Clinical trials: Spinal Disorder
Osteoarthritis, Hip, Osteoarthritis, Knee
Non-invasive Evaluation of Upper and Lower Body Function With Showmotion
It is very important to understand joint and body kinematics and muscles activity in clinical settings, which is relevant to identify issues related to the spine, the upper and lower limbs due to injury.
- Conditions
- Osteoarthritis, Hip, Osteoarthritis, Knee, Osteoarthritis, Spine
- Trial name
- NCT04137835
- Testing
- Showmotion
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Post Dural Puncture Headache
"Isometric Lower Limbs Exercises Affect on Cardiac Parameters and Headache in Patient After Spinal Anesthesia"
the Objectives of this clinical trial is : 1. Examine the effect of lower limbs isometric muscle exercises on cardiac parameters in patients after spinal anesthesia. 2.
- Trial name
- LILE-SPA (NCT07547150)
- Testing
- Lower Limb Isometric Exercise
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Karbala University
Cannabis Use
Investigating Cannabis Use Parameters on Anesthesia and Inflammation in Lumbar Spinal Surgeries
Cannabis is the most commonly used illicit drug in the United States with reported rates of use increasing from approximately 50 million in 2020 to 61.8 million in 2023 among individuals aged 12 or older.
- Trial name
- NCT07354412
- Where
- 2 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Neurogenic Bladder, Spinal Cord Injuries
Patient Reported Outcomes for Bladder Management Strategies in Spinal Cord Injury
The investigators goal is to create a better understanding of patient reported outcomes for bladder management strategies (clean intermittent catheterization (CIC), indwelling catheter (IDC) and bladder surgery.
- Conditions
- Neurogenic Bladder, Spinal Cord Injuries, Quality of Life, Incontinence
- Trial name
- NBRG-PCORI (NCT02616081)
- Testing
- Clean Intermittent Catheterization, Indwelling Catheter, Surgery
- Where
- 3 sites in United States
- Volunteers
- 1,479 people, healthy volunteers welcome
- Sponsor
- University of Utah
To Evaluate the Effectiveness if Microscope in Discectomy
Short Clinical Outcome of Microscope Assisted Discectomy: Results of 90 Cases in Iraq
A total of (90) patients involved in this study a randomized sampling use. The adult patient between (17) and (50) years of age complaining of lower back pain; and or radiculopathy and neurological symptoms, whom failed to…
- Trial name
- NCT04109781
- Testing
- Microscope assisted discectomy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Radicular Pain, Lumbar Surgery
Return to Work After Lumbar Surgery: a Nationwide Survey of Spinal Surgeons' Practices
This national cross-sectional survey investigates the current practices and perceptions of Belgian spinal surgeons regarding return to work (RTW) after lumbar surgery for radicular pain.
- Conditions
- Radicular Pain, Lumbar Surgery, Radicular Pain Related to Lumbosacral Disc Disease, Fusion of Spine, Lumbar Region
- Trial name
- NCT07193758
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ankylosing Spondylitis (AS)
Phase Ia Study of MST-931 in Healthy Adult Subjects
A Phase 1a, randomized, double-blind study of MST-931 in healthy participants. The purpose of this research is to investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of a single…
- Trial name
- NCT07903493
- Testing
- MST-931
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mabsoft Therapeutics (Shanghai) Co., Ltd.
Spinal Cord Injuries, Amyotrophic Lateral Sclerosis
Interactions Between Neurostimulation and Physical Exercise
People with cervical spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS) have reduced connections in the nerve circuits between the brain and the hands.
- Trial name
- NCT03076632
- Testing
- Cervical plus transcranial stimulation, Cervical stimulation plus hand/wrist exercise, Electromyographic (EMG)-triggered (closed-loop) stimulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bronx VA Medical Center
Amyotrophic Lateral Sclerosis (ALS)
A First in Human Study of ORT247 in Healthy Volunteers
This is a single center, double-blinded, randomized, placebo controlled single ascending dose clinical study, with the primary purpose of evaluating the safety, tolerability, pharmacokinetics (PK), and immunohistochemistry of…
- Trial name
- NCT06769620
- Testing
- ORT247
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Orthogonal Neuroscience Inc.
Spinal Cord Injuries
Postprandial Lipid Tracer and Exercise in Spinal Cord Injury
This study investigates the effect of upper extremity exercise on postprandial lipemia (PPL) in persons with spinal cord injury (SCI).
- Trial name
- PPLT (NCT03691532)
- Testing
- Seated control (CON), Arm cycle exercise (ACE), Liquid meal
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Miami
Amyotrophic Lateral Sclerosis
Investigation of Cannabinoid 2-receptor Expression in the Brain and Spine of ALS-patients Compared to Healthy Controls With PET (18F-RoSMALS)
This clinical trial is a phase 1 study in which investigations with the weakly radioactive substance [18F]-RoSMA-18-d6 are being carried out for the first time.
- Trial name
- 18F-RoSMALS (NCT05880563)
- Testing
- [18F]-RoSMA-18-d6
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Markus Weber
Spinal Muscular Atrophy (SMA), Neuromuscular Disease
Ultrasonographic Muscle Assessment and Functional Scales in Spinal Muscular Atrophy
This study aims to investigate the relationship between ultrasonographic muscle thickness measurement and echogenicity assessment with functional scales in children with spinal muscular atrophy (SMA).
- Trial name
- NCT06599606
- Testing
- Ultrasonographic Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Poliomyelitis
Trail To Evaluate the Immune Effects of Primary and Booster Immunizations With Poliovirus Vaccine
Trail To Evaluate the Immunity Duration of healthy children who already took part in " The safety and immunogenicity by different sequential schedules of bOPV and bOPV in dragee candy with sIPV, a randomized, double blind, single…
- Trial name
- NCT03821441
- Testing
- bOPV(Candy), bOPV(Liquid)
- Where
- China
- Volunteers
- 1,165 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Scoliosis Idiopathic, Scoliosis; Adolescence
Comparison of the Effects of Controlled Schroth Exercise and Home Exercise Programs
The aim of this study is to compare the effects of Schroth 3D exercise method on home symmetry, trunk topography, scapula symmetry, pelvic symmetry, health related quality of life and cosmetic deformity perception in adolescents…
- Trial name
- NCT04203394
- Testing
- Schroth Exercise Group, Home Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Spinal Cord Injury
Mechanisms of Orthostatic Intolerance in Spinal Cord Injured Individuals and Following Bed Rest
The primary purpose of this study is to investigate the relationship between the extent of neurologic (nerve) impairment in patients with spinal cord injuries and how well the nerves passing down the spine to the heart and blood…
- Trial name
- NCT00175773
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Neural Tube Defects, Folic Acid Deficiency
Salt-FA to Increase Folate Levels
Question: How effective is folic acid-fortified iodized salt in increasing serum folate concentrations among non-pregnant and non-lactating women of reproductive age? Hypothesis: Folic acid-fortified iodized salt can increase…
- Conditions
- Neural Tube Defects, Folic Acid Deficiency, Spina Bifida, Anencephaly-Spina Bifida
- Trial name
- NCT06174883
- Testing
- Folic acid fortified iodized salt
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hydrocephalus and Neuroscience Institute
Stroke, Able Bodied
Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways
The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons.
- Trial name
- NCT07401186
- Testing
- Bipolar Neural Stimulation Electrode
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Peter C. Gerszten, MD
Pain, Stenosis
Clinical Outcome Study of the Triad Allograft for Posterior Lumbar Fusion
The purpose of the study is to prospectively measure pain, function, and patient satisfaction in 70 consecutive patients treated by lumbar fusion using the Triad allograft.
- Conditions
- Pain, Stenosis, Spondylolisthesis
- Trial name
- NCT00205101
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Spondyloarthritis, Ruminococcus Gnavus
The Role of Intestinal Microbiota Dysbiosis in the Development of Spondyloarthritis
The primary objective of this case-control study aims to explore the role of bacterium Ruminococcus gnavus (R. gnavus) with intestinal biopsy and faecal sampling in the initiation and the development of spondyloarthritis (SPA) in…
- Trial name
- RUMINOSPA (NCT04853212)
- Testing
- Biopsy
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ankylosing Spondylitis, Rheumatic Arthritis
Biomarkers in Inflammatory Rheumatic Diseases Diagnosis
Ankylosing spondylitis (AS), Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) are three diseases where early diagnosis remains a major challenge.
- Conditions
- Ankylosing Spondylitis, Rheumatic Arthritis, Systemic Lupus Erythematosus
- Trial name
- BIRDD (NCT06778343)
- Where
- Portugal
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa