Clinical trials: Spinal Disorders/Injuries, active
Spinal Cord Injury
The Effect of Probiotic and Prebiotic Supplementation on Gastrointestinal Health in Individuals With Chronic Spinal Cord Injury
The goal of this clinical trial is to evaluate the effect of probiotic and prebiotic supplementation in individuals with chronic spinal cord injury experiencing gastrointestinal complaints.
- Trial name
- PRO-GIDSCI (NCT06870331)
- Testing
- Probiotic, Prebiotic
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Spinal Cord Injury
Improving 24-hour Blood Pressure Stability in Spinal Cord Injury With Low Oxygen Therapy
This study examines the effects of low oxygen therapy (LOT) on the stability of 24-hour blood pressure in persons with chronic cervical spinal cord injury.
- Trial name
- NCT06691165
- Testing
- Low oxygen therapy (LOT)
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Glen Foster
Spinal Cord Injuries
Electrical Stimulation for Spasticity in Spinal Cord Injury
This study examines the immediate and long-term effects of lumbosacral TENS on spasticity and residual voluntary force control in spinal cord injury in comparison to no TENS.
- Trial name
- NCT05103436
- Testing
- TENS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Spinal Cord Injury, Tetraplegia C1-C4
Innovative Brain-Computer Interface for People With Spinal Cord Injury
The goal of this clinical trial is to demonstrate control of digital devices through a brain implant in people with spinal cord injury.
- Conditions
- Spinal Cord Injury, Tetraplegia C1-C4, Quadriplegia
- Trial name
- INTENSE-BCI (NCT07640711)
- Testing
- ECoG (electrocorticography) sensing
- Where
- Netherlands
- Volunteers
- 1 people
- Sponsor
- UMC Utrecht
Spinal Cord Injury (SCI)
Safety and Usability of the ATLAS 2030 Exoskeleton in Pediatric Patients With Spinal Cord Injury
The goal of this clinical trial is to analyze the usability and safety of the robotic gait ATLAS 2030 in a cohort of pediatric patients with Spinal Cord Injury, with the aim of extending its indication for use to pediatric spinal…
- Trial name
- NCT06772077
- Testing
- Rehabilitation treatment with ATLAS2030
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- MarsiBionics
Spinal Cord Injury
Implantable Wireless Brain-Machine Interface System for Spinal Cord Injury: Efficacy and Safety Study
This is a prospective, open-label, multi-center, single-arm study to evaluate the efficacy and safety of an implantable wireless brain-machine interface (BMI) system in patients with spinal cord injury.
- Trial name
- NCT07603752
- Testing
- WRS
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.
Acute Spinal Cord Injury, Blood Pressure
TSCS for Acute SCI
This project will focus on a novel approach to stabilizing blood pressure (BP) during inpatient rehabilitation after acute SCI. After SCI, people have unstable blood pressure, ranging from too low (orthostatic hypotension) to too…
- Conditions
- Acute Spinal Cord Injury, Blood Pressure, Hypotension
- Trial name
- NCT05305118
- Testing
- TSCS Mapping, Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Spinal Cord Injuries
Walking Rehabilitation After Spinal Cord Injury: Locomotor Training Using Adaptive Robotics
Locomotor training is an established rehabilitation approach that is beneficial for improving walking function in individuals with spinal cord injuries (SCIs).
- Trial name
- NCT03504826
- Testing
- Hybrid Assistive Limb (HAL)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Brooks Rehabilitation
Spinal Cord Injuries, Traumatic Spinal Cord Injury
SCIVAX: Biomarkers of Immune Dysfunction and Vaccine Responsiveness in Chronic SCI
The purpose of this observational research study is to better understand immune responses to vaccines against viruses (influenza or SARS-CoV2).
- Conditions
- Spinal Cord Injuries, Traumatic Spinal Cord Injury, Healthy Controls, Flu Vaccine
- Trial name
- SCIVAX (NCT05869968)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Spinal Cord Injuries
Spinal Cord Stimulation for Autonomic Recovery in Inpatient Rehabilitation After Acute SCI
This study is a randomized, single-blind, two-arm sham-controlled clinical trial to evaluate the safety and efficacy of transcutaneous spinal cord stimulation (tSCS) over the lower thoracic and upper lumbar spinal cord segments…
- Trial name
- NCT06540859
- Testing
- Transcutaneous Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Washington
Spinal Cord Injury
C-Brace II Spinal Cord Injury
A randomized, repeated measures comparative design study to compare use of a micro-processor controlled knee-ankle-foot orthosis vs.
- Trial name
- NCT03930056
- Testing
- C-Brace II, Traditional Care KAFO intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Shirley Ryan AbilityLab
Chronic Pain, Chronic Pain Due to Injury
Virtual Pain Education for Spinal Cord Stimulation Patients
Chronic pain is a leading cause of disability in the United States. When standard treatments fail, many patients develop treatment resistant pain and undergo Spinal Cord Stimulation (SCS) therapy.
- Conditions
- Chronic Pain, Chronic Pain Due to Injury, Failed Back Syndrome, Persistent Spinal Pain Syndrome
- Trial name
- SCS-PNE (NCT07743905)
- Testing
- SCS-PNE intervention
- Volunteers
- 50 people
- Sponsor
- University of Arkansas
Spinal Cord Injuries
Spinal Cord Injury Neurorecovery Collaboration
SCINC is an adaptive design Master protocol that seeks to determine if there is "sufficient promise" of beneficial effect of treatment combinations to enhance motor recovery in pre-specified strata of people with a spinal cord…
- Trial name
- SCINC (NCT06871254)
- Testing
- Therapeutic Intermittent Hypoxia (TIH) + Exercise Training (ET)
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- University of Melbourne
Spinal Cord Injury, Acute, Spinal Cord Injury at C4 Level With Complete Lesion
Safety and Exploratory Efficacy of Transplantation Therapy Using PSA-NCAM(+) NPC in AIS-A Level of Sub-acute SCI
This study intends to evaluate the safety and exploratory efficacy of transplantation therapy using neural precursor cells (PSA-NCAM(+) NPC) derived from the human embryonic stem cell line for the treatment of paralysis and other…
- Conditions
- Spinal Cord Injury, Acute, Spinal Cord Injury at C4 Level With Complete Lesion, Spinal Cord Injury at C5-C7 Level With Complete Lesion
- Trial name
- SB-SCI-001 (NCT04812431)
- Testing
- Neural precursor cells derived from human embryonic stem cell line
- Where
- 2 sites in South Korea
- Volunteers
- 5 people
- Sponsor
- S.Biomedics Co., Ltd.
Chronic Spinal Cord Injury
RESTORES Trial: RESToration Of Rehabilitative Function With Epidural Spinal Stimulation
Spinal Cord Injury (SCI), being a devastating diagnosis, has little to no recovery which leads to a long-standing of debilitating impairment for affected patients.
- Trial name
- RS-01 (NCT05644171)
- Testing
- RESToration Of Rehabilitative function with Epidural spinal Stimulation
- Where
- Singapore
- Volunteers
- 18 people
- Sponsor
- National Neuroscience Institute
Spinal Cord Injury
The Effects of Eccentric Compared to Standard Strength Training in Primary Spinal Cord Injury Rehabilitation
The goal of this clinical trial is to assess the effects of eccentric arm-crank (KREHA) training compared to standard clinical routine strength (STAN) training in individuals undergoing primary spinal cord injury (SCI)…
- Trial name
- KREHA3 (NCT06905470)
- Testing
- Eccentric (KREHA) training, Standard clinical routine strength (STAN) training
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma
Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord
This phase II clinical trial studies how well thermal ablation and spine stereotactic radiosurgery work in treating patients with cancer that has spread to the spine (spine metastases) and is at risk for compressing the spinal…
- Conditions
- Malignant Digestive System Neoplasm, Metastatic Head and Neck Carcinoma, Metastatic Kidney Carcinoma, Metastatic Malignant Neoplasm in the Spine
- Trial name
- NCT02713269
- Testing
- Computed Tomography, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Spinal Cord Injuries (SCI)
The Predictive Value of Lower Extremity Hypertonia on Neurogenic Detrusor Overactivity After Spinal Cord Injury
The goal of this observational study is to evaluate whether increased lower extremity muscle tone can serve as an independent predictor of neurogenic detrusor overactivity (NDO) in adult patients (aged 18-80 years) with upper…
- Trial name
- NCT07695662
- Volunteers
- 300 people
- Sponsor
- Shengjing Hospital
Spinal Cord Injuries, Cerebral Palsy
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Spinal Dysraphism, Brain Injuries
- Trial name
- NCT02592291
- Testing
- MHealth
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh