Clinical trials: Spinal Disorder
Orthostatic Hypotension, Spinal Cord Injuries
A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.
The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position.
- Trial name
- NCT00248807
- Testing
- 1.25 mg enalaprilat IV, Head up tilt (HUT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cerebral Palsy, Spina Bifida
Virtual Peer Health Coaching for Adolescents With Disabilities
Participation in physical activity (PA) confers clear physical and psychosocial benefits. Yet, many adolescents with physical disabilities such as cerebral palsy and spina bifida do not engage in regular PA, putting them at…
- Trial name
- NCT05587634
- Testing
- Virtual Peer Health Coaching
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Poliomyelitis, Polio
A Study of the Safety of IMOVAX Polio™ in China
This study is designed to obtain post-marketing safety data on IMOVAX Polio™ vaccine in China. Primary Objective: To describe the safety profile after each dose of IMOVAX Polio™ administered at 2, 3, and 4 months of age in…
- Trial name
- NCT01244464
- Testing
- IMOVAX Polio™-Inactivated types 1, 2, and 3 poliovirus D vaccine
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Sanofi
Spinal Cord Injury, Pain
Neurofeedback Treatment of Pain in Persons With Spinal Cord Injury (SCI)
There has been little research on how chronic pain is related to brain activity. The purpose of this study is to learn more about pain and brain activity by finding any differences in brain activity among people who have moderate…
- Trial name
- NCT00947999
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Washington
Amyotrophic Lateral Sclerosis (ALS)
DNA, Blood and Skin Cell Repository for Research on ALS and Related Neurodegenerative Disorders at Mayo Clinic Florida
This study is intended to obtain clinical information and establish a repository of DNA, RNA, peripheral blood monocyte, lymphocyte and skin tissue samples from people with ALS and related neurodegenerative motor neuron diseases…
- Trial name
- NCT01699451
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Spinal Cord Injuries, Pain, Neuropathic
Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury
The development of neuropathic pain is one of the most debilitating sequels after a spinal cord injury (SCI). The overall aim of this study is to investigate potential underlying pathophysiological mechanisms of neuropathic pain…
- Conditions
- Spinal Cord Injuries, Pain, Neuropathic, Nociceptive Pain, Neuropathy
- Trial name
- NCT06443281
- Testing
- Neurophysiology, Cardiovascular test, Experimental pain paradigms
- Where
- Switzerland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Lumbar Disc Herniation, Radiculopathy Lumbar
Comparison of the Effectiveness of Erector Spina Plane Block and Transforaminal Anterior Epidural Injections
Low back pain is one of the leading causes of disability and its social burden and economic cost are quite high. The lifetime prevalence in the population is frequently reported between 40% and 70%.
- Trial name
- NCT05719792
- Testing
- Transforaminal Epidural Steroid Injection, Erector Spina Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University
Inflammatory Bowel Diseases
Regulation of Mucosal Healing in Inflammatory Bowel Disease
The objective of the current study is to compare non-healing colonic ulcers in patients with inflammatory bowel disease (IBD) with iatrogenic colonic ulcers (biopsy sites) in healthy control patients and patients with rheumatoid…
- Trial name
- NCT04504136
- Testing
- Serial Biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Terrence A Barrett
Radiographic Axial Spondyloarthritis
Respiratory Function and S-index in Radiographic Axial Spondyloarthritis
Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory disease that may lead to reduced chest expansion and impaired respiratory function due to thoracic involvement.
- Trial name
- NCT07515131
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Gazi University
Nerve Pain, Neuropathic Pain
PETMRI for Chronic Pain from Spinal or Peripheral Nerve Origin
The purpose of this study is to compare the uptake of [18F]FTC-146 in healthy volunteers to that of individuals suffering from chronic pain with Spinal or Peripheral Nerve Origin.
- Conditions
- Nerve Pain, Neuropathic Pain, Nociceptive Pain, MIxed Pain (Nociceptive and Neuropathic)
- Trial name
- NCT06599151
- Testing
- [18F]FTC-146
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Stanford University
Rheumatoid Arthritis, Osteoarthritis
Compare the Effect of Eupatilin and Rebamipide on the Prevention of Gastroenteropathy
The purpose of this study is to evaluate the efficacy of eupatilin on the prevention of gastroenteropathy in patients with NSAIDs and low dose steroid by comparing with rebamipide.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis, Other Musculoskeletal Disorder
- Trial name
- CEERS (NCT04885751)
- Testing
- Eupatilin, Rebamipide
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Seoul National University Boramae Hospital
Ankylosing Spondylitis, Swallowing Disorder.Other Specified
Evaluation of Functions of Swallowing and Voice in Ankylosing Spondylitis Patients
In this study was to determine whether changes that occurred over time had an impact on the swallowing and voice functions depend of Ankylosing spondylitis patients.
- Conditions
- Ankylosing Spondylitis, Swallowing Disorder.Other Specified, Voice Alteration
- Trial name
- NCT04437394
- Testing
- flexible endoscopic evaluation of swallowing, The analysis of voice
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yavuz Atar
Degenerative Spine Disease, Sagittal Balance
Evaluation of Deterioration in Body Posture of Older Patients During Gait Compared to Stance
The goal of this observational study is to analyze how spinal alignment changes when walking compared to standing still in adults aged 50 to 80 years who have sagittal imbalance. The main questions we aim to answer are: 1.
- Trial name
- NCT06557837
- Testing
- Questionnaires and pain assessment, Standing sagittal whole spine X-ray, Dynamic test
- Where
- 2 sites in Slovenia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Basal Energy Expenditure, Spasticity
Energy Costs of Spasticity in Spinal Cord Injury: A Pilot Investigation
The purpose of this study is to determine if there is a relationship between spasticity and relative changes in Basal Energy Expenditure in persons with spinal cord injury.
- Trial name
- NCT00572845
- Testing
- Weaning of Antispasticity Medication
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Sarcopenia, Spinal Disease
Spinal Sarcopenia Cohort Study (SarcoSpine)
Sarcopenia on lumbar paraspinal muscles is receiving renewed attention as a cause of spinal degeneration. However, there are few studies on the precise concept and diagnostic criteria for spinal sarcopenia.
- Trial name
- SarcoSpine (NCT03962530)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hypogonadism, Spinal Cord Injury
Provocative Testing Using LHRH and hCG of the Pituitary-Gonadal Axis in Persons With Spinal Cord Injury.
There is evidence that has shown that serum testosterone levels are low in persons with chronic spinal cord injury (SCI). The question arises as to whether the defect in testosterone production is from the hypothalamic pituitary…
- Trial name
- NCT00223860
- Testing
- Human chorionic gonadotropin (hCG), Luteinizing hormone releasing hormone (LHRH)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Poliomyelitis
Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh
The purpose of this clinical trial is to assess the safety and tolerability (primary objective), immunogenicity (primary and secondary objectives), fecal shedding of vaccine viruses (secondary objective) and the potential for…
- Trial name
- NCT05644184
- Testing
- Novel Live Attenuated Type 1 Oral Poliomyelitis Vaccine (nOPV1), Sabin Monovalent Oral Poliomyelitis Vaccine Type 1 (mOPV1)
- Where
- Bangladesh
- Volunteers
- 2,232 people, healthy volunteers welcome
- Sponsor
- PATH
Asthma
The Effect of Anti-IL17 on Airway Hyperresponsiveness and Resistance
This observational longitudinal cohort study aims to assess the effect of monoclonal antibodies targeting interleukin 17 (anti-IL-17) on airway hyperreactivity and airway resistance.
- Trial name
- NCT06224634
- Where
- Denmark
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Poliomyelitis
A Study to Evaluate Immunogenicity of Various Schedules of Inactivated Polio Vaccine
The study will evaluate the humoral immunogenicity in various schedule combinations of full dose inactivated polio vaccines (IPV) via intramuscular administration (IM) and of the fractional dose of inactivated poliovaccine…
- Trial name
- NCT03016949
- Testing
- IPV, f-IPV
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fidec Corporation
Amyotrophic Lateral Sclerosis, Brainstem Stroke
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases.
- Conditions
- Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism
- Trial name
- BCI-FIT (NCT04468919)
- Testing
- BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University