Clinical trials: Spondylarthropathy
Axial Spondyloarthritis
Microbiome and Axial Spondyloarthritis
The purpose of this interventional study is to identify the root cause(s) of AxSpA (Axial Spondyloarthritis) relapses, which are likely due to the combination of nutrition, gut microbiome activities, leaky gut, and human genes…
- Trial name
- NCT04713995
- Testing
- Dietary recommendations
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Viome
Psoriatic Arthritis
Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Psoriatic Arthritis Who Have an Inadequate Response or Are Intolerant to Biologic DMARD Therapy
The primary objective of this study is to evaluate the effect of filgotinib compared to placebo as assessed by the American College of Rheumatology 20% improvement (ACR20) response in participants with active psoriatic arthritis…
- Trial name
- PENGUIN 2 (NCT04115839)
- Testing
- Filgotinib
- Where
- 59 sites in United States, Australia and 9 more
- Volunteers
- 106 people
- Sponsor
- Gilead Sciences
Psoriatic Arthritis, Psoriasis
Pain Mechanisms and Ultrasonographic Disease Activity in Psoriatic Arthritis
The objective of the study is to investigate pain mechanisms, comorbidity status, biomarkers, patient reported outcome measures, ultrasonographic (US) inflammatory activity and association between these features in patients with…
- Conditions
- Psoriatic Arthritis, Psoriasis, Healthy Controls
- Trial name
- PIPA (NCT02572700)
- Testing
- Clinical examination, blood sampling, ultrasonic assessment, and questionnaires
- Where
- Denmark
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Frederiksberg University Hospital
Spinal Spondyloarthropathies, Axial Spondyloarthritis
Diagnostic Criteria in the Diagnosis of Spinal Spondyloarthropathies in Patients With Chronic Low Back Pain (Study P05320)(COMPLETED)
This is a multi-national, multi-site, observational study to determine which of two strategies, when used by referring physicians is superior in the diagnosis of axial spondyloarthritis (AS) by rheumatologists.
- Trial name
- NCT00726765
- Volunteers
- 1,090 people
- Sponsor
- Merck Sharp & Dohme LLC
Psoriasis, Psoriatic Arthritis
Role of Intermittent Fasting in Psoriasis and Psoriatic Arthritis
Our study aims to determine whether intermittent fasting (IMF) is a valid method to improve psoriasis and psoriatic arthritis (PsA) disease severity and quality of life.
- Trial name
- NCT05590247
- Testing
- Intermittent Fasting Diet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Ankylosing Spondylitis
Genetic Determinants of Ankylosing Spondylitis Severity
This study will explore how genes-units of heredity-may influence the severity of ankylosing spondylitis. It will examine whether some genes may cause people with ankylosing spondylitis to have more rapid fusion of the bones of…
- Trial name
- NCT00056849
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Rheumatoid Arthritis, Bone Resorption
Differences in Bone Cell Activity Between Rheumatoid Arthritis and Ankylosing Spondylitis
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are characterized by chronic systemic inflammation and share common pathogenic pathways.
- Conditions
- Rheumatoid Arthritis, Bone Resorption, Ankylosing Spondylitis
- Trial name
- NCT01417455
- Where
- Portugal
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Instituto de Medicina Molecular João Lobo Antunes
Axial Spondyloarthritis and Ankylosing Spondylitis
Effects of Land- and Water-Based Exercise in Axial Spondyloarthritis
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by pain, morning stiffness, restricted spinal mobility, and systemic manifestations.
- Trial name
- NCT07833033
- Testing
- Land-Based Combined Exercise Program, Aquatic Combined Exercise Program, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Izmir University of Economics
Psoriasis, Psoriatic Arthritis
Immune Metabolic Associations in Psoriatic Arthritis
To use apremilast in clinical practice as a molecular probe to evaluate the effects of PDE4 inhibition on the cardiometabolic status and immune profile in patients with PsA and psoriasis.
- Trial name
- IMAPA (NCT03399708)
- Testing
- Apremilast 30mg
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS Greater Glasgow and Clyde
Nr-axial Spondyloarthritis, Non-Radiographical Axial Spondyloarthritis
Efficacy and Safety of Xeligekimab in the Treatment of Non-Radiographic Axial Spondyloarthritis
Subjects who have signed the informed consent form will undergo examinations and assessments according to the inclusion/exclusion criteria specified in the trial protocol.
- Trial name
- NCT07339566
- Testing
- Xeligekimab injection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Lingli Dong
Psoriasis, Psoriatic Arthritis
Identification of New Prognostic Markers in Psoriatic Arthritis
Identification of possible markers associated with the onset and / or progression of psoriatic arthritis through comparison in patients with psoriasis alone (Ps) and patients with psoriasis with joint involvement (PsA), plasma…
- Trial name
- NCT03455166
- Testing
- Serum Markers
- Volunteers
- 100 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Rheumatoid Arthritis, Spondylitis, Ankylosing
Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases
Introduction: Patients with autoimmune rheumatic diseases (ARDs), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PAs), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), primary…
- Conditions
- Rheumatoid Arthritis, Spondylitis, Ankylosing, Spondyloarthritis, Systemic Lupus Erythematosus
- Trial name
- RZVRheum (NCT05879419)
- Testing
- Recombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation
- Where
- Brazil
- Volunteers
- 2,005 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Ankylosing Spondylitis (AS), Back Pain
Efficacy of the Erector Spinae Plane Block for Persistent Back Pain in Patients With Ankylosing Spondylitis
Despite adequate control of disease activity with standard medical therapies, there remains an ongoing need for complementary and interventional approaches for the management of persistent back pain in patients with ankylosing…
- Conditions
- Ankylosing Spondylitis (AS), Back Pain, ESPB, Regional Anesthesia
- Trial name
- NCT07633730
- Testing
- Erector spinae plane block(ESBP)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Marmara University
Psoriatic Arthritis
Study of ATI-450 vs Placebo in Patients With Moderate to Severe Psoriatic Arthritis
This is a Phase 2a study to investigate the efficacy, safety, tolerability, PK, and PD of ATI-450 versus placebo in patients with moderate to severe psoriatic arthritis.
- Trial name
- NCT05511519
- Testing
- ATI-450
- Where
- 22 sites in United States, Poland
- Volunteers
- 47 people
- Sponsor
- Aclaris Therapeutics, Inc.
Ankylosing Spondylitis
Total Glucosides Paeony Capsules in Maintaining Clinical Remission in Patients With Ankylosing Spondylitis Which Achieve Clinical Remission After Anti-TNF Therapy
This is a prospective, randomized, open-label clinical trial to evaluate the efficacy and safety of total glucosides paeony capsules in maintaining clinical remission in patients with ankylosing spondylitis which achieved…
- Trial name
- NCT01517620
- Testing
- Total Glucosides Paeony Capsules
- Where
- 2 sites in China
- Volunteers
- 38 people
- Sponsor
- Sun Yat-sen University
Arthritis, Psoriatic
A Study of Guselkumab in Participants With Psoriatic Arthritis (PsA) in a Real-World Setting
The purpose of this study is to assess how well guselkumab works in improving symptoms of psoriatic arthritis (an inflammatory disease that affects the joints in participants with psoriasis, a skin condition that causes red…
- Trial name
- GURU (NCT07220824)
- Where
- 21 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Janssen Research & Development, LLC
Psoriatic Arthritis
Effectiveness of Treatment With Tofacitinib in Patients With Psoriatic Arthritis in Routine Clinical Practice
This is a Multinational Study of Tofacitinib in Patients Treated for Psoriatic Arthritis in order to evaluate the effectiveness of treatment with tofacitinib on disease activity, remission, and Quality of Life, in a real-world…
- Trial name
- NCT04517669
- Where
- 41 sites in Belgium, Denmark and 6 more
- Volunteers
- 116 people
- Sponsor
- Pfizer
Spondylitis, Ankylosing
A Study Investigating an Exercise and Education Programme for Individuals With Ankylosing Spondylitis
Ankylosing Spondylitis(AS) is a chronic, inflammatory, rheumatic disease (Khan, 2002). AS is associated with increased work disability and use of healthcare resources (Ward et al, 2008).
- Trial name
- NCT00764686
- Testing
- Exercise and Education
- Where
- Ireland
- Volunteers
- 18 people
- Sponsor
- University College Dublin
Erosive Osteoarthritis, Psoriatic Arthritis
microRNA in Erosive Hand Osteoarthritis and Psoriatic Arthritis
Erosive osteoarthritis of the hand (EHOA) is a rare subset of HOA that affects mainly postmenopausal middle-aged women, featured by prominent signs of inflammation, severe progression, and typical radiographic changes of the…
- Trial name
- NCT05683769
- Testing
- miRNA
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Siena
Psoriatic Arthritis
Psoriatic Arthritis D2P Screening
The overarching goal of this study is to develop a direct-to-patient screening approach that will improve early Psoriatic Arthritis (PsA) detection in patients with psoriasis.
- Trial name
- NCT04110522
- Testing
- Direct to patient PsA Screening Questionnaire
- Where
- 2 sites in United States
- Volunteers
- 18,000 people
- Sponsor
- Jessica Walsh
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