Clinical trials: Spinal Cord Injury/Disorder
Tetraplegia, Hypothermia
Body Temperature in Persons With Tetraplegia When Exposed to Cold
The ability to maintain normal body core temperature (Tcore = 98.6°F) is impaired in persons with tetraplegia. Despite the known challenges to the ability of persons with spinal cord injury (SCI) to maintain Tcore, and the…
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT01822535
- Testing
- Midodrine hydrochloride
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injuries
Experience of Rehabilitation Amongst Individuals With Paraplegia
This study is a qualitative study exploring the facilitators to physical and vocational rehabilitation and also explores the barriers in empowering individuals with paraplegia
- Trial name
- NCT05267223
- Testing
- Semi-structured interviews
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Asir John Samuel
Chronic Pain
Evaluation of Alexithymia in Chronic Pain Patients With Spinal Cord Stimulation
The purpose of this study is to investigate the relationship between alexithymia levels and clinical parameters, including pain intensity and quality of life, in chronic pain patients treated with spinal cord stimulation (SCS).
- Trial name
- NCT07696286
- Testing
- Psychometric Questionnaires and Retrospective Data Collection
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Marmara University
Spinal Cord Injuries, Traumatic Spinal Cord Injury
SCIVAX: Biomarkers of Immune Dysfunction and Vaccine Responsiveness in Chronic SCI
The purpose of this observational research study is to better understand immune responses to vaccines against viruses (influenza or SARS-CoV2).
- Conditions
- Spinal Cord Injuries, Traumatic Spinal Cord Injury, Healthy Controls, Flu Vaccine
- Trial name
- SCIVAX (NCT05869968)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Spinal Cord Injuries, Paraplegia
Gait Training for Individuals With Paraplegia Using the H-MEX Exoskeleton
This study evaluates the feasibility and effects of H-MEX powered exoskeleton in individuals with paraplegia as a result of spinal cord injury.
- Trial name
- NCT04055610
- Testing
- Gait training using H-MEX exoskeleton
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Hanyang University Seoul Hospital
Obesity, Metabolic Disease
Diet and Fat Mass After Traumatic Spinal Cord Injury
This is a randomized clinical controlled trial (RCT) to investigate the impact of a personalized nutritional intervention on functional and clinical outcomes the first year after traumatic spinal cord injury.
- Conditions
- Obesity, Metabolic Disease, Spinal Cord Injuries
- Trial name
- NCT04109586
- Testing
- Personalized nutritional therapy
- Where
- Norway
- Volunteers
- 62 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Tetraplegia, Spinal Cord Injuries
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with…
- Conditions
- Tetraplegia, Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions
- Trial name
- BrainGate2 (NCT00912041)
- Testing
- Placement of the BrainGate2 sensor(s) into the motor-related cortex
- Where
- 6 sites in United States
- Volunteers
- 27 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Neuropathic Pain, Allodynia
Botulinum Toxin Type A for Treating Allodynic Pain in SCI and MS
This study will examine the efficacy of Botulinum Toxin Type A ("Botox") in treating Allodynic-type neuropathic pain in people with spinal cord injury or multiple sclerosis.
- Trial name
- NCT01911377
- Testing
- Botulinum Toxin Type A, Normal Saline for Injection
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Manitoba
Spinal Cord Injury
Aquatic vs. Land Locomotor Training Overground Locomotor Training in Improving Ambulatory Function and Health-Related Quality of Life
The aim of this study is to define and evaluate the efficacy of Aquatic Locomotor Training (ALT) compared to overground Locomotor Training in improving ambulatory function and health-related quality of life.
- Trial name
- ALT (NCT02774603)
- Testing
- Aquatic Locomotor Training, Land Locomotor Training
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Spinal Cord Injuries, Rehabilitation
Feasibility of Home-Based Rehabilitation on Body Composition, Some Anthropometric Measures and Muscular Strength After Interruption 4-5 Years of Spinal Cord Injury: Serial Cases Study on ISIS War Survivors in Iraq
Feasibility of Home-Based Rehabilitation on Body Composition, some Anthropometric Measures and Muscular Strength after interruption 4-5 years of Spinal Cord Injury: Serial Cases Study on ISIS War Survivors in Iraq Summary…
- Conditions
- Spinal Cord Injuries, Rehabilitation, Exercises
- Trial name
- HBRP-SCI (NCT06230627)
- Testing
- Home-Based Rehabilitation rogram
- Where
- Tunisia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Mosul
Spinal Cord Injury, Autonomic Dysreflexia
The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury
Dysregulation of blood pressure (BP), secondary to decentralized autonomic nervous system (ANS) control of the cardiovascular system, often results in chronic hypotension and orthostatic hypotension (OH) in persons with spinal…
- Conditions
- Spinal Cord Injury, Autonomic Dysreflexia, Baroreceptor Integrity, Sympathetic Integrity
- Trial name
- NCT02893553
- Testing
- Midodrine Hydrochloride, Pyridostigmine Bromide, Mirabegron
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Spinal Cord Injury at T7-T10 Level, War Injuries Due to Bullets and Fragments
Effects of a Home-Based Rehabilitation on Anthropometric Measures, Sensory-Motor Functions and Independence After Spinal Cord Injury
Background: The scarcity of resources for spinal cord injury (SCI) rehabilitation constitutes a significant obstacle, particularly in war-torn regions experiencing a rise in such injuries.
- Conditions
- Spinal Cord Injury at T7-T10 Level, War Injuries Due to Bullets and Fragments, Spinal Cord Injury L1- L5, Spinal Cord Injury No Sensory/Motor in S4-S5
- Trial name
- HBRSCI (NCT06444672)
- Testing
- Home-based Rehabilitation program, Knee-Ankle-Foot-Orthosis
- Where
- Iraq
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Mosul
Stroke, Able Bodied
Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways
The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons.
- Trial name
- NCT07401186
- Testing
- Bipolar Neural Stimulation Electrode
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Peter C. Gerszten, MD
Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS)
Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)
The goal of this clinical trial is to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different areas of the brain to allow adults affected by disabling paralysis (see Eligibility…
- Conditions
- Tetraplegia/Tetraparesis, Amyotrophic Lateral Sclerosis (ALS), Muscular Disorders, Atrophic, Brain Stem Stroke
- Trial name
- INTENT (NCT07521930)
- Testing
- INTENT Neural Interface System
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Paraplegia, Tetraplegia
Short-Term Transcutaneous or Epidural Spinal Stimulation for Enabling Motor Function in Humans With SCI
A study comparing short-term delivery of epidural spinal stimulation versus transcutaneous spinal stimulation.
- Conditions
- Paraplegia, Tetraplegia, Paralysis, Quadraplegia
- Trial name
- NCT05095454
- Testing
- Percutaneous epidural electrical spinal stimulation, Transcutaneous electrical spinal stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Kristin Zhao, PhD
Spinal Cord Diseases, Spinal Cord Injuries
Multi-speed Ergonomic Wheelchair
Over one million Americans rely on their upper extremities for manual wheelchair propulsion. Shoulder overuse injuries are prevalent among manual wheelchair users and these injuries often result in shoulder pain.
- Trial name
- NCT05776030
- Testing
- Single Speed Ergonomic Wheelchair, Multi-Speed Ergonomic Wheelchair
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Spinal Cord Injuries
Task-oriented Arm/Hand Skill Rehabilitation and Therapy Dose Dimensions in Subacute Spinal Cord Injury Rehabilitation
The study is a multicenter longitudinal observational study. The therapy content and the therapy dosage of arm/skill training for patients with cervical spinal cord injury (SCI) will be observed for the primary objective.
- Trial name
- NCT05452707
- Testing
- Observation and questionnaire of active therapy
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 47 people
- Sponsor
- Hasselt University
Spinal Cord Injuries (SCI), Spinal Cord Injury
Study on Preliminary Safety and Efficacy of Epidural Electrical Stimulation to Manage Lower Urinary Tract Dysfunction After Spinal Cord Injury
This clinical trial aims to assess the preliminary safety and efficacy of Epidural Electrical Stimulation (EES) therapy in managing lower urinary tract dysfunction in individuals with sub-acute or chronic spinal cord injury…
- Trial name
- ReeVoid (NCT06845904)
- Testing
- WaveWriter Alpha™ neurostimulation system
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Spinal Cord Injuries, Exercise Training
Effect of Upper-body Rowing on Cardiometabolic Risk in Spinal Cord Injured Wheelchair Users
This randomized controlled trial will determine the effects of 12-weeks of wheelchair user-modified upper-body rowing on both traditional cardiometabolic risk factors in SCI manual wheelchair users.
- Trial name
- NCT04390087
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Aalborg University