Clinical trials: Spinal Reflexes
Healthy
Nervous System Function in Normal Volunteers During Cycling Training
This study will identify changes that occur in the nervous system of healthy normal volunteers while they are learning a cycling task.
- Trial name
- NCT00055588
- Testing
- Locomotor training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Pain
Non-invasive Modulation of Spinal Cord Nociceptive Reflexes
The aims of this study are threefold. First, to investigate whether spinal nociceptive processing - represented here by the nociceptive flexion reflex (NFR) - is influenced by thoracic transcutaneous spinal direct current…
- Trial name
- NCT05711498
- Testing
- Transcutaneous spinal direct current stimulation (tsDCS)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Max Planck Research Group Pain Perception
Relaxation; Joint, Limitation, Mobility
Comparing the Reciprocal Inhibition Method and Post-isometric Inhibition Method of Muscle Energy Technique on the Spinal Reflex Excitability in Healthy Subjects
This a cross-over study to compare the effect of two different muscle energy techniques (MET) including post-isometric inhibition and reciprocal inhibition on the spinal reflex excitability.
- Conditions
- Relaxation; Joint, Limitation, Mobility, Relaxation; Lumbosacral
- Trial name
- NCT03980106
- Testing
- Reciprocal Inhibition Muscle Energy Technique, Post-Isometric Inhibition Muscle Energy Technique
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of North Georgia
Spinal Reflex Excitability, Balance
Effects of EMG-Biofeedback Balance Training on Hoffman's Reflex
The purpose of this study is to gain a further understanding of the effects of EMG-biofeedback balance training and we will be analyzing changes in spinal reflex excitability by responses from the calve muscles and data about…
- Trial name
- NCT06418503
- Testing
- Balance Training, EMG-Biofeedback Training
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- McMaster University
Vibration
Non-invasive Vibratory Stimulation of the Knee Muscles for the Improvement of the Somatosensory Input and Motor Performance
The goal of this interventional cross-sectional study is to evaluate motor responses to non-invasive vibratory stimulation applied to the hamstring muscle tendons in healthy individuals.
- Trial name
- VIBMOT (NCT07424066)
- Testing
- Vibratory stimulation
- Where
- Italy
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Stroke, Healthy
Operant Conditioning for Neuromodulation
Emerging evidence demonstrates that animals and people can exert control over the level of excitability in spinal and corticospinal neural circuits that contribute to movement.
- Trial name
- NCT03461159
- Testing
- Operant conditioning of H-reflexes, Operant conditioning of motor evoked potentials
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stacey Dejong
Compression of Spinal Nerve Root, Spinal Disorder
Soleus H-Reflex in Different Sitting Postures
The purpose of this study was to examine the effect of prolonged sitting duration and three different sitting postures (erect, slumped, and slouched sitting postures) on spinal nerve root function by measuring the soleus (SOL)…
- Conditions
- Compression of Spinal Nerve Root, Spinal Disorder, Low Back Pain
- Trial name
- NCT01744899
- Testing
- Sitting posture
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University
Vibration, H-reflex
Load Dependent Modulation of Spinal Excitability: Linking H-Reflex Supression and Whole Body Vibration Induced Reflex Latency
This study examines how different standing postures and whole-body vibration conditions affect spinal reflex activity. Participants will stand in various positions-with and without vibration of two amplitudes-and H-reflex…
- Trial name
- SRML (NCT07253467)
- Testing
- Whole Body Vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Healthy
Spinal Reflexes in Motor Skill Learning
This study will test a spinal cord reflex called reciprocal inhibition before, during, and after learning a motor skill to see if the reflex becomes stronger by learning the movement.
- Trial name
- NCT00076583
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amyotrophic Lateral Sclerosis
Contralateral R1 in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting both upper and lower motor neurons. Electroneuromyography is an important tool for the diagnosis.
- Trial name
- MOTOBLINK (NCT06206629)
- Testing
- blink reflex evaluation
- Where
- 2 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
H-reflex, Spinal Reflexes
H-Reflex Suppression by Bone Myoregulation Reflex During Mechanical Loading in Standing Humans
This study aims to investigate how standing posture and mechanical loading affect reflex responses in the lower limb. Specifically, it focuses on the H-reflex-a type of spinal cord reflex-and how it changes during quiet standing…
- Conditions
- H-reflex, Spinal Reflexes, Posture, Weight-Bearing
- Trial name
- BMR-HREF (NCT07043595)
- Testing
- Whole-Body Vibration (WBV)
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Cerebral Palsy, Spastic Cerebral Palsy
Operant Conditioning of the Soleus Stretch Reflex in Adults With Cerebral Palsy
12 adults with spastic CP will complete 6 baseline sessions and 24 down conditioning sessions held 3 times/week. All clinical and physiological assessments collected at baseline will be reassessed after study completion, and…
- Trial name
- SRC-CP (NCT05571033)
- Testing
- Spinal reflex conditioning
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Burke Medical Research Institute
Healthy Young Adults
Remote Ischemic Conditioning and Spinal Reflex Modulation
Remote ischemic conditioning (RIC) is a clinically feasible method that protects distant organs from severe injury through brief, sub lethal periods of ischemia followed by re-perfusion.
- Trial name
- NCT06860464
- Testing
- Remote Ischemic Condtioning (RIC), Balance training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Spinal Cord Injury(SCI)
The Reversal of Neuromuscular Adaptation in Human With Spinal Cord Injury II
Following injury to the spinal cord, the spinal circuit undergoes a series of adaptations. In parallel with the spinal circuit adaptation, the muscular properties also adapt.
- Trial name
- NCT01968096
- Testing
- home-based ankle continuous passive motion machine.
- Where
- Taiwan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Subluxation of Joint of Lumbar Spine
The Effects of Spinal Manipulation on Central Nervous System Activity Measured by Reflexive Calf Muscle Recruitment
This study investigated the effects of spinal manipulation on central nervous system activity. The presence of postactivation potentiation, an increase in muscular force production following prior muscular contractions, was…
- Trial name
- NCT02848456
- Testing
- Spinal Manipulation, Max Voluntary Isometric Contraction, SM+MVIC
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Grant Sanders
Restless Legs Syndrome
Effect of Ropinirole on Spinal Cord Reflexes and Restless Legs Syndrome
This study will examine the effects of the drug Ropinirole on spinal cord reflexes and on symptoms of restless legs syndrome (RLS).
- Trial name
- NCT00051961
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hypotension, Spinal Anesthesia
Pupillary Light Reflex to Predict Post-Spinal Hypotension in Elective Cesarean Delivery
This prospective observational cohort study investigates whether pre-anesthetic pupillary light reflex (PLR) parameters can predict the risk of hypotension following spinal anesthesia in women undergoing elective cesarean…
- Conditions
- Hypotension, Spinal Anesthesia, Cesarean Delivery
- Trial name
- NCT07678723
- Testing
- Not applicable- observational study
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Hemiplegia and/or Hemiparesis Following Stroke, Anterior Circulation Stroke of Uncertain Pathology
Effect of Transcutaneous Electrical Nerve Stimulation on Post-stroke Patients
The subjects will be asked to attend minimum 15 separate sessions, 6 for testing changes in reflex behaviors, 3 for testing changes in the influence of descending motor tracts on spinal motor neurons, 3 for each testing…
- Trial name
- TENS (NCT06541015)
- Testing
- InTENSity 10 TENS Stimulator
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Brain Death
Neurophysiological Examination in Patients With Brain Death
This study examines muscle movements of elecromyography in adults with brain death. Half of the participants will have brain death, the other half will be healthy volunteers.
- Trial name
- NCT03262896
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Mental Fatigue
Mental Fatigue Effects on Posture and Spinal Reflexes
This randomized crossover study investigates the effects of mental fatigue on postural control and spinal reflex excitability in healthy physically active adults aged 18-35 years.
- Trial name
- NCT07650903
- Testing
- Mental Fatigue Induction, Control Condition
- Where
- Belgium
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University