Clinical trials: Spine Osteoarthritis
Psoriatic Arthritis, Overweight or Obesity
A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)
The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with active PsA and obesity or overweight with at least 1 weight-related…
- Trial name
- NCT06864026
- Testing
- Tirzepatide
- Where
- 55 sites in United States, Puerto Rico
- Volunteers
- 200 people
- Sponsor
- Eli Lilly and Company
Psoriatic Arthritis
Effect of Exercise and Diet on Psoriatic Arthritis
Psoriatic arthritis (PsA) is a particular pattern of inflammatory arthritis often seen in association with psoriasis. PsA patients have a higher prevalence of comorbidities including obesity, metabolic syndrome, depression and…
- Trial name
- NCT02188641
- Testing
- Diet, Exercise, Diet and Exercise
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- University of Alexandria
Arthritis, Rheumatoid, Arthritis, Psoriatic
WORKWELL: Testing Work Advice for People With Arthritis
Background: Inflammatory arthritis (IA) causes work disability, absenteeism (sick leave) and presenteeism (reduced productivity) at high cost to individuals, employers and society.
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Arthritis, Inflammatory
- Trial name
- WORKWELL (NCT03942783)
- Testing
- WORKWELL, Control
- Where
- 18 sites in United Kingdom
- Volunteers
- 249 people
- Sponsor
- University of Salford
Psoriatic Arthritis, Psoriasis
Exploratory Study on Quality of Life in Patient With Moderate Psoriasis and Moderate Psoriatic Arthritis
This exploratory study will be used to identify questions that will be part of a new QoL questionnaire for patients with psoriasis and psoriatic arthritis and to determine the sample size needed for its validation.
- Trial name
- NCT01139918
- Where
- 10 sites in Canada
- Volunteers
- 105 people
- Sponsor
- Innovaderm Research Inc.
Psoriatic Arthritis, Spondyloarthritis, Axial
A Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic Arthritis
A Randomized, Placebo-controlled, Multicenter, Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients with Active Psoriatic Arthritis (UP-SPOUT)
- Trial name
- UP-SPOUT (NCT06454188)
- Testing
- Upadacitinib 15 MG [Rinvoq]
- Where
- 5 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- CARE ARTHRITIS LTD.
Psoriatic Arthritis
Treatment With Apremilast in Patients With Psoriatic Arthritis
Apremilast (Otezla®) is a Federal Drug Administration (FDA)-approved treatment for psoriatic arthritis and psoriasis. Although there are a lot of data demonstrating how apremilast works in the laboratory, there are very few…
- Trial name
- NCT02558361
- Testing
- Treatment with Apremilast
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of South Florida
Arthritis, Spondylitis, Ankylosing
Natural History and Development of Spondyloarthritis
Background: Spondyloarthritis (SpA) is a group of bone and joint disorders that may cause back and joint pain and stiffness. In some cases, SpA can lead to abnormal bone growth affecting the joints and spine.
- Trial name
- NCT01422694
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Psoriatic Arthritis (PsA)
Impact of Glucagon-like Peptide-1 (GLP-1) Analogs on Disease Outcomes in Psoriatic Arthritis: A Pragmatic Randomized Controlled Trial
Psoriatic arthritis (PsA) is a chronic inflammatory condition that affects the joints but can also have an effect on multiple parts of the body.
- Trial name
- NCT07111494
- Testing
- GLP-1 agonists, Nutrition Counseling
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Medical College of Wisconsin
Non-radiographic Axial Spondyloarthritis
Evaluate the Preliminary Efficacy, Safety, and PK of Subcutaneous JS005 in Chinese Adult Patients With Active Nr-axSpA
The purpose of this study is to evaluate preliminary efficacy, safety pharmacokinetic (PK) characteristics, pharmacodynamics (PD) haracteristics and immunogenicity of JS005 at different doses in Chinese patients with active…
- Trial name
- NCT05242588
- Testing
- JS005
- Where
- 25 sites in China
- Volunteers
- 23 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Rheumatoid Arthritis (RA, Ankylosing Spondylitis
Skin Autofluorescence Assessment of Advanced Glycation End Products in Rheumatic Diseases
Rheumatic diseases are chronic inflammatory conditions that can lead to long-term tissue damage and increased cardiovascular and metabolic risk.
- Conditions
- Rheumatoid Arthritis (RA, Ankylosing Spondylitis, Psoriatic Arthritis, Reactive Arthritis (ReA)
- Trial name
- NCT07329556
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Bursa City Hospital
Psoriatic Arthritis
Disease Impact and Its Correlation With Disease Activity in Psoriatic Arthritis
Psoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disorder that causes joint pain, stiffness, skin lesions, and functional disability, significantly affecting patients' quality of life.
- Trial name
- NCT07793773
- Volunteers
- 80 people
- Sponsor
- Assiut University
Enthesitis Related Arthritis (ERA)
A Study of the Efficacy and Safety of Adalimumab in Pediatric Subjects With Enthesitis Related Arthritis
The purpose of this study is to evaluate the efficacy and safety of adalimumab given subcutaneously every other week (eow) as compared to placebo in pediatric subjects with Enthesitis Related Arthritis (ERA).
- Trial name
- NCT01166282
- Testing
- adalimumab
- Volunteers
- 46 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Rheumatoid Arthritis, Inflammatory Arthritis
Safety and Effectiveness of Live Zoster Vaccine in Anti-Tumor Necrosis Factor (TNF) Users (VERVE Trial)
The VaricElla zosteR VaccinE (VERVE) trial evaluates the safety and effectiveness of the Herpes zoster (HZ) vaccine for shingles, Zostavax, in patients over 50 years old with arthritis and other diseases who are using anti-tumor…
- Conditions
- Rheumatoid Arthritis, Inflammatory Arthritis, Arthritis, Psoriatic Arthritis
- Trial name
- NCT02538341
- Testing
- Herpes Zoster (HZ) Vaccine
- Where
- 34 sites in United States
- Volunteers
- 617 people
- Sponsor
- University of Alabama at Birmingham
Psoriatic Arthritis
Mat Pilates Exercise Program in Patients With Axial Psoriatic Arthritis
The aim of this study is to investigate the effectiveness of mat Pilates exercises on spinal mobility, spinal muscle endurance, disease activity, fatigue, emotional well-being, physical performance, and overall quality of life in…
- Trial name
- NCT06176586
- Testing
- Mat Pilates Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Izmir Katip Celebi University
Rheumatoid Arthritis, Psoriatic Arthritis
Therapeutic Strategy Associated With bDMARDs or tsDMARDs in Rheumatoid Arthritis and Psoriatic Arthritis
This is a longitudinal, observational, prospective, multicentre study conducted in France, among a representative sample of rheumatology doctors.
- Trial name
- STRATEGE2 (NCT05082805)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Nordic Pharma SAS
Rheumatoid Arthritis, Sjogren's Syndrome
Creating Health Course Study for People With Rheumatological Conditions and Mood Disorders
The goal of this project is to critically evaluate the effectiveness of an online health program designed to improve diet and self-care in patients with rheumatological conditions, including rheumatoid arthritis (RA), Sjogren's…
- Conditions
- Rheumatoid Arthritis, Sjogren's Syndrome, Systemic Lupus Erythematosus, Mixed Connective Tissue Disease
- Trial name
- NCT07180537
- Testing
- Creating Health Online Course, Delayed access to Creating Health Online Course
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Terry L. Wahls
Ankylosing Spondylitis and Psoriatic Arthritis Patients
TNFAIP3 Gene Expression in Ankylosing Spondylitis and Psoriatic Arthritis Patients and Its Relation to Disease Activity
1. Identify gene expression of TNFAIP3 in ankylosing spondylitis and psoriatic arthritis patients. 2. Detect relation between TNFAIP3 and disease activity. Inclusion criteria: 1.
- Trial name
- NCT07507487
- Testing
- Detection of TNFAIP3 gene expression by real time PCR.
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Asmaa Hassan mohamed Abdel Mawjoud
Arthritis, Psoriatic
A Study of the Safety and Effectiveness of Infliximab for the Treatment of Psoriatic Arthritis
The purpose of this study is to determine if Infliximab is safe and effective in the treatment of psoriatic arthritis. Infliximab (Remicade) targets specific proteins in the body's immune system to help control the development of…
- Trial name
- NCT00051623
- Testing
- Infliximab
- Volunteers
- 70 people
- Sponsor
- Centocor, Inc.
Psoriatic Arthritis
Use of Telemedicine to Address 'Off Target' Symptoms in Psoriatic Arthritis (PsA)
This will be a single-arm interventional study to test the acceptability, feasibility, and effectiveness of structured telemedicine visits to encourage lifestyle changes that will improve quality of life, disease impact, and…
- Trial name
- PsOWell (NCT05631223)
- Testing
- Telemedicine
- Where
- 2 sites in United States
- Volunteers
- 101 people
- Sponsor
- University of Pennsylvania
Inflammatory Bowel Disease
Analysis of Birth Outcomes of Swedish, Danish and Finnish Women Exposed to Remicade With Inflammatory Bowel Disease, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Psoriasis
The purpose of this study is collection and analysis of information pertaining to pregnancy outcomes in women exposed to infliximab during pregnancy, relative to the background risk in similar but non-biologic exposed patients…
- Trial name
- NCT00658827
- Testing
- No intervention
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Janssen Biotech, Inc.