Clinical trials: Spine Osteoarthritis
Psoriatic Arthritis (PsA)
Prevention of Psoriatic Arthritis Inflammation Through Digital Care: A Feasibility Mixed-Methods Study
This is an international, multicentre, feasibility mixed-methods, single-arm study evaluating the implementation of the iPROLEPSIS digital health promotion programme for adults with psoriatic arthritis (PsA) in real-world…
- Trial name
- PPIDC (NCT07772544)
- Testing
- iPROLEPSIS Digital Health Ecossystem
- Where
- 4 sites in Greece, Portugal
- Volunteers
- 72 people
- Sponsor
- Sociedade Portuguesa de Reumatologia
Rheumatoid Arthritis, Psoriatic Arthritis
Yoga-mindfulness for Pain Management in Inflammatory Arthritis
This study evaluates the potential effects on pain, pain-related symptoms and quality of life of a yoga-mindfulness program, compared to patient education and physiotherapy, for patients with inflammatory arthritis and persistent…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Pain
- Trial name
- NCT04065958
- Testing
- Yoga-mindfulness, Patient education and physiotherapy
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Psoriatic Arthritis, Upadacitinib
Upadacitinib Versus IL-17 Inhibitors in Patients With Psoriatic Arthritis
Psoriatic arthritis (PsA) is a chronic inflammatory disease with heterogeneous musculoskeletal and dermatologic manifestations, leading to significant functional impairment and reduced quality of life.
- Conditions
- Psoriatic Arthritis, Upadacitinib, Interleukin-17 Inhibitors
- Trial name
- UVIPWP (NCT07386717)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University First Hospital
Spine Osteoarthritis, Spa Resorts
Effectiveness of Spa Treatment, Outpatient Physiotherapy and no Physiotherapy in Spine Osteoarthritis
In the first study group will participate patients with spine osteoarthritis who will be treated in polish spas in Subcarpathian Region. Complex physiotherapy including balneotherapy will be applied in study group participants.
- Trial name
- NCT03974308
- Testing
- Comprehensive physiotherapy including balneotherapy and filling questionaire, Comprehensive physiotherapy without balneotherapy and filling questionaire, No intervention, only filling questionaire
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- University of Rzeszow
Ankylosing Spondylitis
Electroacupuncture for Relieving Pain in Ankylosing Spondylitis
Background: Ankylosing spondylitis imposes burdens on individuals and society that AS costs 3 times higher than general population. Conventional approaches for AS have their limitation.
- Trial name
- NCT02697968
- Testing
- Electroacupuncture
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Arthritis, Psoriatic
Study Evaluating Safety and Adherence to Treatment With Etanercept in Adults With Psoriatic Arthritis
The aim of this study is to evaluate if the data obtained in controlled clinical trials are confirmed when Enbrel is used in usual clinical practice in Belgium according to local reimbursement criteria.
- Trial name
- PROVE (NCT00938015)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 303 people
- Sponsor
- Pfizer
Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR)
AYLo - AutoimmunitY and Loss of y
The AYLo study (AutoimmunitY and Loss of y - Investigating the Role of Hematopoietic Mutations and Mosaic Mutation in the Y Chromosome in Autoimmune Rheumatologic Diseases) aims to systematically investigate hematopoietic…
- Conditions
- Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR), ANCA Associated Vasculitis (AAV), Idiopathic Inflammatory Myopathies
- Trial name
- AYLo (NCT06696027)
- Testing
- Single nucleotide polymorphisms (SNP), 3'mRNA sequencing, Enzyme-linked immunosorbent assay (ELISA) and Legendplex Array
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Ankylosing Spondylitis
Study Evaluating Enbrel (Etanercept) in Patients With Ankylosing Spondylitis
The purpose of this study is to investigate the incidence of adverse events for patients with AS treated with Enbrel in usual care settings.
- Trial name
- NCT00227227
- Where
- Germany
- Volunteers
- 750 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Spondyloarthritis
A Study of Novel Immune Modulating Biomarkers in Patients With Spondyloarthritis With Axial Involvement
Spondyloarthritis refers to a set of inflammatory disorders that mainly afflict the spine, joints and ligaments. A subtype of spondyloarthritis is Ankylosing Spondylitis - now known as axial spondyloarthropathy - which is…
- Trial name
- NCT01969188
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Psoriatic Arthritis
Monocyte Chemoattractant Protein-1 in Psoriatic Arthritis Patients
1. Evaluate serum levels of (MCP-1) in PsA with or without cardiovascular affaction . 2. Detect subclinical cardiovascular affaction in patients with PsA for early diagnosis and management .
- Trial name
- NCT05637905
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Assiut University
Spondylitis, Ankylosing
Blocking Tumor Necrosis Factor in Ankylosing Spondylitis
The Division of Rheumatology at University of California San Francisco is conducting a research study on the treatment of ankylosing spondylitis (AS) with a new therapy currently used for people with other forms of arthritis.
- Trial name
- NCT00000433
- Testing
- Anti-Tumor Necrosis Factor
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Exercise Capacity, Axial Spondyloarthritis
Exercise Capacity, Cardiovascular Risk Factors and Disease-related Variables in Axial Spondyloarthritis
The investigators aimed to study the associations between exercise capacity and cardiovascular (CV) risk factors in axial spondyloarthritis (axSpA) patients and to determine possible relationships with disease-related variables.
- Trial name
- NCT04706650
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Muğla Sıtkı Koçman University
Platelet-Rich Plasma
Platelet-Rich Plasma (PRP) for Treatment of Symptomatic Lumbar Facet Syndrome of the Spine
The purpose of this study is to investigate the feasibility of standardized autologous platelet rich plasma injections into osteoarthritic lumbar facet joints to treat back pain and improve patient function.
- Trial name
- NCT04522674
- Testing
- Autologous platelet rich plasma
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Colorado, Denver
Ankylosing Spondylitis
Efficacy and Safety of Loxoprofen Hydrogel Patch in Patients With Ankylosing Spondylitis
To assess the efficacy and safety of loxoprofen sodium hydrogel patch (LX-P) versus loxoprofen sodium tablet (LX-T) in patients with active ankylosing spondylitis(AS).
- Trial name
- NCT03800797
- Testing
- Loxoprofen sodium hydrogel patch, Loxoprofen sodium tablet
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Sun Yat-sen University
Osteomyelitis; Vertebra, Endocarditis, Bacterial
T2MR PCR Detection of ESKAPE Pathogens in Patients With Pyogenic Spondylodiscitis and Infective Endocarditis
Our prospective observational study focuses on the rapid detection of etiologic agents of pyogenic spondylodiscitis and infective endocarditis using the T2 Bacteria Panel (T2Biosystems).
- Trial name
- NCT05644990
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Ankylosing Spondylitis
A Study to Evaluate the Long Term Safety and Efficacy of Bimekizumab in Subjects With Ankylosing Spondylitis
This is a study to assess the long term safety and tolerability of bimekizumab in subjects with ankylosing spondylitis
- Trial name
- BE AGILE 2 (NCT03355573)
- Testing
- Bimekizumab
- Where
- 50 sites in United States, Bulgaria and 8 more
- Volunteers
- 255 people
- Sponsor
- UCB Biopharma SRL
Rheumatoid Arthritis, Systemic Lupus
Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease
The overall objective of this project is to study the influence of modern anti-inflammatory treatments in established inflammatory rheumatic diseases (IRD) on antibody response elicited by pneumococcal vaccination using 13-valent…
- Conditions
- Rheumatoid Arthritis, Systemic Lupus, Sjögren Syndrome, Systemic Vasculitis
- Trial name
- IPS-BOOSTER (NCT03762824)
- Testing
- 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Skane
Spondyloarthritis
A Study to Evaluate Efficacy and Safety of Upadacitinib in Adults With Axial Spondyloarthritis
This protocol includes 2 standalone studies with randomization, data collection, analysis and reporting conducted independently.
- Trial name
- SELECT-AXIS 2 (NCT04169373)
- Testing
- Upadacitinib
- Where
- 212 sites in United States, Argentina and 23 more
- Volunteers
- 734 people
- Sponsor
- AbbVie
Rheumatoid Arthritis (RA), Crohn's Disease (CD)
UCB Cimzia Pregnancy Follow-up Study
The purpose of this observational follow-up study is to collect data systematically on pregnancies and offspring of women who become pregnant while participating in a Certolizumab Pegol (CZP) study or whose pregnancies have…
- Conditions
- Rheumatoid Arthritis (RA), Crohn's Disease (CD), Psoriatic Arthritis (PsA), Axial Spondyloarthritis and Ankylosing Spondylitis
- Trial name
- NCT02775656
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Arthritis, Psoriatic
16-week Efficacy and 2-year Safety, Tolerability and Efficacy of Secukinumab in Participants With Active Psoriatic Arthritis
The purpose of this study was to provide 16-week efficacy, safety and tolerability data versus placebo to support the use of secukinumab 150 mg by subcutaneous (s.c.) self-administration with or without a loading regimen and…
- Trial name
- FUTURE 4 (NCT02294227)
- Testing
- Secukinumab
- Where
- 64 sites in United States, Australia and 11 more
- Volunteers
- 341 people
- Sponsor
- Novartis Pharmaceuticals