Clinical trials: Spinal Surgery
Postoperative Pain
Erector Spinae Plane Block Impact on Quality of Recovery After Lumbar Spinal Decompression
Erector spinae plane block (ESPB) as a new trunk fascia block technique was proposed in 2016. ESPB has aroused the interest of many nerve block experts. The benefits of ESPB are not yet demonstrated.
- Trial name
- ESPB (NCT04943549)
- Testing
- Bupivacain
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Benha University
Shivering
Comparative Study Between the Prophylactic Intravenous Administrations of Acetaminophen vs Dexamethasone vs Pethidine Regarding the Incidence of Shivering Induced by Single Shot Spinal Anesthesia in the Orthopedic Surgeries of the Lower Limbs
Single Shot Spinal anesthesia (SSSA) is associated with considerable perioperative shivering and can be challenging to treat. Some pharmacologic agents like N-methyl d-aspartate receptor antagonists, magnesium sulfate and opioid…
- Trial name
- NCT05284409
- Testing
- Pethidine, Acetaminophen, Dexamethasone
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postoperative Nausea and Vomiting
Gabapentin to Reduce Postoperative Nausea and Vomiting
The intrathecal administration of morphine is gaining popularity. It is easy to do and can reduce the pain after surgery up to 24 hours.
- Trial name
- NCT02944981
- Testing
- Gabapentin
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Spinal Metastases, Spinal Tumor
En Bloc Resection Versus Separation Surgery Combined With Radiotherapy for the Treatment of Spinal Oligometastatic Tumor.
The purpose of this clinical trial is to explore the impact of En bloc surgery and separation surgery combined with radiation therapy on the prognosis and survival of patients with spinal oligometastatic cancer, describe the…
- Conditions
- Spinal Metastases, Spinal Tumor, Radiotherapy, Malignant Bone Tumor
- Trial name
- NCT06120426
- Testing
- total en bloc spondylectomy
- Where
- China
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Knee Surgery, Pelvic Surgery
ED50 of Dexmedetomidine as an Adjuvant to 0.5% Hyperbaric Bupivacaine 12.5 mg for Spinal Anesthesia in Hip and Knee Surgery: An Up-and-Down Method Approach
Determine ED50 dexmedetomidine adjuvant that can provide spinal anesthetic sensory blockade duration of 200 minutes on knee and pelvis surgery with up-and-down method.
- Conditions
- Knee Surgery, Pelvic Surgery, Spinal Aneshtesia
- Trial name
- NCT07144215
- Testing
- Dexmedetomidine 3 mcg, Dexmedetomidine 4 mcg, Dexmedetomidine 5 mcg
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Lumbar Spine Disc Herniation
Effects of Addition of Magnesium Sulfate in Spinal Anesthesia on Sensory-Motor Blocks and Postoperative Pain in Lumbar Disk Herniation Surgery
The purpose of this study is to Compare three methods of intrathecal bupivacaine; bupivacaine-fentanyl; bupivacaine-fentanyl-magnesium sulfate on sensory-motor blocks and postoperative pain in patients undergoing lumbar disk…
- Trial name
- NCT01843296
- Testing
- Magnesium Sulfate, Spinal Anesthesia, Bupivacaine
- Where
- Iran
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Dexamethasone, Spinal Anesthesia
Dexamethasone and Duration of Spinal Anesthesia
This study will evaluate whether intravenous dexamethasone affects the duration of spinal anesthesia in patients undergoing lower abdominal surgery.
- Conditions
- Dexamethasone, Spinal Anesthesia, Adjuvant
- Trial name
- NCT07819682
- Testing
- Dexamethasone
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Pakistan
Lumbar Spinal Stenosis, Spinal Instability
Flexion-Extension Radiograph Imaging Protocol Reliability Study
Orthopedic surgeons often face the dilemma of whether to add fusion to a decompression procedure of the spine. Their decision mainly relies on personal experience to determine if a level is unstable preoperatively or if a…
- Trial name
- NCT05633550
- Testing
- Flexion-extension radiographs
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital
Dexmedetomidine
Dexmedetomidine in Obturator Nerve Block as an Analgesic in Transurethral Surgeries
in our study, we will investigate the impact of adding dexmedetomidine to bupivacaine for the potency of the obturator nerve block and prevention of the postoperative pain associated with transurethral surgery in comparison of…
- Trial name
- NCT06229054
- Testing
- Dexmedetomidine, Bupivacaine Hydrochloride
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cairo University
Arthroscopic Knee Surgery
Study to Find Optimal Dose of Local Spinal Anesthetic (Mepivacaine) Combined With Narcotic (Fentanyl) For Knee Surgery
Prolonged motor block and delayed ability to walk are limitations of spinal anesthesia in ambulatory (same-day) surgery. This can be improved by lowering the dose of local anesthetic (a medication that, when injected around…
- Trial name
- NCT01701102
- Testing
- Mepivacaine (24 mg) plus fentanyl, Mepivacaine (27 mg) plus fentanyl, Mepivacaine (30 mg) plus fentanyl
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Lumbar Disc Herniation
Comparison of Different Treatment Methods in Lumbal Disc Herniation Treatment
The aim of this study is to determine the effectiveness of three different treatment methods which consists spinal decompression, deep friction massage and exercise.
- Trial name
- NCT02572622
- Testing
- non -surgical spinal decompression therapy, deep friction massage,, electrotherapy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia, Orthopedic Hip Sugery in Eldely Patients
Comparison of Norepinehrine Versus Phenylepherine Infusion for Prevention of Post-spinal Hypotension
This prospective randomized double-blinded clinical trial aims to compare the efficacy and hemodynamic effects of prophylactic norepinephrine infusion versus phenylephrine infusion for prevention of spinal anesthesia-induced…
- Trial name
- NCT07662408
- Testing
- Norepinephrine, Phenylephrine
- Where
- Egypt
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Sohag University
Lumbar Disc Herniation
Lidocaine Versus Esmolol for Optimizing Surgical Field Visibility
Intra-operative blood loss is an important attribution and predictor of the lumbar spine surgery and patient outcome. Stripping the muscle off bone makes more exposed bleeding spine surface is one of causes for blood loss during…
- Trial name
- NCT04260685
- Testing
- Lidocaine, Esmolol
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Spinal Diseases, Spinal Fusion
Intraoperative Disinfection by Pulse Irrigation With Povidone-Iodine Solution in Spine Surgery
The purpose of this study was to evaluate the efficacy, in preventing Spinal Surgical Infection, of intraoperative pulsatile irrigation with a 2000-ml saline solution of PVP-Iodine in a group of patients undergoing complex spine…
- Conditions
- Spinal Diseases, Spinal Fusion, Spine Injury, Infection, Hospital
- Trial name
- NCT03249363
- Testing
- Group A - Pulsed PVP-I Irrigation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Rome Tor Vergata
Pain, Postoperative
Does a ThoracoLumbar Interfacial Plane (TLIP) Block With Liposomal Bupivacaine Provide TLIP Block in Spinal Surgery
The investigators are looking to recruit patients into a study demonstrating the effectiveness of a superficial nerve block involving the thoracolumbar interfascial plane (TLIP) in reducing postoperative pain in those undergoing…
- Trial name
- NCT04865211
- Testing
- Liposomal bupivacaine, Bupivacaine Injection
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System
Post-Surgical Complication
Comparsion of IV Dexmedetomidine, Tramdol and Ketamine for Post Spinal Anesthesia Shivering.
To study control of post spinal shivering in patients undergoing lower segment cesarean section using dexmedetomidine, tramadol and ketamine
- Trial name
- NCT05311722
- Testing
- Dexmedetomidine, Ketamine, Tramadol
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Medical College
Low Back Pain, Lumbosacral Radiculopathy
A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief
The purpose of this study is to collect information about how patients feel when doctors manage their pain after lumbar spine surgery using a combination of EXPAREL® and bupivacaine injected into the lumbar spine at the end of…
- Conditions
- Low Back Pain, Lumbosacral Radiculopathy, Lumbar Disc Degeneration, Lumbar Disc Herniation
- Trial name
- NCT03514277
- Testing
- Exparel, Bupivacaine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Pain
The Effect of Pregabalin and Dexamethasone on Acute and Chronic Pain After Lumbar Spinal Surgery
Multimodal analgesia may be important for optimal postoperative pain treatment and facilitation of early mobilization and recovery.
- Trial name
- NCT01168531
- Testing
- Pregabalin, dexamethasone
- Where
- South Korea
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Umbilical Cord Blood, Cesarean Section Surgery
Effect of Delivery Time on Umbilical Cord Blood Gas Parameters in Cesarean Sections Under General and Spinal Anesthesia
The goal of this observational study is to evaluate the effect of neonatal delivery time on umbilical cord blood gas parameters in pregnant women undergoing elective cesarean section under general or spinal anesthesia.
- Conditions
- Umbilical Cord Blood, Cesarean Section Surgery, General Anesthesia, Spinal Anesthesia
- Trial name
- DELTA-CS (NCT07321041)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Vasoplegia
Postoperative Hemodynamics Comparison After High Spinal Block With or Without Intrathecal Morphine.
There is paucity of literature on the effects of intrathecal morphine on the postoperative hemodynamics in the cardiac-surgical patients.We planned this study to compare the post-operative hemodynamic effects (particularly the…
- Trial name
- NCT02825056
- Testing
- Bupivacaine, Bupivacaine + Morphine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh