Clinical trials: Spine Osteoarthritis
Ankylosing Spondylitis
Study to Assess Change in Disease Activity and Adverse Events of RINVOQ in Adult Participants With Ankylosing Spondylitis in the Real-World Japan
Axial spondyloarthritis (axSpA), which encompasses radiographic axSpA (r-axSpA, also known as ankylosing spondylitis [AS]) is an immune-mediated inflammatory disease primarily affecting the axial skeleton.
- Trial name
- SELECT AXIS RW (NCT05609643)
- Where
- 61 sites in Japan
- Volunteers
- 69 people
- Sponsor
- AbbVie
Rheumatoid Arthritis, Polyarthritis
Construct Validity and Responsiveness of EQ-5D-3L in Patients With Rheumatic Disease
The aim of this study is to investigate the construct validity (convergent and known-groups) and responsiveness of EQ-5D-3L in patients with rheumatoid arthritis, polyarthritis, psoriatic arthritis, and ankylosing spondylitis.
- Conditions
- Rheumatoid Arthritis, Polyarthritis, Psoriatic Arthritis, Ankylosing Spondylitis
- Trial name
- NCT06568029
- Testing
- Questionnaire
- Where
- Sweden
- Volunteers
- 77,651 people
- Sponsor
- Karolinska Institutet
Vertebral Osteomyelitis, Spondylodiscitis
Conservative Versus Surgical Treatment of Native Vertebral Osteomyelitis
The optimal treatment of uncomplicated native vertebral osteomyelitis (NVO) is unknown. While some authors recommend surgical treatment (consisting of spinal debridement, decompression and instrumentation using hardware…
- Conditions
- Vertebral Osteomyelitis, Spondylodiscitis, Surgical Procedure, Unspecified
- Trial name
- NCT04436328
- Testing
- Surgical treatment, Antimicrobial treatment
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Lupus or SLE, Spondyloarthritis
Evaluation of Plasma Vitamin C Levels in a Population of Chronic Rheumatism in Immuno-Rheumatology
Scurvy is an almost forgotten carential pathology, caused by a deep vitamin C (or ascorbic acid) deficiency, a priori exceptional in industrialized countries.
- Trial name
- VitCRIC (NCT05345899)
- Testing
- Evaluation of vitamin C level in plasma, Evaluation of quality of life
- Where
- France
- Volunteers
- 107 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Axial Spondyloarthritis, Ankylosing Spondylitis
A Study to Assess the Safety of Subcutaneous Secukinumab for Treatment in Adult Indian Participants With Axial Spondyloarthritis (axSpA), Ankylosing Spondylitis (AS), and Non-Radiographic Axial Spondyloarthritis (nr-axSpA)
The aim of this study is to assess the safety of secukinumab in Indian adult participants with axSpA, AS, and nr-axSpA over a 16-week treatment period.
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, Non-Radiographic Axial Spondyloarthritis
- Trial name
- NCT07737730
- Volunteers
- 60 people
- Sponsor
- Novartis Pharmaceuticals
Comparative Efficacy and Safety of Thalidomide and Sulfasalazine in Moderate to Severe Ankylosing Spondylitis: A Real-World Study From Bangladesh, Condition ...Moderate to Severe Axial Spondyloarthopathy
Comparative Efficacy and Safety of Thalidomide and Sulfasalazine in Moderate to Severe Ankylosing Spondylitis: A Real-World Study From Bangladesh
the present study was conducted to determine the comparative efficacy and safety of thalidomide and SSZ in moderate to severe cases of ankylosing spondylitis in Bangladesh.
- Trial name
- NCT06985134
- Testing
- Comparative Efficacy and Safety of Thalidomide and Sulfasalazine in Moderate to Severe Ankylosing Spondylitis: A Real-World Study from Bangladesh
- Where
- Bangladesh
- Volunteers
- 93 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Arthritis, Psoriatic
Efficacy, Safety, and Tolerability Study of Apremilast to Treat Early Oligoarticular Psoriatic Arthritis.
This clinical study will test the effects of a drug called apremilast in oligoarticular psoriatic arthritis with less than 5 years of disease duration.
- Trial name
- FOREMOST (NCT03747939)
- Testing
- Apremilast (CC-10004)
- Where
- 114 sites in United States, Austria and 9 more
- Volunteers
- 310 people
- Sponsor
- Amgen
Ankylosing Spondylitis
Interleukin-17 (IL-17) Inhibitor in Combination With Tumor Necrosis Factor α (TNFα )Inhibitor for the Treatment of Ankylosing Spondylitis
The aim of the study is to investigate the efficacy and safety of adalimumab in combination with secukinumab for the treatment of ankylosing spondylitis.
- Trial name
- NCT06833112
- Testing
- Secukinumab, Adalimumab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Affiliated Hospital Of Guizhou Medical University
Brucella Spondylitis
Radiomics Analysis Based on MRI to Detect Brucella Spondylitis
Brucella spondylitis, an infectious spinal disease caused by the invasion of Brucella bacteria into the body. Its diagnosis relies mainly on laboratory and imaging tests.
- Trial name
- NCT06220500
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Affiliated Hospital of Inner Mongolia Medical University
Spinal Tuberculosis
Cobalt Alloy Pedicle Screw Implantation for Severe Kyphosis Deformity in Spinal Tuberculosis
To investigate whether implantation of cobalt alloy pedicle screws is effective in treating severe kyphosis deformity in spinal tuberculosis, and to determine the factors that are likely to have influenced the curative effects.
- Trial name
- NCT02971644
- Testing
- cobalt alloy pedicle screw implantation
- Volunteers
- 84 people
- Sponsor
- Affiliated Hospital of Hebei University
Arthritis, Rheumatoid, Spondyloarthritis
Accelerometry in Follow up of Arthritis - a Pilot Study
This is a proof-of-concept study. The main goal is to evaluate if the accelerometry signal recorded from patients with arthritis in different disease activity stages, allows for assessment of the activity status.
- Conditions
- Arthritis, Rheumatoid, Spondyloarthritis, Psoriatic Arthritis
- Trial name
- WIAp (NCT05301621)
- Testing
- Akcelerometry follow up
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Helse Forde
Cohort Study, Psoriatic Arthritis (PsA)
APACHE Cohort (A Psoriatic Arthritis CoHort)
Psoriatic arthritis (PsA) is a chronic inflammatory rheumatic disease, belonging to the wide spectrum of spondyloarthritis, but with the particularity to be associated with personal psoriasis or familial psoriasis.
- Conditions
- Cohort Study, Psoriatic Arthritis (PsA), Recent Peripheral Arthritis
- Trial name
- APACHE (NCT03768271)
- Where
- 3 sites in France
- Volunteers
- 425 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Psoriatic Arthritis
Neuropathic Pain in Psoriatic Arthritis
Pathogenesis of inflammatory diseases is suitable for eliciting neuropathic pain. The aim of this study is to evaluate the frequency of NP among PsA patients and relationship between disease activity, quality of life…
- Trial name
- NCT05223049
- Testing
- painDETECT questionnaire, Douleur Neuropathique 4 questionnaire (DN4), Short form-36
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Bezmialem Vakif University
Arthritis, Psoriatic, Psoriasis
Mind Matters: A High Touch, Low Cost Approach to Improving Mental Health Outcomes in Patients With Psoriatic Diseases
Despite advances in effective psoriatic disease treatment, the disease still has a serious impact on mental health and well-being of millions of patients.
- Trial name
- NCT05571696
- Testing
- Immune Strength
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Elaine Husni
Ankylosing Spondylitis
An Observational, Retrospective, Multicenter, National Study for the Monitoring of Subjects Who Participated in the LoadET Clinical Trial
Previous studies suggest that an increase in doses of weekly etanercept from 50 mg to 100 mg improves the efficacy of the treatment in patients with cutaneous psoriasis, rheumatoid arthritis, and psoriatic arthritis.
- Trial name
- RELOADET (NCT01793285)
- Testing
- ETANERCEPT
- Where
- 15 sites in Spain
- Volunteers
- 85 people
- Sponsor
- Pfizer
Knee Osteoarthristis, Hip Osteoarthritis
Clinical Validation of SMARTDIAGO for Remote Functional Assessment of Musculoskeletal Conditions
Clinical validation of SMARTDIAGO, an artificial intelligence-based system for remote functional assessment of patients with musculoskeletal disorders and functional frailty.
- Conditions
- Knee Osteoarthristis, Hip Osteoarthritis, Spine Disease, Shoulder Disease
- Trial name
- SMARTDIAGO (NCT07880210)
- Testing
- SMARTDIAGO Remote Functional Assessment
- Where
- 2 sites in Chile
- Volunteers
- 350 people
- Sponsor
- University of Chile
Psoriasis, Psoriatic Arthritis
Effectiveness of Interdisciplinary Care Compared to Usual Care in Patients With Immune-Mediated Inflammatory Diseases
The overall aim of this study is to determine the effectiveness of an interdisciplinary combined clinic intervention compared to usual care in a population of patients with two or more Immune-mediated inflammatory diseases…
- Conditions
- Psoriasis, Psoriatic Arthritis, Axial Spondyloarthritis, Hidradenitis Suppurativa
- Trial name
- NCAS-1 (NCT04200690)
- Testing
- Interdisciplinary management, Usual-care management
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University of Aarhus
Axial Spondyloarthritis, Psoriatic Arthritis
Secukinumab (Cosentyx®) Effectiveness in Axial Spondyloarthritis and Psoriatic Arthritis Patients Using Artificial Intelligence (SpAINET): Spanish Multicenter, Retrospective, Real World Evidence Study
This was a multicenter, retrospective, and non-interventional study using secondary data captured in the Electronic Health Records (EHRs).
- Trial name
- NCT05677542
- Testing
- secukinumab
- Where
- 3 sites in Spain
- Volunteers
- 758 people
- Sponsor
- Novartis Pharmaceuticals
Axial Spondyloarthritis, Ankylosing Spondylitis
Vilamakitug in Spondyloarthritis Placebo-controlled Investigation for Efficacy
The goal of this clinical trial is to find out if the study drug will work as a new therapy for axSpA patients. This study is placebo-controlled, and evaluates if study drug can treat symptoms of axSpA, including global disease…
- Conditions
- Axial Spondyloarthritis, Ankylosing Spondylitis, r-axSpA, Nr-axSpA
- Trial name
- V-SPINE (NCT06526377)
- Testing
- vilamakitug
- Volunteers
- 150 people
- Sponsor
- XBiotech, Inc.
Crohn's Disease, Rheumatoid Arthritis
OTIS Cimzia Pregnancy Registry
The purpose of the OTIS Autoimmune Diseases in Pregnancy Study is to monitor planned and unplanned pregnancies exposed to certain medications, to evaluate the possible teratogenic effect of these medications and to follow live…
- Conditions
- Crohn's Disease, Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01797224
- Where
- United States
- Volunteers
- 925 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
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