgFUS) using the ExAblate 2100 device and radiotherapy in the treatment of metastatic bone…
- Trial name
- NCT03404362
- Testing
- Bone Metastases Pain treatment
- Where
- 2 sites in Italy
- Volunteers
- 198 people
- Sponsor
- University of Roma La Sapienza
Spinal Neoplasms
Standard Dose Versus High Dose Stereotactic Spine Radiosurgery for Metastatic Spinal Neoplasms
The goal of this clinical trial is to learn if a higher dose of Stereotactic Spine Radiosurgery (SSRS), an advanced radiation technique, is better for treating cancer that has spread to the spine (spinal metastases).
- Trial name
- NCT07039968
- Testing
- Spine Stereotactic Radiosurgery (SSRS)
- Where
- 2 sites in Taiwan
- Volunteers
- 196 people
- Sponsor
- National Taiwan University Hospital
Metastatic Cancer, Pain
Image-Guided Radiosurgery or Stereotactic Body Radiation Therapy in Treating Patients With Localized Spine Metastasis
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Trial name
- NCT00922974
- Testing
- External beam radiation therapy, Radiosurgery/SBRT
- Where
- 38 sites in United States, Canada and 1 more
- Volunteers
- 399 people
- Sponsor
- Radiation Therapy Oncology Group
Spinal Cord Injuries
Musculoskeletal Plasticity After Spinal Cord Injury
Patients with spinal cord injury (SCI) experience metabolic syndrome, diabetes, obesity, pressure ulcers, and cardiovascular disease at far greater rates than the general population.
- Trial name
- NCT02622295
- Testing
- Single-session electrically induced exercise, Electrically-induced exercise training
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Richard K Shields
Melanoma, Ovarian Cancer
Randomized Study Comparing Two Dosing Schedules for Hypofractionated Image-Guided Radiation Therapy
The purpose of this study is to find out which way of giving high-dose radiation works best for treatment of cancer that has spread to bone, the spine, soft tissue, or lymph nodes.
- Conditions
- Melanoma, Ovarian Cancer, Sarcoma, Bone
- Trial name
- NCT01223248
- Testing
- IGIMRT using a single dose of 24 Gy, IGIMRT 27 Gy in 3 fractions
- Where
- 4 sites in United States, Italy and 1 more
- Volunteers
- 220 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Vertebral Bony Metastases
Intensity-modulated Radiotherapy With Integrated-boost in Patients With Spinal Bone Metastases
The primary goal of the study is to determine the local control-rate after radiotherapy (RT) with and without simultaneous integrated boost (SIB) concepts in patients with bone metastases of the spine.
- Trial name
- IRON-2 (NCT02832765)
- Testing
- A, B, C
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Heidelberg University