Clinical trials: Spinal Puncture
Spinal Muscular Atrophy, Spine Deformity
Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy
The primary objective of the clinical investigation is to demonstrate successful clinical use of the ThecaFlex DRx™ System in delivering nusinersen in subjects with spinal muscular atrophy (SMA).
- Conditions
- Spinal Muscular Atrophy, Spine Deformity, Scoliosis
- Trial name
- PIERRE (NCT05866419)
- Testing
- ThecaFlex DRx System
- Where
- 21 sites in United States, Germany and 3 more
- Volunteers
- 90 people
- Sponsor
- Alcyone Therapeutics, Inc
NPH (Normal Pressure Hydrocephalus)
The Effects of Exercise on Gait Characteristics, Balance, and Performance in Patients With Normal Pressure Hydrocephalus
The goal of this study is to investigate effect of exercise program on balance, gait and performance in patients with normal pressure hydrocephalus applied with lumbar puncture.
- Trial name
- NCT05679934
- Testing
- Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Dokuz Eylul University
Spinal Puncture Complications
Management Following Lumbar Puncture In Children
The study is carried out in a prospectively randomly controlled way. In the context of acknowledgement and understanding from parents, by comparing with traditional process (lying without the pillow and fasting water and food for…
- Trial name
- MFLPIC (NCT02590718)
- Testing
- optimized postoperative management
- Volunteers
- 200 people
- Sponsor
- Beijing Children's Hospital
Aneurysmal Subarachnoid Hemorrhage, Headache
SubArachnoid Hemorrhage HEadache Treated by Lumbar Puncture
Headache control is one of the major challenges in patients who suffered an acute aneurysmal subarachnoid hemorrhage (aSAH). Headache affects 90% of the patient and is resistant to the major pain medication.
- Trial name
- SAH-HELP (NCT03754335)
- Testing
- Lumbar puncture
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Toulouse
Hematologic Diseases, Neoplasms
A Dose Finding Study of Remifentanil and Propofol for Lumbar Punctures in Children
This study will examine whether the combination of two anaesthetic medications, propofol and remifentanil, is suitable for short duration surgical procedures, providing a shorter recovery time and fewer side effects than either…
- Trial name
- NCT00213239
- Testing
- Remifentanil
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- The Hospital for Sick Children
Cesarean Section, Postoperative Nausea and Vomiting (PONV)
Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery.
- Conditions
- Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus
- Trial name
- NCT07440667
- Testing
- Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h), Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Nigde Omer Halisdemir University
Neurologic Disorder
Stress Ball During Lumbar Puncture the Effect of the Application on Anxiety Level
Individuals who come to the neurology clinic to undergo lumbar puncture, and meet the inclusion criteria, and agree to participate in the study will be given a stress ball during the procedure and will be asked to squeeze this…
- Trial name
- NCT06146543
- Testing
- Stress ball
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Atlas University
Central Nervous System Infections, Pseudotumor Cerebri
A Study to Test Performance of Needle Placements for Neuraxial Procedures Using Tactile Imaging vs Control
This study will compare the VerTouch device to the conventional palpation technique for performing diagnostic and therapeutic neuraxial procedures.
- Conditions
- Central Nervous System Infections, Pseudotumor Cerebri, Neurological Disorder, Cancer
- Trial name
- NCT04796935
- Testing
- Tactile Imaging (VerTouch), Control (palpation)
- Where
- 3 sites in United States
- Volunteers
- 95 people
- Sponsor
- IntuiTap Medical, Inc
Epilepsy
Herpes Virus-6 and Epilepsy
This study will explore whether the human herpes virus-6 is associated with epileptic seizures. The virus may be involved in brain scarring, called mesial temporal sclerosis, which is seen in some epilepsy patients.
- Trial name
- NCT00085683
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Post-Dural Puncture Headache
Contribution of Ondansetron to Preventing Post-Dural Puncture Headaches Following Spinal Anesthesia
A prospective, bicentric, randomized, double-blind controlled study including parturients scheduled for elective caesarean delivery under spinal anaesthesia and randomized and assigned to one of the two groups: Group O…
- Trial name
- OPDPH (NCT06444737)
- Testing
- Intravenous ondansetron, Intravenous normal saline
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- Mongi Slim Hospital
Leukemia, Lymphoma
A Randomized Study Evaluating the Incidence of Post Lumbar Puncture Headache With Atraumatic Needles in Hematology
Lumbar punctures are implemented for the diagnosis of patients with hematologic symptoms as well as for the intrathecal chemotherapy injections.
- Trial name
- SPPLAASH (NCT03126045)
- Testing
- Standard needle, Atraumatic needle
- Where
- 2 sites in France
- Volunteers
- 68 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
HIV - Human Immunodeficiency Virus, Cognitive Symptoms
COMO: Cognition Study With HIV+ Patients (CTNPT 015)
The purpose of this study is to contribute evidence towards the potential to improve cognition in HIV+ individuals experiencing cognitive decline through personalized change in antiretroviral (ARV) medication.
- Trial name
- COMO (NCT02144688)
- Testing
- Change in antiretrovirals
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Marie-Josée Brouillette
Multiple Sclerosis, Chronic Progressive, Nervous System Diseases
Intrathecal Rituximab in Progressive Multiple Sclerosis
The goal of investigators is to study the kinetics of action of a single dose of intrathecally-infused rituximab upon cerebro-spinal fluid (CSF) biological targets in progressive MS patients.
- Trial name
- EFFRITE (NCT02545959)
- Testing
- Rituximab IT, methylprednisolone IV, Rituximab IV
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier de PAU
To Determine the Onset of Analgesia (Numerical Rating Scale for Pain = 1) in Minutes
Comparison of Labor Analgesia Between Modified Combined Spinal-Epidural and Dural Puncture Epidural Techniques
Epidural, Combined Spinal-Epidural, and more recently dural puncture epidural are forms of neuraxial anesthesia used to provide pain relief in laboring women .
- Trial name
- NCT03258879
- Testing
- Modified CSE, Dural puncture epidural
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Ultrasound Therapy; Complications
Utility of Ultrasound-Guided Site Marking in Pediatric Lumbar Punctures
The standard way to identify landmarks in the spine before inserting a needle for a lumbar puncture is to feel by touch. The purpose of this research is to determine if doing an ultrasound to identify landmarks before performing…
- Trial name
- NCT04828746
- Testing
- Ultrasound Guided Skin Marking
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Post-Lumbar Puncture Headache
A Prospective Study of a Modified Lumbar Puncture (LP) Procedure That Reduces Post-Lumbar Puncture Headaches (PLPH) in Patients
The purpose of this study is to o determine whether the modified LP procedure reduces the incidence of PLPH to 5% or lower, to determine whether the modified LP procedure reduces the frequency of epidural blood patch (EBP) usage…
- Trial name
- NCT06062446
- Testing
- Modified Lumbar Puncture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The University of Texas Health Science Center, Houston
HER2 Positive Untreated Metastatic Breast Cancer, Asymptomatic or Low Symptomatic Brain Metastasis in Breast Cancer
Intrathecal Pertuzumab and Trastuzumab in Patients With New Untreated Asymptomatic or Low Symptomatic Brain Metastasis in HER2 Positive Breast Cancer
The purpose of this research study is to determine how well pertuzumab and trastuzumab works in treating breast cancer that has spread to the brain.
- Trial name
- NCT02598427
- Testing
- Pertuzumab, Trastuzumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Kimberly Blackwell
Headache
Juvenile Postlumbar Puncture Headache After Puncture With Needles With Quincke Tip or With Sprotte Tip
The purpose of this study is to compare postlumbar puncture complaints as headache or backache after lumbar puncture with needles with Quincke design or with Sprotte design in children and adolescents.
- Trial name
- NCT00450060
- Testing
- lumbar puncture with Quincke-design needles, lumbar puncture with Sprotte-design needles
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Heidelberg University